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Kurooka H., Kuroda K., and Honjo T. Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res 26 (1998) 5448-5455
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(1998)
Nucleic Acids Res
, vol.26
, pp. 5448-5455
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Kurooka, H.1
Kuroda, K.2
Honjo, T.3
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49
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3142779379
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Identification of two binding regions for the suppressor of hairless protein within the intracellular domain of Drosophila notch
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The authors report the biochemical and in vivo characterization of a novel region downstream of ANK in NotchIC termed PPD. PPD facilitates the interaction of NotchIC with CSL.
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Le Gall M., and Giniger E. Identification of two binding regions for the suppressor of hairless protein within the intracellular domain of Drosophila notch. J Biol Chem 279 (2004) 29418-29426. The authors report the biochemical and in vivo characterization of a novel region downstream of ANK in NotchIC termed PPD. PPD facilitates the interaction of NotchIC with CSL.
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(2004)
J Biol Chem
, vol.279
, pp. 29418-29426
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Le Gall, M.1
Giniger, E.2
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50
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28144455439
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LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans
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The second of two excellent papers identifying and characterizing the DTS region of NotchIC, which is important for endocytic regulation of NotchIC and cross-talk with Ras signaling pathways.
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Shaye D.D., and Greenwald I. LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Development 132 (2005) 5081-5092. The second of two excellent papers identifying and characterizing the DTS region of NotchIC, which is important for endocytic regulation of NotchIC and cross-talk with Ras signaling pathways.
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(2005)
Development
, vol.132
, pp. 5081-5092
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Shaye, D.D.1
Greenwald, I.2
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51
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33746944018
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Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1
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The authors identified the S4 region of NotchIC, which resides in the C terminus and is phosphorylated and a negative regulator of the pathway. Deletion of S4 in truncation mutants of NotchIC is observed in T-cell acute lymphoblastic leukemia.
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Chiang M.Y., Xu M.L., Histen G., Shestova O., Roy M., Nam Y., Blacklow S.C., Sacks D.B., Pear W.S., and Aster J.C. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol 26 (2006) 6261-6271. The authors identified the S4 region of NotchIC, which resides in the C terminus and is phosphorylated and a negative regulator of the pathway. Deletion of S4 in truncation mutants of NotchIC is observed in T-cell acute lymphoblastic leukemia.
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(2006)
Mol Cell Biol
, vol.26
, pp. 6261-6271
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Chiang, M.Y.1
Xu, M.L.2
Histen, G.3
Shestova, O.4
Roy, M.5
Nam, Y.6
Blacklow, S.C.7
Sacks, D.B.8
Pear, W.S.9
Aster, J.C.10
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52
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2442706456
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The ankyrin repeat as molecular architecture for protein recognition
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Mosavi L.K., Cammett T.J., Desrosiers D.C., and Peng Z.Y. The ankyrin repeat as molecular architecture for protein recognition. Protein Sci 13 (2004) 1435-1448
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(2004)
Protein Sci
, vol.13
, pp. 1435-1448
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Mosavi, L.K.1
Cammett, T.J.2
Desrosiers, D.C.3
Peng, Z.Y.4
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53
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0035807867
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Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 1. Solution conformational and hydrodynamic properties
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Zweifel M.E., and Barrick D. Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 1. Solution conformational and hydrodynamic properties. Biochemistry 40 (2001) 14344-14356
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(2001)
Biochemistry
, vol.40
, pp. 14344-14356
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Zweifel, M.E.1
Barrick, D.2
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54
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1642344776
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Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data
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An excellent re-examination of the Notch literature in the context of the Drosophila ankyrin repeat structure, emphasizing the careful interpretation of mutagenesis data in the absence of structure.
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Lubman O.Y., Korolev S.V., and Kopan R. Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell 13 (2004) 619-626. An excellent re-examination of the Notch literature in the context of the Drosophila ankyrin repeat structure, emphasizing the careful interpretation of mutagenesis data in the absence of structure.
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(2004)
Mol Cell
, vol.13
, pp. 619-626
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Lubman, O.Y.1
Korolev, S.V.2
Kopan, R.3
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55
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4644306518
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An experimentally determined protein folding energy landscape
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Mello C.C., and Barrick D. An experimentally determined protein folding energy landscape. Proc Natl Acad Sci USA 101 (2004) 14102-14107
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(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 14102-14107
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Mello, C.C.1
Barrick, D.2
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56
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33845683490
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Quantitative dissection of the Notch:CSL interaction: insights into the Notch transcriptional switch
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10.1016/j.jmb.2006.09.071. This comprehensive thermodynamic and biochemical characterization of the interaction of CSL BTD with NotchIC not only complements the recent structures of these complexes, but also provides the first quantitative binding data for the BTD-RAM interaction.
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Lubman O.Y., Ilagan M.X., Kopan R., and Barrick D. Quantitative dissection of the Notch:CSL interaction: insights into the Notch transcriptional switch. J Mol Biol (2006) 10.1016/j.jmb.2006.09.071. This comprehensive thermodynamic and biochemical characterization of the interaction of CSL BTD with NotchIC not only complements the recent structures of these complexes, but also provides the first quantitative binding data for the BTD-RAM interaction.
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(2006)
J Mol Biol
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Lubman, O.Y.1
Ilagan, M.X.2
Kopan, R.3
Barrick, D.4
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57
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0030501419
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Use of non-crystallographic symmetry in protein structure refinement
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Kleywegt G.J. Use of non-crystallographic symmetry in protein structure refinement. Acta Crystallogr D Biol Crystallogr 52 (1996) 842-857
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(1996)
Acta Crystallogr D Biol Crystallogr
, vol.52
, pp. 842-857
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Kleywegt, G.J.1
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58
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0015222647
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The interpretation of protein structures: estimation of static accessibility
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Lee B., and Richards F.M. The interpretation of protein structures: estimation of static accessibility. J Mol Biol 55 (1971) 379-400
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(1971)
J Mol Biol
, vol.55
, pp. 379-400
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Lee, B.1
Richards, F.M.2
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