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Volumn 116, Issue , 2012, Pages 87-129

HDAC Inhibitors: Roles of DNA damage and repair

Author keywords

Chromatin remodeling; DNA damage; DNA repair response; Double strand break; Genomic instability; Histone deacetylase inhibitors; Histone deacteylase; Nonhomologous end joining; Sirtuins

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CASPASE 3; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DACINOSTAT; DNA METHYLTRANSFERASE 1; DNA TOPOISOMERASE INHIBITOR; ENTINOSTAT; FLAP ENDONUCLEASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE INHIBITOR; HISTONE H2AX; KU ANTIGEN; MRE11 PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PANOBINOSTAT; RAD50 PROTEIN; RAD51 PROTEIN; ROMIDEPSIN; SIRTUIN 1; TRANSCRIPTION FACTOR E2F1; UNINDEXED DRUG; VORINOSTAT; XERODERMA PIGMENTOSUM GROUP A PROTEIN;

EID: 84867801148     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394387-3.00003-3     Document Type: Chapter
Times cited : (122)

References (185)
  • 3
    • 0022366477 scopus 로고
    • Enhancement of radiation injury in human colon tumor cells by the maturational agent sodium butyrate (NaB)
    • Arundel C.M., Glicksman A.S., Leith J.T. Enhancement of radiation injury in human colon tumor cells by the maturational agent sodium butyrate (NaB). Radiation Research 1985, 104:443-448.
    • (1985) Radiation Research , vol.104 , pp. 443-448
    • Arundel, C.M.1    Glicksman, A.S.2    Leith, J.T.3
  • 5
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 6
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 7
    • 33644859838 scopus 로고    scopus 로고
    • DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines
    • Basile V., Mantovani R., Imbriano C. DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. The Journal of Biological Chemistry 2006, 281:2347-2357.
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 2347-2357
    • Basile, V.1    Mantovani, R.2    Imbriano, C.3
  • 8
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K., Krause K.H. The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiological Reviews 2007, 87:245-313.
    • (2007) Physiological Reviews , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 9
    • 70350763838 scopus 로고    scopus 로고
    • ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
    • Beucher A., Birraux J., Tchouandong L., Barton O., Shibata A., Conrad S., et al. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. The EMBO Journal 2009, 28:3413-3427.
    • (2009) The EMBO Journal , vol.28 , pp. 3413-3427
    • Beucher, A.1    Birraux, J.2    Tchouandong, L.3    Barton, O.4    Shibata, A.5    Conrad, S.6
  • 10
    • 66249124267 scopus 로고    scopus 로고
    • PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells
    • Bhalla S., Balasubramanian S., David K., Sirisawad M., Buggy J., Mauro L., et al. PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clinical Cancer Research 2009, 15:3354-3365.
    • (2009) Clinical Cancer Research , vol.15 , pp. 3354-3365
    • Bhalla, S.1    Balasubramanian, S.2    David, K.3    Sirisawad, M.4    Buggy, J.5    Mauro, L.6
  • 11
    • 41549156540 scopus 로고    scopus 로고
    • Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control
    • Bhaskara S., Chyla B.J., Amann J.M., Knutson S.K., Cortez D., Sun Z.W., et al. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Molecular Cell 2008, 30:61-72.
    • (2008) Molecular Cell , vol.30 , pp. 61-72
    • Bhaskara, S.1    Chyla, B.J.2    Amann, J.M.3    Knutson, S.K.4    Cortez, D.5    Sun, Z.W.6
  • 13
    • 34047112221 scopus 로고    scopus 로고
    • Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
    • Bindra R.S., Glazer P.M. Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene 2007, 26:2048-2057.
    • (2007) Oncogene , vol.26 , pp. 2048-2057
    • Bindra, R.S.1    Glazer, P.M.2
  • 15
    • 27144475816 scopus 로고    scopus 로고
    • Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
    • Bradbury C.A., Khanim F.L., Hayden R., Bunce C.M., White D.A., Drayson M.T., et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 2005, 19:1751-1759.
    • (2005) Leukemia , vol.19 , pp. 1751-1759
    • Bradbury, C.A.1    Khanim, F.L.2    Hayden, R.3    Bunce, C.M.4    White, D.A.5    Drayson, M.T.6
  • 18
    • 33847618236 scopus 로고    scopus 로고
    • Mammalian single-strand break repair: Mechanisms and links with chromatin
    • Caldecott K.W. Mammalian single-strand break repair: Mechanisms and links with chromatin. DNA Repair 2007, 6:443-453.
    • (2007) DNA Repair , vol.6 , pp. 443-453
    • Caldecott, K.W.1
  • 19
    • 0033583204 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
    • Calsou P., Frit P., Humbert O., Muller C., Chen D.J., Salles B. The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA. The Journal of Biological Chemistry 1999, 274:7848-7856.
    • (1999) The Journal of Biological Chemistry , vol.274 , pp. 7848-7856
    • Calsou, P.1    Frit, P.2    Humbert, O.3    Muller, C.4    Chen, D.J.5    Salles, B.6
  • 20
    • 1642576220 scopus 로고    scopus 로고
    • Enhanced radiation-induced cell killing and prolongation of gH2AX foci expression by the histone deacetylase inhibitor MS-275
    • Camphausen K., Burgan W., Cerra M., Oswald K.A., Trepel J.B., Lee M.J., et al. Enhanced radiation-induced cell killing and prolongation of gH2AX foci expression by the histone deacetylase inhibitor MS-275. Cancer Research 2004, 64:316-321.
    • (2004) Cancer Research , vol.64 , pp. 316-321
    • Camphausen, K.1    Burgan, W.2    Cerra, M.3    Oswald, K.A.4    Trepel, J.B.5    Lee, M.J.6
  • 22
    • 49349098483 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy
    • Carew J.S., Giles F.J., Nawrocki S.T. Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy. Cancer Letters 2008, 269:7-17.
    • (2008) Cancer Letters , vol.269 , pp. 7-17
    • Carew, J.S.1    Giles, F.J.2    Nawrocki, S.T.3
  • 23
    • 3042786456 scopus 로고    scopus 로고
    • Characterization of the 5'flanking region of the human Chk1 gene: Identification of E2F1 functional sites
    • Carrassa L., Broggini M., Vikhanskaya F., Damia G. Characterization of the 5'flanking region of the human Chk1 gene: Identification of E2F1 functional sites. Cell Cycle 2003, 2:604-609.
