-
1
-
-
77952270503
-
Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma
-
Adams H., Fritzsche F.R., Dirnhofer S., Kristiansen G., Tzankov A. Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert Opinion on Therapeutic Targets 2010, 14:577-584.
-
(2010)
Expert Opinion on Therapeutic Targets
, vol.14
, pp. 577-584
-
-
Adams, H.1
Fritzsche, F.R.2
Dirnhofer, S.3
Kristiansen, G.4
Tzankov, A.5
-
3
-
-
0022366477
-
Enhancement of radiation injury in human colon tumor cells by the maturational agent sodium butyrate (NaB)
-
Arundel C.M., Glicksman A.S., Leith J.T. Enhancement of radiation injury in human colon tumor cells by the maturational agent sodium butyrate (NaB). Radiation Research 1985, 104:443-448.
-
(1985)
Radiation Research
, vol.104
, pp. 443-448
-
-
Arundel, C.M.1
Glicksman, A.S.2
Leith, J.T.3
-
5
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
6
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
7
-
-
33644859838
-
DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines
-
Basile V., Mantovani R., Imbriano C. DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. The Journal of Biological Chemistry 2006, 281:2347-2357.
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 2347-2357
-
-
Basile, V.1
Mantovani, R.2
Imbriano, C.3
-
8
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
Bedard K., Krause K.H. The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiological Reviews 2007, 87:245-313.
-
(2007)
Physiological Reviews
, vol.87
, pp. 245-313
-
-
Bedard, K.1
Krause, K.H.2
-
9
-
-
70350763838
-
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
-
Beucher A., Birraux J., Tchouandong L., Barton O., Shibata A., Conrad S., et al. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. The EMBO Journal 2009, 28:3413-3427.
-
(2009)
The EMBO Journal
, vol.28
, pp. 3413-3427
-
-
Beucher, A.1
Birraux, J.2
Tchouandong, L.3
Barton, O.4
Shibata, A.5
Conrad, S.6
-
10
-
-
66249124267
-
PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells
-
Bhalla S., Balasubramanian S., David K., Sirisawad M., Buggy J., Mauro L., et al. PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clinical Cancer Research 2009, 15:3354-3365.
-
(2009)
Clinical Cancer Research
, vol.15
, pp. 3354-3365
-
-
Bhalla, S.1
Balasubramanian, S.2
David, K.3
Sirisawad, M.4
Buggy, J.5
Mauro, L.6
-
11
-
-
41549156540
-
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control
-
Bhaskara S., Chyla B.J., Amann J.M., Knutson S.K., Cortez D., Sun Z.W., et al. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Molecular Cell 2008, 30:61-72.
-
(2008)
Molecular Cell
, vol.30
, pp. 61-72
-
-
Bhaskara, S.1
Chyla, B.J.2
Amann, J.M.3
Knutson, S.K.4
Cortez, D.5
Sun, Z.W.6
-
12
-
-
78249276172
-
Hdac3 is essential for the maintenance of chromatin structure and genome stability
-
Bhaskara S., Knutson S.K., Jiang G., Chandrasekharan M.B., Wilson A.J., Zheng S., et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 2010, 18:436-447.
-
(2010)
Cancer Cell
, vol.18
, pp. 436-447
-
-
Bhaskara, S.1
Knutson, S.K.2
Jiang, G.3
Chandrasekharan, M.B.4
Wilson, A.J.5
Zheng, S.6
-
13
-
-
34047112221
-
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
-
Bindra R.S., Glazer P.M. Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene 2007, 26:2048-2057.
-
(2007)
Oncogene
, vol.26
, pp. 2048-2057
-
-
Bindra, R.S.1
Glazer, P.M.2
-
15
-
-
27144475816
-
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
-
Bradbury C.A., Khanim F.L., Hayden R., Bunce C.M., White D.A., Drayson M.T., et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 2005, 19:1751-1759.
-
(2005)
Leukemia
, vol.19
, pp. 1751-1759
-
-
Bradbury, C.A.1
Khanim, F.L.2
Hayden, R.3
Bunce, C.M.4
White, D.A.5
Drayson, M.T.6
-
16
-
-
0030615230
-
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia
-
Brown D., Kogan S., Lagasse E., Weissman I., Alcalay M., Pelicci P.G., et al. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:2551-2556.
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, pp. 2551-2556
-
-
Brown, D.1
Kogan, S.2
Lagasse, E.3
Weissman, I.4
Alcalay, M.5
Pelicci, P.G.6
-
17
-
-
0037015071
-
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
-
Butler L.M., Zhou X., Xu W.S., Scher H.I., Rifkind R.A., Marks P.A., et al. The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:11700-11705.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 11700-11705
-
-
Butler, L.M.1
Zhou, X.2
Xu, W.S.3
Scher, H.I.4
Rifkind, R.A.5
Marks, P.A.6
-
18
-
-
33847618236
-
Mammalian single-strand break repair: Mechanisms and links with chromatin
-
Caldecott K.W. Mammalian single-strand break repair: Mechanisms and links with chromatin. DNA Repair 2007, 6:443-453.
-
(2007)
DNA Repair
, vol.6
, pp. 443-453
-
-
Caldecott, K.W.1
-
19
-
-
0033583204
-
The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
-
Calsou P., Frit P., Humbert O., Muller C., Chen D.J., Salles B. The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA. The Journal of Biological Chemistry 1999, 274:7848-7856.
-
(1999)
The Journal of Biological Chemistry
, vol.274
, pp. 7848-7856
-
-
Calsou, P.1
Frit, P.2
Humbert, O.3
Muller, C.4
Chen, D.J.5
Salles, B.6
-
20
-
-
1642576220
-
Enhanced radiation-induced cell killing and prolongation of gH2AX foci expression by the histone deacetylase inhibitor MS-275
-
Camphausen K., Burgan W., Cerra M., Oswald K.A., Trepel J.B., Lee M.J., et al. Enhanced radiation-induced cell killing and prolongation of gH2AX foci expression by the histone deacetylase inhibitor MS-275. Cancer Research 2004, 64:316-321.
-
(2004)
Cancer Research
, vol.64
, pp. 316-321
-
-
Camphausen, K.1
Burgan, W.2
Cerra, M.3
Oswald, K.A.4
Trepel, J.B.5
Lee, M.J.6
-
22
-
-
49349098483
-
Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy
-
Carew J.S., Giles F.J., Nawrocki S.T. Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy. Cancer Letters 2008, 269:7-17.
-
(2008)
Cancer Letters
, vol.269
, pp. 7-17
-
-
Carew, J.S.1
Giles, F.J.2
Nawrocki, S.T.3
-
23
-
-
3042786456
-
Characterization of the 5'flanking region of the human Chk1 gene: Identification of E2F1 functional sites
-
Carrassa L., Broggini M., Vikhanskaya F., Damia G. Characterization of the 5'flanking region of the human Chk1 gene: Identification of E2F1 functional sites. Cell Cycle 2003, 2:604-609.
-
(2003)
Cell Cycle
, vol.2
, pp. 604-609
-
-
Carrassa, L.1
Broggini, M.2
Vikhanskaya, F.3
Damia, G.4
-
24
-
-
79960821550
-
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells
-
Cea M., Soncini D., Fruscione F., Raffaghello L., Garuti A., Emionite L., et al. Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. PLoS One 2011, 6:e22739.
-
(2011)
PLoS One
, vol.6
-
-
Cea, M.1
Soncini, D.2
Fruscione, F.3
Raffaghello, L.4
Garuti, A.5
Emionite, L.6
-
25
-
-
84855363380
-
Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide
-
Chang J., Varghese D.S., Gillam M.C., Peyton M., Modi B., Schiltz R.L., et al. Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. British Journal of Cancer 2012, 106:116-125.
-
(2012)
British Journal of Cancer
, vol.106
, pp. 116-125
-
-
Chang, J.1
Varghese, D.S.2
Gillam, M.C.3
Peyton, M.4
Modi, B.5
Schiltz, R.L.6
-
26
-
-
81155148158
-
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
-
Chauhan D., Bandi M., Singh A.V., Ray A., Raje N., Richardson P., et al. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. British Journal of Haematology 2011, 155:588-598.
-
(2011)
British Journal of Haematology
, vol.155
, pp. 588-598
-
-
Chauhan, D.1
Bandi, M.2
Singh, A.V.3
Ray, A.4
Raje, N.5
Richardson, P.6
-
27
-
-
51649114803
-
Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells
-
Chen G., Li A., Zhao M., Gao Y., Zhou T., Xu Y., et al. Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells. Journal of Proteome Research 2008, 7:2733-2742.
