Two pathways for lysophosphatidic acid production

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1781, Issue 9, 2008, Pages 513-518

  Aoki, Junken ^a,b   Inoue, Asuka ^a,b   Okudaira, Shinichi ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Autotaxin; G protein coupled receptor; LPA; LPA receptor; Lysophosphatidic acid; mPA PLA1 LIPH; P2Y5

Indexed keywords

AUTOTAXIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR;

AMINO ACID SEQUENCE; ANGIOGENESIS; BODY FLUID; DEACYLATION; DIABETES MELLITUS; HAIR GROWTH; HUMAN; IMPLANTATION; INTESTINE INJURY; KIDNEY FIBROSIS; LIPOGENESIS; LUNG FIBROSIS; LYMPH NODE; NEUROPATHIC PAIN; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FAMILY; RADIATION INJURY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; LIPASE; LYSOPHOSPHOLIPIDS; PHOSPHODIESTERASE I; PYROPHOSPHATASES; RECEPTORS, LYSOPHOSPHATIDIC ACID;

MUS;

EID: 49949098676     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2008.06.005     Document Type: Review

References (94)

1. Moolenaar W.H., van M.L., and Giepmans B.N. The ins and outs of lysophosphatidic acid signaling. Bioessays 26 8 (2004) 870-881
2. Tigyi G., and Parrill A.L. Molecular mechanisms of lysophosphatidic acid action. Prog. Lipid Res. 42 6 (2003) 498-526
3. Tokumura A. A family of phospholipid autacoids: occurrence, metabolism and bioactions. Prog. Lipid Res. 34 2 (1995) 151-184
4. Tigyi G. Physiological responses to lysophosphatidic acid and related glycero-phospholipids. Prostaglandins 64 1-4 (2001) 47-62
5. Hayashi K., et al. Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ. Res. 89 3 (2001) 251-258
6. Yoshida K., et al. Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo. Circulation 108 14 (2003) 1746-1752
7. Mills G.B., and Moolenaar W.H. The emerging role of lysophosphatidic acid in cancer. Nat. Rev. Cancer 3 8 (2003) 582-591
8. An S., et al. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273 14 (1998) 7906-7910
9. Bandoh K., et al. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274 39 (1999) 27776-27785
10. Hecht J.H., et al. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135 4 (1996) 1071-1083
11. Noguchi K., Ishii S., and Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278 28 (2003) 25600-25606
12. Lee C.W., et al. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J. Biol. Chem. 281 33 (2006) 23589-23597
13. Kotarsky K., et al. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. J. Pharmacol. Exp. Ther. 318 2 (2006) 619-628
14. Tabata K., et al. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun. 363 3 (2007) 861-866
15. Pasternack S.M., et al. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet 40 3 (2008) 329-334
16. Shimomura Y., et al. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat. Genet. 40 3 (2008) 335-339
17. Aoki J. Mechanisms of lysophosphatidic acid production. Semin. Cell Dev. Biol. 15 5 (2004) 477-489
18. Tokumura A., et al. Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats. Life Sci. 65 3 (1999) 245-253
19. Gesta S., et al. Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis. J. Lipid. Res. 43 6 (2002) 904-910
20. Tokumura A., et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J. Biol. Chem. 277 42 (2002) 39436-39442
21. Umezu-Goto M., et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 158 2 (2002) 227-233
22. Hiramatsu T., et al. Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. J. Biol. Chem. 278 (2003) 49438-49447
23. Sonoda H., et al. A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid. J. Biol. Chem. 277 37 (2002) 34254-34263
24. Ishii I., et al. Lysophospholipid receptors: signaling and biology. Annu. Rev. Biochem. 73 321 (2004) 321-354
25. McIntyre T.M., et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl. Acad. Sci. U. S. A. 100 1 (2003) 131-136
26. Murakami M., et al. Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun. 371 4 (2008) 707-712
27. Contos J.J., et al. Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. U. S. A. 97 24 (2000) 13384-13389
28. Inoue M., et al. Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat. Med. 10 7 (2004) 712-718
29. Pradere J.P., et al. LPA1 receptor activation promotes renal interstitial fibrosis. J. Am. Soc. Nephrol. 18 12 (2007) 3110-3118