    • (2003) Cell Cycle , vol.2 , pp. 604-609
    • Carrassa, L.1    Broggini, M.2    Vikhanskaya, F.3    Damia, G.4
  • 24
    • 79960821550 scopus 로고    scopus 로고
    • Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells
    • Cea M., Soncini D., Fruscione F., Raffaghello L., Garuti A., Emionite L., et al. Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. PLoS One 2011, 6:e22739.
    • (2011) PLoS One , vol.6
    • Cea, M.1    Soncini, D.2    Fruscione, F.3    Raffaghello, L.4    Garuti, A.5    Emionite, L.6
  • 27
    • 51649114803 scopus 로고    scopus 로고
    • Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells
    • Chen G., Li A., Zhao M., Gao Y., Zhou T., Xu Y., et al. Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells. Journal of Proteome Research 2008, 7:2733-2742.
    • (2008) Journal of Proteome Research , vol.7 , pp. 2733-2742
    • Chen, G.1    Li, A.2    Zhao, M.3    Gao, Y.4    Zhou, T.5    Xu, Y.6
  • 28
    • 34548036251 scopus 로고    scopus 로고
    • Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells
    • Chen Z.X., Pervaiz S. Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death and Differentiation 2007, 14:1617-1627.
    • (2007) Cell Death and Differentiation , vol.14 , pp. 1617-1627
    • Chen, Z.X.1    Pervaiz, S.2
  • 29
    • 34347206854 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation
    • Chen C.S., Wang Y.C., Yang H.C., Huang P.H., Kulp S.K., Yang C.C., et al. Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation. Cancer Research 2007, 67:5318-5327.
    • (2007) Cancer Research , vol.67 , pp. 5318-5327
    • Chen, C.S.1    Wang, Y.C.2    Yang, H.C.3    Huang, P.H.4    Kulp, S.K.5    Yang, C.C.6
  • 30
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
    • (2009) Science , vol.325 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3    Nielsen, M.L.4    Rehman, M.5    Walther, T.C.6
  • 31
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia A., Elledge S.J. The DNA damage response: Making it safe to play with knives. Molecular Cell 2010, 40:179-204.
    • (2010) Molecular Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 32
    • 0030065418 scopus 로고    scopus 로고
    • Superoxide anion is a natural inhibitor of FAS-mediated cell death
    • Clement M.V., Stamenkovic I. Superoxide anion is a natural inhibitor of FAS-mediated cell death. The EMBO Journal 1996, 15:216-225.
    • (1996) The EMBO Journal , vol.15 , pp. 216-225
    • Clement, M.V.1    Stamenkovic, I.2
  • 34
    • 3142740860 scopus 로고    scopus 로고
    • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    • Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392.
    • (2004) Science , vol.305 , pp. 390-392
    • Cohen, H.Y.1    Miller, C.2    Bitterman, K.J.3    Wall, N.R.4    Hekking, B.5    Kessler, B.6
  • 35
    • 20744449274 scopus 로고    scopus 로고
    • Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation
    • Dai Y., Rahmani M., Dent P., Grant S. Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation. Molecular and Cellular Biology 2005, 25:5429-5444.
    • (2005) Molecular and Cellular Biology , vol.25 , pp. 5429-5444
    • Dai, Y.1    Rahmani, M.2    Dent, P.3    Grant, S.4
  • 36
    • 80052784486 scopus 로고    scopus 로고
    • Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo
    • Dasmahapatra G., Lembersky D., Son M.P., Attkisson E., Dent P., Fisher R.I., et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Molecular Cancer Therapeutics 2011, 10:1686-1697.
    • (2011) Molecular Cancer Therapeutics , vol.10 , pp. 1686-1697
    • Dasmahapatra, G.1    Lembersky, D.2    Son, M.P.3    Attkisson, E.4    Dent, P.5    Fisher, R.I.6
  • 37
    • 63649110740 scopus 로고    scopus 로고
    • Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates
    • Deriano L., Stracker T.H., Baker A., Petrini J.H., Roth D.B. Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Molecular Cell 2009, 34:13-25.
    • (2009) Molecular Cell , vol.34 , pp. 13-25
    • Deriano, L.1    Stracker, T.H.2    Baker, A.3    Petrini, J.H.4    Roth, D.B.5
  • 39
    • 18244373706 scopus 로고    scopus 로고
    • Enhanced pharmacodynamic and antitumor properties of a histone deacetylase inhibitor encapsulated in liposomes or ErbB2-targeted immunoliposomes
    • Drummond D.C., Marx C., Guo Z., Scott G., Noble C., Wang D., et al. Enhanced pharmacodynamic and antitumor properties of a histone deacetylase inhibitor encapsulated in liposomes or ErbB2-targeted immunoliposomes. Clinical Cancer Research 2005, 11:3392-3401.
    • (2005) Clinical Cancer Research , vol.11 , pp. 3392-3401
    • Drummond, D.C.1    Marx, C.2    Guo, Z.3    Scott, G.4    Noble, C.5    Wang, D.6
  • 42
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J., Coates J., Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434:605-611.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 43
    • 0027156140 scopus 로고
    • EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA
    • Falzon M., Fewell J.W., Kuff E.L. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. The Journal of Biological Chemistry 1993, 268:10546-10552.
    • (1993) The Journal of Biological Chemistry , vol.268 , pp. 10546-10552
    • Falzon, M.1    Fewell, J.W.2    Kuff, E.L.3
  • 44
    • 77955501963 scopus 로고    scopus 로고
    • SIRT1 regulates UV-induced DNA repair through deacetylating XPA
    • Fan W., Luo J. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Molecular Cell 2010, 39:247-258.
    • (2010) Molecular Cell , vol.39 , pp. 247-258
    • Fan, W.1    Luo, J.2
  • 45
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga M.F., Ballestar E., Villar-Garea A., Boix-Chornet M., Espada J., Schotta G., et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nature Genetics 2005, 37:391-400.
    • (2005) Nature Genetics , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3    Boix-Chornet, M.4    Espada, J.5    Schotta, G.6
  • 46
    • 33748427812 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: A mechanism for leukemia-specific HDI-dependent apoptosis?
    • Gaymes T.J., Padua R.A., Pla M., Orr S., Omidvar N., Chomienne C., et al. Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: A mechanism for leukemia-specific HDI-dependent apoptosis?. Molecular Cancer Research 2006, 4:563-573.
    • (2006) Molecular Cancer Research , vol.4 , pp. 563-573
    • Gaymes, T.J.1    Padua, R.A.2    Pla, M.3    Orr, S.4    Omidvar, N.5    Chomienne, C.6
  • 47
    • 84860186290 scopus 로고    scopus 로고
    • CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1-arrest, ROS-dependent apoptosis and differentiation in human leukemia cells
    • Gong K., Xie J., Yi H., Li W. CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1-arrest, ROS-dependent apoptosis and differentiation in human leukemia cells. The Biochemical Journal 2012, 443(3):735-746.
