γδ and αβ T cell lineage choice: Resolution by a stronger sense of being

Seminars in Immunology

Volumn 22, Issue 4, 2010, Pages 228-236

  Wong, Gladys W ^a   Zúñiga Pflücker, Juan Carlos ^a  

^a Sunnybrook Health Sciences Centre   (Canada)

Author keywords

Id3; Lineage commitment; Notch; T cell differentiation; TCR signal strength

Indexed keywords

INHIBITOR OF DIFFERENTIATION 3; INTERLEUKIN 17; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

CELL LINEAGE; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; GAMMA DELTA T LYMPHOCYTE; GENE REARRANGEMENT; HUMAN; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; STOCHASTIC MODEL; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; IMMUNOLOGY; METABOLISM; T LYMPHOCYTE;

ANIMALS; CELL LINEAGE; HUMANS; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77954661064     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2010.04.005     Document Type: Review

References (127)

1. Hedrick S.M., Cohen D.I., Nielsen E.A., Davis M.M. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 1984, 308:149-153.
2. Saito H., Kranz D.M., Takagaki Y., Hayday A.C., Eisen H.N., Tonegawa S. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature 1984, 309:757-762.
3. Hannum C.H., Kappler J.W., Trowbridge I.S., Marrack P., Freed J.H. Immunoglobulin-like nature of the alpha-chain of a human T-cell antigen/MHC receptor. Nature 1984, 312:65-67.
4. Robertson M. The capture of the snark. Nature 1984, 312:16-17.
5. Hayday A.C., Saito H., Gillies S.D., Kranz D.M., Tanigawa G., Eisen H.N., et al. Structure, organization, and somatic rearrangement of T cell gamma genes. Cell 1985, 40:259-269.
6. Ishida I., Verbeek S., Bonneville M., Itohara S., Berns A., Tonegawa S. T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells. Proc Natl Acad Sci USA 1990, 87:3067-3071.
7. Bonneville M., Ishida I., Mombaerts P., Katsuki M., Verbeek S., Berns A., et al. Blockage of alpha beta T-cell development by TCR gamma delta transgenes. Nature 1989, 342:931-934.
8. Thompson S.D., Pelkonen J., Hurwitz J.L. Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors. Proc Natl Acad Sci USA 1990, 87:5583-5586.
9. Pardoll D.M., Fowlkes B.J., Bluestone J.A., Kruisbeek A., Maloy W.L., Coligan J.E., et al. Differential expression of two distinct T-cell receptors during thymocyte development. Nature 1987, 326:79-81.
10. Kang J., Volkmann A., Raulet D.H. Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling. J Exp Med 2001, 193:689-698.
11. Haks M.C., Lefebvre J.M., Lauritsen J.P., Carleton M., Rhodes M., Miyazaki T., et al. Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Immunity 2005, 22:595-606.
12. Hayes S.M., Li L., Love P.E. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity 2005, 22:583-593.
13. Pennington D.J., Silva-Santos B., Hayday A.C. Gammadelta T cell development-having the strength to get there. Curr Opin Immunol 2005, 17:108-115.
14. Livak F., Petrie H.T., Crispe I.N., Schatz D.G. In-frame TCR delta gene rearrangements play a critical role in the alpha beta/gamma delta T cell lineage decision. Immunity 1995, 2:617-627.
15. Godfrey D.I., Kennedy J., Suda T., Zlotnik A. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol 1993, 150:4244-4252.
16. Petrie H.T., Scollay R., Shortman K. Commitment to the T cell receptor-alpha beta or -gamma delta lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes. Eur J Immunol 1992, 22:2185-2188.
17. Dudley E.C., Girardi M., Owen M.J., Hayday A.C. Alpha beta and gamma delta T cells can share a late common precursor. Curr Biol 1995, 5:659-669.
18. Livak F., Tourigny M., Schatz D.G., Petrie H.T. Characterization of TCR gene rearrangements during adult murine T cell development. J Immunol 1999, 162:2575-2580.
19. Capone M., Hockett R.D., Zlotnik A. Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes. Proc Natl Acad Sci USA 1998, 95:12522-12527.
