Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist

Biochemical and Biophysical Research Communications

Volumn 299, Issue 3, 2002, Pages 483-487

  Osada, Makoto ^a   Yatomi, Yutaka ^a,b   Ohmori, Tsukasa ^a   Ikeda, Hitoshi ^a   Ozaki, Yukio ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Endothelial differentiation gene; Lysophospholipid; Migration; Sphingosine 1 phosphate; Vascular endothelial cell; Vascular smooth muscle cell

Indexed keywords

CHEMICAL COMPOUND; JTE 013; PROTEIN; PROTEIN ENDOTHELIAL DIFFERENTIATION GENE 5 ANTAGONIST; PYRAZOLOPYRIDINE; PYRIDINE DERIVATIVE; RECEPTOR PROTEIN; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MIGRATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; UMBILICAL VEIN; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

CALCIUM SIGNALING; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FLUORESCENT DYES; FURA-2; HUMANS; IMMEDIATE-EARLY PROTEINS; LYSOPHOSPHOLIPIDS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PYRAZOLES; PYRIDINES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHOLIPID; SPHINGOSINE;

EID: 0036434445     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02671-2     Document Type: Article

References (21)

1. S. Spiegel, S. Milstien, Sphingosine 1-phosphate, a key cell signaling molecule, J. Biol. Chem. 277 (2002) 25851-25854.
2. Y. Yatomi, Y. Ozaki, T. Ohmori, Y. Igarashi, Sphingosine 1-phosphate: Synthesis and release, Prostaglandins Other Lipid Mediat. 64 (2001) 107-122.
3. D. English, J.G. Garcia, D.N. Brindley, Platelet-released phospholipids link haemostasis and angiogenesis, Cardiovasc. Res. 49 (2001) 588-599.
4. T. Levade, N. Auge, R.J. Veldman, O. Cuvillier, A. Negre-Salvayre, R. Salvayre, Sphingolipid mediators in cardiovascular cell biology and pathology, Circ. Res. 89 (2001) 957-968.
5. S. Spiegel, S. Milstien, Functions of a new family of sphingosine-1-phosphate receptors, Biochim. Biophys. Acta 1484 (2000) 107-116.
6. Y. Takuwa, H. Okamoto, N. Takuwa, K. Gonda, N. Sugimoto, S. Sakurada, Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophos-pholipid mediator, Mol. Cell. Endocrinol. 177 (2001) 3-11.
7. M.J. Kluk, T. Hla, Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors, Biochim. Biophys. Acta 1582 (2002) 72-80.
8. S. Mandala, R. Hajdu, J. Bergstrom, J. Xie, J. Milligan, R. Thornton, G. Shei, D. Card, C. Keohane, M. Rosenbach, J. Hale, C.L. Lynch, K. Rupprecht, W. Parsons, H. Rosen, Alteration of lymphocyte traAcking by sphingosine-1-phosphate receptor agonists, Science 296 (2002) 346-349.
9. Y. Yatomi, S. Yamamura, F. Ruan, Y. Igarashi, Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid, J. Biol. Chem. 272 (1997) 5291-5297.
10. Y. Yatomi, Y. Igarashi, L. Yang, N. Hisano, R. Qi, N. Asazuma, K. Satoh, Y. Ozaki, S. Kume, Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum, J. Biochem. 121 (1997) 969-973.
11. M.A. Marletta, Another activation switch for endothelial nitric oxide synthase: Why does it have to be so complicated?, Trends Biochem. Sci. 26 (2001) 519-521.
12. Y. Liu, R. Wada, T. Yamashita, Y. Mi, C.X. Deng, J.P. Hobson, H.M. Rosenfeldt, V.E. Nava, S.S. Chae, M.J. Lee, C.H. Liu, T. Hla, S. Spiegel, R.L. Proia, Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation, J. Clin. Invest. 106 (2000) 951-961.
13. T. Ohmori, Y. Yatomi, H. Okamoto, Y. Miura, G. Rile, K. Satoh, Y. Ozaki, Gi-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: Possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways, J. Biol. Chem. 276 (2001) 5274-5280.
14. Y. Miura, Y. Yatomi, G. Rile, T. Ohmori, K. Satoh, Y. Ozaki, Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets, J. Biochem. 127 (2000) 909-914.
15. M.J. Lee, S. Thangada, K.P. Claffey, N. Ancellin, C.H. Liu, M. Kluk, M. Volpi, R.I. Sha'afi, T. Hla, Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate, Cell 99 (1999) 301-312.
16. M.J. Lee, S. Thangada, J.H. Paik, G.P. Sapkota, N. Ancellin, S.S. Chae, M. Wu, M. Morales-Ruiz, W.C. Sessa, D.R. Alessi, T. Hla, Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis, Mol. Cell 8 (2001) 693-704.
17. H. Okamoto, N. Takuwa, T. Yokomizo, N. Sugimoto, S. Sakurada, H. Shigematsu, Y. Takuwa, Inhibitory regulation of Rac activation, membrane ruRing, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3, Mol. Cell. Biol. 20 (2000) 9247-9261.
18. Y. Ryu, N. Takuwa, N. Sugimoto, S. Sakurada, S. Usui, H. Okamoto, O. Matsui, Y. Takuwa, Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells, Circ. Res. 90 (2002) 325-332.
19. K.E. Bornfeldt, L.M. Graves, E.W. Raines, Y. Igarashi, G. Wayman, S. Yamamura, Y. Yatomi, J.S. Sidhu, E.G. Krebs, S. Hakomori, R. Ross, Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemotactic signal transduction, J. Cell Biol. 130 (1995) 193-206.
20. J. Folkman, Angiogenesis in cancer, vascular, rheumatoid and other disease, Nature Med. 1 (1995) 27-31.
21. T.O. Daniel, D. Abrahamson, Endothelial signal integration in vascular assembly, Annu. Rev. Physiol. 62 (2000) 649-671.