    • (2012) The Biochemical Journal , vol.443 , Issue.3 , pp. 735-746
    • Gong, K.1    Xie, J.2    Yi, H.3    Li, W.4
  • 48
    • 34447555612 scopus 로고    scopus 로고
    • Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated
    • Gopal Y.N., Arora T.S., Van Dyke M.W. Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated. Chemistry & Biology 2007, 14:813-823.
    • (2007) Chemistry & Biology , vol.14 , pp. 813-823
    • Gopal, Y.N.1    Arora, T.S.2    Van Dyke, M.W.3
  • 49
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore S.D., Baylin S., Sugar E., Carraway H., Miller C.B., Carducci M., et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Research 2006, 66:6361-6369.
    • (2006) Cancer Research , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3    Carraway, H.4    Miller, C.B.5    Carducci, M.6
  • 50
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb T.M., Jackson S.P. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen. Cell 1993, 72:131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 51
    • 77951091964 scopus 로고    scopus 로고
    • Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
    • Hajji N., Wallenborg K., Vlachos P., Fullgrabe J., Hermanson O., Joseph B. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. Oncogene 2010, 29:2192-2204.
    • (2010) Oncogene , vol.29 , pp. 2192-2204
    • Hajji, N.1    Wallenborg, K.2    Vlachos, P.3    Fullgrabe, J.4    Hermanson, O.5    Joseph, B.6
  • 53
    • 70350088548 scopus 로고    scopus 로고
    • Mechanisms of double-strand break repair in somatic mammalian cells
    • Hartlerode A.J., Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. The Biochemical Journal 2009, 423:157-168.
    • (2009) The Biochemical Journal , vol.423 , pp. 157-168
    • Hartlerode, A.J.1    Scully, R.2
  • 54
    • 0027217531 scopus 로고
    • Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin
    • Hayashi T., Ueno Y., Okamoto T. Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. The Journal of Biological Chemistry 1993, 268:11380-11388.
    • (1993) The Journal of Biological Chemistry , vol.268 , pp. 11380-11388
    • Hayashi, T.1    Ueno, Y.2    Okamoto, T.3
  • 57
    • 0029060757 scopus 로고
    • Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event
    • Huang P., Plunkett W. Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event. Cancer Chemotherapy and Pharmacology 1995, 36:181-188.
    • (1995) Cancer Chemotherapy and Pharmacology , vol.36 , pp. 181-188
    • Huang, P.1    Plunkett, W.2
  • 58
    • 66149114020 scopus 로고    scopus 로고
    • Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    • Huertas P., Jackson S.P. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. The Journal of Biological Chemistry 2009, 284:9558-9565.
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 9558-9565
    • Huertas, P.1    Jackson, S.P.2
  • 59
    • 69949173301 scopus 로고    scopus 로고
    • Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence
    • Iliakis G. Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence. Radiotherapy and Oncology 2009, 92:310-315.
    • (2009) Radiotherapy and Oncology , vol.92 , pp. 310-315
    • Iliakis, G.1
  • 60
    • 13444274622 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
    • Insinga A., Monestiroli S., Ronzoni S., Gelmetti V., Marchesi F., Viale A., et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nature Medicine 2005, 11:71-76.
    • (2005) Nature Medicine , vol.11 , pp. 71-76
    • Insinga, A.1    Monestiroli, S.2    Ronzoni, S.3    Gelmetti, V.4    Marchesi, F.5    Viale, A.6
  • 63
    • 33744942683 scopus 로고    scopus 로고
    • The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM
    • Jiang X., Sun Y., Chen S., Roy K., Price B.D. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. The Journal of Biological Chemistry 2006, 281:15741-15746.
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 15741-15746
    • Jiang, X.1    Sun, Y.2    Chen, S.3    Roy, K.4    Price, B.D.5
  • 65
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • Johnstone R.W. Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer. Nature Reviews. Drug Discovery 2002, 1:287-299.
    • (2002) Nature Reviews. Drug Discovery , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 66
    • 77955292345 scopus 로고    scopus 로고
    • Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor
    • Kachhap S.K., Rosmus N., Collis S.J., Kortenhorst M.S., Wissing M.D., Hedayati M., et al. Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor. PLoS One 2010, 5:e11208.
    • (2010) PLoS One , vol.5
    • Kachhap, S.K.1    Rosmus, N.2    Collis, S.J.3    Kortenhorst, M.S.4    Wissing, M.D.5    Hedayati, M.6
  • 67
    • 77956550868 scopus 로고    scopus 로고
    • Human SIRT6 promotes DNA end resection through CtIP deacetylation
    • Kaidi A., Weinert B.T., Choudhary C., Jackson S.P. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010, 329:1348-1353.
    • (2010) Science , vol.329 , pp. 1348-1353
    • Kaidi, A.1    Weinert, B.T.2    Choudhary, C.3    Jackson, S.P.4
  • 70
    • 38449099535 scopus 로고    scopus 로고
    • The epigenetic modifier, valproic acid, enhances radiation sensitivity
    • Karagiannis T.C., Kn H., El-Osta A. The epigenetic modifier, valproic acid, enhances radiation sensitivity. Epigenetics 2006, 1:131-137.
    • (2006) Epigenetics , vol.1 , pp. 131-137
    • Karagiannis, T.C.1    Kn, H.2    El-Osta, A.3
  • 71
    • 84863717308 scopus 로고    scopus 로고
    • Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis
    • Kerr E., Holohan C., McLaughlin K.M., Majkut J., Dolan S., Redmond K., et al. Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. Cell Death and Differentiation 2012, 19(8):1317-1327.
    • (2012) Cell Death and Differentiation , vol.19 , Issue.8 , pp. 1317-1327
    • Kerr, E.1    Holohan, C.2    McLaughlin, K.M.3    Majkut, J.4    Dolan, S.5    Redmond, K.6
  • 72
    • 84855471990 scopus 로고    scopus 로고
    • HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications
    • Khan O., La Thangue N.B. HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications. Immunology and Cell Biology 2012, 90:85-94.
    • (2012) Immunology and Cell Biology , vol.90 , pp. 85-94
    • Khan, O.1    La Thangue, N.B.2
  • 73
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna K.K., Jackson S.P. DNA double-strand breaks: Signaling, repair and the cancer connection. Nature Genetics 2001, 27:247-254.
