Structure-based design of novel boronic acid-based inhibitors of autotaxin

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4619-4626

  Albers, Harald M H G ^a   Hendrickx, Loes J D ^a   Van Tol, Rob J P ^a   Hausmann, Jens ^a   Perrakis, Anastassis ^a   Ovaa, Huib ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[4 [[3 (4 FLUOROBENZYL) 2,4 DIOXO 1,3 THIAZOLAN 5 YLIDEN]METHYL]PHENOXY]METHYL]BENZENE BORONIC ACID; [4 [[4 [(2,5 DIOXOPYRROLIDIN 3 YLIDENE)METHYL]PHENOXY]METHYL]PHENYL]BORONIC ACID; [4 [[4 [[1 (4 FLUOROBENZYL) 2,5 DIOXOPYRROLIDIN 3 YLIDENE]METHYL]PHENOXY]METHYL]PHENYL]BORONIC ACID; [4 [[4 [[1 (4 FLUOROBENZYL) 3 METHYL 2,5 DIOXOIMIDAZOLIDIN 4 YLIDENE]METHYL]PHENOXY]METHYL]PHENYL]BORONIC ACID; [4 [[4 [[3 (4 FLUOROBENZYL) 2 OXO 2,3 DIHYDROTHIAZOL 5 YL]METHYL]PHENOXY]METHYL]PHENYL]BORONIC ACID; [4 [[4 [[3 (4 FLUOROBENZYL) 2,4 DIOXOTHIAZOLIDIN 5 YL]METHYL]PHENOXY]METHYL]PHENYL]BORONIC ACID; [4 [[4 [[3 (4 FLUOROBENZYL) 4 HYDROXY 2 OXOTHIAZOLIDIN 5 YL]METHYL]PHENOXY]METHYL]PHENYL]BORONIC ACID; [4 [[[2 (4 FLUOROBENZYL) 1,3 DIOXO 1,2,3,5,10,10A HEXAHYDROIMIDAZO[1,5 B]ISOQUINOLIN 7 YL]OXY]METHYL]PHENYL]BORONIC ACID; AUTOTAXIN; AUTOTAXIN INHIBITOR; BORONIC ACID DERIVATIVE; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR DOCKING;

ANIMALS; BINDING SITES; BORONIC ACIDS; DRUG DESIGN; MODELS, MOLECULAR; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960200367     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200310q     Document Type: Article

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