Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development

Molecular Biology of the Cell

Volumn 9, Issue 7, 1998, Pages 1709-1723

  Klueg, Kristin M ^a   Parody, Todd R ^a   Muskavitch, Marc A T ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; LIGAND;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALIA; HEXAPODA;

EID: 0031846155     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.7.1709     Document Type: Article

References (55)

1. Artavanis-Tsakonas, S., Matsuno, K., and Fortini, M.E. (1995). Notch signaling. Science 268, 225-232.
2. Authier, F., Posner, B.I., and Bergeron, J.J.M. (1996). Endosomal proteolysis of internalized proteins. FEBS Lett. 389, 55-60.
3. Baker, R., and Schubiger, G. (1996). Autonomous and nonautonomous Notch functions for embryonic muscle and epidermis development in Drosophila. Development 122, 617-626.
4. Bate, M., Rushton, E., and Frasch, M. (1993). A dual requirement for neurogenic genes in Drosophila myogenesis. Dev. Suppl. 149-161.
5. Bieber, A.J., Snow, P.M., Hortsch, M., Patel, N.H., Jacobs, J.R., Traquina, Z.R., Schilling, J., and Goodman, C.S. (1989). Drosophila neuroglian: a member of the immunogobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1. Cell 59, 447-460.
6. Bisgrove, B.W., Andrews, M.E., and Raff, R.A. (1991). Fibropellins, products of an EGF repeat-containing gene, form a unique extracellular matrix structure that surrounds the sea urchin embryo. Dev. Biol. 146, 89-99.
7. Blaumueller, C.M., Qi, H., Zagouras, P., and Artavanis-Tsakonas, S. (1997). Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 90, 281-291.
8. Bosenberg, M.W., and Massagué, J. (1993). Juxtacrine cell signaling molecule. Curr. Opin. Cell Biol. 5, 832-838.
9. Bunch, T.A., Grinblat, Y., and Goldstein, L.S.B. (1988). Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res. 16, 1043-1061.
10. Cagan, R.L., Krämer, H., Hart, A.C., and Zipursky, S.L. (1992). The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cell 69, 393-399.
11. Chang, C.-P. et al. (1993). Ligand-induced internalization of the epidermal growth factor receptor is mediated by the multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. J. Cell Biol. 268, 19312-19320.
12. Corbin, V., Michelson, A.M., Abmayr, S.M., Neel, V., Alcamo, E., Maniatis, T., and Young, M.W. (1991). A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 6, 311-323.
13. de la Pompa, J.L. et al. (1997). Conservation of the Notch signaling pathway in mammalian neurogenesis. Development 124, 1139-1148.
14. Evan, G.I., Lewis, G.K., Ramsay, G., and Bishop, J.M. (1985). Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5, 3610-3616.
15. Evans, E., Berk, D., and Leung, A. (1991). Detachment of agglutinin-bonded red blood cells. I. Forces to rupture molecular-point attachments. Biophys. J. 59, 838-848.
16. Fagotto, F., and Gumbiner, B.M. (1996). Cell contact-dependent signaling. Dev. Biol. 180, 445-454.
17. Fehon, R.G., Kooh, P.J., Rebay, I., Regan, C.L., Xu, T., Muskavitch, M.A., T., and S. Artavanis-Tsakonas. (1990). Molecular interactions between the protein products of the neurogenic loci Notch and Delta. two EGF homologous genes in Drosophila. Cell 61, 523-534.
18. Fleming, R.J., Scottgale, T.N., Diederich, R.J., and S. Artavanis-Tsakonas. (1990). The gene Serrate encodes a putative EGF-like transmembrane essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 4, 2188-2201.
19. Grell, M., Douni, E., Wajant, H., Lohden, M., Clauss, M., Maxeiner, W., Kollias, G., and Pfizenmaier, K. (1995). The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80-kDa tumor necrosis factor receptor. Cell 83, 793-802.
20. Hart, A.C., Krämer, H., and Zipursky, S.L. (1993). Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor. Nature 361, 732-736.
21. Hartenstein, A.Y., Rugendorff, A., Tepass, U., and Hartenstein, V. (1992). The function of the neurogenic genes during epithelial development in the Drosophila embryo. Development 116, 1203-1219.
22. Henderson, S.T., Gao, D., Lambie, E.J., and Kimble, J. (1994). lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development 120, 2913-2924.
23. Hopp, T.P., Prickett, K.S., Price, V.L., Libby, R.T., March, C.J., Cerretti, D.P., Urdal, D.L., and Conlon, P.J. (1988). A short polypeptide marker sequence useful for recombinant protein identification and purification. Bio/Technology 6, 1204-1210.
24. Hortsch, M., Bieber, A.J., Patel, N.H., and Goodman, C.S. (1990). Differential splicing generates a nervous system-specific form of Drosophila neuroglian. Neuron 4, 697-709.
25. Hortsch, M., Wang, Y.E., Marikar, Y., and Bieber, A.J. (1995). The cytoplasmic domain of the Drosophila cell adhesion molecule neuroglian is not essential for its homophilic adhesive properties in S2 cells. J. Cell Biol. 270, 18809-18817.