-
(2008)
Journal of Proteome Research
, vol.7
, pp. 2733-2742
-
-
Chen, G.1
Li, A.2
Zhao, M.3
Gao, Y.4
Zhou, T.5
Xu, Y.6
-
28
-
-
34548036251
-
Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells
-
Chen Z.X., Pervaiz S. Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death and Differentiation 2007, 14:1617-1627.
-
(2007)
Cell Death and Differentiation
, vol.14
, pp. 1617-1627
-
-
Chen, Z.X.1
Pervaiz, S.2
-
29
-
-
34347206854
-
Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation
-
Chen C.S., Wang Y.C., Yang H.C., Huang P.H., Kulp S.K., Yang C.C., et al. Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation. Cancer Research 2007, 67:5318-5327.
-
(2007)
Cancer Research
, vol.67
, pp. 5318-5327
-
-
Chen, C.S.1
Wang, Y.C.2
Yang, H.C.3
Huang, P.H.4
Kulp, S.K.5
Yang, C.C.6
-
30
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
-
31
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
Ciccia A., Elledge S.J. The DNA damage response: Making it safe to play with knives. Molecular Cell 2010, 40:179-204.
-
(2010)
Molecular Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
32
-
-
0030065418
-
Superoxide anion is a natural inhibitor of FAS-mediated cell death
-
Clement M.V., Stamenkovic I. Superoxide anion is a natural inhibitor of FAS-mediated cell death. The EMBO Journal 1996, 15:216-225.
-
(1996)
The EMBO Journal
, vol.15
, pp. 216-225
-
-
Clement, M.V.1
Stamenkovic, I.2
-
33
-
-
12144286529
-
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
-
Cohen H.Y., Lavu S., Bitterman K.J., Hekking B., Imahiyerobo T.A., Miller C., et al. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Molecular Cell 2004, 13:627-638.
-
(2004)
Molecular Cell
, vol.13
, pp. 627-638
-
-
Cohen, H.Y.1
Lavu, S.2
Bitterman, K.J.3
Hekking, B.4
Imahiyerobo, T.A.5
Miller, C.6
-
34
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392.
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
-
35
-
-
20744449274
-
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation
-
Dai Y., Rahmani M., Dent P., Grant S. Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation. Molecular and Cellular Biology 2005, 25:5429-5444.
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 5429-5444
-
-
Dai, Y.1
Rahmani, M.2
Dent, P.3
Grant, S.4
-
36
-
-
80052784486
-
Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo
-
Dasmahapatra G., Lembersky D., Son M.P., Attkisson E., Dent P., Fisher R.I., et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Molecular Cancer Therapeutics 2011, 10:1686-1697.
-
(2011)
Molecular Cancer Therapeutics
, vol.10
, pp. 1686-1697
-
-
Dasmahapatra, G.1
Lembersky, D.2
Son, M.P.3
Attkisson, E.4
Dent, P.5
Fisher, R.I.6
-
37
-
-
63649110740
-
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates
-
Deriano L., Stracker T.H., Baker A., Petrini J.H., Roth D.B. Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Molecular Cell 2009, 34:13-25.
-
(2009)
Molecular Cell
, vol.34
, pp. 13-25
-
-
Deriano, L.1
Stracker, T.H.2
Baker, A.3
Petrini, J.H.4
Roth, D.B.5
-
38
-
-
68249135624
-
Multiple functions of MRN in end-joining pathways during isotype class switching
-
Dinkelmann M., Spehalski E., Stoneham T., Buis J., Wu Y., Sekiguchi J.M., et al. Multiple functions of MRN in end-joining pathways during isotype class switching. Nature Structural & Molecular Biology 2009, 16:808-813.
-
(2009)
Nature Structural & Molecular Biology
, vol.16
, pp. 808-813
-
-
Dinkelmann, M.1
Spehalski, E.2
Stoneham, T.3
Buis, J.4
Wu, Y.5
Sekiguchi, J.M.6
-
39
-
-
18244373706
-
Enhanced pharmacodynamic and antitumor properties of a histone deacetylase inhibitor encapsulated in liposomes or ErbB2-targeted immunoliposomes
-
Drummond D.C., Marx C., Guo Z., Scott G., Noble C., Wang D., et al. Enhanced pharmacodynamic and antitumor properties of a histone deacetylase inhibitor encapsulated in liposomes or ErbB2-targeted immunoliposomes. Clinical Cancer Research 2005, 11:3392-3401.
-
(2005)
Clinical Cancer Research
, vol.11
, pp. 3392-3401
-
-
Drummond, D.C.1
Marx, C.2
Guo, Z.3
Scott, G.4
Noble, C.5
Wang, D.6
-
40
-
-
58149310725
-
Histone deacetylase inhibitors and genomic instability
-
Eot-Houllier G., Fulcrand G., Magnaghi-Jaulin L., Jaulin C. Histone deacetylase inhibitors and genomic instability. Cancer Letters 2009, 274:169-176.
-
(2009)
Cancer Letters
, vol.274
, pp. 169-176
-
-
Eot-Houllier, G.1
Fulcrand, G.2
Magnaghi-Jaulin, L.3
Jaulin, C.4
-
42
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J., Coates J., Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434:605-611.
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
43
-
-
0027156140
-
EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA
-
Falzon M., Fewell J.W., Kuff E.L. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. The Journal of Biological Chemistry 1993, 268:10546-10552.
-
(1993)
The Journal of Biological Chemistry
, vol.268
, pp. 10546-10552
-
-
Falzon, M.1
Fewell, J.W.2
Kuff, E.L.3
-
44
-
-
77955501963
-
SIRT1 regulates UV-induced DNA repair through deacetylating XPA
-
Fan W., Luo J. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Molecular Cell 2010, 39:247-258.
-
(2010)
Molecular Cell
, vol.39
, pp. 247-258
-
-
Fan, W.1
Luo, J.2
-
45
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga M.F., Ballestar E., Villar-Garea A., Boix-Chornet M., Espada J., Schotta G., et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nature Genetics 2005, 37:391-400.
-
(2005)
Nature Genetics
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
-
46
-
-
33748427812
-
Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: A mechanism for leukemia-specific HDI-dependent apoptosis?
-
Gaymes T.J., Padua R.A., Pla M., Orr S., Omidvar N., Chomienne C., et al. Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: A mechanism for leukemia-specific HDI-dependent apoptosis?. Molecular Cancer Research 2006, 4:563-573.
-
(2006)
Molecular Cancer Research
, vol.4
, pp. 563-573
-
-
Gaymes, T.J.1
Padua, R.A.2
Pla, M.3
Orr, S.4
Omidvar, N.5
Chomienne, C.6
-
47
-
-
84860186290
-
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1-arrest, ROS-dependent apoptosis and differentiation in human leukemia cells
-
Gong K., Xie J., Yi H., Li W. CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1-arrest, ROS-dependent apoptosis and differentiation in human leukemia cells. The Biochemical Journal 2012, 443(3):735-746.
-
(2012)
The Biochemical Journal
, vol.443
, Issue.3
, pp. 735-746
-
-
Gong, K.1
Xie, J.2
Yi, H.3
Li, W.4
-
48
-
-
34447555612
-
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated
-
Gopal Y.N., Arora T.S., Van Dyke M.W. Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated. Chemistry & Biology 2007, 14:813-823.
-
(2007)
Chemistry & Biology
, vol.14
, pp. 813-823
-
-
Gopal, Y.N.1
Arora, T.S.2
Van Dyke, M.W.3
-
49
-
-
33745714230
-
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
-
Gore S.D., Baylin S., Sugar E., Carraway H., Miller C.B., Carducci M., et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Research 2006, 66:6361-6369.
-
(2006)
Cancer Research
, vol.66
, pp. 6361-6369
-
-
Gore, S.D.1
Baylin, S.2
Sugar, E.3
Carraway, H.4
Miller, C.B.5
Carducci, M.6
-
50
-
-
0027397867
-
The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
-
Gottlieb T.M., Jackson S.P. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen. Cell 1993, 72:131-142.
-
(1993)
Cell
, vol.72
, pp. 131-142
-
-
Gottlieb, T.M.1
Jackson, S.P.2
-
51
-
-
77951091964
-
Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
-
Hajji N., Wallenborg K., Vlachos P., Fullgrabe J., Hermanson O., Joseph B. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. Oncogene 2010, 29:2192-2204.