20. Hoffman E.S., Passoni L., Crompton T., Leu T.M., Schatz D.G., Koff A., et al. Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev 1996, 10:948-962.
21. Mallick C.A., Dudley E.C., Viney J.L., Owen M.J., Hayday A.C. Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development. Cell 1993, 73:513-519.
22. Dudley E.C., Petrie H.T., Shah L.M., Owen M.J., Hayday A.C. T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1994, 1:83-93.
23. von Boehmer H., Fehling H.J. Structure and function of the pre-T cell receptor. Ann Rev Immunol 1997, 15:433-452.
24. Saint-Ruf C., Ungewiss K., Groettrup M., Bruno L., Fehling H.J., von Boehmer H. Analysis and expression of a cloned pre-T cell receptor gene. Science 1994, 266:1208-1212.
25. Mombaerts P., Clarke A.R., Rudnicki M.A., Iacomini J., Itohara S., Lafaille J.J., et al. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491]. Nature 1992, 360:225-231.
26. Kang J., Coles M., Cado D., Raulet D.H. The developmental fate of T cells is critically influenced by TCRgammadelta expression. Immunity 1998, 8:427-438.
27. Passoni L., Hoffman E.S., Kim S., Crompton T., Pao W., Dong M.Q., et al. Intrathymic delta selection events in gammadelta cell development. Immunity 1997, 7:83-95.
28. Pennington D.J., Silva-Santos B., Shires J., Theodoridis E., Pollitt C., Wise E.L., et al. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol 2003, 4:991-998.
29. Pereira P., Zijlstra M., McMaster J., Loring J.M., Jaenisch R., Tonegawa S. Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice. EMBO J 1992, 11:25-31.
30. Silva-Santos B., Pennington D.J., Hayday A.C. Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors. Science 2005, 307:925-928.
31. Burtrum D.B., Kim S., Dudley E.C., Hayday A.C., Petrie H.T. TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development. J Immunol 1996, 157:4293-4296.
32. Schmitt T.M., Zúñiga-Pflücker J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 2002, 17:749-756.
33. Zuniga-Pflucker J.C. T-cell development made simple. Nat Rev Immunol 2004, 4:67-72.
34. Ciofani M., Knowles G.C., Wiest D.L., von Boehmer H., Zuniga-Pflucker J.C. Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity 2006, 25:105-116.
35. Kreslavsky T., Garbe A.I., Krueger A., von Boehmer H. T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis. J Exp Med 2008, 205:1173-1186.
36. Saint-Ruf C., Panigada M., Azogui O., Debey P., von Boehmer H., Grassi F. Different initiation of pre-TCR and gammadeltaTCR signalling. Nature 2000, 406:524-527.
37. Livak F., Wilson A., MacDonald H.R., Schatz D.G. Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain. Eur J Immunol 1997, 27:2948-2958.
38. Fehling H.J., Krotkova A., Saint-Ruf C., von Boehmer H. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature 1995, 375:795-798.
39. Terrence K., Pavlovich C.P., Matechak E.O., Fowlkes B.J. Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells. J Exp Med 2000, 192:537-548.
40. Bruno L., Fehling H.J., von Boehmer H. The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. Immunity 1996, 5:343-352.
41. Hayes S.M., Love P.E. Distinct structure and signaling potential of the gamma delta TCR complex. Immunity 2002, 16:827-838.
42. Delgado P., Fernandez E., Dave V., Kappes D., Alarcon B. CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature 2000, 406:426-430.
43. Werlen G., Hausmann B., Palmer E. A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity. Nature 2000, 406:422-426.
44. Love P.E., Shores E.W., Johnson M.D., Tremblay M.L., Lee E.J., Grinberg A., et al. T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. Science 1993, 261:918-921.
45. Shores E.W., Huang K., Tran T., Lee E., Grinberg A., Love P.E. Role of TCR zeta chain in T cell development and selection. Science 1994, 266:1047-1050.
46. Bhandoola A., Bosselut R., Yu Q., Cowan M.L., Feigenbaum L., Love P.E., et al. CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain. Eur J Immunol 2002, 32:1811-1817.