    • (2001) Nature Genetics , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 75
    • 77955713258 scopus 로고    scopus 로고
    • TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L)
    • Kim J.J., Lee S.B., Park J.K., Yoo Y.D. TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L). Cell Death and Differentiation 2010, 17:1420-1434.
    • (2010) Cell Death and Differentiation , vol.17 , pp. 1420-1434
    • Kim, J.J.1    Lee, S.B.2    Park, J.K.3    Yoo, Y.D.4
  • 76
    • 74049094817 scopus 로고    scopus 로고
    • SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
    • Kim H.S., Patel K., Muldoon-Jacobs K., Bisht K.S., Aykin-Burns N., Pennington J.D., et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010, 17:41-52.
    • (2010) Cancer Cell , vol.17 , pp. 41-52
    • Kim, H.S.1    Patel, K.2    Muldoon-Jacobs, K.3    Bisht, K.S.4    Aykin-Burns, N.5    Pennington, J.D.6
  • 78
    • 82155171284 scopus 로고    scopus 로고
    • Regulation of reactive oxygen species in stem cells and cancer stem cells
    • Kobayashi C.I., Suda T. Regulation of reactive oxygen species in stem cells and cancer stem cells. Journal of Cellular Physiology 2012, 227:421-430.
    • (2012) Journal of Cellular Physiology , vol.227 , pp. 421-430
    • Kobayashi, C.I.1    Suda, T.2
  • 82
    • 79959697571 scopus 로고    scopus 로고
    • Assessment of oxidative stress-induced DNA damage by immunoflourescent analysis of 8-oxodG
    • Lee S.F., Pervaiz S. Assessment of oxidative stress-induced DNA damage by immunoflourescent analysis of 8-oxodG. Methods in Cell Biology 2011, 103:99-113.
    • (2011) Methods in Cell Biology , vol.103 , pp. 99-113
    • Lee, S.F.1    Pervaiz, S.2
  • 83
    • 43149118368 scopus 로고    scopus 로고
    • Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
    • Li K., Casta A., Wang R., Lozada E., Fan W., Kane S., et al. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. The Journal of Biological Chemistry 2008, 283:7590-7598.
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 7590-7598
    • Li, K.1    Casta, A.2    Wang, R.3    Lozada, E.4    Fan, W.5    Kane, S.6
  • 85
    • 0033520969 scopus 로고    scopus 로고
    • Quality control by DNA repair
    • Lindahl T., Wood R.D. Quality control by DNA repair. Science 1999, 286:1897-1905.
    • (1999) Science , vol.286 , pp. 1897-1905
    • Lindahl, T.1    Wood, R.D.2
  • 86
    • 0032061317 scopus 로고    scopus 로고
    • XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
    • Liu N., Lamerdin J.E., Tebbs R.S., Schild D., Tucker J.D., Shen M.R., et al. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Molecular Cell 1998, 1:783-793.
    • (1998) Molecular Cell , vol.1 , pp. 783-793
    • Liu, N.1    Lamerdin, J.E.2    Tebbs, R.S.3    Schild, D.4    Tucker, J.D.5    Shen, M.R.6
  • 87
    • 62449178216 scopus 로고    scopus 로고
    • The critical role of the class III histone deacetylase SIRT1 in cancer
    • Liu T., Liu P.Y., Marshall G.M. The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Research 2009, 69:1702-1705.
    • (2009) Cancer Research , vol.69 , pp. 1702-1705
    • Liu, T.1    Liu, P.Y.2    Marshall, G.M.3
  • 88
    • 28444433678 scopus 로고    scopus 로고
    • The two edges of the ATM sword: Co-operation between repair and checkpoint functions
    • Lobrich M., Jeggo P.A. The two edges of the ATM sword: Co-operation between repair and checkpoint functions. Radiotherapy and Oncology 2005, 76:112-118.
    • (2005) Radiotherapy and Oncology , vol.76 , pp. 112-118
    • Lobrich, M.1    Jeggo, P.A.2
  • 89
    • 14944375437 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress
    • Louis M., Rosato R.R., Brault L., Osbild S., Battaglia E., Yang X.H., et al. The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress. International Journal of Oncology 2004, 25:1701-1711.
    • (2004) International Journal of Oncology , vol.25 , pp. 1701-1711
    • Louis, M.1    Rosato, R.R.2    Brault, L.3    Osbild, S.4    Battaglia, E.5    Yang, X.H.6
  • 90
    • 80053555789 scopus 로고    scopus 로고
    • More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
    • Lukas J., Lukas C., Bartek J. More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nature Cell Biology 2011, 13:1161-1169.
    • (2011) Nature Cell Biology , vol.13 , pp. 1161-1169
    • Lukas, J.1    Lukas, C.2    Bartek, J.3
  • 91
    • 0034676439 scopus 로고    scopus 로고
    • Deacetylation of p53 modulates its effect on cell growth and apoptosis
    • Luo J., Su F., Chen D., Shiloh A., Gu W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 2000, 408:377-381.
    • (2000) Nature , vol.408 , pp. 377-381
    • Luo, J.1    Su, F.2    Chen, D.3    Shiloh, A.4    Gu, W.5
  • 92
    • 29844445035 scopus 로고    scopus 로고
    • NF-kappaB modulation and ionizing radiation: Mechanisms and future directions for cancer treatment
    • Magne N., Toillon R.A., Bottero V., Didelot C., Houtte P.V., Gerard J.P., et al. NF-kappaB modulation and ionizing radiation: Mechanisms and future directions for cancer treatment. Cancer Letters 2006, 231:158-168.
    • (2006) Cancer Letters , vol.231 , pp. 158-168
    • Magne, N.1    Toillon, R.A.2    Bottero, V.3    Didelot, C.4    Houtte, P.V.5    Gerard, J.P.6
  • 93
    • 79959363092 scopus 로고    scopus 로고
    • SIRT6 promotes DNA repair under stress by activating PARP1
    • Mao Z., Hine C., Tian X., Van Meter M., Au M., Vaidya A., et al. SIRT6 promotes DNA repair under stress by activating PARP1. Science 2011, 332:1443-1446.
    • (2011) Science , vol.332 , pp. 1443-1446
    • Mao, Z.1    Hine, C.2    Tian, X.3    Van Meter, M.4    Au, M.5    Vaidya, A.6
  • 94
    • 33751185927 scopus 로고    scopus 로고
    • Thioredoxin in cancer-Role of histone deacetylase inhibitors
    • Marks P.A. Thioredoxin in cancer-Role of histone deacetylase inhibitors. Seminars in Cancer Biology 2006, 16:436-443.
