Notch receptor-ligand interactions during T cell development, a ligand endocytosis-driven mechanism

Current Topics in Microbiology and Immunology

Volumn 360, Issue , 2012, Pages 19-46

  Shah, Divya K ^a   Zúñiga Pflücker, Juan Carlos ^a  

^a Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA SERRATE LAG2 PROTEIN; MEMBRANE PROTEIN; MINDBOMB PROTEIN; NEURALIZED PROTEIN; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL LINEAGE; ENDOCYTOSIS; GENE FUNCTION; HUMAN; LIGAND BINDING; LOSS OF FUNCTION MUTATION; LYMPHOCYTOPOIESIS; MECHANOTRANSDUCTION; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS;

CELL DIFFERENTIATION; CELL LINEAGE; ENDOCYTOSIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; PROTEIN BINDING; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 84868321525     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2012-225     Document Type: Article

References (174)

1. Abe N, Hozumi K, Hirano K., Yagita H, Habu S. (2010) Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate. Eur J Immunol 40:2608-2617
2. Acar M, Jafar-Nejad H, Takeuchi H., Rajan A, Ibrani D, Rana N.A., Pan H., Haltiwanger RS, Bellen H.J. (2008) Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132:247-258 (Pubitemid 351172433)
3. Aguado R, Martin-Blanco N, Caraballo M., Canelles M. (2010) The endocytic adaptor Numb regulates thymus size by modulating pre-TCR signaling during asymmetric division. Blood 116:1705-1714
4. Ahimou F, Mok LP, Bardot B, Wesley C. (2004) The adhesion force of Notch with Delta and the rate of Notch signaling. J Cell Biol 167:1217-1229 (Pubitemid 40066635)
5. Anderson AC, Kitchens EA, Chan S.W., St Hill C, Jan YN, Zhong W, Robey E.A. (2005) The Notch regulator Numb links the Notch and TCR signaling pathways. J Immunol 174:890-897 (Pubitemid 40094284)
6. Artavanis-Tsakonas S., Muskavitch MA, Yedvobnick B. (1983) Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc Natl Acad Sci U S A 80:1977-1981 (Pubitemid 13079217)
7. Banks SM, Cho B, Eun S.H., Lee JH, Windler SL, Xie X, Bilder D., Fischer J.A. (2011) The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS ONE 6:e18259
8. Bardin AJ, Schweisguth F. (2006) Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Dev Cell 10:245-255 (Pubitemid 43174957)
9. Barsi JC, Rajendra R, Wu J.I., Artzt K. (2005) Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Mech Dev 122:1106-1117 (Pubitemid 41262427)
10. Bellavia D, Campese AF, Alesse E, Vacca A., Felli MP, Balestri A, Stoppacciaro A, Tiveron C., Tatangelo L, Giovarelli M, Gaetano C., Ruco L, Hoffman ES, Hayday AC, Lendahl U, Frati L, Gulino A, Screpanti I (2000) Constitutive activation of NF-kappaB and T-cell leukemia/ lymphoma in Notch3 transgenic mice. EMBO J 19:3337-3348 (Pubitemid 30428211)
11. Besseyrias V, Fiorini E, Strobl L.J., Zimber-Strobl U, Dumortier A, Koch U., Arcangeli ML, Ezine S, Macdonald HR, Radtke F. (2007) Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med 204:331-343 (Pubitemid 46294549)
12. Bettenhausen B, Hrabe de Angelis M, Simon D, Guenet JL, Gossler A (1995) Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121:2407-2418
13. Bhandoola A, von Boehmer H, Petrie HT, Zuniga-Pflucker JC (2007) Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26:678-689 (Pubitemid 46907669)
14. Blaumueller CM, Qi H, Zagouras P., Artavanis-Tsakonas S (1997) Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 90:281-291 (Pubitemid 27329713)
15. Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7:678-689 (Pubitemid 44268213)
16. Chen W, Casey Corliss D (2004) Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis. Dev Biol 267:361-373 (Pubitemid 38328578)
