Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium

Journal of Antibiotics

Volumn 53, Issue 8, 2000, Pages 759-764

  Kono, K ^a   Tanaka, M ^a   Ogita, T ^a   Kohama, T ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC COMPOUND; B 5354A; B 5354B; B 5354C; FUNCTIONAL GROUP; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; SPHINGOSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; IC 50; KINETICS; LIVER CYTOSOL; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

EID: 0033863770     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.759     Document Type: Article

References (18)

1. Sphingosine 1-phosphate: A prototype of a new class of second messengers
2. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
3. B-5354a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determination
4. Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways
5. N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets
6. Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities
7. Protein kinase C and platelet inhibition by D-erythro-sphingosine comparison with N,N-dimethylsphingosine and commercial preparation
8. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
9. F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete
10. Sphingolipid base metabolism
11. Scyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissiama: Taxonomy of the producing organism, fermentation, isolation and physico-chemical properties
12. Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells
13. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
14. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation
15. Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway
16. Effect of acidic phospholipids on sphingosine kinase
17. A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma
18. N,N-dimethylsphingosine phosphorylation in human platelets