Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels

Arthritis and Rheumatism

Volumn 62, Issue 7, 2010, Pages 2117-2126

  Bu, Shizhong ^a,b   Asano, Yoshihide ^a,b   Bujor, Andreea ^c   Highland, Kristin ^b   Hant, Faye ^b   Trojanowska, Maria ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBROTIC AGENT; COLLAGEN; DIHYDROSPHINGOSINE 1 PHOSPHATE; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMAD3 PROTEIN; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; FEMALE; FIBROBLAST; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKIN BIOPSY; SYSTEMIC SCLEROSIS; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; FEMALE; FIBROBLASTS; HUMANS; MALE; PTEN PHOSPHOHYDROLASE; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SPHINGOSINE; UP-REGULATION;

EID: 77954230505     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27463     Document Type: Article

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