-
(2010)
Oncogene
, vol.29
, pp. 2192-2204
-
-
Hajji, N.1
Wallenborg, K.2
Vlachos, P.3
Fullgrabe, J.4
Hermanson, O.5
Joseph, B.6
-
53
-
-
70350088548
-
Mechanisms of double-strand break repair in somatic mammalian cells
-
Hartlerode A.J., Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. The Biochemical Journal 2009, 423:157-168.
-
(2009)
The Biochemical Journal
, vol.423
, pp. 157-168
-
-
Hartlerode, A.J.1
Scully, R.2
-
54
-
-
0027217531
-
Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin
-
Hayashi T., Ueno Y., Okamoto T. Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. The Journal of Biological Chemistry 1993, 268:11380-11388.
-
(1993)
The Journal of Biological Chemistry
, vol.268
, pp. 11380-11388
-
-
Hayashi, T.1
Ueno, Y.2
Okamoto, T.3
-
55
-
-
0030936568
-
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
-
Hirota K., Matsui M., Iwata S., Nishiyama A., Mori K., Yodoi J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:3633-3638.
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, pp. 3633-3638
-
-
Hirota, K.1
Matsui, M.2
Iwata, S.3
Nishiyama, A.4
Mori, K.5
Yodoi, J.6
-
57
-
-
0029060757
-
Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event
-
Huang P., Plunkett W. Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event. Cancer Chemotherapy and Pharmacology 1995, 36:181-188.
-
(1995)
Cancer Chemotherapy and Pharmacology
, vol.36
, pp. 181-188
-
-
Huang, P.1
Plunkett, W.2
-
58
-
-
66149114020
-
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
-
Huertas P., Jackson S.P. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. The Journal of Biological Chemistry 2009, 284:9558-9565.
-
(2009)
The Journal of Biological Chemistry
, vol.284
, pp. 9558-9565
-
-
Huertas, P.1
Jackson, S.P.2
-
59
-
-
69949173301
-
Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence
-
Iliakis G. Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence. Radiotherapy and Oncology 2009, 92:310-315.
-
(2009)
Radiotherapy and Oncology
, vol.92
, pp. 310-315
-
-
Iliakis, G.1
-
60
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
-
Insinga A., Monestiroli S., Ronzoni S., Gelmetti V., Marchesi F., Viale A., et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nature Medicine 2005, 11:71-76.
-
(2005)
Nature Medicine
, vol.11
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
Gelmetti, V.4
Marchesi, F.5
Viale, A.6
-
61
-
-
0037112901
-
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
-
Ito A., Kawaguchi Y., Lai C.H., Kovacs J.J., Higashimoto Y., Appella E., et al. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. The EMBO Journal 2002, 21:6236-6245.
-
(2002)
The EMBO Journal
, vol.21
, pp. 6236-6245
-
-
Ito, A.1
Kawaguchi, Y.2
Lai, C.H.3
Kovacs, J.J.4
Higashimoto, Y.5
Appella, E.6
-
62
-
-
33847647624
-
SIRT1 promotes DNA repair activity and deacetylation of Ku70
-
Jeong J., Juhn K., Lee H., Kim S.H., Min B.H., Lee K.M., et al. SIRT1 promotes DNA repair activity and deacetylation of Ku70. Experimental & Molecular Medicine 2007, 39:8-13.
-
(2007)
Experimental & Molecular Medicine
, vol.39
, pp. 8-13
-
-
Jeong, J.1
Juhn, K.2
Lee, H.3
Kim, S.H.4
Min, B.H.5
Lee, K.M.6
-
63
-
-
33744942683
-
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM
-
Jiang X., Sun Y., Chen S., Roy K., Price B.D. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. The Journal of Biological Chemistry 2006, 281:15741-15746.
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 15741-15746
-
-
Jiang, X.1
Sun, Y.2
Chen, S.3
Roy, K.4
Price, B.D.5
-
64
-
-
77949743508
-
Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues
-
Jin K.L., Pak J.H., Park J.Y., Choi W.H., Lee J.Y., Kim J.H., et al. Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues. Journal of Gynecologic Oncology 2008, 19:185-190.
-
(2008)
Journal of Gynecologic Oncology
, vol.19
, pp. 185-190
-
-
Jin, K.L.1
Pak, J.H.2
Park, J.Y.3
Choi, W.H.4
Lee, J.Y.5
Kim, J.H.6
-
65
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone R.W. Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer. Nature Reviews. Drug Discovery 2002, 1:287-299.
-
(2002)
Nature Reviews. Drug Discovery
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
66
-
-
77955292345
-
Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor
-
Kachhap S.K., Rosmus N., Collis S.J., Kortenhorst M.S., Wissing M.D., Hedayati M., et al. Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor. PLoS One 2010, 5:e11208.
-
(2010)
PLoS One
, vol.5
-
-
Kachhap, S.K.1
Rosmus, N.2
Collis, S.J.3
Kortenhorst, M.S.4
Wissing, M.D.5
Hedayati, M.6
-
67
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi A., Weinert B.T., Choudhary C., Jackson S.P. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010, 329:1348-1353.
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.P.4
-
68
-
-
77957684701
-
Sachchidanand Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
-
Kalle A.M., Mallika A., Badiger J., Alinakhi, Talukdar P., Sachchidanand Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochemical and Biophysical Research Communications 2010, 401:13-19.
-
(2010)
Biochemical and Biophysical Research Communications
, vol.401
, pp. 13-19
-
-
Kalle, A.M.1
Mallika, A.2
Badiger, J.3
Alinakhi4
Talukdar, P.5
-
69
-
-
0037417373
-
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
-
Kao G.D., McKenna W.G., Guenther M.G., Muschel R.J., Lazar M.A., Yen T.J. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. The Journal of Cell Biology 2003, 160:1017-1027.
-
(2003)
The Journal of Cell Biology
, vol.160
, pp. 1017-1027
-
-
Kao, G.D.1
McKenna, W.G.2
Guenther, M.G.3
Muschel, R.J.4
Lazar, M.A.5
Yen, T.J.6
-
70
-
-
38449099535
-
The epigenetic modifier, valproic acid, enhances radiation sensitivity
-
Karagiannis T.C., Kn H., El-Osta A. The epigenetic modifier, valproic acid, enhances radiation sensitivity. Epigenetics 2006, 1:131-137.
-
(2006)
Epigenetics
, vol.1
, pp. 131-137
-
-
Karagiannis, T.C.1
Kn, H.2
El-Osta, A.3
-
71
-
-
84863717308
-
Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis
-
Kerr E., Holohan C., McLaughlin K.M., Majkut J., Dolan S., Redmond K., et al. Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. Cell Death and Differentiation 2012, 19(8):1317-1327.
-
(2012)
Cell Death and Differentiation
, vol.19
, Issue.8
, pp. 1317-1327
-
-
Kerr, E.1
Holohan, C.2
McLaughlin, K.M.3
Majkut, J.4
Dolan, S.5
Redmond, K.6
-
72
-
-
84855471990
-
HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications
-
Khan O., La Thangue N.B. HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications. Immunology and Cell Biology 2012, 90:85-94.
-
(2012)
Immunology and Cell Biology
, vol.90
, pp. 85-94
-
-
Khan, O.1
La Thangue, N.B.2
-
73
-
-
0035093737
-
DNA double-strand breaks: Signaling, repair and the cancer connection
-
Khanna K.K., Jackson S.P. DNA double-strand breaks: Signaling, repair and the cancer connection. Nature Genetics 2001, 27:247-254.
-
(2001)
Nature Genetics
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
74
-
-
0033615547
-
Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
-
Kim G.D., Choi Y.H., Dimtchev A., Jeong S.J., Dritschilo A., Jung M. Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. The Journal of Biological Chemistry 1999, 274:31127-31130.
-
(1999)
The Journal of Biological Chemistry
, vol.274
, pp. 31127-31130
-
-
Kim, G.D.1
Choi, Y.H.2
Dimtchev, A.3
Jeong, S.J.4
Dritschilo, A.5
Jung, M.6
-
75
-
-
77955713258
-
TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L)
-
Kim J.J., Lee S.B., Park J.K., Yoo Y.D. TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L). Cell Death and Differentiation 2010, 17:1420-1434.
-
(2010)
Cell Death and Differentiation
, vol.17
, pp. 1420-1434
-
-
Kim, J.J.1
Lee, S.B.2
Park, J.K.3
Yoo, Y.D.4
-
76
-
-
74049094817
-
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
-
Kim H.S., Patel K., Muldoon-Jacobs K., Bisht K.S., Aykin-Burns N., Pennington J.D., et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010, 17:41-52.
