A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: Implication for treating hyperproliferative disorders

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Huwiler, Andrea ^a   Bourquin, Florence ^b   Kotelevets, Nataliya ^a   Pastukhov, Oleksandr ^a   Capitani, Guido ^c   Grütter, Markus G ^b   Zangemeister Wittke, Uwe ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CONNECTIVE TISSUE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; DRUG DERIVATIVE; LYASE; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE LYASE (ALDOLASE); SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE 1-PHOSPHATE LYASE (ALDOLASE);

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOMA CELL; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRAIN MCF 7; CELL TYPE; CHORIOALLANTOIS; CONTROLLED STUDY; DISEASE MODEL; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESANGIUM CELL; MOUSE; NONHUMAN; PROKARYOTE; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SYMBIOBACTERIUM THERMOPHILUM; WILD TYPE; ANIMAL; CHICK EMBRYO; DRUG EFFECT; HYDROLYSIS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); TUMOR CELL LINE;

MUS; PROKARYOTA; SYMBIOBACTERIUM THERMOPHILUM;

ALDEHYDE-LYASES; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CHICK EMBRYO; HYDROLYSIS; LYSOPHOSPHOLIPIDS; MICE; NEOVASCULARIZATION, PATHOLOGIC; SPHINGOSINE;

EID: 79960934070     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022436     Document Type: Article

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