17. Chen H, Ko G, Zatti A., Di Giacomo G, Liu L, Raiteri E., Perucco E, Collesi C, Min W., Zeiss C, De Camilli P, Cremona O (2009) Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A vol. Proc Natl Acad Sci U S A vol 106:13838-13843
18. Chitnis A (2006) Why is delta endocytosis required for effective activation of notch? Dev Dyn 235:886-894
19. Ciofani M, Zuniga-Pflucker JC (2005) Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 6:881-888 (Pubitemid 43090442)
20. Ciofani M, Zuniga-Pflucker JC (2007) The thymus as an inductive site for T lymphopoiesis. Annu Rev Cell Dev Biol 23:463-493
21. Ciofani M, Schmitt TM, Ciofani A, Michie A.M., Cuburu N., Aublin A, Maryanski JL, Zuniga-Pflucker JC (2004) Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J Immunol 172:5230-5239 (Pubitemid 38542020)
22. Ciofani M, Knowles GC, Wiest D.L., von Boehmer H, Zuniga-Pflucker JC (2006) Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity 25:105-116 (Pubitemid 44066824)
23. Commisso C, Boulianne G.L. (2007) The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling. Mol Biol Cell 18:1-13 (Pubitemid 46066705)
24. Cordle J, Johnson S, Tay J.Z., Roversi P., Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P., Jin B, Redfield C, Baron M, Lea SM, Handford PA (2008) A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol 15:849-857
25. D'Souza B., Meloty-Kapella L, Weinmaster G. (2010) Canonical and non-canonical Notch ligands. Curr Top Dev Biol 92:73-129
26. Daskalaki A, Shalaby NA, Kux K, Tsoumpekos G., Tsibidis GD, Muskavitch MA, Delidakis C. (2011) Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized. J Cell Biol 195:1017-1031
27. Deblandre GA, Lai EC, Kintner C. (2001) Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling. Dev Cell 1:795-806 (Pubitemid 33586134)
28. Deftos ML, Huang E, Ojala E.W., Forbush KA, Bevan M.J. (2000) Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13:73-84
29. Del Amo F.F., Smith DE, Swiatek P.J., Gendron-Maguire M, Greenspan RJ, McMahon A.P., Gridley T. (1992) Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development 115:737-744
30. Dunwoodie SL, Henrique D, Harrison S.M., Beddington R.S. (1997) Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 124:3065-3076 (Pubitemid 27387084)
31. Ellisen LW, Bird J, West D.C., Soreng AL, Reynolds TC, Smith SD, Sklar J. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649-661 (Pubitemid 121001701)
32. Emery G, Hutterer A, Berdnik D., Mayer B, Wirtz-Peitz F, Gaitan MG, Knoblich J.A. (2005) Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Cell 122:763-773 (Pubitemid 41242640)
33. Eun SH, Banks SM, Fischer J.A. (2008) Auxilin is essential for Delta signaling. Development 135:1089-1095 (Pubitemid 351578137)
34. Fang D, Kerppola T.K. (2004) Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes. Proc Natl Acad Sci U S A 101: 14782-14787 (Pubitemid 39410752)
35. Felli MP, Maroder M, Mitsiadis T.A., Campese AF, Bellavia D, Vacca A, Mann R.S., Frati L., Lendahl U, Gulino A, Screpanti I. (1999) Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int Immunol 11:1017-1025 (Pubitemid 29338742)
36. Fiorini E, Merck E, Wilson A., Ferrero I, Jiang W, Koch U., Auderset F, Laurenti E, Tacchini-Cottier F, Pierres M., Radtke F, Luther SA, Macdonald HR (2009) Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. J Immunol 183:7212-7222
37. Fontana JR, Posakony J.W. (2009) Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Dev Biol 333:373-385
38. French MB, Koch U, Shaye R.E., McGill MA, Dho SE, Guidos CJ, McGlade C.J. (2002) Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification. J Immunol 168:3173-3180 (Pubitemid 34250376)
39. Fryer CJ, Lamar E, Turbachova I., Kintner C, Jones K.A. (2002) Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev 16:1397-1411 (Pubitemid 34615092)