-
(2010)
Cancer Cell
, vol.17
, pp. 41-52
-
-
Kim, H.S.1
Patel, K.2
Muldoon-Jacobs, K.3
Bisht, K.S.4
Aykin-Burns, N.5
Pennington, J.D.6
-
77
-
-
24744469490
-
SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
-
Kobayashi Y., Furukawa-Hibi Y., Chen C., Horio Y., Isobe K., Ikeda K., et al. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. International Journal of Molecular Medicine 2005, 16:237-243.
-
(2005)
International Journal of Molecular Medicine
, vol.16
, pp. 237-243
-
-
Kobayashi, Y.1
Furukawa-Hibi, Y.2
Chen, C.3
Horio, Y.4
Isobe, K.5
Ikeda, K.6
-
78
-
-
82155171284
-
Regulation of reactive oxygen species in stem cells and cancer stem cells
-
Kobayashi C.I., Suda T. Regulation of reactive oxygen species in stem cells and cancer stem cells. Journal of Cellular Physiology 2012, 227:421-430.
-
(2012)
Journal of Cellular Physiology
, vol.227
, pp. 421-430
-
-
Kobayashi, C.I.1
Suda, T.2
-
79
-
-
79953157671
-
Histone deacetylases 9 and 10 are required for homologous recombination
-
Kotian S., Liyanarachchi S., Zelent A., Parvin J.D. Histone deacetylases 9 and 10 are required for homologous recombination. The Journal of Biological Chemistry 2011, 286:7722-7726.
-
(2011)
The Journal of Biological Chemistry
, vol.286
, pp. 7722-7726
-
-
Kotian, S.1
Liyanarachchi, S.2
Zelent, A.3
Parvin, J.D.4
-
80
-
-
78649861862
-
Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins)
-
Lawson M., Uciechowska U., Schemies J., Rumpf T., Jung M., Sippl W. Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins). Biochimica et Biophysica Acta 2010, 1799:726-739.
-
(2010)
Biochimica et Biophysica Acta
, vol.1799
, pp. 726-739
-
-
Lawson, M.1
Uciechowska, U.2
Schemies, J.3
Rumpf, T.4
Jung, M.5
Sippl, W.6
-
81
-
-
77957091318
-
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair
-
Lee J.H., Choy M.L., Ngo L., Foster S.S., Marks P.A. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:14639-14644.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 14639-14644
-
-
Lee, J.H.1
Choy, M.L.2
Ngo, L.3
Foster, S.S.4
Marks, P.A.5
-
82
-
-
79959697571
-
Assessment of oxidative stress-induced DNA damage by immunoflourescent analysis of 8-oxodG
-
Lee S.F., Pervaiz S. Assessment of oxidative stress-induced DNA damage by immunoflourescent analysis of 8-oxodG. Methods in Cell Biology 2011, 103:99-113.
-
(2011)
Methods in Cell Biology
, vol.103
, pp. 99-113
-
-
Lee, S.F.1
Pervaiz, S.2
-
83
-
-
43149118368
-
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
-
Li K., Casta A., Wang R., Lozada E., Fan W., Kane S., et al. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. The Journal of Biological Chemistry 2008, 283:7590-7598.
-
(2008)
The Journal of Biological Chemistry
, vol.283
, pp. 7590-7598
-
-
Li, K.1
Casta, A.2
Wang, R.3
Lozada, E.4
Fan, W.5
Kane, S.6
-
84
-
-
80054087824
-
Mitochondrial ROS generation for regulation of autophagic pathways in cancer
-
Li Z.Y., Yang Y., Ming M., Liu B. Mitochondrial ROS generation for regulation of autophagic pathways in cancer. Biochemical and Biophysical Research Communications 2011, 414:5-8.
-
(2011)
Biochemical and Biophysical Research Communications
, vol.414
, pp. 5-8
-
-
Li, Z.Y.1
Yang, Y.2
Ming, M.3
Liu, B.4
-
85
-
-
0033520969
-
Quality control by DNA repair
-
Lindahl T., Wood R.D. Quality control by DNA repair. Science 1999, 286:1897-1905.
-
(1999)
Science
, vol.286
, pp. 1897-1905
-
-
Lindahl, T.1
Wood, R.D.2
-
86
-
-
0032061317
-
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
-
Liu N., Lamerdin J.E., Tebbs R.S., Schild D., Tucker J.D., Shen M.R., et al. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Molecular Cell 1998, 1:783-793.
-
(1998)
Molecular Cell
, vol.1
, pp. 783-793
-
-
Liu, N.1
Lamerdin, J.E.2
Tebbs, R.S.3
Schild, D.4
Tucker, J.D.5
Shen, M.R.6
-
87
-
-
62449178216
-
The critical role of the class III histone deacetylase SIRT1 in cancer
-
Liu T., Liu P.Y., Marshall G.M. The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Research 2009, 69:1702-1705.
-
(2009)
Cancer Research
, vol.69
, pp. 1702-1705
-
-
Liu, T.1
Liu, P.Y.2
Marshall, G.M.3
-
88
-
-
28444433678
-
The two edges of the ATM sword: Co-operation between repair and checkpoint functions
-
Lobrich M., Jeggo P.A. The two edges of the ATM sword: Co-operation between repair and checkpoint functions. Radiotherapy and Oncology 2005, 76:112-118.
-
(2005)
Radiotherapy and Oncology
, vol.76
, pp. 112-118
-
-
Lobrich, M.1
Jeggo, P.A.2
-
89
-
-
14944375437
-
The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress
-
Louis M., Rosato R.R., Brault L., Osbild S., Battaglia E., Yang X.H., et al. The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress. International Journal of Oncology 2004, 25:1701-1711.
-
(2004)
International Journal of Oncology
, vol.25
, pp. 1701-1711
-
-
Louis, M.1
Rosato, R.R.2
Brault, L.3
Osbild, S.4
Battaglia, E.5
Yang, X.H.6
-
90
-
-
80053555789
-
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
-
Lukas J., Lukas C., Bartek J. More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nature Cell Biology 2011, 13:1161-1169.
-
(2011)
Nature Cell Biology
, vol.13
, pp. 1161-1169
-
-
Lukas, J.1
Lukas, C.2
Bartek, J.3
-
91
-
-
0034676439
-
Deacetylation of p53 modulates its effect on cell growth and apoptosis
-
Luo J., Su F., Chen D., Shiloh A., Gu W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 2000, 408:377-381.
-
(2000)
Nature
, vol.408
, pp. 377-381
-
-
Luo, J.1
Su, F.2
Chen, D.3
Shiloh, A.4
Gu, W.5
-
92
-
-
29844445035
-
NF-kappaB modulation and ionizing radiation: Mechanisms and future directions for cancer treatment
-
Magne N., Toillon R.A., Bottero V., Didelot C., Houtte P.V., Gerard J.P., et al. NF-kappaB modulation and ionizing radiation: Mechanisms and future directions for cancer treatment. Cancer Letters 2006, 231:158-168.
-
(2006)
Cancer Letters
, vol.231
, pp. 158-168
-
-
Magne, N.1
Toillon, R.A.2
Bottero, V.3
Didelot, C.4
Houtte, P.V.5
Gerard, J.P.6
-
93
-
-
79959363092
-
SIRT6 promotes DNA repair under stress by activating PARP1
-
Mao Z., Hine C., Tian X., Van Meter M., Au M., Vaidya A., et al. SIRT6 promotes DNA repair under stress by activating PARP1. Science 2011, 332:1443-1446.
-
(2011)
Science
, vol.332
, pp. 1443-1446
-
-
Mao, Z.1
Hine, C.2
Tian, X.3
Van Meter, M.4
Au, M.5
Vaidya, A.6
-
94
-
-
33751185927
-
Thioredoxin in cancer-Role of histone deacetylase inhibitors
-
Marks P.A. Thioredoxin in cancer-Role of histone deacetylase inhibitors. Seminars in Cancer Biology 2006, 16:436-443.
-
(2006)
Seminars in Cancer Biology
, vol.16
, pp. 436-443
-
-
Marks, P.A.1
-
95
-
-
0034596309
-
Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
-
Marks P.A., Richon V.M., Rifkind R.A. Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells. Journal of the National Cancer Institute 2000, 92:1210-1216.
