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Volumn 94, Issue 6, 2012, Pages 1469-1482

Real-time monitoring and control of microbial bioprocesses with focus on the specific growth rate: Current state and perspectives

Author keywords

Growth model; Monod model; Process analytical technology (PAT); Recombinant protein production

Indexed keywords

BATCH CELL CULTURE; CHEMICAL SENSORS; PHYSIOLOGY;

EID: 84867298270     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4095-z     Document Type: Review
Times cited : (59)

References (114)
  • 1
    • 0032485022 scopus 로고    scopus 로고
    • Growth and product formation of aspergillus oryzae during submerged cultivations: Verification of a morphologically structured model using fluorescent probes
    • doi:10.1002/(SICI)1097-0290(19980205)57:3<321:: AID-BIT9>3.0.CO;2-J
    • Agger T, Spohr AB, Carlsen M, Nielsen J (1998) Growth and product formation of Aspergillus oryzae during submerged cultivations: verification of a morphologically structured model using fluorescent probes. Biotechnol Bioeng 57(3): 321-329. doi:10.1002/(SICI)1097-0290(19980205)57:33.0.CO;2-J
    • (1998) Biotechnol Bioeng , vol.57 , Issue.3 , pp. 321-329
    • Agger, T.1    Spohr, A.B.2    Carlsen, M.3    Nielsen, J.4
  • 2
    • 77950340182 scopus 로고    scopus 로고
    • Optimization of the heterologous production of a rhizopus oryzae lipase in pichia pastoris system using mixed substrates on controlled fed-batch bioprocess
    • doi:10.1016/j.enzmictec.2010.01.005
    • Arnau C, Ramon R, Casas C, Valero F (2010) Optimization of the heterologous production of a Rhizopus oryzae lipase in Pichia pastoris system using mixed substrates on controlled fed-batch bioprocess. Enzyme Microb Technol 46(6): 494-500. doi:10.1016/j.enzmictec.2010.01.005. http://www.sciencedirect. com/science/article/pii/S0141022910000177
    • (2010) Enzyme Microb Technol , vol.46 , Issue.6 , pp. 494-500
    • Arnau, C.1    Ramon, R.2    Casas, C.3    Valero, F.4
  • 3
    • 15744400671 scopus 로고    scopus 로고
    • A feedforward-feedback substrate controller based on a kalman filter for a fed-batch cultivation of escherichia coli producing phytase
    • doi:10.1016/j.compchemeng.2004.11.011
    • Arndt M, Kleist S, Miksch G, Friehs K, Flaschel E, Trierweiler J, Hitzmann B (2005) A feedforward-feedback substrate controller based on a kalman filter for a fed-batch cultivation of Escherichia coli producing phytase. Comput Chem Eng 29(5):1113-1120. doi:10.1016/j.compchemeng.2004.11.011. http://www.sciencedirect.com/science/article/B6TFT-4F662JH-3/2/ d35df8f0ed72d34432360916120a5bf2
    • (2005) Comput Chem Eng , vol.29 , Issue.5 , pp. 1113-1120
    • Arndt, M.1    Kleist, S.2    Miksch, G.3    Friehs, K.4    Flaschel, E.5    Trierweiler, J.6    Hitzmann, B.7
  • 4
    • 33750931964 scopus 로고    scopus 로고
    • Over-production of human interferongamma by hcdc of recombinant escherichia coli
    • doi:10.1016/j.procbio.2006. 07.009
    • Babaeipour V, Shojaosadati S, Robatjazi S, Khalilzadeh R, Maghsoudi N (2007) Over-production of human interferongamma by HCDC of recombinant Escherichia coli. Process Biochem 42(1):112-117. doi:10.1016/j.procbio.2006. 07.009. http://www.sciencedirect.com/science/article/pii/S1359511306002753
    • (2007) Process Biochem , vol.42 , Issue.1 , pp. 112-117
    • Babaeipour, V.1    Shojaosadati, S.2    Robatjazi, S.3    Khalilzadeh, R.4    Maghsoudi, N.5
  • 5
    • 0022806520 scopus 로고
    • On-line estimation of microbial specific growth rates
    • doi:10.1016/0005-1098(86)90007-5
    • Bastin G, Dochain D (1986) On-line estimation of microbial specific growth rates. Automatica 22(6):705-709. doi:10.1016/0005-1098(86)90007-5. http://www.sciencedirect. com/science/article/pii/0005109886900075