40. Fryer CJ, White JB, Jones K.A. (2004) Mastermind recruits CycC: CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 16:509-520 (Pubitemid 39531875)
41. Geffers I, Serth K, Chapman G., Jaekel R, Schuster-Gossler K, Cordes R, Sparrow D.B., Kremmer E., Dunwoodie SL, Klein T, Gossler A. (2007) Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol 178:465-476 (Pubitemid 47196154)
42. Gibb DR, Saleem SJ, Chaimowitz N.S., Mathews J., Conrad D.H. (2011) The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity. Mol Immunol 48:1319-1327
43. Glittenberg M, Pitsouli C, Garvey C., Delidakis C, Bray S. (2006) Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J 25:4697-4706 (Pubitemid 44607016)
44. Gordon WR, Vardar-Ulu D, Histen G., Sanchez-Irizarry C, Aster JC, Blacklow S.C. (2007) Structural basis for autoinhibition of Notch. Nat Struct Mol Biol 14:295-300 (Pubitemid 46608349)
45. Gordon WR, Arnett KL, Blacklow S.C. (2008) The molecular logic of Notch signaling-a structural and biochemical perspective. J Cell Sci 121:3109-3119
46. Gordon WR, Roy M, Vardar-Ulu D, Garfinkel M., Mansour MR, Aster JC, Blacklow S.C. (2009) Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood 113:4381-4390
47. Gossens K, Naus S, Hollander G.A., Ziltener H.J. (2010) Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity. PLoS ONE 5:e12766
48. Gravano DM, Manilay J.O. (2010) Inhibition of proteolysis of Delta-like-1 does not promote or reduce T-cell developmental potential. Immunol Cell Biol 88:746-753
49. Guo M, Jan LY, Jan Y.N. (1996) Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17:27-41 (Pubitemid 26251589)
50. Gupta-Rossi N., Le Bail O, Gonen H, Brou C., Logeat F, Six E, Ciechanover A., Israel A. (2001) Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem 276:34371-34378
51. Haidl ID, Huber G, Eichmann K. (2002) An ADAM family member with expression in thymic epithelial cells and related tissues. Gene 283:163-170 (Pubitemid 34178520)
52. Hamel S, Fantini J, Schweisguth F. (2010) Notch ligand activity is modulated by glyco-sphingolipid membrane composition in Drosophila melanogaster. J Cell Biol 188:581-594
53. Han H, Tanigaki K, Yamamoto N., Kuroda K, Yoshimoto M, Nakahata T., Ikuta K, Honjo T. (2002) Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol 14:637-645 (Pubitemid 34649719)
54. Hansson EM, Lanner F, Das D., Mutvei A, Marklund U, Ericson J., Farnebo F, Stumm G, Stenmark H., Andersson ER, Lendahl U (2010) Control of Notch-ligand endocytosis by ligand-receptor interaction. J Cell Sci 123:2931-2942
55. Hasserjian RP, Aster JC, Davi F, Weinberg D.S., Sklar J. (1996) Modulated expression of notch1 during thymocyte development. Blood 88:970-976 (Pubitemid 26333321)
56. Hayes SM, Li L, Love P.E. (2005) TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity 22:583-593 (Pubitemid 40719194)
57. He F, Saito K, Kobayashi N, Harada T, Watanabe S, Kigawa T, Guntert P, Ohara O, Tanaka A, Unzai S, Muto Y, Yokoyama S (2009) Structural and functional characterization of the NHR1 domain of the Drosophila neuralized E3 ligase in the notch signaling pathway. J Mol Biol 393:478-495
58. Heuss SF, Ndiaye-Lobry D, Six E.M., Israel A., Logeat F. (2008) The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc Natl Acad Sci U S A 105:11212-11217
59. Hicks C, Ladi E, Lindsell C., Hsieh JJ, Hayward SD, Collazo A, Weinmaster G. (2002) A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling. J Neurosci Res 68:655-667 (Pubitemid 34594983)
60. Hoyne GF, Chapman G, Sontani Y., Pursglove SE, Dunwoodie S.L. (2011) A cell autonomous role for the Notch ligand Delta-like 3 in alphabeta T-cell development. Immunol Cell Biol 89:696-705
61. Hozumi K, Negishi N, Suzuki D., Abe N, Sotomaru Y, Tamaoki N., Mailhos C, Ish-Horowicz D, Habu S, Owen M.J. (2004) Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat Immunol 5:638-644 (Pubitemid 38811889)
62. Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, Zuklys S, Hollander GA, Shima DT, Habu S (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development. J Exp Med 205:2507-2513
63. Itoh M, Kim CH, Palardy G, Oda T., Jiang YJ, Maust D, Yeo SY, Lorick K, Wright G.J., Ariza-McNaughton L, Weissman AM, Lewis J, Chandrasekharappa S.C., Chitnis A.B. (2003) Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell 4:67-82 (Pubitemid 36109145)
64. Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS (2002) Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity 16:231-243 (Pubitemid 34211963)
65. Jafar-Nejad H., Andrews HK, Acar M, Bayat V., Wirtz-Peitz F, Mehta SQ, Knoblich J.A., Bellen H.J. (2005) Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell 9:351-363 (Pubitemid 41235805)
66. Jaleco AC, Neves H, Hooijberg E., Gameiro P, Clode N, Haury M., Henrique D, Parreira L. (2001) Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med 194:991-1002
67. Jarriault S, Brou C, Logeat F., Schroeter EH, Kopan R, Israel A. (1995) Signalling downstream of activated mammalian Notch. Nature 377:355-358
68. Jiang R, Lan Y, Chapman H.D., Shawber C., Norton CR, Serreze DV, Weinmaster G, Gridley T. (1998) Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev 12:1046-1057 (Pubitemid 28204610)
69. Johnston SH, Rauskolb C, Wilson R., Prabhakaran B, Irvine KD, Vogt T.F. (1997) A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development 124:2245-2254 (Pubitemid 27283245)
70. Jung J, Mo JS, Kim M.Y., Ann EJ, Yoon JH, Park H.S. (2011) Regulation of Notch1 signaling by Delta-like ligand 1 intracellular domain through physical interaction. Mol Cells 32:161-165
71. Kandachar V, Bai T, Chang H.C. (2008) The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis. BMC Dev Biol 8:50
72. Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z., Downes M, Kintner CR, Evans R.M., Kadesch T. (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 12:2269-2277 (Pubitemid 28371348)
73. Klueg KM, Parody TR, Muskavitch M.A. (1998) Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. Mol Biol Cell 9:1709-1723 (Pubitemid 28337518)
74. Koch U, Lacombe TA, Holland D, Bowman J.L., Cohen BL, Egan SE, Guidos C.J. (2001) Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity 15:225-236 (Pubitemid 32816872)
75. Koch U, Fiorini E, Benedito R., Besseyrias V, Schuster-Gossler K, Pierres M, Manley N.R., Duarte A., Macdonald HR, Radtke F. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med 205:2515-2523
76. Komatsu H, Chao MY, Larkins-Ford J, Corkins M.E., Somers GA, Tucey T, Dionne HM, White J.Q., Wani K., Boxem M, Hart A.C. (2008) OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS Biol 6:e196
77. Koo BK, Lim HS, Song R, Yoon MJ, Yoon KJ, Moon JS, Kim YW, Kwon MC, Yoo KW, Kong MP, Lee J, Chitnis AB, Kim CH, Kong YY (2005a) Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development 132:3459-3470 (Pubitemid 41246120)
78. Koo BK, Yoon KJ, Yoo K.W., Lim HS, Song R, So JH, Kim C.H., Kong Y.Y. (2005b) Mind bomb-2 is an E3 ligase for Notch ligand. J Biol Chem 280:22335-22342 (Pubitemid 40827890)
79. Koo BK, Yoon MJ, Yoon K.J., Im SK, Kim YY, Kim CH, Suh P.G., Jan YN, Kong Y.Y. (2007) An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One 2:e1221
80. Kopan R, Ilagan M.X. (2009) The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137:216-233
81. Kovall RA (2007) Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex. Curr Opin Struct Biol 17:117-127 (Pubitemid 46240808)
82. Kuroda K, Han H, Tani S., Tanigaki K, Tun T, Furukawa T., Taniguchi Y, Kurooka H, Hamada Y., Toyokuni S, Honjo T (2003) Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 18:301-312 (Pubitemid 36263003)