-
(2000)
Journal of the National Cancer Institute
, vol.92
, pp. 1210-1216
-
-
Marks, P.A.1
Richon, V.M.2
Rifkind, R.A.3
-
96
-
-
65349137584
-
Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas
-
Marquard L., Poulsen C.B., Gjerdrum L.M., de Nully Brown P., Christensen I.J., Jensen P.B., et al. Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. Histopathology 2009, 54:688-698.
-
(2009)
Histopathology
, vol.54
, pp. 688-698
-
-
Marquard, L.1
Poulsen, C.B.2
Gjerdrum, L.M.3
de Nully Brown, P.4
Christensen, I.J.5
Jensen, P.B.6
-
97
-
-
58949084649
-
Base excision repair of oxidative DNA damage and association with cancer and aging
-
Maynard S., Schurman S.H., Harboe C., de Souza-Pinto N.C., Bohr V.A. Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis 2009, 30:2-10.
-
(2009)
Carcinogenesis
, vol.30
, pp. 2-10
-
-
Maynard, S.1
Schurman, S.H.2
Harboe, C.3
de Souza-Pinto, N.C.4
Bohr, V.A.5
-
98
-
-
66049150672
-
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
-
McCord R.A., Michishita E., Hong T., Berber E., Boxer L.D., Kusumoto R., et al. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany, NY) 2009, 1:109-121.
-
(2009)
Aging (Albany, NY)
, vol.1
, pp. 109-121
-
-
McCord, R.A.1
Michishita, E.2
Hong, T.3
Berber, E.4
Boxer, L.D.5
Kusumoto, R.6
-
99
-
-
84858302440
-
Sirtuins, bioageing, and cancer
-
McGuinness D., McGuinness D.H., McCaul J.A., Shiels P.G. Sirtuins, bioageing, and cancer. Journal of Aging Research 2011, 2011:235754.
-
(2011)
Journal of Aging Research
, vol.2011
, pp. 235754
-
-
McGuinness, D.1
McGuinness, D.H.2
McCaul, J.A.3
Shiels, P.G.4
-
100
-
-
0034733694
-
Base excision repair in yeast and mammals
-
Memisoglu A., Samson L. Base excision repair in yeast and mammals. Mutation Research 2000, 451:39-51.
-
(2000)
Mutation Research
, vol.451
, pp. 39-51
-
-
Memisoglu, A.1
Samson, L.2
-
101
-
-
77952853306
-
Histone deacetylases and epigenetic therapies of hematological malignancies
-
Mercurio C., Minucci S., Pelicci P.G. Histone deacetylases and epigenetic therapies of hematological malignancies. Pharmacological Research 2010, 62:18-34.
-
(2010)
Pharmacological Research
, vol.62
, pp. 18-34
-
-
Mercurio, C.1
Minucci, S.2
Pelicci, P.G.3
-
102
-
-
0028170326
-
Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress
-
Michiels C., Raes M., Toussaint O., Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radical Biology & Medicine 1994, 17:235-248.
-
(1994)
Free Radical Biology & Medicine
, vol.17
, pp. 235-248
-
-
Michiels, C.1
Raes, M.2
Toussaint, O.3
Remacle, J.4
-
103
-
-
80052653226
-
Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors
-
Miller C.P., Singh M.M., Rivera-Del Valle N., Manton C.A., Chandra J. Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors. Journal of Biomedicine and Biotechnology 2011, 2011:514261.
-
(2011)
Journal of Biomedicine and Biotechnology
, vol.2011
, pp. 514261
-
-
Miller, C.P.1
Singh, M.M.2
Rivera-Del Valle, N.3
Manton, C.A.4
Chandra, J.5
-
104
-
-
77956341931
-
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
-
Miller K.M., Tjeertes J.V., Coates J., Legube G., Polo S.E., Britton S., et al. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nature Structural & Molecular Biology 2010, 17:1144-1151.
-
(2010)
Nature Structural & Molecular Biology
, vol.17
, pp. 1144-1151
-
-
Miller, K.M.1
Tjeertes, J.V.2
Coates, J.3
Legube, G.4
Polo, S.E.5
Britton, S.6
-
105
-
-
65549095526
-
Nucleases and helicases take center stage in homologous recombination
-
Mimitou E.P., Symington L.S. Nucleases and helicases take center stage in homologous recombination. Trends in Biochemical Sciences 2009, 34:264-272.
-
(2009)
Trends in Biochemical Sciences
, vol.34
, pp. 264-272
-
-
Mimitou, E.P.1
Symington, L.S.2
-
107
-
-
78651105018
-
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
-
Ming M., Shea C.R., Guo X., Li X., Soltani K., Han W., et al. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:22623-22628.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 22623-22628
-
-
Ming, M.1
Shea, C.R.2
Guo, X.3
Li, X.4
Soltani, K.5
Han, W.6
-
108
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S., Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nature Reviews. Cancer 2006, 6:38-51.
-
(2006)
Nature Reviews. Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
109
-
-
62849083222
-
The emerging role of nuclear architecture in DNA repair and genome maintenance
-
Misteli T., Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nature Reviews. Molecular Cell Biology 2009, 10:243-254.
-
(2009)
Nature Reviews. Molecular Cell Biology
, vol.10
, pp. 243-254
-
-
Misteli, T.1
Soutoglou, E.2
-
110
-
-
78650873024
-
Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage
-
Miyamoto S. Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage. Cell Research 2011, 21:116-130.
-
(2011)
Cell Research
, vol.21
, pp. 116-130
-
-
Miyamoto, S.1
-
111
-
-
79961196710
-
Cellular redox pathways as a therapeutic target in the treatment of cancer
-
Montero A.J., Jassem J. Cellular redox pathways as a therapeutic target in the treatment of cancer. Drugs 2011, 71:1385-1396.
-
(2011)
Drugs
, vol.71
, pp. 1385-1396
-
-
Montero, A.J.1
Jassem, J.2
-
112
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006, 124:315-329.
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
-
113
-
-
33845501150
-
Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal
-
Moufarij M.A., Sampath D., Keating M.J., Plunkett W. Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal. Blood 2006, 108:4187-4193.
-
(2006)
Blood
, vol.108
, pp. 4187-4193
-
-
Moufarij, M.A.1
Sampath, D.2
Keating, M.J.3
Plunkett, W.4
-
114
-
-
27644586649
-
Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity
-
Munshi A., Kurland J.F., Nishikawa T., Tanaka T., Hobbs M.L., Tucker S.L., et al. Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clinical Cancer Research 2005, 11:4912-4922.
-
(2005)
Clinical Cancer Research
, vol.11
, pp. 4912-4922
-
-
Munshi, A.1
Kurland, J.F.2
Nishikawa, T.3
Tanaka, T.4
Hobbs, M.L.5
Tucker, S.L.6
-
115
-
-
33748360764
-
Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of g-H2AX foci
-
Munshi A., Tanaka T., Hobbs M.L., Tucker S.L., Richon V.M., Meyn R.E. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of g-H2AX foci. Molecular Cancer Therapeutics 2006, 5:1967-1974.
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, pp. 1967-1974
-
-
Munshi, A.1
Tanaka, T.2
Hobbs, M.L.3
Tucker, S.L.4
Richon, V.M.5
Meyn, R.E.6
-
116
-
-
30344444484
-
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
-
Murr R., Loizou J.I., Yang Y.G., Cuenin C., Li H., Wang Z.Q., et al. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nature Cell Biology 2006, 8:91-99.
-
(2006)
Nature Cell Biology
, vol.8
, pp. 91-99
-
-
Murr, R.1
Loizou, J.I.2
Yang, Y.G.3
Cuenin, C.4
Li, H.5
Wang, Z.Q.6
-
117
-
-
38449100788
-
Expression profile of class I histone deacetylases in human cancer tissues
-
Nakagawa M., Oda Y., Eguchi T., Aishima S., Yao T., Hosoi F., et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncology Reports 2007, 18:769-774.
-
(2007)
Oncology Reports
, vol.18
, pp. 769-774
-
-
Nakagawa, M.1
Oda, Y.2
Eguchi, T.3
Aishima, S.4
Yao, T.5
Hosoi, F.6
-
118
-
-
0028106431
-
Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide
-
Nakamura H., Matsuda M., Furuke K., Kitaoka Y., Iwata S., Toda K., et al. Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide. Immunology Letters 1994, 42:75-80.
-
(1994)
Immunology Letters
, vol.42
, pp. 75-80
-
-
Nakamura, H.1
Matsuda, M.2
Furuke, K.3
Kitaoka, Y.4
Iwata, S.5
Toda, K.6
-
119
-
-
79955148265
-
Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization
-
Nalabothula N., Carrier F. Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization. Epigenomics 2011, 3:145-155.