    • (2006) Seminars in Cancer Biology , vol.16 , pp. 436-443
    • Marks, P.A.1
  • 95
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
    • Marks P.A., Richon V.M., Rifkind R.A. Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells. Journal of the National Cancer Institute 2000, 92:1210-1216.
    • (2000) Journal of the National Cancer Institute , vol.92 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 98
    • 66049150672 scopus 로고    scopus 로고
    • SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
    • McCord R.A., Michishita E., Hong T., Berber E., Boxer L.D., Kusumoto R., et al. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany, NY) 2009, 1:109-121.
    • (2009) Aging (Albany, NY) , vol.1 , pp. 109-121
    • McCord, R.A.1    Michishita, E.2    Hong, T.3    Berber, E.4    Boxer, L.D.5    Kusumoto, R.6
  • 100
    • 0034733694 scopus 로고    scopus 로고
    • Base excision repair in yeast and mammals
    • Memisoglu A., Samson L. Base excision repair in yeast and mammals. Mutation Research 2000, 451:39-51.
    • (2000) Mutation Research , vol.451 , pp. 39-51
    • Memisoglu, A.1    Samson, L.2
  • 101
    • 77952853306 scopus 로고    scopus 로고
    • Histone deacetylases and epigenetic therapies of hematological malignancies
    • Mercurio C., Minucci S., Pelicci P.G. Histone deacetylases and epigenetic therapies of hematological malignancies. Pharmacological Research 2010, 62:18-34.
    • (2010) Pharmacological Research , vol.62 , pp. 18-34
    • Mercurio, C.1    Minucci, S.2    Pelicci, P.G.3
  • 102
    • 0028170326 scopus 로고
    • Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress
    • Michiels C., Raes M., Toussaint O., Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radical Biology & Medicine 1994, 17:235-248.
    • (1994) Free Radical Biology & Medicine , vol.17 , pp. 235-248
    • Michiels, C.1    Raes, M.2    Toussaint, O.3    Remacle, J.4
  • 105
    • 65549095526 scopus 로고    scopus 로고
    • Nucleases and helicases take center stage in homologous recombination
    • Mimitou E.P., Symington L.S. Nucleases and helicases take center stage in homologous recombination. Trends in Biochemical Sciences 2009, 34:264-272.
    • (2009) Trends in Biochemical Sciences , vol.34 , pp. 264-272
    • Mimitou, E.P.1    Symington, L.S.2
  • 106
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • Mimori T., Hardin J.A. Mechanism of interaction between Ku protein and DNA. The Journal of Biological Chemistry 1986, 261:10375-10379.
    • (1986) The Journal of Biological Chemistry , vol.261 , pp. 10375-10379
    • Mimori, T.1    Hardin, J.A.2
  • 108
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci S., Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nature Reviews. Cancer 2006, 6:38-51.
    • (2006) Nature Reviews. Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 109
    • 62849083222 scopus 로고    scopus 로고
    • The emerging role of nuclear architecture in DNA repair and genome maintenance
    • Misteli T., Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nature Reviews. Molecular Cell Biology 2009, 10:243-254.
    • (2009) Nature Reviews. Molecular Cell Biology , vol.10 , pp. 243-254
    • Misteli, T.1    Soutoglou, E.2
  • 110
    • 78650873024 scopus 로고    scopus 로고
    • Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage
    • Miyamoto S. Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage. Cell Research 2011, 21:116-130.
    • (2011) Cell Research , vol.21 , pp. 116-130
    • Miyamoto, S.1
  • 111
    • 79961196710 scopus 로고    scopus 로고
    • Cellular redox pathways as a therapeutic target in the treatment of cancer
    • Montero A.J., Jassem J. Cellular redox pathways as a therapeutic target in the treatment of cancer. Drugs 2011, 71:1385-1396.
    • (2011) Drugs , vol.71 , pp. 1385-1396
    • Montero, A.J.1    Jassem, J.2
  • 112
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006, 124:315-329.
    • (2006) Cell , vol.124 , pp. 315-329
    • Mostoslavsky, R.1    Chua, K.F.2    Lombard, D.B.3    Pang, W.W.4    Fischer, M.R.5    Gellon, L.6
  • 113
    • 33845501150 scopus 로고    scopus 로고
    • Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal
    • Moufarij M.A., Sampath D., Keating M.J., Plunkett W. Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal. Blood 2006, 108:4187-4193.
    • (2006) Blood , vol.108 , pp. 4187-4193
    • Moufarij, M.A.1    Sampath, D.2    Keating, M.J.3    Plunkett, W.4
  • 114
    • 27644586649 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity
    • Munshi A., Kurland J.F., Nishikawa T., Tanaka T., Hobbs M.L., Tucker S.L., et al. Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clinical Cancer Research 2005, 11:4912-4922.
    • (2005) Clinical Cancer Research , vol.11 , pp. 4912-4922
    • Munshi, A.1    Kurland, J.F.2    Nishikawa, T.3    Tanaka, T.4    Hobbs, M.L.5    Tucker, S.L.6
  • 115
    • 33748360764 scopus 로고    scopus 로고
    • Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of g-H2AX foci
    • Munshi A., Tanaka T., Hobbs M.L., Tucker S.L., Richon V.M., Meyn R.E. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of g-H2AX foci. Molecular Cancer Therapeutics 2006, 5:1967-1974.
    • (2006) Molecular Cancer Therapeutics , vol.5 , pp. 1967-1974
    • Munshi, A.1    Tanaka, T.2    Hobbs, M.L.3    Tucker, S.L.4    Richon, V.M.5    Meyn, R.E.6
  • 116
    • 30344444484 scopus 로고    scopus 로고
    • Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
    • Murr R., Loizou J.I., Yang Y.G., Cuenin C., Li H., Wang Z.Q., et al. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nature Cell Biology 2006, 8:91-99.
    • (2006) Nature Cell Biology , vol.8 , pp. 91-99
    • Murr, R.1    Loizou, J.I.2    Yang, Y.G.3    Cuenin, C.4    Li, H.5    Wang, Z.Q.6
  • 117
    • 38449100788 scopus 로고    scopus 로고
    • Expression profile of class I histone deacetylases in human cancer tissues
    • Nakagawa M., Oda Y., Eguchi T., Aishima S., Yao T., Hosoi F., et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncology Reports 2007, 18:769-774.
    • (2007) Oncology Reports , vol.18 , pp. 769-774
    • Nakagawa, M.1    Oda, Y.2    Eguchi, T.3    Aishima, S.4    Yao, T.5    Hosoi, F.6
  • 118
    • 0028106431 scopus 로고
    • Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide
    • Nakamura H., Matsuda M., Furuke K., Kitaoka Y., Iwata S., Toda K., et al. Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide. Immunology Letters 1994, 42:75-80.