83. Ladi E, Nichols JT, Ge W, Miyamoto A., Yao C, Yang LT, Boulter J, Sun Y.E., Kintner C., Weinmaster G. (2005) The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol 170: 983-992 (Pubitemid 41306297)
84. Lai EC, Deblandre GA, Kintner C, Rubin G.M. (2001) Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Dev Cell 1:783-794 (Pubitemid 33586133)
85. Lai EC, Roegiers F, Qin X., Jan YN, Rubin G.M. (2005) The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132:2319-2332 (Pubitemid 40872802)
86. Laky K, Fowlkes B.J. (2007) Presenilins regulate alphabeta T cell development by modulating TCR signaling. J Exp Med 204:2115-2129 (Pubitemid 47360873)
87. Lamar E, Deblandre G, Wettstein D., Gawantka V, Pollet N, Niehrs C., Kintner C. (2001) Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev 15:1885-1899 (Pubitemid 32738619)
88. Lardelli M, Lendahl U. (1993) Motch A and motch B-two mouse Notch homologues coexpressed in a wide variety of tissues. Exp Cell Res 204:364-372 (Pubitemid 23200201)
89. Lardelli M, Dahlstrand J, Lendahl U. (1994) The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech Dev 46:123-136 (Pubitemid 24179069)
90. Le Borgne R., Schweisguth F. (2003a) Notch signaling: endocytosis makes delta signal better. Curr Biol 13:R273-R275 (Pubitemid 36391925)
91. Le Borgne R., Schweisguth F. (2003b) Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev Cell 5:139-148 (Pubitemid 36827348)
92. Lehar SM, Dooley J, Farr A.G., Bevan M.J. (2005) Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood 105:1440-1447 (Pubitemid 40223659)
93. Lehmann RJF, Dietrich U, Campos-Ortega JA (1983) On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster. Roux's Arch Dev Biol 192:62-74 (Pubitemid 13087455)
94. Li N, Boyd K, Dempsey P.J., Vignali D.A. (2007) Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J Immunol 178:4214-4221 (Pubitemid 46492371)
95. Lindsell CE, Shawber CJ, Boulter J, Weinmaster G. (1995) Jagged: a mammalian ligand that activates Notch1. Cell 80:909-917
96. Liu AP, Aguet F, Danuser G., Schmid S.L. (2010) Local clustering of transferrin receptors promotes clathrin-coated pit initiation. J Cell Biol 191:1381-1393
97. Maillard I, Weng AP, Carpenter A.C., Rodriguez CG, Sai H, Xu L, Allman D., Aster JC, Pear W.S. (2004) Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood 104:1696-1702 (Pubitemid 39202276)
98. Maillard I, Tu L, Sambandam A., Yashiro-Ohtani Y, Millholland J, Keeshan K., Shestova O, Xu L, Bhandoola A, Pear WS(2006) The requirementfor Notch signaling atthe beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J Exp Med 203:2239-2245 (Pubitemid 44498358)
99. Mancini SJ, Mantei N, Dumortier A., Suter U, MacDonald HR, Radtke F. (2005) Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood 105:2340-2342 (Pubitemid 40387028)
100. Matsuno K, Ito M, Hori K., Miyashita F, Suzuki S, Kishi N., Artavanis-Tsakonas S, Okano H. (2002) Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development 129:1049-1059 (Pubitemid 34874128)
101. McGill MA, McGlade CJ(2003) Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 278:23196-23203 (Pubitemid 36830386)
102. McMahon HT, Gallop J.L. (2005) Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature 438:590-596 (Pubitemid 41740562)
103. Michie AM, Zuniga-Pflucker JC (2002) Regulation of thymocyte differentiation: pre-TCR signals and beta-selection. Semin Immunol 14:311-323 (Pubitemid 35021287)
104. Mishra-Gorur K., Rand MD, Perez-Villamil B, Artavanis-Tsakonas S (2002) Down-regulation of Delta by proteolytic processing. J Cell Biol 159:313-324 (Pubitemid 35283400)