-
(2011)
Epigenomics
, vol.3
, pp. 145-155
-
-
Nalabothula, N.1
Carrier, F.2
-
120
-
-
78650575875
-
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents
-
Namdar M., Perez G., Ngo L., Marks P.A. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:20003-20008.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 20003-20008
-
-
Namdar, M.1
Perez, G.2
Ngo, L.3
Marks, P.A.4
-
121
-
-
13444306459
-
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
-
Nebbioso A., Clarke N., Voltz E., Germain E., Ambrosino C., Bontempo P., et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nature Medicine 2005, 11:77-84.
-
(2005)
Nature Medicine
, vol.11
, pp. 77-84
-
-
Nebbioso, A.1
Clarke, N.2
Voltz, E.3
Germain, E.4
Ambrosino, C.5
Bontempo, P.6
-
122
-
-
83355166904
-
Death receptor pathway activation and increase of ROS production by the triple epigenetic inhibitor UVI5008
-
Nebbioso A., Pereira R., Khanwalkar H., Matarese F., Garcia-Rodriguez J., Miceli M., et al. Death receptor pathway activation and increase of ROS production by the triple epigenetic inhibitor UVI5008. Molecular Cancer Therapeutics 2011, 10:2394-2404.
-
(2011)
Molecular Cancer Therapeutics
, vol.10
, pp. 2394-2404
-
-
Nebbioso, A.1
Pereira, R.2
Khanwalkar, H.3
Matarese, F.4
Garcia-Rodriguez, J.5
Miceli, M.6
-
123
-
-
79956056274
-
HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo
-
Nguyen T., Dai Y., Attkisson E., Kramer L., Jordan N., Nguyen N., et al. HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo. Clinical Cancer Research 2011, 17:3219-3232.
-
(2011)
Clinical Cancer Research
, vol.17
, pp. 3219-3232
-
-
Nguyen, T.1
Dai, Y.2
Attkisson, E.3
Kramer, L.4
Jordan, N.5
Nguyen, N.6
-
124
-
-
35348821296
-
A backup DNA repair pathway moves to the forefront
-
Nussenzweig A., Nussenzweig M.C. A backup DNA repair pathway moves to the forefront. Cell 2007, 131:223-225.
-
(2007)
Cell
, vol.131
, pp. 223-225
-
-
Nussenzweig, A.1
Nussenzweig, M.C.2
-
125
-
-
29244437908
-
The role of double-strand break repair-Insights from human genetics
-
O'Driscoll M., Jeggo P.A. The role of double-strand break repair-Insights from human genetics. Nature Reviews. Genetics 2006, 7:45-54.
-
(2006)
Nature Reviews. Genetics
, vol.7
, pp. 45-54
-
-
O'Driscoll, M.1
Jeggo, P.A.2
-
126
-
-
50849104569
-
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
-
O'Hagan H.M., Mohammad H.P., Baylin S.B. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genetics 2008, 4:e1000155.
-
(2008)
PLoS Genetics
, vol.4
-
-
O'Hagan, H.M.1
Mohammad, H.P.2
Baylin, S.B.3
-
127
-
-
79955613209
-
Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors
-
Ogiwara H., Ui A., Otsuka A., Satoh H., Yokomi I., Nakajima S., et al. Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene 2011, 30:2135-2146.
-
(2011)
Oncogene
, vol.30
, pp. 2135-2146
-
-
Ogiwara, H.1
Ui, A.2
Otsuka, A.3
Satoh, H.4
Yokomi, I.5
Nakajima, S.6
-
128
-
-
33748367886
-
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction
-
Park J.H., Park E.J., Lee H.S., Kim S.J., Hur S.K., Imbalzano A.N., et al. Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. The EMBO Journal 2006, 25:3986-3997.
-
(2006)
The EMBO Journal
, vol.25
, pp. 3986-3997
-
-
Park, J.H.1
Park, E.J.2
Lee, H.S.3
Kim, S.J.4
Hur, S.K.5
Imbalzano, A.N.6
-
129
-
-
83255186739
-
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
-
Peng L., Yuan Z., Ling H., Fukasawa K., Robertson K., Olashaw N., et al. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Molecular and Cellular Biology 2011, 31:4720-4734.
-
(2011)
Molecular and Cellular Biology
, vol.31
, pp. 4720-4734
-
-
Peng, L.1
Yuan, Z.2
Ling, H.3
Fukasawa, K.4
Robertson, K.5
Olashaw, N.6
-
131
-
-
79251566746
-
Physical and functional HAT/HDAC interplay regulates protein acetylation balance
-
Peserico A., Simone C. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Journal of Biomedicine and Biotechnology 2011, 2011:371832.
-
(2011)
Journal of Biomedicine and Biotechnology
, vol.2011
, pp. 371832
-
-
Peserico, A.1
Simone, C.2
-
132
-
-
33746189731
-
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing
-
Petalcorin M.I., Sandall J., Wigley D.B., Boulton S.J. CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. Journal of Molecular Biology 2006, 361:231-242.
-
(2006)
Journal of Molecular Biology
, vol.361
, pp. 231-242
-
-
Petalcorin, M.I.1
Sandall, J.2
Wigley, D.B.3
Boulton, S.J.4
-
133
-
-
79958695612
-
Vorinostat induces reactive oxygen species and DNA damage in acute myeloid leukemia cells
-
Petruccelli L.A., Dupere-Richer D., Pettersson F., Retrouvey H., Skoulikas S., Miller W.H. Vorinostat induces reactive oxygen species and DNA damage in acute myeloid leukemia cells. PLoS One 2011, 6:e20987.
-
(2011)
PLoS One
, vol.6
-
-
Petruccelli, L.A.1
Dupere-Richer, D.2
Pettersson, F.3
Retrouvey, H.4
Skoulikas, S.5
Miller, W.H.6
-
134
-
-
77956870690
-
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
-
Polo S.E., Kaidi A., Baskcomb L., Galanty Y., Jackson S.P. Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. The EMBO Journal 2010, 29:3130-3139.
-
(2010)
The EMBO Journal
, vol.29
, pp. 3130-3139
-
-
Polo, S.E.1
Kaidi, A.2
Baskcomb, L.3
Galanty, Y.4
Jackson, S.P.5
-
135
-
-
4143070452
-
Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression
-
Rahman I., Marwick J., Kirkham P. Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochemical Pharmacology 2004, 68:1255-1267.
-
(2004)
Biochemical Pharmacology
, vol.68
, pp. 1255-1267
-
-
Rahman, I.1
Marwick, J.2
Kirkham, P.3
-
136
-
-
15944406971
-
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
-
Rahmani M., Reese E., Dai Y., Bauer C., Payne S.G., Dent P., et al. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Research 2005, 65:2422-2432.
-
(2005)
Cancer Research
, vol.65
, pp. 2422-2432
-
-
Rahmani, M.1
Reese, E.2
Dai, Y.3
Bauer, C.4
Payne, S.G.5
Dent, P.6
-
137
-
-
81555226055
-
Sirtuins: Molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription
-
Rajendran R., Garva R., Krstic-Demonacos M., Demonacos C. Sirtuins: Molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. Journal of Biomedicine and Biotechnology 2011, 2011:368276.
-
(2011)
Journal of Biomedicine and Biotechnology
, vol.2011
, pp. 368276
-
-
Rajendran, R.1
Garva, R.2
Krstic-Demonacos, M.3
Demonacos, C.4
-
138
-
-
68249138694
-
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells
-
Rass E., Grabarz A., Plo I., Gautier J., Bertrand P., Lopez B.S. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nature Structural & Molecular Biology 2009, 16:819-824.
-
(2009)
Nature Structural & Molecular Biology
, vol.16
, pp. 819-824
-
-
Rass, E.1
Grabarz, A.2
Plo, I.3
Gautier, J.4
Bertrand, P.5
Lopez, B.S.6
-
139
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
-
Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C., Recio M.J., et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Molecular Cell 2004, 16:715-724.
-
(2004)
Molecular Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
Kuhne, M.2
Rief, N.3
Doherty, A.4
Smith, G.C.5
Recio, M.J.6
-
140
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. The Journal of Biological Chemistry 1998, 273:5858-5868.
-
(1998)
The Journal of Biological Chemistry
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
141
-
-
0038079767
-
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
-
Rosato R.R., Almenara J.A., Grant S. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Research 2003, 63:3637-3645.