    • (1986) Automatica , vol.22 , Issue.6 , pp. 705-709
    • Bastin, G.1    Dochain, D.2
  • 6
    • 84859555595 scopus 로고    scopus 로고
    • Nonlinear pi control of fed-batch processes for growth rate regulation
    • doi:10.1016/j.jprocont.2012. 02.011
    • Battista HD, Pico J, Pico-Marco E (2012) Nonlinear PI control of fed-batch processes for growth rate regulation. J Process Control 22(4):789-797. doi:10.1016/j.jprocont.2012. 02.011. http://www.sciencedirect.com/science/ article/pii/S0959152412000601
    • (2012) J Process Control , vol.22 , Issue.4 , pp. 789-797
    • Battista, H.D.1    Pico, J.2    Pico-Marco, E.3
  • 7
    • 12944303639 scopus 로고    scopus 로고
    • On the estimation of the pseudostoichiometric matrix for macroscopic mass balance modelling of biotechnological processes
    • doi:10.1016/j.mbs.2004.10.004
    • Bernard O, Bastin G (2005) On the estimation of the pseudostoichiometric matrix for macroscopic mass balance modelling of biotechnological processes. Math Biosci 193(1):51-77. doi:10.1016/j.mbs.2004.10.004. http://www. sciencedirect. com/science/article/pii/S0025556404001634
    • (2005) Math Biosci , vol.193 , Issue.1 , pp. 51-77
    • Bernard, O.1    Bastin, G.2
  • 8
    • 33646092543 scopus 로고    scopus 로고
    • Specific growth rate determines the sensitivity of escherichia coli to thermal, uva, and solar disinfection
    • Berney M, Weilenmann HU, Ihssen J, Bassin C, Egli T (2006) Specific growth rate determines the sensitivity of Escherichia coli to thermal, UVA, and solar disinfection. Appl Environ Microbiol 4:2586-2593
    • (2006) Appl Environ Microbiol , vol.4 , pp. 2586-2593
    • Berney, M.1    Weilenmann, H.U.2    Ihssen, J.3    Bassin, C.4    Egli, T.5
  • 9
    • 77249162122 scopus 로고    scopus 로고
    • Calorimetric control for high cell density cultivation of a recombinant escherichia coli strain
    • doi:10.1016/j.jbiotec.2010.01.004
    • Biener R, Steinkmper A, Hofmann J (2010) Calorimetric control for high cell density cultivation of a recombinant Escherichia coli strain. J Biotechnol 146(1-2):45-53. doi:10.1016/j.jbiotec.2010.01.004. http://www.sciencedirect. com/science/article/pii/S0168165610000313
    • (2010) J Biotechnol , vol.146 , Issue.1-2 , pp. 45-53
    • Biener, R.1    Steinkmper, A.2    Hofmann, J.3
  • 10
    • 84864045866 scopus 로고    scopus 로고
    • Calorimetric control of the specific growth rate during fed-batch cultures of saccharomyces cerevisiae
    • doi:10.1016/j.jbiotec.2012. 03.006
    • Biener R, Steinkmper A, Horn T (2012) Calorimetric control of the specific growth rate during fed-batch cultures of Saccharomyces cerevisiae. J Biotechnol. doi:10.1016/j.jbiotec.2012. 03.006. http://www.sciencedirect.com/ science/article/pii/S0168165612001733
    • (2012) J Biotechnol.
    • Biener, R.1    Steinkmper, A.2    Horn, T.3
  • 11
    • 0032917885 scopus 로고    scopus 로고
    • Error analysis of metabolic-rate measurements in mammalian-cell culture by carbon and nitrogen balances
    • doi:10.1023/A:1008063324292
    • Bonarius H, Houtman J, Schmid G, de Gooijer C, Tramper J (1999) Error analysis of metabolic-rate measurements in mammalian-cell culture by carbon and nitrogen balances. Cytotechnology 29:167-176. doi:10.1023/A:1008063324292
    • (1999) Cytotechnology , vol.29 , pp. 167-176
    • Bonarius, H.1    Houtman, J.2    Schmid, G.3    De Gooijer, C.4    Tramper, J.5
  • 12
    • 12444300176 scopus 로고    scopus 로고
    • Control of yeast fed-batch process through regulation of extracellular ethanol concentration
    • doi:10.1007/s00449-004-0384-y
    • Cannizzaro C, Valentinotti S, von Stockar U (2004) Control of yeast fed-batch process through regulation of extracellular ethanol concentration. Bioprocess Biosyst Eng 26:377-383. doi:10.1007/s00449-004-0384-y