105. Mohtashami M, Shah DK, Nakase H, Kianizad K., Petrie HT, Zuniga-Pflucker JC (2010) Direct comparison of Dll1-and Dll4-mediated Notch activation levels shows differential lymph-omyeloid lineage commitment outcomes. J Immunol 185:867-876
106. Morgan TH (1917) The theory of the gene. Yale University Press, New Haven
107. Nichols JT, Miyamoto A, Olsen S.L., D'Souza B, Yao C, Weinmaster G. (2007) DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol 176:445-458
108. Oberg C, Li J, Pauley A., Wolf E, Gurney M, Lendahl U. (2001) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 276:35847-35853
109. Okajima T, Irvine K.D. (2002) Regulation of notch signaling by o-linked fucose. Cell 111:893-904 (Pubitemid 36109160)
110. Oswald F, Winkler M, Cao Y., Astrahantseff K, Bourteele S, Knochel W., Borggrefe T. (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol 25:10379-10390 (Pubitemid 41681962)
111. Overstreet E, Fitch E, Fischer J.A. (2004) Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. Development 131:5355-5366 (Pubitemid 39567276)
112. Panin VM, Papayannopoulos V, Wilson R., Irvine K.D. (1997) Fringe modulates Notch-ligand interactions. Nature 387:908-912 (Pubitemid 27289592)
113. Parks AL, Klueg KM, Stout J.R., Muskavitch M.A. (2000) Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 127:1373-1385 (Pubitemid 30232589)
114. Parks AL, Stout JR, Shepard S.B., Klueg KM, Dos Santos AA, Parody TR, Vaskova M, Muskavitch M.A. (2006) Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila. Genetics 174:1947-1961 (Pubitemid 46011585)
115. Pavlopoulos E, Pitsouli C, Klueg K.M., Muskavitch MA, Moschonas NK, Delidakis C. (2001) neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev Cell 1:807-816 (Pubitemid 33586135)
116. Petrie HT, Zuniga-Pflucker JC (2007) Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu Rev Immunol 25:649-679 (Pubitemid 46697920)
117. Pintar A, De Biasio A, Popovic M, Ivanova N., Pongor S. (2007) The intracellular region of Notch ligands: does the tail make the difference? Biol Direct 2:19
118. Pitsouli C, Delidakis C. (2005) The interplay between DSL proteins and ubiquitin ligases in Notch signaling. Development 132:4041-4050 (Pubitemid 41488854)
119. Pui JC, Allman D, Xu L., DeRocco S, Karnell FG, Bakkour S, Lee J.Y., Kadesch T., Hardy RR, Aster JC, Pear W.S. (1999) Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11:299-308 (Pubitemid 29463238)
120. Radtke F, Wilson A, Stark G., Bauer M, van Meerwijk J, MacDonald HR, Aguet M. (1999) Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10:547-558 (Pubitemid 29262657)
121. Rebay I, Fleming RJ, Fehon R.G., Cherbas L., Cherbas P, Artavanis-Tsakonas S (1991) Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67:687-699 (Pubitemid 121001482)
122. Reizis B, Leder P. (2002) Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev 16:295-300 (Pubitemid 34111409)
123. Rhyu MS, Jan LY, Jan Y.N. (1994) Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76:477-491 (Pubitemid 24064169)
124. Robey E, Chang D, Itano A., Cado D, Alexander H, Lans D., Weinmaster G, Salmon P. (1996) An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87:483-492 (Pubitemid 26374322)
125. Ruan Y, Tecott L, Jiang M.M., Jan LY, Jan Y.N. (2001) Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized. Proc Natl Acad Sci U S A 98:9907-9912 (Pubitemid 32769402)
126. Sasamura T, Sasaki N, Miyashita F., Nakao S, Ishikawa HO, Ito M, Kitagawa M., Harigaya K, Spana E, Bilder D., Perrimon N, Matsuno K (2003) neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development 130:4785-4795 (Pubitemid 37321863)
127. Schmitt TM, Zuniga-Pflucker JC (2002) Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17:749-756 (Pubitemid 35477794)
128. Schmitt TM, Ciofani M, Petrie H.T., Zuniga-Pflucker JC (2004) Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J Exp Med 200:469-479 (Pubitemid 39121904)