30. Tager A.M., et al. The lysophosphatidic acid receptor LPA(1) links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat. Med. 14 1 (2008) 45-54
31. Hama K., et al. Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J. Biol. Chem. 279 (2004) 17634-17639
32. Deng W., et al. Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis. Gastroenterology 123 1 (2002) 206-216
33. Deng W., et al. The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology 132 5 (2007) 1834-1851
34. Hama K., et al. Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice. Biol. Reprod. 77 6 (2007) 954-959
35. Ye X., et al. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature 435 7038 (2005) 104-108
36. Sano T., et al. Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine-1-phosphate generation in blood. J. Biol. Chem. 277 (2002) 21197-21206
37. Baker D.L., et al. Quantitative analysis of lysophosphatidic acid in human blood fractions. Ann. N. Y. Acad. Sci. 905 267 (2000) 267-269
38. Tokumura A., et al. Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma. Biochim. Biophys. Acta 875 1 (1986) 31-38
39. Gerrard J.M., and Robinson P. Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin. Biochim. Biophys. Acta 1001 3 (1989) 282-285
40. Eichholtz T., et al. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem. J. (1993) 677-680
41. Sugiura T., et al. Lysophosphatidic acid, a growth factor-like lipid, in the saliva. J. Lipid Res. 43 12 (2002) 2049-2055
42. Nakane S., et al. Hen egg yolk and white contain high amounts of lysophosphatidic acids, growth factor-like lipids: distinct molecular species compositions. Lipids 36 4 (2001) 413-419
43. Jalink K., et al. Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis. Biochem. J. 307 (1995) 609-616
44. Tokumura A., et al. Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta. Am. J. Physiol. 267 (1994) C204-210
45. Bandoh K., et al. Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species - structure-activity relationship of cloned LPA receptors. FEBS Lett. 478 (2000) 159-165
46. Aoki J., et al. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J. Biol. Chem. 277 (2002) 48737-48744
47. Stracke M.L., Clair T., and Liotta L.A. Autotaxin, tumor motility-stimulating exophosphodiesterase. Adv. Enzyme Regul. 37 135 (1997) 135-144
48. Stracke M.L., et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J. Biol. Chem. 267 4 (1992) 2524-2529
49. Yang S.Y., et al. Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin. Exp. Metastasis 19 7 (2002) 603-608
50. Stassar M.J., et al. Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br. J. Cancer 85 9 (2001) 1372-1382
51. Baumforth K.R., et al. Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Blood 106 6 (2005) 2138-2146
52. Zhang G., et al. Expression of autotaxin mRNA in human hepatocellular carcinoma. Chin. Med. J. (Engl) 112 4 (1999) 330-332
53. Kishi Y., et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcoholine to lysophosphatidic acid. J. Biol. Chem. 281 (2006) 17492-17500
54. Watanabe N., et al. Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C. J. Clin. Gastroenterol. 41 6 (2007) 616-623
55. Nakamura K., et al. Suppression of lysophosphatidic acid and lysophosphatidylcholine formation in the plasma in vitro: proposal of a plasma sample preparation method for laboratory testing of these lipids. Anal. Biochem. 367 1 (2007) 20-27
56. Tanaka M., et al. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J. Biol. Chem. 281 35 (2006) 25822-25830
57. Tsuda S., et al. Cyclic phosphatidic acid is produced by autotaxin in blood. J. Biol. Chem. 281 36 (2006) 26081-26088
58. van Meeteren L.A., et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol. Cell Biol. 26 13 (2006) 5015-5022
59. Kanda H., et al. Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat. Immunol. 9 4 (2008) 415-423
60. Kishi Y., et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J. Biol. Chem. 281 25 (2006) 17492-17500
61. Van Leeuwen F., et al. Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. J. Biol. Chem. 278 1 (2003) 400-406
62. Shida D., et al. Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. Cancer Res. 63 7 (2003) 1706-1711