    • (1994) Immunology Letters , vol.42 , pp. 75-80
    • Nakamura, H.1    Matsuda, M.2    Furuke, K.3    Kitaoka, Y.4    Iwata, S.5    Toda, K.6
  • 119
    • 79955148265 scopus 로고    scopus 로고
    • Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization
    • Nalabothula N., Carrier F. Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization. Epigenomics 2011, 3:145-155.
    • (2011) Epigenomics , vol.3 , pp. 145-155
    • Nalabothula, N.1    Carrier, F.2
  • 121
    • 13444306459 scopus 로고    scopus 로고
    • Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
    • Nebbioso A., Clarke N., Voltz E., Germain E., Ambrosino C., Bontempo P., et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nature Medicine 2005, 11:77-84.
    • (2005) Nature Medicine , vol.11 , pp. 77-84
    • Nebbioso, A.1    Clarke, N.2    Voltz, E.3    Germain, E.4    Ambrosino, C.5    Bontempo, P.6
  • 123
    • 79956056274 scopus 로고    scopus 로고
    • HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo
    • Nguyen T., Dai Y., Attkisson E., Kramer L., Jordan N., Nguyen N., et al. HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo. Clinical Cancer Research 2011, 17:3219-3232.
    • (2011) Clinical Cancer Research , vol.17 , pp. 3219-3232
    • Nguyen, T.1    Dai, Y.2    Attkisson, E.3    Kramer, L.4    Jordan, N.5    Nguyen, N.6
  • 124
    • 35348821296 scopus 로고    scopus 로고
    • A backup DNA repair pathway moves to the forefront
    • Nussenzweig A., Nussenzweig M.C. A backup DNA repair pathway moves to the forefront. Cell 2007, 131:223-225.
    • (2007) Cell , vol.131 , pp. 223-225
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 125
    • 29244437908 scopus 로고    scopus 로고
    • The role of double-strand break repair-Insights from human genetics
    • O'Driscoll M., Jeggo P.A. The role of double-strand break repair-Insights from human genetics. Nature Reviews. Genetics 2006, 7:45-54.
    • (2006) Nature Reviews. Genetics , vol.7 , pp. 45-54
    • O'Driscoll, M.1    Jeggo, P.A.2
  • 126
    • 50849104569 scopus 로고    scopus 로고
    • Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
    • O'Hagan H.M., Mohammad H.P., Baylin S.B. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genetics 2008, 4:e1000155.
    • (2008) PLoS Genetics , vol.4
    • O'Hagan, H.M.1    Mohammad, H.P.2    Baylin, S.B.3
  • 127
    • 79955613209 scopus 로고    scopus 로고
    • Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors
    • Ogiwara H., Ui A., Otsuka A., Satoh H., Yokomi I., Nakajima S., et al. Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene 2011, 30:2135-2146.
    • (2011) Oncogene , vol.30 , pp. 2135-2146
    • Ogiwara, H.1    Ui, A.2    Otsuka, A.3    Satoh, H.4    Yokomi, I.5    Nakajima, S.6
  • 128
    • 33748367886 scopus 로고    scopus 로고
    • Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction
    • Park J.H., Park E.J., Lee H.S., Kim S.J., Hur S.K., Imbalzano A.N., et al. Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. The EMBO Journal 2006, 25:3986-3997.
    • (2006) The EMBO Journal , vol.25 , pp. 3986-3997
    • Park, J.H.1    Park, E.J.2    Lee, H.S.3    Kim, S.J.4    Hur, S.K.5    Imbalzano, A.N.6
  • 131
    • 79251566746 scopus 로고    scopus 로고
    • Physical and functional HAT/HDAC interplay regulates protein acetylation balance
    • Peserico A., Simone C. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Journal of Biomedicine and Biotechnology 2011, 2011:371832.
    • (2011) Journal of Biomedicine and Biotechnology , vol.2011 , pp. 371832
    • Peserico, A.1    Simone, C.2
  • 132
    • 33746189731 scopus 로고    scopus 로고
    • CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing
    • Petalcorin M.I., Sandall J., Wigley D.B., Boulton S.J. CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. Journal of Molecular Biology 2006, 361:231-242.
    • (2006) Journal of Molecular Biology , vol.361 , pp. 231-242
    • Petalcorin, M.I.1    Sandall, J.2    Wigley, D.B.3    Boulton, S.J.4
  • 134
    • 77956870690 scopus 로고    scopus 로고
    • Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
    • Polo S.E., Kaidi A., Baskcomb L., Galanty Y., Jackson S.P. Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. The EMBO Journal 2010, 29:3130-3139.
    • (2010) The EMBO Journal , vol.29 , pp. 3130-3139
    • Polo, S.E.1    Kaidi, A.2    Baskcomb, L.3    Galanty, Y.4    Jackson, S.P.5
  • 135
    • 4143070452 scopus 로고    scopus 로고
    • Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression
    • Rahman I., Marwick J., Kirkham P. Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochemical Pharmacology 2004, 68:1255-1267.
    • (2004) Biochemical Pharmacology , vol.68 , pp. 1255-1267
    • Rahman, I.1    Marwick, J.2    Kirkham, P.3
  • 136
    • 15944406971 scopus 로고    scopus 로고
    • Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
    • Rahmani M., Reese E., Dai Y., Bauer C., Payne S.G., Dent P., et al. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Research 2005, 65:2422-2432.
    • (2005) Cancer Research , vol.65 , pp. 2422-2432
    • Rahmani, M.1    Reese, E.2    Dai, Y.3    Bauer, C.4    Payne, S.G.5    Dent, P.6
  • 137
    • 81555226055 scopus 로고    scopus 로고
    • Sirtuins: Molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription
    • Rajendran R., Garva R., Krstic-Demonacos M., Demonacos C. Sirtuins: Molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. Journal of Biomedicine and Biotechnology 2011, 2011:368276.
    • (2011) Journal of Biomedicine and Biotechnology , vol.2011 , pp. 368276
    • Rajendran, R.1    Garva, R.2    Krstic-Demonacos, M.3    Demonacos, C.4
  • 139
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    • Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C., Recio M.J., et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Molecular Cell 2004, 16:715-724.
    • (2004) Molecular Cell , vol.16 , pp. 715-724
    • Riballo, E.1    Kuhne, M.2    Rief, N.3    Doherty, A.4    Smith, G.C.5    Recio, M.J.6
  • 141
    • 0038079767 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
    • Rosato R.R., Almenara J.A., Grant S. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Research 2003, 63:3637-3645.