129. Seugnet L, Simpson P, Haenlin M. (1997) Requirement for dynamin during Notch signaling in Drosophila neurogenesis. Dev Biol 192:585-598 (Pubitemid 28066957)
130. Shawber C, Boulter J, Lindsell C.E., Weinmaster G. (1996) Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev Biol 180:370-376 (Pubitemid 26426184)
131. Shi S, Stanley P. (2003) Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A 100:5234-5239 (Pubitemid 36542688)
132. Shi J, Fallahi M, Luo J.L., Petrie H.T. (2011) Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis. Blood 118:2511-2519
133. Shimizu K, Chiba S, Kumano K., Hosoya N, Takahashi T, Kanda Y., Hamada Y, Yazaki Y, Hirai H. (1999) Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem 274:32961-32969 (Pubitemid 129535335)
134. Shutter JR, Scully S, Fan W., Richards WG, Kitajewski J, Deblandre GA, Kintner C.R., Stark K.L. (2000) Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev 14:1313-1318 (Pubitemid 30397075)
135. Skwarek LC, Garroni MK, Commisso C, Boulianne G.L. (2007) Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signaling. Dev Cell 13:783-795 (Pubitemid 350163041)
136. Song R, Koo BK, Yoon K.J., Yoon MJ, Yoo KW, Kim HT, Oh H.J., Kim YY, Han JK, Kim CH, Kong Y.Y. (2006) Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. J Biol Chem 281:36391-36400 (Pubitemid 46041373)
137. Song R, Kim YW, Koo B.K., Jeong HW, Yoon MJ, Yoon KJ, Jun D.J., Im SK, Shin J, Kong MP, Kim K.T., Yoon K., Kong Y.Y. (2008) Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. J Exp Med 205:2525-2536
138. Spana EP, Doe C.Q. (1996) Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 17:21-26 (Pubitemid 26251588)
139. Stanley P, Okajima T. (2010) Roles of glycosylation in Notch signaling. Curr Top Dev Biol 92:131-164
140. Staub O, Rotin D. (2006) Role of ubiquitylation in cellular membrane transport. Physiol Rev 86:669-707
141. Su DM, Navarre S, Oh W.J., Condie BG, Manley N.R. (2003) A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation. Nat Immunol 4:1128-1135 (Pubitemid 37428041)
142. Suliman S, Tan J, Xu K., Kousis PC, Kowalski PE, Chang G, Egan S.E., Guidos C. (2011) Notch3 is dispensable for thymocyte beta-selection and Notch1-induced T cell leukemogenesis. PLoS ONE 6:e24937
143. Takeuchi T, Adachi Y, Ohtsuki Y. (2005) Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. DNA Cell Biol 24:339-344 (Pubitemid 40656507)
144. Tamura K, Taniguchi Y, Minoguchi S., Sakai T, Tun T, Furukawa T., Honjo T. (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol 5:1416-1423 (Pubitemid 3009974)
145. Tanigaki K, Tsuji M, Yamamoto N., Han H, Tsukada J, Inoue H., Kubo M, Honjo T. (2004) Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 20:611-622 (Pubitemid 38638130)
146. Thompson PK, Zuniga-Pflucker JC (2011) On becoming a T cell, a convergence of factors kick it up a Notch along the way. Semin Immunol 23:350-359
147. Tian X, Hansen D, Schedl T., Skeath J.B. (2004) Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Development 131:5807-5815 (Pubitemid 40123898)
148. Tian L, Wu X, Chi C., Han M, Xu T, Zhuang Y. (2008) ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol 20:1181-1187
149. Tien AC, Rajan A, Bellen H.J. (2009) A Notch updated. J Cell Biol 184:621-629
150. Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN(1989) numb, agene requiredindetermination of cell fate during sensory organ formation in Drosophila embryos. Cell 58:349-360
151. Uyttendaele H, Marazzi G, Wu G., Yan Q, Sassoon D, Kitajewski J. (1996) Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122:2251-2259 (Pubitemid 26235824)
