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Volumn 17, Issue 1, 2007, Pages 117-127

Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex

Author keywords

[No Author keywords available]

Indexed keywords

CELLULOSE; DNA; NOTCH1 RECEPTOR;

EID: 33846928274     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sbi.2006.11.004     Document Type: Review
Times cited : (75)

References (58)
  • 1
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: a simple pathway becomes complex
    • A recent and comprehensive review of canonical Notch signaling.
    • Bray S.J. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7 (2006) 678-689. A recent and comprehensive review of canonical Notch signaling.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 2
    • 17644382970 scopus 로고    scopus 로고
    • Regulation of lymphoid development, differentiation, and function by the Notch pathway
    • Maillard I., Fang T., and Pear W.S. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol 23 (2005) 945-974
    • (2005) Annu Rev Immunol , vol.23 , pp. 945-974
    • Maillard, I.1    Fang, T.2    Pear, W.S.3
  • 3
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison S.J., and Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441 (2006) 1068-1074
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 4
    • 0037390535 scopus 로고    scopus 로고
    • Notch signaling and inherited disease syndromes
    • Gridley T. Notch signaling and inherited disease syndromes. Hum Mol Genet 12 (2003) R9-R13
    • (2003) Hum Mol Genet , vol.12
    • Gridley, T.1
  • 5
    • 33748196362 scopus 로고    scopus 로고
    • Molecular genetics of aortic valve disease
    • Garg V. Molecular genetics of aortic valve disease. Curr Opin Cardiol 21 (2006) 180-184
    • (2006) Curr Opin Cardiol , vol.21 , pp. 180-184
    • Garg, V.1
  • 6
    • 33644782668 scopus 로고    scopus 로고
    • Recent insights into the role of Notch signaling in tumorigenesis
    • Leong K.G., and Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 107 (2006) 2223-2233
    • (2006) Blood , vol.107 , pp. 2223-2233
    • Leong, K.G.1    Karsan, A.2
  • 7
    • 0032525964 scopus 로고    scopus 로고
    • LIN-12/Notch signaling: lessons from worms and flies
    • Greenwald I. LIN-12/Notch signaling: lessons from worms and flies. Genes Dev 12 (1998) 1751-1762
    • (1998) Genes Dev , vol.12 , pp. 1751-1762
    • Greenwald, I.1
  • 8
    • 33749461057 scopus 로고    scopus 로고
    • Interplay between Notch signaling and epigenetic silencers in cancer
    • Dominguez M. Interplay between Notch signaling and epigenetic silencers in cancer. Cancer Res 66 (2006) 8931-8934
    • (2006) Cancer Res , vol.66 , pp. 8931-8934
    • Dominguez, M.1
  • 10
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: multiple effectors of the Notch signaling pathway
    • Iso T., Kedes L., and Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 194 (2003) 237-255
    • (2003) J Cell Physiol , vol.194 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 11
    • 0034902568 scopus 로고    scopus 로고
    • Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic)
    • Ronchini C., and Capobianco A.J. Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol 21 (2001) 5925-5934
    • (2001) Mol Cell Biol , vol.21 , pp. 5925-5934
    • Ronchini, C.1    Capobianco, A.J.2
  • 12
    • 0037044820 scopus 로고    scopus 로고
    • Binding of C/EBP and RBP (CBF1) to overlapping sites regulates interleukin-6 gene expression
    • Vales L.D., and Friedl E.M. Binding of C/EBP and RBP (CBF1) to overlapping sites regulates interleukin-6 gene expression. J Biol Chem 277 (2002) 42438-42446
    • (2002) J Biol Chem , vol.277 , pp. 42438-42446
    • Vales, L.D.1    Friedl, E.M.2
  • 15
    • 33745131039 scopus 로고    scopus 로고
    • Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
    • ••] identify Myc as a direct Notch target gene and show that overexpression of Myc via Notch signaling is involved in the pathogenesis of leukemia and breast cancer, respectively.
