Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate

European Journal of Immunology

Volumn 40, Issue 9, 2010, Pages 2608-2617

  Abe, Natsumi ^a   Hozumi, Katsuto ^a   Hirano, Ken Ichi ^a   Yagita, Hideo ^b   Habu, Sonoko ^b  

^a TOKAI UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Notch ligand; Notch signaling; T cell development

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CALCIUM BINDING PROTEIN; DLL4 PROTEIN, MOUSE; HES1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; JAG2 PROTEIN, MOUSE; MEMBRANE PROTEIN; NOTCH RECEPTOR; SERRATE PROTEINS; SIGNAL PEPTIDE;

3T3 CELL LINE; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PATHOLOGY; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; HOMEODOMAIN PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MUTAGENESIS, SITE-DIRECTED; NIH 3T3 CELLS; PROTEIN ENGINEERING; RECEPTORS, NOTCH; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77956484908     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200940006     Document Type: Article

References (44)

1. Artavanis-Tsakonas, S., Rand, M. D. and Lake, R. J., Notch signaling: cell fate control and signal integration in development. Science 1999. 284: 770-776.
2. Jundt, F., Anagnostopoulos, I., Foster, R., Mathas, S., Stein, H. and Dorken, B., Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 2002. 99: 3398-3403. (Pubitemid 34525322)
3. Sade, H., Krishna, S. and Sarin, A., The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J. Biol. Chem. 2004. 279: 2937-2944.
4. Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C. et al., Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 2001. 20: 3427-3436.
5. Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J., MacDonald, H. R. and Aguet, M., Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999. 10: 547-558. (Pubitemid 29262657)
6. Han, H., Tanigaki, K., Yamamoto, N., Kuroda, K., Yoshimoto, M., Nakahata, T., Ikuta, K. and Honjo, T., Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 2002. 14: 637-645.
7. Pui, J. C., Allman, D., Xu, L., DeRocco, S., Karnell, F. G., Bakkour, S., Lee, J. Y. et al., Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 1999. 11: 299-308.
8. Hozumi, K., Abe, N., Chiba, S., Hirai, H. and Habu, S., Active form of Notch members can enforce T lymphopoiesis on lymphoid progenitors in the monolayer culture specific for B cell development. J. Immunol. 2003. 170: 4973-4979. (Pubitemid 36554726)
9. Schmitt, T. M. and Züñiga-Pflücker, J. C., Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 2002. 17: 749-756.
10. Hozumi, K., Negishi, N., Suzuki, D., Abe, N., Sotomaru, Y., Tamaoki, N., Mailhos, C. et al., Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat. Immunol. 2004. 5: 638-644.
11. Hozumi, K., Mailhos, C., Negishi, N., Hirano, K., Yahata, T., Ando, K., Zuklys, S. et al., Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 2008. 205: 2507-2513.
12. Jaleco, A. C., Neves, H., Hooijberg, E., Gameiro, P., Clode, N., Haury, M., Henrique, D. and Parreira, L., Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J. Exp. Med. 2001. 194: 991-1002.
13. Lehar, S. M., Dooley, J., Farr, A. G. and Bevan, M. J., Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood 2005. 105: 1440-1447.
14. Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P. et al., Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003. 425: 841-846.
15. Koch, U., Lacombe, T. A., Holland, D., Bowman, J. L., Cohen, B. L., Egan, S. E. and Guidos, C. J., Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity 2001. 15: 225-236.
16. Tan, J. B., Visan, I., Yuan, J. S. and Guidos, C. J., Requirement for Notch1 signals at sequential early stages of intrathymic T cell development. Nat. Immunol. 2005. 6: 671-679.
17. Visan, I., Tan, J. B., Yuan, J. S., Harper, J. A., Koch, U. and Guidos, C. J., Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat. Immunol. 2006. 7: 634-643.
18. Tsukumo, S., Hirose, K., Maekawa, Y., Kishihara, K. and Yasutomo, K., Lunatic fringe controls T cell differentiation through modulating notch signaling. J. Immunol. 2006. 177: 8365-8371. (Pubitemid 44893798)
19. Moriyama, Y., Sekine, C., Koyanagi, A., Koyama, N., Ogata, H., Chiba, S., Hirose, S. et al., Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. Int. Immunol. 2008. 20: 763-773.