-
(2003)
Cancer Research
, vol.63
, pp. 3637-3645
-
-
Rosato, R.R.1
Almenara, J.A.2
Grant, S.3
-
142
-
-
55749113687
-
Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions
-
Rosato R.R., Almenara J.A., Maggio S.C., Coe S., Atadja P., Dent P., et al. Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions. Molecular Cancer Therapeutics 2008, 7:3285-3297.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 3285-3297
-
-
Rosato, R.R.1
Almenara, J.A.2
Maggio, S.C.3
Coe, S.4
Atadja, P.5
Dent, P.6
-
143
-
-
77951241720
-
Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway
-
Rosato R.R., Kolla S.S., Hock S.K., Almenara J.A., Patel A., Amin S., et al. Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway. The Journal of Biological Chemistry 2010, 285:10064-10077.
-
(2010)
The Journal of Biological Chemistry
, vol.285
, pp. 10064-10077
-
-
Rosato, R.R.1
Kolla, S.S.2
Hock, S.K.3
Almenara, J.A.4
Patel, A.5
Amin, S.6
-
144
-
-
30044434594
-
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
-
Rosato R.R., Maggio S.C., Almenara J.A., Payne S.G., Atadja P., Spiegel S., et al. The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide. Molecular Pharmacology 2006, 69:216-225.
-
(2006)
Molecular Pharmacology
, vol.69
, pp. 216-225
-
-
Rosato, R.R.1
Maggio, S.C.2
Almenara, J.A.3
Payne, S.G.4
Atadja, P.5
Spiegel, S.6
-
145
-
-
77956673574
-
Epigenetic modifications in double-strand break DNA damage signaling and repair
-
Rossetto D., Truman A.W., Kron S.J., Cote J. Epigenetic modifications in double-strand break DNA damage signaling and repair. Clinical Cancer Research 2010, 16:4543-4552.
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 4543-4552
-
-
Rossetto, D.1
Truman, A.W.2
Kron, S.J.3
Cote, J.4
-
147
-
-
0022976432
-
Nonhomologous recombination in mammalian cells: Role for short sequence homologies in the joining reaction
-
Roth D.B., Wilson J.H. Nonhomologous recombination in mammalian cells: Role for short sequence homologies in the joining reaction. Molecular and Cellular Biology 1986, 6:4295-4304.
-
(1986)
Molecular and Cellular Biology
, vol.6
, pp. 4295-4304
-
-
Roth, D.B.1
Wilson, J.H.2
-
148
-
-
0035845541
-
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
-
Ruefli A.A., Ausserlechner M.J., Bernhard D., Sutton V.R., Tainton K.M., Kofler R., et al. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:10833-10838.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 10833-10838
-
-
Ruefli, A.A.1
Ausserlechner, M.J.2
Bernhard, D.3
Sutton, V.R.4
Tainton, K.M.5
Kofler, R.6
-
149
-
-
0032080283
-
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
-
Saitoh M., Nishitoh H., Fujii M., Takeda K., Tobiume K., Sawada Y., et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. The EMBO Journal 1998, 17:2596-2606.
-
(1998)
The EMBO Journal
, vol.17
, pp. 2596-2606
-
-
Saitoh, M.1
Nishitoh, H.2
Fujii, M.3
Takeda, K.4
Tobiume, K.5
Sawada, Y.6
-
150
-
-
51649128895
-
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks
-
Sallmyr A., Tomkinson A.E., Rassool F.V. Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks. Blood 2008, 112:1413-1423.
-
(2008)
Blood
, vol.112
, pp. 1413-1423
-
-
Sallmyr, A.1
Tomkinson, A.E.2
Rassool, F.V.3
-
151
-
-
3943107573
-
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
-
Sancar A., Lindsey-Boltz L.A., Unsal-Kacmaz K., Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annual Review of Biochemistry 2004, 73:39-85.
-
(2004)
Annual Review of Biochemistry
, vol.73
, pp. 39-85
-
-
Sancar, A.1
Lindsey-Boltz, L.A.2
Unsal-Kacmaz, K.3
Linn, S.4
-
152
-
-
35548947600
-
Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells
-
Sanda T., Okamoto T., Uchida Y., Nakagawa H., Iida S., Kayukawa S., et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 2007, 21:2344-2353.
-
(2007)
Leukemia
, vol.21
, pp. 2344-2353
-
-
Sanda, T.1
Okamoto, T.2
Uchida, Y.3
Nakagawa, H.4
Iida, S.5
Kayukawa, S.6
-
153
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori A.A., Lukas C., Coates J., Mistrik M., Fu S., Bartek J., et al. Human CtIP promotes DNA end resection. Nature 2007, 450:509-514.
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
Bartek, J.6
-
154
-
-
0033135256
-
Hematopoietic growth factors signal through the formation of reactive oxygen species
-
Sattler M., Winkler T., Verma S., Byrne C.H., Shrikhande G., Salgia R., et al. Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 1999, 93:2928-2935.
-
(1999)
Blood
, vol.93
, pp. 2928-2935
-
-
Sattler, M.1
Winkler, T.2
Verma, S.3
Byrne, C.H.4
Shrikhande, G.5
Salgia, R.6
-
155
-
-
0035111895
-
Recent progress in the biology, chemistry and structural biology of DNA glycosylases
-
Scharer O.D., Jiricny J. Recent progress in the biology, chemistry and structural biology of DNA glycosylases. BioEssays 2001, 23:270-281.
-
(2001)
BioEssays
, vol.23
, pp. 270-281
-
-
Scharer, O.D.1
Jiricny, J.2
-
156
-
-
34247271282
-
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
-
Scher M.B., Vaquero A., Reinberg D. SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes & Development 2007, 21:920-928.
-
(2007)
Genes & Development
, vol.21
, pp. 920-928
-
-
Scher, M.B.1
Vaquero, A.2
Reinberg, D.3
-
157
-
-
64549139803
-
Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeutics
-
Selvi R.B., Kundu T.K. Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeutics. Biotechnology Journal 2009, 4:375-390.
-
(2009)
Biotechnology Journal
, vol.4
, pp. 375-390
-
-
Selvi, R.B.1
Kundu, T.K.2
-
158
-
-
77954360144
-
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
-
Sharma G.G., So S., Gupta A., Kumar R., Cayrou C., Avvakumov N., et al. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Molecular and Cellular Biology 2010, 30:3582-3595.
-
(2010)
Molecular and Cellular Biology
, vol.30
, pp. 3582-3595
-
-
Sharma, G.G.1
So, S.2
Gupta, A.3
Kumar, R.4
Cayrou, C.5
Avvakumov, N.6
-
159
-
-
0032933430
-
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit
-
Singleton B.K., Torres-Arzayus M.I., Rottinghaus S.T., Taccioli G.E., Jeggo P.A. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Molecular and Cellular Biology 1999, 19:3267-3277.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 3267-3277
-
-
Singleton, B.K.1
Torres-Arzayus, M.I.2
Rottinghaus, S.T.3
Taccioli, G.E.4
Jeggo, P.A.5
-
160
-
-
33847340207
-
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair
-
Sonoda E., Zhao G.Y., Kohzaki M., Dhar P.K., Kikuchi K., Redon C., et al. Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair. DNA Repair 2007, 6:280-292.
-
(2007)
DNA Repair
, vol.6
, pp. 280-292
-
-
Sonoda, E.1
Zhao, G.Y.2
Kohzaki, M.3
Dhar, P.K.4
Kikuchi, K.5
Redon, C.6
-
161
-
-
24944516931
-
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
-
Sun Y., Jiang X., Chen S., Fernandes N., Price B.D. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:13182-13187.
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 13182-13187
-
-
Sun, Y.1
Jiang, X.2
Chen, S.3
Fernandes, N.4
Price, B.D.5
-
162
-
-
77953495958
-
Tip60: Connecting chromatin to DNA damage signaling
-
Sun Y., Jiang X., Price B.D. Tip60: Connecting chromatin to DNA damage signaling. Cell Cycle 2010, 9:930-936.
-
(2010)
Cell Cycle
, vol.9
, pp. 930-936
-
-
Sun, Y.1
Jiang, X.2
Price, B.D.3
-
163
-
-
70449518412
-
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
-
Sun Y., Jiang X., Xu Y., Ayrapetov M.K., Moreau L.A., Whetstine J.R., et al. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nature Cell Biology 2009, 11:1376-1382.