    • ••] identify Myc as a direct Notch target gene and show that overexpression of Myc via Notch signaling is involved in the pathogenesis of leukemia and breast cancer, respectively.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9262-9267
    • Klinakis, A.1    Szabolcs, M.2    Politi, K.3    Kiaris, H.4    Artavanis-Tsakonas, S.5    Efstratiadis, A.6
  • 16
    • 5444247778 scopus 로고    scopus 로고
    • Notch signaling: the demise of elegant simplicity
    • Kadesch T. Notch signaling: the demise of elegant simplicity. Curr Opin Genet Dev 14 (2004) 506-512
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 506-512
    • Kadesch, T.1
  • 17
    • 0034671686 scopus 로고    scopus 로고
    • Notch signaling: from the outside in
    • Mumm J.S., and Kopan R. Notch signaling: from the outside in. Dev Biol 228 (2000) 151-165
    • (2000) Dev Biol , vol.228 , pp. 151-165
    • Mumm, J.S.1    Kopan, R.2
  • 18
    • 18844414504 scopus 로고    scopus 로고
    • The roles of receptor and ligand endocytosis in regulating Notch signaling
    • Le Borgne R., Bardin A., and Schweisguth F. The roles of receptor and ligand endocytosis in regulating Notch signaling. Development 132 (2005) 1751-1762
    • (2005) Development , vol.132 , pp. 1751-1762
    • Le Borgne, R.1    Bardin, A.2    Schweisguth, F.3
  • 19
    • 2642601104 scopus 로고    scopus 로고
    • The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription
    • Olave I., Reinberg D., and Vales L.D. The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. Genes Dev 12 (1998) 1621-1637
    • (1998) Genes Dev , vol.12 , pp. 1621-1637
    • Olave, I.1    Reinberg, D.2    Vales, L.D.3
  • 20
    • 0036747296 scopus 로고    scopus 로고
    • Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins
    • Lai E.C. Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep 3 (2002) 840-845
    • (2002) EMBO Rep , vol.3 , pp. 840-845
    • Lai, E.C.1
  • 22
    • 0033524444 scopus 로고    scopus 로고
    • CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
    • Hsieh J.J., Zhou S., Chen L., Young D.B., and Hayward S.D. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci USA 96 (1999) 23-28
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 23-28
    • Hsieh, J.J.1    Zhou, S.2    Chen, L.3    Young, D.B.4    Hayward, S.D.5
  • 23
    • 0036682974 scopus 로고    scopus 로고
    • Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
    • Barolo S., Stone T., Bang A.G., and Posakony J.W. Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev 16 (2002) 1964-1976
    • (2002) Genes Dev , vol.16 , pp. 1964-1976
    • Barolo, S.1    Stone, T.2    Bang, A.G.3    Posakony, J.W.4
  • 25
    • 0034073379 scopus 로고    scopus 로고
    • SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function
    • Zhou S., Fujimuro M., Hsieh J.J., Chen L., Miyamoto A., Weinmaster G., and Hayward S.D. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol 20 (2000) 2400-2410
    • (2000) Mol Cell Biol , vol.20 , pp. 2400-2410
    • Zhou, S.1    Fujimuro, M.2    Hsieh, J.J.3    Chen, L.4    Miyamoto, A.5    Weinmaster, G.6    Hayward, S.D.7
  • 26
    • 0033920386 scopus 로고    scopus 로고
    • A role for SKIP in EBNA2 activation of CBF1-repressed promoters
    • Zhou S., Fujimuro M., Hsieh J.J., Chen L., and Hayward S.D. A role for SKIP in EBNA2 activation of CBF1-repressed promoters. J Virol 74 (2000) 1939-1947
    • (2000) J Virol , vol.74 , pp. 1939-1947
    • Zhou, S.1    Fujimuro, M.2    Hsieh, J.J.3    Chen, L.4    Hayward, S.D.5
  • 27
    • 0036682519 scopus 로고    scopus 로고
    • The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway
    • Liang Y., Chang J., Lynch S.J., Lukac D.M., and Ganem D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev 16 (2002) 1977-1989
    • (2002) Genes Dev , vol.16 , pp. 1977-1989
    • Liang, Y.1    Chang, J.2    Lynch, S.J.3    Lukac, D.M.4    Ganem, D.5
  • 28
    • 0036840497 scopus 로고    scopus 로고
    • p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
    • Wallberg A.E., Pedersen K., Lendahl U., and Roeder R.G. p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol 22 (2002) 7812-7819
    • (2002) Mol Cell Biol , vol.22 , pp. 7812-7819
    • Wallberg, A.E.1    Pedersen, K.2    Lendahl, U.3    Roeder, R.G.4
  • 29
    • 0036606776 scopus 로고    scopus 로고
    • Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
    • Fryer C.J., Lamar E., Turbachova I., Kintner C., and Jones K.A. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev 16 (2002) 1397-1411
    • (2002) Genes Dev , vol.16 , pp. 1397-1411
    • Fryer, C.J.1    Lamar, E.2    Turbachova, I.3    Kintner, C.4    Jones, K.A.5
  • 30
    • 0034595665 scopus 로고    scopus 로고
    • Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
    • Kurooka H., and Honjo T. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem 275 (2000) 17211-17220
    • (2000) J Biol Chem , vol.275 , pp. 17211-17220
    • Kurooka, H.1    Honjo, T.2
  • 31
    • 33646203458 scopus 로고    scopus 로고
    • Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability
    • This comprehensive study of the transcriptional potency of the four mammalian NotchIC paralogs in cell culture demonstrates the importance of cellular and promoter context.