47. Azzam H.S., Grinberg A., Lui K., Shen H., Shores E.W., Love P.E. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med 1998, 188:2301-2311.
48. Tarakhovsky A., Kanner S.B., Hombach J., Ledbetter J.A., Muller W., Killeen N., et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 1995, 269:535-537.
49. Washburn T., Schweighoffer E., Gridley T., Chang D., Fowlkes B.J., Cado D., et al. Notch activity influences the alphabeta versus gammadelta T cell lineage decision. Cell 1997, 88:833-843.
50. Grusby M.J., Glimcher L.H. Immune responses in MHC class II-deficient mice. Ann Rev Immunol 1995, 13:417-435.
51. Koller B.H., Marrack P., Kappler J.W., Smithies O. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 1990, 248:1227-1230.
52. Panigada M., Porcellini S., Barbier E., Hoeflinger S., Cazenave P.A., Gu H., et al. Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med 2002, 195:1585-1597.
53. Yamasaki S., Ishikawa E., Sakuma M., Ogata K., Sakata-Sogawa K., Hiroshima M., et al. Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol 2006, 7:67-75.
54. Prinz I., Sansoni A., Kissenpfennig A., Ardouin L., Malissen M., Malissen B. Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nat Immunol 2006, 7:995-1003.
55. Lewis J.M., Girardi M., Roberts S.J., Barbee S.D., Hayday A.C., Tigelaar R.E. Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant. Nat Immunol 2006, 7:843-850.
56. Chien Y.H., Konigshofer Y. Antigen recognition by gammadelta T cells. Immunol Rev 2007, 215:46-58.
57. Wells F.B., Gahm S.J., Hedrick S.M., Bluestone J.A., Dent A., Matis L.A. Requirement for positive selection of gamma delta receptor-bearing T cells. Science 1991, 253:903-905.
58. Schweighoffer E., Fowlkes B.J. Positive selection is not required for thymic maturation of transgenic gamma delta T cells. J Exp Med 1996, 183:2033-2041.
59. Crowley M.P., Reich Z., Mavaddat N., Altman J.D., Chien Y. The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gammadelta T cell, G8. J Exp Med 1997, 185:1223-1230.
60. Adams E.J., Chien Y.H., Garcia K.C. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science 2005, 308:227-231.
61. Penninger J., Kishihara K., Molina T., Wallace V.A., Timms E., Hedrick S.M., et al. Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science 1993, 260:358-361.
62. Quong M.W., Romanow W.J., Murre C. E protein function in lymphocyte development. Annu Rev Immunol 2002, 20:301-322.
63. Greenbaum S., Zhuang Y. Regulation of early lymphocyte development by E2A family proteins. Semin Immunol 2002, 14:405-414.
64. Murre C. Helix-loop-helix proteins and lymphocyte development. Nat Immunol 2005, 6:1079-1086.
65. Heemskerk M.H., Blom B., Nolan G., Stegmann A.P., Bakker A.Q., Weijer K., et al. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J Exp Med 1997, 186:1597-1602.
66. Murre C., McCaw P.S., Baltimore D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 1989, 56:777-783.
67. Murre C., McCaw P.S., Vaessin H., Caudy M., Jan L.Y., Jan Y.N., et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 1989, 58:537-544.
68. Voronova A., Baltimore D. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. Proc Natl Acad Sci USA 1990, 87:4722-4726.
69. Takeuchi A., Yamasaki S., Takase K., Nakatsu F., Arase H., Onodera M., et al. E2A and HEB activate the pre-TCR alpha promoter during immature T cell development. J Immunol 2001, 167:2157-2163.
70. Schwartz R., Engel I., Fallahi-Sichani M., Petrie H.T., Murre C. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Proc Natl Acad Sci USA 2006, 103:9976-9981.
71. Bain G., Engel I., Robanus Maandag E.C., te Riele H.P., Voland J.R., Sharp L.L., et al. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol 1997, 17:4782-4791.
72. Barndt R.J., Dai M., Zhuang Y. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol Cell Biol 2000, 20:6677-6685.