26. Huppert, S.S., Jacobsen, T.L., and Muskavitch, M.A.T. (1997). Feedback regulation is central to Delta-Notch signaling required for Drosophila wing vein morphogenesis. Development 124, 3283-3291.
27. Kooh, P.J., Fehon, R.G., and Muskavitch, M.A.T. (1993). Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development 117, 493-507.
28. Kopan, R., Schroeter, E.H., Weintraub, H., and Nye, J.S. (1996). Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl. Acad. Sci. USA 93, 1683-1688.
29. Kopczynski, C.C., Alton, A.K., Fechtel, K., Kooh, P.J., and Muskavitch, M.A. (1988). Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factors of vertebrates. Genes Dev. 2, 1723-1735.
30. Krämer, H., Cagan, R.L., and Zipursky, S.L. (1991). Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature 352, 207-212.
31. Krämer, H. (1993). Patrilocal cell-cell interactions: sevenless captures its bride. Trends Cell Biol. 3, 103-105.
32. Krämer, H., and Phistry, M. (1996). Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies. J. Cell Biol. 133, 1205-1215.
33. Lazarides, E., and Revel, J.P. (1979). The molecular basis of cell movement. Sci. Am. 240, 100-113.
34. Lehmann, R., Jiménez, F., Dietrich, U., and Campos-Ortega, J.A. (1983). On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster. Roux's Arch. Dev. Biol. 192, 62-74.
35. Lieber, T., Wesley, C., Alcamo, E., Hassel, B., Krane, J., Campos-Ortega, J.A., and Young, M.W. (1992). Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro. Neuron 9, 847-859.
36. Matsumoto, B., Defoe, D.M., and Besharse, J.C. (1987). Membrane turnover in rod photoreceptors: ensheathment and phagocytosis of outer segment distal tips by pseudopodia of the retinal pigment epithelium. Proc. R. Soc. Lond. B. Biol. Sci. 230, 339-354.
37. Muskavitch, M.A.T. (1994). Delta-Notch signaling and Drosophila cell fate choice. Dev. Biol. 166, 415-430.
38. Pan, D., and Rubin, G.M. (1997). Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90, 271-280.
39. Parody, T.R., and Muskavitch, M.A.T. (1993). The pleiotropic function of Delta during postembryonic development of Drosophila melanogaster. Genetics 135, 527-539.
40. Parks, A.L., and Muskavitch, M.A.T. (1993). Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev. Biol. 157, 484-496.
41. Parks, A.L., Turner, F.R., and Muskavitch, M.A.T. (1995). Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development. Mech. Dev. 50, 201-216.
42. Rebay, I., Fleming, R.J., Fehon, R.G., Cherbas, L.F., Cherbas, P.T., and Artavanis-Tsakonas, S. (1991). Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67, 687-699.
43. Robinson, M.S., Watts, C., and Zerial, M. (1996). Membrane dynamics in endocytosis. Cell 84, 13-21.
44. Seugnet, L., Simpson, P., and Haenlin, M. (1997). Requirement for dynamin during Notch signalling in Drosophila neurogenesis. Dev. Biol. 199, 585-598.
45. Shepard, S.B. (1991). A Genetic and Molecular Analysis of Interactions between the Drosophila melanogaster neurogenic genes Delta and Notch. Ph.D. Thesis. Bloomington, IN: Indiana University.
46. Schneider, I. (1972). Cell lines derived from late embryonic stages of Drosophila melanogaster. J. Embryol. Exp. Morphol. 27, 353-365.
47. Sun, X., and Artavanis-Tsakonas, S. (1996). The intracellular deletions of DELTA and SERRATE define dominant negative forms of the Drosophila Notch ligands. Development 122, 2465-2474.
48. Sun, X., and Artavanis-Tsakonas, S. (1997). Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development 124, 3439-3448.
49. Technau, G.M., and Campos-Ortega, J.A. (1987). Cell autonomy of expression of neurogenic genes of Drosophila melanogaster. Proc Natl. Acad. Sci. USA 84, 4500-4504.
50. Thomas, U., Speicher, S.A., and Knust, E. (1991). The Drosophila gene Serrate encodes and EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development 111, 749-761.
51. Vässin, H., Bremer, K.A., Knust, E., and Campos-Ortega, J.A. (1987). The neurogenic Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J. 6, 3431-3440.
52. Vässin, H., and Campos-Ortega, J.A. (1987). Genetic analysis of Delta, a neurogenic gene of Drosophila melanogaster. Genetics 116, 433-445.
53. Wharton, K.A., Johansen, K.M., Xu, T., and Artavanis-Tsakonas, S. (1985). Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43, 567-581.
54. Yochem, J., and Greenwald, I. (1989). glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins. Cell 58, 553-563.
55. Xia, Z., Goldsmith, H.L., and van de Ven, T.G. M. (1994). Flow-induced detachment of red blood cells adhering to surfaces by specific antigen-antibody bonds. Biophys. J. 66, 1222-1230.