Review of mammalian DNA repair and translational implications

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 1, 2000, Pages 1-9

  Hansen, W K ^a   Kelley, M R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BUSULFAN; CARMUSTINE; CISPLATIN; DNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROCARBAZINE; TEMOZOLOMIDE;

ANIMAL CELL; BASE MISPAIRING; DNA DRUG COMPLEX; DNA REPAIR; DRUG MECHANISM; EXCISION REPAIR; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSLATION REGULATION;

ANIMALS; BASE PAIR MISMATCH; DNA REPAIR; HUMANS; NEOPLASMS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE;

EID: 0033815382     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (48)

1. Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - A case of imbalanced DNA repair
2. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: Definition of a family of DNA repair enzymes
3. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
4. The role of DNA mismatch repair in drug resistance
5. MutS homologs in mammalian cells
6. Different DNA polymerases are involved in the short- and long-patch base
7. Increased resistance to N,N',N''-triethylenethiophosphoramide (thiotepa) in cells expressing the Escherichia coli formamidopyrimidine-DNA glycosylase
8. Recognition of oxidized abasic sites by repair endonucleases
9. 6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts
10. The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation
11. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
12. Yeast DNA 3'-repair diesterase is the major cellular apurinic/apyrimidinic endonuclease: Substrate specificity and kinetics
13. Kinetics of excision of purine lesions from DNA by Escherichia coli F pg protein
14. Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
15. Second pathway for completion of human DNA base excision-repair: Reconstitution with purified proteins and requirement for DNase IV (FEN1)
16. Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours
17. Homogeneous Escherichia coli endonuclease IV. Characterization of an enzyme that recognizes oxidative damage in DNA
18. DNA repair and gene therapy: Implications for translational uses
19. DNA excision repair pathways
20. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
21. Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo
22. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
23. Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs
24. DNA mismatch repair gene mutations in human cancer
25. 6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs
26. Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs
27. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
28. Overproduction, purification, and characterization of the XPC subunit of the human DNA repair excision nuclease
29. Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice
30. MSH2 deficient mice are viable and susceptible to lymphoid tumours
31. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants
32. Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
33. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase
34. DNA excision repair
35. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps
36. 6-alkylguanine
37. The multistep nature of cancer
38. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress
39. Life without DNA repair
40. Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1
41. DNA repair in eukaryotes
42. Instability of short tandem repeats (microsatellites) in human cancers
43. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
44. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
45. Human DNA repair systems: An overview
46. Apoptosis induced by overexpression of hMSH2 or hMLH1