S1P 3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

Cardiovascular Research

Volumn 85, Issue 3, 2010, Pages 484-493

  Takuwa, Noriko ^a,b   Ohkura, Sei Ichiro ^a   Takashima, Shin Ichiro ^a   Ohtani, Keisuke ^a   Okamoto, Yasuo ^a   Tanaka, Tamotsu ^c   Hirano, Kaoru ^c   Usui, Soichiro ^a   Wang, Fei ^a   Du, Wa ^a   Yoshioka, Kazuaki ^a   Banno, Yoshiko ^d   Sasaki, Motoko ^a   Ichi, Ikuyo ^e   Okamura, Miwa ^f   Sugimoto, Naotoshi ^a   Mizugishi, Kiyomi ^a   Nakanuma, Yasuni ^a   Ishii, Isao ^g   Takamura, Masayuki ^a   Kaneko, Shuichi ^a   Kojo, Shosuke ^e   Satouchi, Kiyoshi ^c   Mitumori, Kunitoshi ^f   Chun, Jerold ^h   Takuwa, Yoh ^a   more..

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b ISHIKAWA PREFECTURAL NURSING UNIVERSITY   (Japan)

^c FUKUYAMA UNIVERSITY   (Japan)

^d GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e NARA WOMEN'S UNIVERSITY   (Japan)

^f TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^g GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cardiac fibrosis; Ischemia reperfusion injury; Reactive oxygen species; S1P 3; Sphingosine kinase 1 transgenic mouse

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; CANDESARTAN HEXETIL; HYDRALAZINE; MALONALDEHYDE; N 2 MERCAPTOPROPYONYLGLYCINE; PITAVASTATIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD3 PROTEIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; SPHINGOSINE KINASE 1; UNCLASSIFIED DRUG; EDG3 PROTEIN, MOUSE; NEUROPEPTIDE; PHOSPHOTRANSFERASE; QUINOLINE DERIVATIVE; RAC PROTEIN; RAC1 PROTEIN, MOUSE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, MOUSE; SPHINGOSINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; BLOOD PRESSURE; CELL COUNT; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HEART INFARCTION SIZE; HEART MUSCLE DEGENERATION; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART RATE; LIPID PEROXIDATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; TISSUE DEGENERATION; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; HEART MUSCLE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NEUROPEPTIDES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); QUINOLINES; RAC GTP-BINDING PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTORS, LYSOSPHINGOLIPID; RHO GTP-BINDING PROTEINS;

EID: 74249083210     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp312     Document Type: Article

References (31)

1. Spiegel S, Milstien SJ. Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem 2007;282:2125-2129.
2. Gardell SE, Dubin AE, Chun J. Emerging medicinal roles for lysophospholipid receptors. Trends in Molecular Med 2006;12:65-75.
3. Allende ML, Sasaki T, Kawai H, Olivera A, Mi Y, van Echten-Deckert G et al. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem 2004;279:52487-52492.
4. Kharel Y, Lee S, Snyder AH, Sheasley-O'neill SL, Morris MA, Setiady Y et al. Sphin-gosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem 2005;280:36865-36872.
5. Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL. Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 2005;25: 11113-11121.
6. Takuwa Y. Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. Biochim Biophys Acta 2002;1582:112-120.
7. Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: signaling and biology. Ann Rev Biochemistry 2004;73:321-354.
8. Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Biophys Biochim Acta 2008; 1781:483-488.
9. Ryu Y, Takuwa N, Sugimoto N, Sakurada S, Usui S, Okamoto H et al. Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. Circ Res 2002;90:325-332.
10. Landeen LK, Aroonsakool N, Haga JH, Hu BS, Giles WR. Sphingosine-1- phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions. Am J Physiol 2007;292:H2698-H2711.
11. Robert P, Tsui P, Laville MP, Livi GP, Sarau HM, Bril A et al. EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. J Mol Cell Cardiol 2001;33:1589-1606.
12. Zhang J, Honbo N, Goetzl EJ, Chatterjee K, Karliner JS, Gray MO. Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. Am J Physiol 2007;293:H3150-H3158.
13. Ishii I, Friedman B, Ye X, Kawamura S, McGiffert C, Contos JJ et al. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem 2001;276: 33697-33704.
14. Forrest M, Sun SY, Hajdu R, Bergstrom J, Card D, Doherty G et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther 2004;309:758-768.
15. Theilmeier G, Schmidt C, Herrmann J, Keul P, Schafers M, Herrgott I et al. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysopho-spholipid receptor. Circulation 2006;114:1403-1409.
16. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol 2007;292: H2944-H2951.
17. Jin ZQ, Zhang J, Huang Y, Hoover HE, Vessey DA, Karliner JS. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Cardiovasc Res 2007;76:41-50.
18. Murate T, Banno Y, T-Koizumi K, Watanabe K, Mori N, Wada A et al. Cell type-specific localization of sphingosine kinase 1a in human tissues. J Histochem Cytochem 2001;49:845-855.
19. Brown JH, Del Re DP, Sussman MA. The Rac and Rho hall of fame. A dacade of hypertrophic signaling hits. Circ Res 2006;98:730-742.
20. Satoh M, Ogita H, Takeshita K, Mukai Y, Kwiatkowski DJ, Liao JK. Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci USA 2006;103: 7432-7437.
21. Laufs U, Kilter H, Konkol C, Wassmann S, Bohm M, Nickenig G. Impact of HMG CoA reductase inhibition on small GTPases in the heart. Cardiovasc Res 2002;53: 911-920.
22. Sun JZ, Tang XL, Park SW, Qiu Y, Turrens JF, Bolli R. Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myo-cardial stunning in conscious pigs. J Clin Invest 1996;97:562-576.
23. Keller CD, Rivera Gil P, Tölle M, van der Giet M, Chun J et al. Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am J Pathol 2007;170:281-292.
24. Xin C, Ren S, Kleuser B, Shabahang S, Eberhardt W, Radeke H et al. Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-b-induced cell response. J Biol Chem 2004;279:35255-35262.
25. Vogel P, Donoviel MS, Read R, Hansen GM, Hazlewood J, Anderson SJ et al. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE 2009;4:e4112.
26. Ouzounian M, Lee DS, Liu PP. Diastolic heart failure: mechanisms and controversies. Nat Clin Pract Cardiovasc Med 2008;5:375-586.
27. Sirker A, Zhang M, Murdoch C, Shah AM. Involvement of NADPH oxidase in cardiac remodeling and heart failure. Am J Nephrol 2007;27:649-660.
28. Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S et al. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 1999;147:545-558.
29. Mizugishi K, Li C, Olivera A, Bielawski J, Bielawska A, Deng CX et al. Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J Clin Invest 2007;11:2993-3006.
30. Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol 2006;9:7211-7223.
31. Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z et al. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 2008;14:45-54.