73. Wojciechowski J., Lai A., Kondo M., Zhuang Y. E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J Immunol 2007, 178:5717-5726.
74. Engel I., Johns C., Bain G., Rivera R.R., Murre C. Early thymocyte development is regulated by modulation of e2a protein activity. J Exp Med 2001, 194:733-746.
75. Engel I., Murre C. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J 2004, 23:202-211.
76. Benezra R., Davis R.L., Lockshon D., Turner D.L., Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 1990, 61:49-59.
77. Taghon T., Yui M.A., Pant R., Diamond R.A., Rothenberg E.V. Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus. Immunity 2006, 24:53-64.
78. Rivera R.R., Johns C.P., Quan J., Johnson R.S., Murre C. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity 2000, 12:17-26.
79. Blom B., Heemskerk M.H., Verschuren M.C., van Dongen J.J., Stegmann A.P., Bakker A.Q., et al. Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. EMBO J 1999, 18:2793-2802.
80. Ueda-Hayakawa I., Mahlios J., Zhuang Y. Id3 restricts the developmental potential of gammadelta lineage during thymopoiesis. J Immunol 2009, 182:5306-5316.
81. Agata Y., Tamaki N., Sakamoto S., Ikawa T., Masuda K., Kawamoto H., et al. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity 2007, 27:871-884.
82. Bain G., Romanow W.J., Albers K., Havran W.L., Murre C. Positive and negative regulation of V(D)J recombination by the E2A proteins. J Exp Med 1999, 189:289-300.
83. Lauritsen J.P., Wong G.W., Lee S.Y., Lefebvre J.M., Ciofani M., Rhodes M., et al. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity 2009, 31:565-575.
84. Ferrick D.A., Gemmell-Hori L., Sydora B., Mulvania T., Penninger J.M., Kronenberg M., et al. Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice. Int Rev Immunol 1994, 11:295-304.
85. Alonzo E.S., Gottschalk R.A., Das J., Egawa T., Hobbs R.M., Pandolfi P.P., et al. Development of promyelocytic zinc finger and ThPOK-expressing innate gammadelta T cells is controlled by strength of TCR signaling and Id3. J Immunol 2010, 184:1268-1279.
86. Bendelac A., Bonneville M., Kearney J.F. Autoreactivity by design: innate B and T lymphocytes. Nat Rev Immunol 2001, 1:177-186.
87. Bendelac A. Nondeletional pathways for the development of autoreactive thymocytes. Nat Immunol 2004, 5:557-558.
88. Rothenberg E.V., Moore J.E., Yui M.A. Launching the T-cell-lineage developmental programme. Nat Rev Immunol 2008, 8:9-21.
89. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776.
90. Lai E.C. Notch signaling: control of cell communication and cell fate. Development 2004, 131:965-973.
91. Deftos M.L., Bevan M.J. Notch signaling in T cell development. Curr Opin Immunol 2000, 12:166-172.
92. Weinmaster G. The ins and outs of notch signaling. Mol Cell Neurosci 1997, 9:91-102.
93. Struhl G., Adachi A. Nuclear access and action of notch in vivo. Cell 1998, 93:649-660.
94. Deftos M.L., He Y.W., Ojala E.W., Bevan M.J. Correlating notch signaling with thymocyte maturation. Immunity 1998, 9:777-786.
95. Fryer C.J., Lamar E., Turbachova I., Kintner C., Jones K.A. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev 2002, 16:1397-1411.
96. Mumm J.S., Kopan R. Notch signaling: from the outside in. Dev Biol 2000, 228:151-165.
97. Nam Y., Weng A.P., Aster J.C., Blacklow S.C. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem 2003, 278:21232-21239.
98. Wallberg A.E., Pedersen K., Lendahl U., Roeder R.G. p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol 2002, 22:7812-7819.
99. Davis R.L., Turner D.L. Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 2001, 20:8342-8357.
100. Iso T., Kedes L., Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003, 194:237-255.
101. Yamamoto N., Yamamoto S., Inagaki F., Kawaichi M., Fukamizu A., Kishi N., et al. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. J Biol Chem 2001, 276:45031-45040.
