Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19593-19602

  Bu, Shizhong ^a   Kapanadze, Bagrat ^a   Hsu, Tien ^b   Trojanowska, Maria ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CHEMICAL REACTIONS; COLLAGEN; GROWTH (MATERIALS); GROWTH KINETICS; MUSCULOSKELETAL SYSTEM; PEPTIDES; PHOSPHORYLATION; PORT TERMINALS;

COLLAGEN SYNTHESIS; COMPLEX FORMATIONS; CONNECTIVE TISSUES; LIPID MEDIATORS; LIPID PHOSPHATASES; NOVEL FUNCTIONS; OVEREXPRESSION; PATHOLOGICAL TISSUES; SIGNALING PATHWAYS; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE KINASES; TERMINAL DOMAINS; TRANSFORMING GROWTH FACTORS; TRANSFORMING GROWTHS;

CELL GROWTH;

DIHYDROSPHINGOSINE 1 PHOSPHATE; INTERSTITIAL COLLAGENASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; COLLAGEN; DIHYDROSPHINGOSINE 1-PHOSPHATE; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; MULTIENZYME COMPLEX; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PTEN PROTEIN, HUMAN; SMAD2 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CELL GROWTH; CELL NUCLEUS; CELL PROTECTION; CELL STIMULATION; CELL SURVIVAL; COLLAGEN SYNTHESIS; COMPLEX FORMATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID OXIDATION; PATHOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; WASTE; ACTIVE TRANSPORT; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; ENZYME STABILITY; FIBROSIS; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; COLLAGEN; ENZYME STABILITY; FIBROSIS; HUMANS; LYSOPHOSPHOLIPIDS; MULTIENZYME COMPLEXES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SPHINGOSINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 50349102144     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802417200     Document Type: Article

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