-
(2009)
Nature Cell Biology
, vol.11
, pp. 1376-1382
-
-
Sun, Y.1
Jiang, X.2
Xu, Y.3
Ayrapetov, M.K.4
Moreau, L.A.5
Whetstine, J.R.6
-
164
-
-
37549028411
-
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
-
Sun Y., Xu Y., Roy K., Price B.D. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Molecular and Cellular Biology 2007, 27:8502-8509.
-
(2007)
Molecular and Cellular Biology
, vol.27
, pp. 8502-8509
-
-
Sun, Y.1
Xu, Y.2
Roy, K.3
Price, B.D.4
-
165
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao R., Coleman M.C., Pennington J.D., Ozden O., Park S.H., Jiang H., et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Molecular Cell 2010, 40:893-904.
-
(2010)
Molecular Cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
Coleman, M.C.2
Pennington, J.D.3
Ozden, O.4
Park, S.H.5
Jiang, H.6
-
166
-
-
84863337757
-
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
-
Tsai H.C., Li H., Van Neste L., Cai Y., Robert C., Rassool F.V., et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 2012, 21:430-446.
-
(2012)
Cancer Cell
, vol.21
, pp. 430-446
-
-
Tsai, H.C.1
Li, H.2
Van Neste, L.3
Cai, Y.4
Robert, C.5
Rassool, F.V.6
-
167
-
-
77949653651
-
Role of SIRT1 in homologous recombination
-
Uhl M., Csernok A., Aydin S., Kreienberg R., Wiesmuller L., Gatz S.A. Role of SIRT1 in homologous recombination. DNA Repair 2010, 9:383-393.
-
(2010)
DNA Repair
, vol.9
, pp. 383-393
-
-
Uhl, M.1
Csernok, A.2
Aydin, S.3
Kreienberg, R.4
Wiesmuller, L.5
Gatz, S.A.6
-
168
-
-
20044390016
-
Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors
-
Ungerstedt J.S., Sowa Y., Xu W.S., Shao Y., Dokmanovic M., Perez G., et al. Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:673-678.
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 673-678
-
-
Ungerstedt, J.S.1
Sowa, Y.2
Xu, W.S.3
Shao, Y.4
Dokmanovic, M.5
Perez, G.6
-
169
-
-
3142742707
-
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
-
van der Horst A., Tertoolen L.G., de Vries-Smits L.M., Frye R.A., Medema R.H., Burgering B.M. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). The Journal of Biological Chemistry 2004, 279:28873-28879.
-
(2004)
The Journal of Biological Chemistry
, vol.279
, pp. 28873-28879
-
-
van der Horst, A.1
Tertoolen, L.G.2
de Vries-Smits, L.M.3
Frye, R.A.4
Medema, R.H.5
Burgering, B.M.6
-
170
-
-
79952262759
-
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
-
Wagner J.M., Hackanson B., Lubbert M., Jung M. Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clinical Epigenetics 2010, 1:117-136.
-
(2010)
Clinical Epigenetics
, vol.1
, pp. 117-136
-
-
Wagner, J.M.1
Hackanson, B.2
Lubbert, M.3
Jung, M.4
-
171
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker J.R., Corpina R.A., Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001, 412:607-614.
-
(2001)
Nature
, vol.412
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
Goldberg, J.3
-
172
-
-
77951217683
-
SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60
-
Wang J., Chen J. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. The Journal of Biological Chemistry 2010, 285:11458-11464.
-
(2010)
The Journal of Biological Chemistry
, vol.285
, pp. 11458-11464
-
-
Wang, J.1
Chen, J.2
-
173
-
-
20144363082
-
DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
-
Wang H., Rosidi B., Perrault R., Wang M., Zhang L., Windhofer F., et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Research 2005, 65:4020-4030.
-
(2005)
Cancer Research
, vol.65
, pp. 4020-4030
-
-
Wang, H.1
Rosidi, B.2
Perrault, R.3
Wang, M.4
Zhang, L.5
Windhofer, F.6
-
174
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang R.H., Sengupta K., Li C., Kim H.S., Cao L., Xiao C., et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008, 14:312-323.
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
Sengupta, K.2
Li, C.3
Kim, H.S.4
Cao, L.5
Xiao, C.6
-
175
-
-
33845657443
-
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
-
Wang M., Wu W., Rosidi B., Zhang L., Wang H., Iliakis G. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Research 2006, 34:6170-6182.
-
(2006)
Nucleic Acids Research
, vol.34
, pp. 6170-6182
-
-
Wang, M.1
Wu, W.2
Rosidi, B.3
Zhang, L.4
Wang, H.5
Iliakis, G.6
-
176
-
-
38949086502
-
Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
-
Weichert W., Roske A., Gekeler V., Beckers T., Stephan C., Jung K., et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. British Journal of Cancer 2008, 98:604-610.
-
(2008)
British Journal of Cancer
, vol.98
, pp. 604-610
-
-
Weichert, W.1
Roske, A.2
Gekeler, V.3
Beckers, T.4
Stephan, C.5
Jung, K.6
-
177
-
-
33845726097
-
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks
-
Wyatt M.D., Pittman D.L. Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chemical Research in Toxicology 2006, 19:1580-1594.
-
(2006)
Chemical Research in Toxicology
, vol.19
, pp. 1580-1594
-
-
Wyatt, M.D.1
Pittman, D.L.2
-
178
-
-
68249146431
-
Role of mammalian Mre11 in classical and alternative nonhomologous end joining
-
Xie A., Kwok A., Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nature Structural & Molecular Biology 2009, 16:814-818.
-
(2009)
Nature Structural & Molecular Biology
, vol.16
, pp. 814-818
-
-
Xie, A.1
Kwok, A.2
Scully, R.3
-
179
-
-
33750288048
-
Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor
-
Xu W., Ngo L., Perez G., Dokmanovic M., Marks P.A. Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:15540-15545.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 15540-15545
-
-
Xu, W.1
Ngo, L.2
Perez, G.3
Dokmanovic, M.4
Marks, P.A.5
-
180
-
-
34547864236
-
Histone deacetylase inhibitors: Molecular mechanisms of action
-
Xu W.S., Parmigiani R.B., Marks P.A. Histone deacetylase inhibitors: Molecular mechanisms of action. Oncogene 2007, 26:5541-5552.
-
(2007)
Oncogene
, vol.26
, pp. 5541-5552
-
-
Xu, W.S.1
Parmigiani, R.B.2
Marks, P.A.3
-
181
-
-
77950351604
-
SIRT1 deacetylates APE1 and regulates cellular base excision repair
-
Yamamori T., DeRicco J., Naqvi A., Hoffman T.A., Mattagajasingh I., Kasuno K., et al. SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Research 2010, 38:832-845.
-
(2010)
Nucleic Acids Research
, vol.38
, pp. 832-845
-
-
Yamamori, T.1
DeRicco, J.2
Naqvi, A.3
Hoffman, T.A.4
Mattagajasingh, I.5
Kasuno, K.6
-
182
-
-
49349107518
-
Lysine acetylation: Codified crosstalk with other posttranslational modifications
-
Yang X.J., Seto E. Lysine acetylation: Codified crosstalk with other posttranslational modifications. Molecular Cell 2008, 31:449-461.
-
(2008)
Molecular Cell
, vol.31
, pp. 449-461
-
-
Yang, X.J.1
Seto, E.2
-
183
-
-
84863116364
-
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
-
Yuan H., Wang Z., Li L., Zhang H., Modi H., Horne D., et al. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood 2012, 119:1904-1914.
-
(2012)
Blood
, vol.119
, pp. 1904-1914
-
-
Yuan, H.1
Wang, Z.2
Li, L.3
Zhang, H.4
Modi, H.5
Horne, D.6
-
184
-
-
34250897968
-
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
-
Yuan Z., Zhang X., Sengupta N., Lane W.S., Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Molecular Cell 2007, 27:149-162.
-
(2007)
Molecular Cell
, vol.27
, pp. 149-162
-
-
Yuan, Z.1
Zhang, X.2
Sengupta, N.3
Lane, W.S.4
Seto, E.5
-
185
-
-
26244441525
-
Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast
-
Zhang Z., Yamashita H., Toyama T., Sugiura H., Ando Y., Mita K., et al. Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast. Breast Cancer Research and Treatment 2005, 94:11-16.
-
(2005)
Breast Cancer Research and Treatment
, vol.94
, pp. 11-16
-
-
Zhang, Z.1
Yamashita, H.2
Toyama, T.3
Sugiura, H.4
Ando, Y.5
Mita, K.6
|