    • Ong C.T., Cheng H.T., Chang L.W., Ohtsuka T., Kageyama R., Stormo G.D., and Kopan R. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem 281 (2006) 5106-5119. This comprehensive study of the transcriptional potency of the four mammalian NotchIC paralogs in cell culture demonstrates the importance of cellular and promoter context.
    • (2006) J Biol Chem , vol.281 , pp. 5106-5119
    • Ong, C.T.1    Cheng, H.T.2    Chang, L.W.3    Ohtsuka, T.4    Kageyama, R.5    Stormo, G.D.6    Kopan, R.7
  • 32
    • 8844229536 scopus 로고    scopus 로고
    • Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
    • An elegant set of ChiP experiments demonstrates how Notch transcription is turned off by phosphorylation and ubiquitin-ligase-mediated degradation.
    • Fryer C.J., White J.B., and Jones K.A. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 16 (2004) 509-520. An elegant set of ChiP experiments demonstrates how Notch transcription is turned off by phosphorylation and ubiquitin-ligase-mediated degradation.
    • (2004) Mol Cell , vol.16 , pp. 509-520
    • Fryer, C.J.1    White, J.B.2    Jones, K.A.3
  • 33
    • 4644317278 scopus 로고    scopus 로고
    • Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
    • The first detailed view of the transcription factor CSL bound to DNA.
    • Kovall R.A., and Hendrickson W.A. Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. EMBO J 23 (2004) 3441-3451. The first detailed view of the transcription factor CSL bound to DNA.
    • (2004) EMBO J , vol.23 , pp. 3441-3451
    • Kovall, R.A.1    Hendrickson, W.A.2
  • 34
    • 17744366374 scopus 로고    scopus 로고
    • The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold
    • Lubman O.Y., Kopan R., Waksman G., and Korolev S. The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Sci 14 (2005) 1274-1281
    • (2005) Protein Sci , vol.14 , pp. 1274-1281
    • Lubman, O.Y.1    Kopan, R.2    Waksman, G.3    Korolev, S.4
  • 36
    • 0142210110 scopus 로고    scopus 로고
    • Structure and stability of the ankyrin domain of the Drosophila Notch receptor
    • Zweifel M.E., Leahy D.J., Hughson F.M., and Barrick D. Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Sci 12 (2003) 2622-2632
    • (2003) Protein Sci , vol.12 , pp. 2622-2632
    • Zweifel, M.E.1    Leahy, D.J.2    Hughson, F.M.3    Barrick, D.4
  • 37
    • 33644761961 scopus 로고    scopus 로고
    • Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA
    • ••].
    • ••].
    • (2006) Cell , vol.124 , pp. 985-996
    • Wilson, J.J.1    Kovall, R.A.2
  • 38
    • 33644749306 scopus 로고    scopus 로고
    • Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
    • ••] describe the CSL-NotchIC-Mastermind ternary complex structures for the worm and human proteins, illuminating the molecular details of an active transcription complex.
    • ••] describe the CSL-NotchIC-Mastermind ternary complex structures for the worm and human proteins, illuminating the molecular details of an active transcription complex.