20. Minoguchi, S., Taniguchi, Y., Kato, H., Okazaki, T., Strobl, L. J., Zimber-Strobl, U., Bornkamm, G. W. and Honjo, T., RBP-L, a transcription factor related to RBP-Jkappa. Mol. Cell Biol. 1997. 17: 2679-2687.
21. Sun, X. and Artavanis-Tsakonas, S., The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development 1996. 122: 2465-2474. (Pubitemid 26265605)
22. Hicks, C., Johnston, S. H., di Sibio, G., Collazo, A., Vogt, T. F. and Weinmaster, G., Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat. Cell Biol. 2000. 2: 515-520.
23. Shimizu, K., Chiba, S., Saito, T., Takahashi, T., Kumano, K., Hamada, Y. and Hirai, H., Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. EMBO J. 2002. 21: 294-302. (Pubitemid 34137291)
24. Wang, W. and Struhl, G., Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila. Development 2005.132: 2883-2894.
25. Le Borgne, R., Remaud, S., Hamel, S. and Schweisguth, F., Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 2005. 3: e96.
26. Lai, E. C., Roegiers, F., Qin, X., Jan, Y. N. and Rubin, G. M., The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 2005. 132: 2319-2332
27. Koo, B. K., Lim, H. S., Song, R., Yoon, M. J., Yoon, K. J., Moon, J. S., Kim, Y. W. et al., Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development 2005. 132: 3459-3470 (Pubitemid 41246120)
28. Koo, B. K., Yoon, M. J., Yoon, K. J., Im, S. K., Kim, Y. Y., Kim, C. H., Suh, P. G. et al., An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS ONE 2007. 11: e1221.
29. Barsi, J. C., Rajendra, R.,Wu, J. I. and Artzt, K., Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Mech. Dev. 2005. 122: 1106-1117.
30. DeHart, S. L., Heikens, M. J. and Tsai, S., Jagged2 promotes the development of natural killer cells and the establishment of functional natural killer cell lines. Blood 2005. 105: 3521-3527. (Pubitemid 40628194)
31. Carotta, S., Brady, J., Wu, L. and Nutt, S. L., Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells. Eur. J. Immunol. 2006. 36: 3294-3304.
32. Rolink, A. G., Balciunaite, G., Demolière, C. and Ceredig, R., The potential involvement of Notch signaling in NK cell development. Immunol. Lett. 2006. 107: 50-57.
33. De Smedt, M., Hoebeke, I., Reynvoet, K., Leclercq, G. and Plum, J., Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment. Blood 2005. 106: 3498-3506.
34. Yang, L. T., Nichols, J. T., Yao, C., Manilay, J. O., Robey, E. A. and Weinmaster, G., Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol. Biol. Cell 2005. 16: 927-942.
35. Stanley, P. and Guidos, C. J., Regulation of Notch signaling during T- and B-cell development by O-fucose glycans. Immunol. Rev. 2009. 230: 201-215.
36. Yuan, J. S., Kousis, P. C., Suliman, S., Visan, I. and Guidos, C. J., Functions of notch signaling in the immune system: consensus and controversies. Annu. Rev. Immunol. 2010. 28: 343-365.
37. Dallas, M. H., Varnum-Finney, B., Delaney, C., Kato, K. and Bernstein, I. D., Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J. Exp. Med. 2005. 201: 1361-1366.
38. Delaney, C., Varnum-Finney, B., Aoyama, K., Brashem-Stein, C. and Bernstein, I. D., Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood 2005. 106: 2693-2699.
39. Schmitt, T. M., Ciofani, M., Petrie, H. T. and Zúñiga- Pflücker, J. C., Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J. Exp. Med. 2004. 200: 469-479.
40. Brooker, R., Hozumi, K. and Lewis, J., Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development 2006. 133: 1277-1286.
41. Cheng, P., Nefedova, Y., Corzo, C. A. and Gabrilovich, D. I., Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands. Blood 2007. 109: 507-515.
42. Santos, M. A., Sarmento, L. M., Rebelo, M., Doce, A. A., Maillard, I., Dumortier, A., Neves, H. et al., Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proc. Natl. Acad. Sci. USA 2007. 104: 15454-15459.
43. Urs, S., Roudabush, A., O'Neill, C. F., Pinz, I., Prudovsky, I., Kacer, D., Tang, Y. et al., Soluble forms of the Notch Ligands Delta1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distinct phenotypes. Am. J. Pathol. 2008. 173: 865-878.
44. Shimizu, K., Chiba, S., Saito, T., Kumano, K. and Hirai, H., Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. Biochem. Biophys. Res. Commun. 2000. 276: 385-389.