63. Ohta, et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol. Pharmacol. 64 4 (2003) 994-1005
64. T. Yamada, et al., Lysophosphatidic acid in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1, J. Biol. Chem. 279 (8) (2004) 6595-6560.
65. Inoue M., et al. Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. Mol. Pain 4 1 (2008) 6
66. Blakemore W.F., and Franklin R.J. Remyelination in experimental models of toxin-induced demyelination. Curr. Top. Microbiol. Immunol. 318 (2008) 193-212
67. Inoue M., et al. Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid. Neuroscience (2008)
68. Ferry G., et al. Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J. Biol. Chem. 278 20 (2003) 18162-18169
69. Boucher J., et al. Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia 48 3 (2005) 569-577
70. Tanaka M., et al. Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. FEBS Lett. 571 1-3 (2004) 197-204
71. Sato K., et al. Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources. J. Neurochem. 92 4 (2005) 904-914
72. Nakamura K., et al. Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome. Clin. Chem. Lab. Med. 46 1 (2008) 150-151
73. Nakamura K., et al. Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients. Ann. Clin. Biochem. 44 Pt 6 (2007) 549-556
74. Tokumura A. Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids. Biochim. Biophys. Acta 1582 1-3 (2002) 18-25
75. Tokumura A., et al. Increased production of bioactive lysophosphatidic acid by serum lysophospholipase D in human pregnancy. Biol. Reprod. 67 5 (2002) 1386-1392
76. Tokumura A., et al. Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity. Life Sci. 80 18 (2007) 1641-1649
77. Fourcade O., et al. Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell 80 6 (1995) 919-927
78. Eder A., et al. Constitutive and LPA induced LPA production: Role of PLD and PLA2. Clin. Cancer Res. 6 (2000) 2482-2491
79. Shen Z., et al. Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells. Gynecol. Oncol. 71 3 (1998) 364-368
80. Aoki J., et al. Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family. Biochimie. 89 2 (2007) 197-204
81. Aoki J., et al. Structure and function of phosphatidylserine-specific phospholipase A1. Biochim. Biophys. Acta. 1582 1-3 (2002) 26-32
82. Inoue A., and Aoki J. Phospholipase A1s - structure, distribution and function (review). Future Lipidology 1 (2006) 687-700
83. K. Inoue, H. Arai, and J. Aoki, Phospholipase A1 - structures, physiological and patho-physiological roles in mammals, Lipases and Phospholipases in Drug Development: from Biochemistry to Molecular Pharmacology, ed. M.G. aPS, Wiley-VCH Verlag GmbH, 2004, pp. 23-39.
84. Morikawa R., et al. Phospholipase A(1) assays using a radiolabeled substrate and mass spectrometry. Methods Enzymol. 434 (2007) 1-13
85. Murakami M., et al. Regulatory functions of phospholipase A2. Crit. Rev. Immunol. 17 3-4 (1997) 225-283
86. Kudo I., et al. Mammalian non-pancreatic phospholipases A2. [Review], Biochim. Biophys. Acta 1170 3 (1993) 217-231
87. Higgs H.N., and Glomset J.A. Identification of a phosphatidic acid-preferring phospholipase A1 from bovine brain and testis. Proc. Natl. Acad. Sci. U. S. A. 91 20 (1994) 9574-9578
88. Hirano K., et al. Properties of phospholipase A1/transacylase in the white muscle of bonito Euthynnus pelamis (Linnaeus). J. Biochem. 122 6 (1997) 1160-1166
89. Pete M.J., Ross A.H., and Exton J.H. Purification and properties of phospholipase A1 from bovine brain. J. Biol. Chem. 269 30 (1994) 19494-19500
90. Watanabe I., et al. Molecular cloning and expression of the gene encoding a phospholipase A1 from Aspergillus oryzae. Biosci. Biotechnol. Biochem. 63 5 (1999) 820-826
91. Horigome K., et al. Selective release of phospholipase A2 and lysophosphatidylserine-specific lysophospholipase from rat platelets. J. Biochem. 101 1 (1987) 53-61
92. Sato T., et al. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family, J. Biol. Chem. 272 4 (1997) 2192-2198
93. Ali G., et al. A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis. Hum. Genet. 121 3-4 (2007) 319-325
94. Kazantseva A., et al. Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH. Science 314 5801 (2006) 982-985