    • (2006) Cell , vol.124 , pp. 973-983
    • Nam, Y.1    Sliz, P.2    Song, L.3    Aster, J.C.4    Blacklow, S.C.5
  • 39
    • 0038079817 scopus 로고    scopus 로고
    • Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex
    • Nam Y., Weng A.P., Aster J.C., and Blacklow S.C. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem 278 (2003) 21232-21239
    • (2003) J Biol Chem , vol.278 , pp. 21232-21239
    • Nam, Y.1    Weng, A.P.2    Aster, J.C.3    Blacklow, S.C.4
  • 40
    • 23444446753 scopus 로고    scopus 로고
    • A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors
    • Meng X., Brodsky M.H., and Wolfe S.A. A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. Nat Biotechnol 23 (2005) 988-994
    • (2005) Nat Biotechnol , vol.23 , pp. 988-994
    • Meng, X.1    Brodsky, M.H.2    Wolfe, S.A.3
  • 42
    • 0028988990 scopus 로고
    • Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2
    • Hsieh J.J., and Hayward S.D. Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268 (1995) 560-563
    • (1995) Science , vol.268 , pp. 560-563
    • Hsieh, J.J.1    Hayward, S.D.2
  • 43
    • 0029583607 scopus 로고
    • Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
    • Tamura K., Taniguchi Y., Minoguchi S., Sakai T., Tun T., Furukawa T., and Honjo T. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol 5 (1995) 1416-1423
    • (1995) Curr Biol , vol.5 , pp. 1416-1423
    • Tamura, K.1    Taniguchi, Y.2    Minoguchi, S.3    Sakai, T.4    Tun, T.5    Furukawa, T.6    Honjo, T.7
  • 46
    • 0036096912 scopus 로고    scopus 로고
    • Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line
    • Jeffries S., Robbins D.J., and Capobianco A.J. Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol 22 (2002) 3927-3941
    • (2002) Mol Cell Biol , vol.22 , pp. 3927-3941
    • Jeffries, S.1    Robbins, D.J.2    Capobianco, A.J.3
  • 47
    • 0033796150 scopus 로고    scopus 로고
    • Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1
    • Aster J.C., Xu L., Karnell F.G., Patriub V., Pui J.C., and Pear W.S. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol 20 (2000) 7505-7515
    • (2000) Mol Cell Biol , vol.20 , pp. 7505-7515
    • Aster, J.C.1    Xu, L.2    Karnell, F.G.3    Patriub, V.4    Pui, J.C.5    Pear, W.S.6
  • 48
    • 0032403190 scopus 로고    scopus 로고
    • Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
    • Kurooka H., Kuroda K., and Honjo T. Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res 26 (1998) 5448-5455
    • (1998) Nucleic Acids Res , vol.26 , pp. 5448-5455
    • Kurooka, H.1    Kuroda, K.2    Honjo, T.3
  • 49
    • 3142779379 scopus 로고    scopus 로고
    • Identification of two binding regions for the suppressor of hairless protein within the intracellular domain of Drosophila notch
    • The authors report the biochemical and in vivo characterization of a novel region downstream of ANK in NotchIC termed PPD. PPD facilitates the interaction of NotchIC with CSL.
    • Le Gall M., and Giniger E. Identification of two binding regions for the suppressor of hairless protein within the intracellular domain of Drosophila notch. J Biol Chem 279 (2004) 29418-29426. The authors report the biochemical and in vivo characterization of a novel region downstream of ANK in NotchIC termed PPD. PPD facilitates the interaction of NotchIC with CSL.
    • (2004) J Biol Chem , vol.279 , pp. 29418-29426
    • Le Gall, M.1    Giniger, E.2
  • 50
    • 28144455439 scopus 로고    scopus 로고
    • LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans
    • The second of two excellent papers identifying and characterizing the DTS region of NotchIC, which is important for endocytic regulation of NotchIC and cross-talk with Ras signaling pathways.
    • Shaye D.D., and Greenwald I. LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Development 132 (2005) 5081-5092. The second of two excellent papers identifying and characterizing the DTS region of NotchIC, which is important for endocytic regulation of NotchIC and cross-talk with Ras signaling pathways.
    • (2005) Development , vol.132 , pp. 5081-5092
    • Shaye, D.D.1    Greenwald, I.2
  • 51
    • 33746944018 scopus 로고    scopus 로고
    • Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1
    • The authors identified the S4 region of NotchIC, which resides in the C terminus and is phosphorylated and a negative regulator of the pathway. Deletion of S4 in truncation mutants of NotchIC is observed in T-cell acute lymphoblastic leukemia.