    • (2004) Bioprocess Biosyst Eng , vol.26 , pp. 377-383
    • Cannizzaro, C.1    Valentinotti, S.2    Von Stockar, U.3
  • 13
    • 33747337529 scopus 로고    scopus 로고
    • On-line measurements and control of viable cell density in cell culture manufacturing processes using radio-frequency impedance
    • doi:10.1007/s10616-005-3974-x
    • Carvell J, Dowd J (2006) On-line measurements and control of viable cell density in cell culture manufacturing processes using radio-frequency impedance. Cytotechnology 50:35-48. doi:10.1007/s10616-005-3974-x
    • (2006) Cytotechnology , vol.50 , pp. 35-48
    • Carvell, J.1    Dowd, J.2
  • 14
    • 79954959102 scopus 로고    scopus 로고
    • Development of natural anti-Tumor drugs by microorganisms
    • doi:10.1016/j.jbiosc. 2010.12.026
    • Chang CC, Chen WC, Ho TF, Wu HS, Wei YH (2011) Development of natural anti-Tumor drugs by microorganisms. J Biosci Bioeng 111(5):501-511. doi:10.1016/j.jbiosc. 2010.12.026. http://www.sciencedirect.com/science/article/ pii/S1389172311000028
    • (2011) J Biosci Bioeng , vol.111 , Issue.5 , pp. 501-511
    • Chang, C.C.1    Chen, W.C.2    Ho, T.F.3    Wu, H.S.4    Wei, Y.H.5
  • 15
    • 79960393946 scopus 로고    scopus 로고
    • Comparison of polysialic acid production in escherichia coli k1 during batch cultivation and fed-batch cultivation applying two different control strategies
    • doi:10.1016/j.jbiotec. 2011.04.009
    • Chen R, John J, Rode B, Hitzmann B, Gerardy-Schahn R, Kasper C, Scheper T (2011) Comparison of polysialic acid production in Escherichia coli K1 during batch cultivation and fed-batch cultivation applying two different control strategies. J Biotechnol 154(4):222-229. doi:10.1016/j.jbiotec. 2011.04.009. http://www.sciencedirect.com/science/article/pii/S0168165611002021
    • (2011) J Biotechnol , vol.154 , Issue.4 , pp. 222-229
    • Chen, R.1    John, J.2    Rode, B.3    Hitzmann, B.4    Gerardy-Schahn, R.5    Kasper, C.6    Scheper, T.7
  • 16
    • 0036211314 scopus 로고    scopus 로고
    • A pseudo-exponential feeding method for control of specific growth rate in fed-batch cultures
    • doi:10.1016/S1369-703X(02)00002-5
    • Cheng LC, Wu JY, Chen TL (2002) A pseudo-exponential feeding method for control of specific growth rate in fed-batch cultures. Biochem Eng J 10(3):227-232. doi:10.1016/S1369-703X(02)00002-5. http://www.sciencedirect.com/ science/article/pii/S1369703X02000025
    • (2002) Biochem Eng J\ , vol.10 , Issue.3 , pp. 227-232
    • Cheng, L.C.1    Wu, J.Y.2    Chen, T.L.3
  • 17
    • 77957293070 scopus 로고    scopus 로고
    • Control of the specific growth rate of bacillus subtilis for the production of biosurfactant lipopeptides in bioreactors with foam overflow
    • Bioprocess Eng -SFGP2009 doi:10.1016/j.procbio. 2010.06.001
    • Chenikher S, Guez J, Coutte F, Pekpe M, Jacques P, Cassar J (2010) Control of the specific growth rate of Bacillus subtilis for the production of biosurfactant lipopeptides in bioreactors with foam overflow. Process Biochem 45(11):1800-1807. Bioprocess Eng -SFGP2009 doi:10.1016/j.procbio. 2010.06.001. http://www.sciencedirect.com/science/article/pii/S1359511310002175
    • (2010) Process Biochem , vol.45 , Issue.11 , pp. 1800-1807
    • Chenikher, S.1    Guez, J.2    Coutte, F.3    Pekpe, M.4    Jacques, P.5    Cassar, J.6
  • 18
    • 0032753139 scopus 로고    scopus 로고
    • On-line estimation of the specific growth rate based on viable biomass measurements: Experimental validation
    • doi:10.1007/s004490050692
    • Claes JE, Van Impe JF (1999) On-line estimation of the specific growth rate based on viable biomass measurements: experimental validation. Bioprocess Biosyst Eng 21:389-395. doi:10.1007/s004490050692