    • (2003) Cancer Research , vol.63 , pp. 3637-3645
    • Rosato, R.R.1    Almenara, J.A.2    Grant, S.3
  • 142
    • 55749113687 scopus 로고    scopus 로고
    • Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions
    • Rosato R.R., Almenara J.A., Maggio S.C., Coe S., Atadja P., Dent P., et al. Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions. Molecular Cancer Therapeutics 2008, 7:3285-3297.
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 3285-3297
    • Rosato, R.R.1    Almenara, J.A.2    Maggio, S.C.3    Coe, S.4    Atadja, P.5    Dent, P.6
  • 143
    • 77951241720 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway
    • Rosato R.R., Kolla S.S., Hock S.K., Almenara J.A., Patel A., Amin S., et al. Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway. The Journal of Biological Chemistry 2010, 285:10064-10077.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 10064-10077
    • Rosato, R.R.1    Kolla, S.S.2    Hock, S.K.3    Almenara, J.A.4    Patel, A.5    Amin, S.6
  • 144
    • 30044434594 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
    • Rosato R.R., Maggio S.C., Almenara J.A., Payne S.G., Atadja P., Spiegel S., et al. The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide. Molecular Pharmacology 2006, 69:216-225.
    • (2006) Molecular Pharmacology , vol.69 , pp. 216-225
    • Rosato, R.R.1    Maggio, S.C.2    Almenara, J.A.3    Payne, S.G.4    Atadja, P.5    Spiegel, S.6
  • 145
    • 77956673574 scopus 로고    scopus 로고
    • Epigenetic modifications in double-strand break DNA damage signaling and repair
    • Rossetto D., Truman A.W., Kron S.J., Cote J. Epigenetic modifications in double-strand break DNA damage signaling and repair. Clinical Cancer Research 2010, 16:4543-4552.
    • (2010) Clinical Cancer Research , vol.16 , pp. 4543-4552
    • Rossetto, D.1    Truman, A.W.2    Kron, S.J.3    Cote, J.4
  • 147
    • 0022976432 scopus 로고
    • Nonhomologous recombination in mammalian cells: Role for short sequence homologies in the joining reaction
    • Roth D.B., Wilson J.H. Nonhomologous recombination in mammalian cells: Role for short sequence homologies in the joining reaction. Molecular and Cellular Biology 1986, 6:4295-4304.
    • (1986) Molecular and Cellular Biology , vol.6 , pp. 4295-4304
    • Roth, D.B.1    Wilson, J.H.2
  • 148
    • 0035845541 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
    • Ruefli A.A., Ausserlechner M.J., Bernhard D., Sutton V.R., Tainton K.M., Kofler R., et al. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:10833-10838.
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , pp. 10833-10838
    • Ruefli, A.A.1    Ausserlechner, M.J.2    Bernhard, D.3    Sutton, V.R.4    Tainton, K.M.5    Kofler, R.6
  • 149
    • 0032080283 scopus 로고    scopus 로고
    • Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    • Saitoh M., Nishitoh H., Fujii M., Takeda K., Tobiume K., Sawada Y., et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. The EMBO Journal 1998, 17:2596-2606.
    • (1998) The EMBO Journal , vol.17 , pp. 2596-2606
    • Saitoh, M.1    Nishitoh, H.2    Fujii, M.3    Takeda, K.4    Tobiume, K.5    Sawada, Y.6
  • 150
    • 51649128895 scopus 로고    scopus 로고
    • Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks
    • Sallmyr A., Tomkinson A.E., Rassool F.V. Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks. Blood 2008, 112:1413-1423.
    • (2008) Blood , vol.112 , pp. 1413-1423
    • Sallmyr, A.1    Tomkinson, A.E.2    Rassool, F.V.3
  • 152
    • 35548947600 scopus 로고    scopus 로고
    • Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells
    • Sanda T., Okamoto T., Uchida Y., Nakagawa H., Iida S., Kayukawa S., et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 2007, 21:2344-2353.
    • (2007) Leukemia , vol.21 , pp. 2344-2353
    • Sanda, T.1    Okamoto, T.2    Uchida, Y.3    Nakagawa, H.4    Iida, S.5    Kayukawa, S.6
  • 154
    • 0033135256 scopus 로고    scopus 로고
    • Hematopoietic growth factors signal through the formation of reactive oxygen species
    • Sattler M., Winkler T., Verma S., Byrne C.H., Shrikhande G., Salgia R., et al. Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 1999, 93:2928-2935.
    • (1999) Blood , vol.93 , pp. 2928-2935
    • Sattler, M.1    Winkler, T.2    Verma, S.3    Byrne, C.H.4    Shrikhande, G.5    Salgia, R.6
  • 155
    • 0035111895 scopus 로고    scopus 로고
    • Recent progress in the biology, chemistry and structural biology of DNA glycosylases
    • Scharer O.D., Jiricny J. Recent progress in the biology, chemistry and structural biology of DNA glycosylases. BioEssays 2001, 23:270-281.
    • (2001) BioEssays , vol.23 , pp. 270-281
    • Scharer, O.D.1    Jiricny, J.2
  • 156
    • 34247271282 scopus 로고    scopus 로고
    • SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
    • Scher M.B., Vaquero A., Reinberg D. SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes & Development 2007, 21:920-928.
    • (2007) Genes & Development , vol.21 , pp. 920-928
    • Scher, M.B.1    Vaquero, A.2    Reinberg, D.3
  • 157
    • 64549139803 scopus 로고    scopus 로고
    • Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeutics
    • Selvi R.B., Kundu T.K. Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeutics. Biotechnology Journal 2009, 4:375-390.
    • (2009) Biotechnology Journal , vol.4 , pp. 375-390
    • Selvi, R.B.1    Kundu, T.K.2
  • 158
    • 77954360144 scopus 로고    scopus 로고
    • MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
    • Sharma G.G., So S., Gupta A., Kumar R., Cayrou C., Avvakumov N., et al. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Molecular and Cellular Biology 2010, 30:3582-3595.
    • (2010) Molecular and Cellular Biology , vol.30 , pp. 3582-3595
    • Sharma, G.G.1    So, S.2    Gupta, A.3    Kumar, R.4    Cayrou, C.5    Avvakumov, N.6
  • 160
    • 33847340207 scopus 로고    scopus 로고
    • Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair
    • Sonoda E., Zhao G.Y., Kohzaki M., Dhar P.K., Kikuchi K., Redon C., et al. Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair. DNA Repair 2007, 6:280-292.