    • Chiang M.Y., Xu M.L., Histen G., Shestova O., Roy M., Nam Y., Blacklow S.C., Sacks D.B., Pear W.S., and Aster J.C. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol 26 (2006) 6261-6271. The authors identified the S4 region of NotchIC, which resides in the C terminus and is phosphorylated and a negative regulator of the pathway. Deletion of S4 in truncation mutants of NotchIC is observed in T-cell acute lymphoblastic leukemia.
    • (2006) Mol Cell Biol , vol.26 , pp. 6261-6271
    • Chiang, M.Y.1    Xu, M.L.2    Histen, G.3    Shestova, O.4    Roy, M.5    Nam, Y.6    Blacklow, S.C.7    Sacks, D.B.8    Pear, W.S.9    Aster, J.C.10
  • 52
    • 2442706456 scopus 로고    scopus 로고
    • The ankyrin repeat as molecular architecture for protein recognition
    • Mosavi L.K., Cammett T.J., Desrosiers D.C., and Peng Z.Y. The ankyrin repeat as molecular architecture for protein recognition. Protein Sci 13 (2004) 1435-1448
    • (2004) Protein Sci , vol.13 , pp. 1435-1448
    • Mosavi, L.K.1    Cammett, T.J.2    Desrosiers, D.C.3    Peng, Z.Y.4
  • 53
    • 0035807867 scopus 로고    scopus 로고
    • Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 1. Solution conformational and hydrodynamic properties
    • Zweifel M.E., and Barrick D. Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 1. Solution conformational and hydrodynamic properties. Biochemistry 40 (2001) 14344-14356
    • (2001) Biochemistry , vol.40 , pp. 14344-14356
    • Zweifel, M.E.1    Barrick, D.2
  • 54
    • 1642344776 scopus 로고    scopus 로고
    • Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data
    • An excellent re-examination of the Notch literature in the context of the Drosophila ankyrin repeat structure, emphasizing the careful interpretation of mutagenesis data in the absence of structure.
    • Lubman O.Y., Korolev S.V., and Kopan R. Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell 13 (2004) 619-626. An excellent re-examination of the Notch literature in the context of the Drosophila ankyrin repeat structure, emphasizing the careful interpretation of mutagenesis data in the absence of structure.
    • (2004) Mol Cell , vol.13 , pp. 619-626
    • Lubman, O.Y.1    Korolev, S.V.2    Kopan, R.3
  • 55
    • 4644306518 scopus 로고    scopus 로고
    • An experimentally determined protein folding energy landscape
    • Mello C.C., and Barrick D. An experimentally determined protein folding energy landscape. Proc Natl Acad Sci USA 101 (2004) 14102-14107
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14102-14107
    • Mello, C.C.1    Barrick, D.2
  • 56
    • 33845683490 scopus 로고    scopus 로고
    • Quantitative dissection of the Notch:CSL interaction: insights into the Notch transcriptional switch
    • 10.1016/j.jmb.2006.09.071. This comprehensive thermodynamic and biochemical characterization of the interaction of CSL BTD with NotchIC not only complements the recent structures of these complexes, but also provides the first quantitative binding data for the BTD-RAM interaction.
    • Lubman O.Y., Ilagan M.X., Kopan R., and Barrick D. Quantitative dissection of the Notch:CSL interaction: insights into the Notch transcriptional switch. J Mol Biol (2006) 10.1016/j.jmb.2006.09.071. This comprehensive thermodynamic and biochemical characterization of the interaction of CSL BTD with NotchIC not only complements the recent structures of these complexes, but also provides the first quantitative binding data for the BTD-RAM interaction.
    • (2006) J Mol Biol
    • Lubman, O.Y.1    Ilagan, M.X.2    Kopan, R.3    Barrick, D.4
  • 57
    • 0030501419 scopus 로고    scopus 로고
    • Use of non-crystallographic symmetry in protein structure refinement
    • Kleywegt G.J. Use of non-crystallographic symmetry in protein structure refinement. Acta Crystallogr D Biol Crystallogr 52 (1996) 842-857
    • (1996) Acta Crystallogr D Biol Crystallogr , vol.52 , pp. 842-857
    • Kleywegt, G.J.1
  • 58
    • 0015222647 scopus 로고
    • The interpretation of protein structures: estimation of static accessibility
    • Lee B., and Richards F.M. The interpretation of protein structures: estimation of static accessibility. J Mol Biol 55 (1971) 379-400
    • (1971) J Mol Biol , vol.55 , pp. 379-400
    • Lee, B.1    Richards, F.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.