102. Michie A.M., Chan A.C., Ciofani M., Carleton M., Lefebvre J.M., He Y., et al. Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. Int Immunol 2007, 19:1421-1430.
103. Radtke F., Wilson A., Stark G., Bauer M., van Meerwijk J., MacDonald H.R., et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999, 10:547-558.
104. Wolfer A., Wilson A., Nemir M., MacDonald H.R., Radtke F. Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta lineage thymocytes. Immunity 2002, 16:869-879.
105. Radtke F., Wilson A., Mancini S.J., MacDonald H.R. Notch regulation of lymphocyte development and function. Nat Immunol 2004, 5:247-253.
106. Tanigaki K., Tsuji M., Yamamoto N., Han H., Tsukada J., Inoue H., et al. Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 2004, 20:611-622.
107. Ciofani M., Schmitt T.M., Ciofani A., Michie A.M., Cuburu N., Aublin A., et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J Immunol 2004, 172:5230-5239.
108. Ciofani M., Zúñiga-Pflücker J.C. Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 2005, 6:881-888.
109. Maillard I., Tu L., Sambandam A., Yashiro-Ohtani Y., Millholland J., Keeshan K., et al. The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J Exp Med 2006, 203:2239-2245.
110. Doerfler P., Shearman M.S., Perlmutter R.M. Presenilin-dependent gamma-secretase activity modulates thymocyte development. Proc Natl Acad Sci USA 2001, 98:9312-9317.
111. Garbe A.I., Krueger A., Gounari F., Zuniga-Pflucker J.C., von Boehmer H. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med 2006, 203:1579-1590.
112. Reynaud-Deonauth S., Zhang H., Afouda A., Taillefert S., Beatus P., Kloc M., et al. Notch signaling is involved in the regulation of Id3 gene transcription during Xenopus embryogenesis. Differentiation 2002, 69:198-208.
113. Ordentlich P., Lin A., Shen C.P., Blaumueller C., Matsuno K., Artavanis-Tsakonas S., et al. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol 1998, 18:2230-2239.
114. Nie L., Xu M., Vladimirova A., Sun X.H. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J 2003, 22:5780-5792.
115. Deed R.W., Hara D., Atherton G.T., Peters G., Norton J.D. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol Cell Biol 1997, 17:6815-6821.
116. Yashiro-Ohtani Y., He Y., Ohtani T., Jones M.E., Shestova O., Xu L., et al. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev 2009, 23:1665-1676.
117. Ikawa T., Kawamoto H., Goldrath A.W., Murre C. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J Exp Med 2006, 203:1329-1342.
118. Lockhart E., Green A.M., Flynn J.L. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol 2006, 177:4662-4669.
119. Roark C.L., Simonian P.L., Fontenot A.P., Born W.K., O'Brien R.L. gammadelta T cells: an important source of IL-17. Curr Opin Immunol 2008, 20:353-357.
120. Jensen K.D., Su X., Shin S., Li L., Youssef S., Yamasaki S., et al. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity 2008, 29:90-100.
121. Serwold T., Hochedlinger K., Inlay M.A., Jaenisch R., Weissman I.L. Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. J Immunol 2007, 179:928-938.
122. Adams E.J., Strop P., Shin S., Chien Y.H., Garcia K.C. An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat Immunol 2008, 9:777-784.
123. Shin S., El-Diwany R., Schaffert S., Adams E.J., Garcia K.C., Pereira P., et al. Antigen recognition determinants of gammadelta T cell receptors. Science 2005, 308:252-255.
124. Dent A.L., Matis L.A., Hooshmand F., Widacki S.M., Bluestone J.A., Hedrick S.M. Self-reactive gamma delta T cells are eliminated in the thymus. Nature 1990, 343:714-719.
125. Yoshimura A., Longmore G., Lodish H.F. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 1990, 348:647-649.
126. Martin B., Hirota K., Cua D.J., Stockinger B., Veldhoen M. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 2009, 31:321-330.
127. Sutton C.E., Lalor S.J., Sweeney C.M., Brereton C.F., Lavelle E.C., Mills K.H. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 2009, 31:331-341.