    • (2007) DNA Repair , vol.6 , pp. 280-292
    • Sonoda, E.1    Zhao, G.Y.2    Kohzaki, M.3    Dhar, P.K.4    Kikuchi, K.5    Redon, C.6
  • 162
    • 77953495958 scopus 로고    scopus 로고
    • Tip60: Connecting chromatin to DNA damage signaling
    • Sun Y., Jiang X., Price B.D. Tip60: Connecting chromatin to DNA damage signaling. Cell Cycle 2010, 9:930-936.
    • (2010) Cell Cycle , vol.9 , pp. 930-936
    • Sun, Y.1    Jiang, X.2    Price, B.D.3
  • 163
    • 70449518412 scopus 로고    scopus 로고
    • Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
    • Sun Y., Jiang X., Xu Y., Ayrapetov M.K., Moreau L.A., Whetstine J.R., et al. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nature Cell Biology 2009, 11:1376-1382.
    • (2009) Nature Cell Biology , vol.11 , pp. 1376-1382
    • Sun, Y.1    Jiang, X.2    Xu, Y.3    Ayrapetov, M.K.4    Moreau, L.A.5    Whetstine, J.R.6
  • 164
    • 37549028411 scopus 로고    scopus 로고
    • DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
    • Sun Y., Xu Y., Roy K., Price B.D. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Molecular and Cellular Biology 2007, 27:8502-8509.
    • (2007) Molecular and Cellular Biology , vol.27 , pp. 8502-8509
    • Sun, Y.1    Xu, Y.2    Roy, K.3    Price, B.D.4
  • 165
    • 78650248160 scopus 로고    scopus 로고
    • Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
    • Tao R., Coleman M.C., Pennington J.D., Ozden O., Park S.H., Jiang H., et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Molecular Cell 2010, 40:893-904.
    • (2010) Molecular Cell , vol.40 , pp. 893-904
    • Tao, R.1    Coleman, M.C.2    Pennington, J.D.3    Ozden, O.4    Park, S.H.5    Jiang, H.6
  • 166
    • 84863337757 scopus 로고    scopus 로고
    • Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    • Tsai H.C., Li H., Van Neste L., Cai Y., Robert C., Rassool F.V., et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 2012, 21:430-446.
    • (2012) Cancer Cell , vol.21 , pp. 430-446
    • Tsai, H.C.1    Li, H.2    Van Neste, L.3    Cai, Y.4    Robert, C.5    Rassool, F.V.6
  • 170
    • 79952262759 scopus 로고    scopus 로고
    • Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
    • Wagner J.M., Hackanson B., Lubbert M., Jung M. Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clinical Epigenetics 2010, 1:117-136.
    • (2010) Clinical Epigenetics , vol.1 , pp. 117-136
    • Wagner, J.M.1    Hackanson, B.2    Lubbert, M.3    Jung, M.4
  • 171
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker J.R., Corpina R.A., Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001, 412:607-614.
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 172
    • 77951217683 scopus 로고    scopus 로고
    • SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60
    • Wang J., Chen J. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. The Journal of Biological Chemistry 2010, 285:11458-11464.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 11458-11464
    • Wang, J.1    Chen, J.2
  • 173
    • 20144363082 scopus 로고    scopus 로고
    • DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
    • Wang H., Rosidi B., Perrault R., Wang M., Zhang L., Windhofer F., et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Research 2005, 65:4020-4030.
    • (2005) Cancer Research , vol.65 , pp. 4020-4030
    • Wang, H.1    Rosidi, B.2    Perrault, R.3    Wang, M.4    Zhang, L.5    Windhofer, F.6
  • 174
    • 53149137486 scopus 로고    scopus 로고
    • Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    • Wang R.H., Sengupta K., Li C., Kim H.S., Cao L., Xiao C., et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008, 14:312-323.
    • (2008) Cancer Cell , vol.14 , pp. 312-323
    • Wang, R.H.1    Sengupta, K.2    Li, C.3    Kim, H.S.4    Cao, L.5    Xiao, C.6
  • 175
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang M., Wu W., Rosidi B., Zhang L., Wang H., Iliakis G. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Research 2006, 34:6170-6182.
    • (2006) Nucleic Acids Research , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Rosidi, B.3    Zhang, L.4    Wang, H.5    Iliakis, G.6
  • 176
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • Weichert W., Roske A., Gekeler V., Beckers T., Stephan C., Jung K., et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. British Journal of Cancer 2008, 98:604-610.
    • (2008) British Journal of Cancer , vol.98 , pp. 604-610
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Stephan, C.5    Jung, K.6
  • 177
    • 33845726097 scopus 로고    scopus 로고
    • Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks
    • Wyatt M.D., Pittman D.L. Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chemical Research in Toxicology 2006, 19:1580-1594.
    • (2006) Chemical Research in Toxicology , vol.19 , pp. 1580-1594
    • Wyatt, M.D.1    Pittman, D.L.2
  • 178
    • 68249146431 scopus 로고    scopus 로고
    • Role of mammalian Mre11 in classical and alternative nonhomologous end joining
    • Xie A., Kwok A., Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nature Structural & Molecular Biology 2009, 16:814-818.
    • (2009) Nature Structural & Molecular Biology , vol.16 , pp. 814-818
    • Xie, A.1    Kwok, A.2    Scully, R.3
  • 180
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • Xu W.S., Parmigiani R.B., Marks P.A. Histone deacetylase inhibitors: Molecular mechanisms of action. Oncogene 2007, 26:5541-5552.
    • (2007) Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 182
    • 49349107518 scopus 로고    scopus 로고
    • Lysine acetylation: Codified crosstalk with other posttranslational modifications
    • Yang X.J., Seto E. Lysine acetylation: Codified crosstalk with other posttranslational modifications. Molecular Cell 2008, 31:449-461.
    • (2008) Molecular Cell , vol.31 , pp. 449-461
    • Yang, X.J.1    Seto, E.2
  • 183
    • 84863116364 scopus 로고    scopus 로고
    • Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
    • Yuan H., Wang Z., Li L., Zhang H., Modi H., Horne D., et al. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood 2012, 119:1904-1914.
    • (2012) Blood , vol.119 , pp. 1904-1914
    • Yuan, H.1    Wang, Z.2    Li, L.3    Zhang, H.4    Modi, H.5    Horne, D.6
  • 184
    • 34250897968 scopus 로고    scopus 로고
    • SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    • Yuan Z., Zhang X., Sengupta N., Lane W.S., Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Molecular Cell 2007, 27:149-162.
    • (2007) Molecular Cell , vol.27 , pp. 149-162
    • Yuan, Z.1    Zhang, X.2    Sengupta, N.3    Lane, W.S.4    Seto, E.5


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