152. Van de Walle I, De Smet G, Gartner M, De Smedt M, Waegemans E, Vandekerckhove B, Leclercq G, Plum J, Aster JC, Bernstein ID, Guidos CJ, Kyewski B, Taghon T (2011) Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions. Blood 117:4449-4459
153. Varas A, Hager-Theodorides AL, Sacedon R., Vicente A, Zapata AG, Crompton T. (2003) The role of morphogens in T-cell development. Trends Immunol 24:197-206 (Pubitemid 36412108)
154. Varnum-Finney B., Wu L, Yu M., Brashem-Stein C, Staats S, Flowers D., Griffin JD, Bernstein I.D. (2000) Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J Cell Sci 113(Pt 23):4313-4318 (Pubitemid 32000694)
155. Vitt UA, Hsu SY, Hsueh A.J. (2001) Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol Endocrinol 15:681-694 (Pubitemid 32411309)
156. Vollrath B, Pudney J, Asa S., Leder P, Fitzgerald K. (2001) Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. Mol Cell Biol 21:7481-7494 (Pubitemid 32953498)
157. Wang W, Struhl G. (2004) Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development 131:5367-5380 (Pubitemid 39562180)
158. Washburn T, Schweighoffer E, Gridley T., Chang D, Fowlkes BJ, Cado D, Robey E. (1997) Notch activity influences the alphabeta versus gammadelta T cell lineage decision. Cell 88:833-843 (Pubitemid 27164271)
159. Weinmaster G, Roberts VJ, Lemke G. (1992) Notch2: a second mammalian Notch gene. Development 116:931-941 (Pubitemid 23042434)
160. Wilson A, Ardiet DL, Saner C, Vilain N., Beermann F, Aguet M, Macdonald H.R., Zilian O. (2007) Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike. J Immunol 178:6746-6751 (Pubitemid 46847398)
161. Windler SL, Bilder D. (2010) Endocytic internalization routes required for delta/notch signaling. Curr Biol 20:538-543
162. Wolfer A, Bakker T, Wilson A., Nicolas M, Ioannidis V, Littman D.R., Lee PP, Wilson CB, Held W, MacDonald H.R., Radtke F. (2001) Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat Immunol 2:235-241 (Pubitemid 33706000)
163. Wolfer A, Wilson A, Nemir M., MacDonald HR, Radtke F. (2002) Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity 16:869-879 (Pubitemid 34786485)
164. Wong GW, Zuniga-Pflucker JC (2010) gammadelta and alphabeta T cell lineage choice: resolution by a stronger sense of being. Semin Immunol 22:228-236
165. Wu L, Aster JC, Blacklow S.C., Lake R., Artavanis-Tsakonas S, Griffin J.D. (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 26:484-489
166. Wu L, Sun T, Kobayashi K., Gao P, Griffin J.D. (2002) Identification of a family of mastermindlike transcriptional coactivators for mammalian notch receptors. Mol Cell Biol 22:7688-7700
167. Xiao S, Su DM, Manley NR (2008) T cell development from kit-negative progenitors in the Foxn1Delta/Delta mutant thymus. J Immunol 180:914-921
168. Yamamoto S, Charng WL, Bellen H.J. (2010) Endocytosis and intracellular trafficking of Notch and its ligands. Curr Top Dev Biol 92:165-200
169. Yeh E, Dermer M, Commisso C., Zhou L, McGlade CJ, Boulianne G.L. (2001) Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr Biol 11:1675-1679 (Pubitemid 33037778)
170. Yuan JS, Tan JB, Visan I, Matei I.R., Urbanellis P., Xu K, Danska JS, Egan S.E., Guidos C.J. (2011) Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed alphabeta T-cell progenitors. Blood 117:1184-1195
171. Zhang C, Li Q, Lim C.H., Qiu X., Jiang Y.J. (2007) The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly. Dev Biol 305:14-27 (Pubitemid 46613794)
172. Zhang L, Widau RC, Herring B.P., Gallagher P.J. (2011) Delta-like 1-Lysine613 regulates notch signaling. Biochim Biophys Acta 1813:2036-2043
173. Zhong W, Jiang MM, Weinmaster G, Jan L.Y., Jan Y.N. (1997) Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 124:1887-1897 (Pubitemid 27270258)
174. Zuniga-Pflucker JC (2004) T-cell development made simple. Nat Rev Immunol 4:67-72 (Pubitemid 38084133)