    • (1999) Bioprocess Biosyst Eng , vol.21 , pp. 389-395
    • Claes, J.E.1    Van Impe, J.F.2
  • 19
    • 0017598991 scopus 로고
    • Computer-Aided material balancing for prediction of fermentation parameters
    • doi:10.1002/bit.260190106
    • Cooney CL, Wang HY, Wang DIC (1977) Computer-Aided material balancing for prediction of fermentation parameters. Biotechnol Bioeng 19(1):55-67. doi:10.1002/bit.260190106
    • (1977) Biotechnol Bioeng , vol.19 , Issue.1 , pp. 55-67
    • Cooney, C.L.1    Wang, H.Y.2    Wang, D.I.C.3
  • 20
    • 2942565809 scopus 로고    scopus 로고
    • Quantitative relationships for specific growth rates and macromolecular compositions of mycobacterium tuberculosis, streptomyces coelicolor a3(2) and escherichia coli br: An integrative theoretical approach
    • Cox RA (2004) Quantitative relationships for specific growth rates and macromolecular compositions of Mycobacterium tuberculosis, Streptomyces coelicolor A3(2) and Escherichia coli br: an integrative theoretical approach. Microbiology 150:1413-1426
    • (2004) Microbiology , vol.150 , pp. 1413-1426
    • Cox, R.A.1
  • 21
    • 66149183267 scopus 로고    scopus 로고
    • Data reconciliation of concentration estimates from mid-infrared and dielectric spectral measurements for improved on-line monitoring of bioprocesses
    • doi:10.1002/btpr.143
    • Dabros M, Amrhein M, Bonvin D, Marison IW, von Stockar U (2009) Data reconciliation of concentration estimates from mid-infrared and dielectric spectral measurements for improved on-line monitoring of bioprocesses. Biotechnol Prog 25(2):578-588. doi:10.1002/btpr.143
    • (2009) Biotechnol Prog , vol.25 , Issue.2 , pp. 578-588
    • Dabros, M.1    Amrhein, M.2    Bonvin, D.3    Marison, I.W.4    Von Stockar, U.5
  • 22
    • 77958085104 scopus 로고    scopus 로고
    • Simple control of specific growth rate in biotechnological fed-batch processes based on enhanced online measurements of biomass
    • doi:10.1007/s00449-010-0438-2
    • Dabros M, Schuler M, Marison I (2010) Simple control of specific growth rate in biotechnological fed-batch processes based on enhanced online measurements of biomass. Bioprocess Biosyst Eng 33(9):1109-18. doi:10.1007/s00449-010-0438-2
    • (2010) Bioprocess Biosyst Eng , vol.33 , Issue.9 , pp. 1109-1118
    • Dabros, M.1    Schuler, M.2    Marison, I.3
  • 23
    • 53949114649 scopus 로고    scopus 로고
    • On-line biomass estimation in biosurfactant production process by candida lipolytica ucp 988
    • doi:10.1007/s10295-008-0443-5
    • da Costa Albuquerque C, de Campos-Takaki G, Fileti A (2008) On-line biomass estimation in biosurfactant production process by Candida lipolytica ucp 988. J Ind Microbiol Biotechnol 35:1425-1433. doi:10.1007/s10295-008-0443-5
    • (2008) J Ind Microbiol Biotechnol , vol.35 , pp. 1425-1433
    • Da Costa Albuquerque, C.1    De Campos-Takaki, G.2    Fileti, A.3
  • 24
    • 0001220306 scopus 로고
    • On the dielectric method of monitoring cellular viability
    • Davey CL, Markx GH, Kell DB (1993) On the dielectric method of monitoring cellular viability. Pure Appl Chem 65:1921-1926
    • (1993) Pure Appl Chem , vol.65 , pp. 1921-1926
    • Davey, C.L.1    Markx, G.H.2    Kell, D.B.3
  • 25
    • 0029927663 scopus 로고    scopus 로고
    • Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically controlled yeast cultures
    • doi:10.1016/0303-2647(95) 01577-9
    • Davey HM, Davey CL, Woodward AM, Edmonds AN, Lee AW, Kell DB (1996) Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically controlled yeast cultures. Biosystems 39(1):43-61. doi:10.1016/0303-2647(95) 01577-9. http://www.sciencedirect.com/science/article/ pii/0303264795015779
    • (1996) Biosystems , vol.39 , Issue.1 , pp. 43-61
    • Davey, H.M.1    Davey, C.L.2    Woodward, A.M.3    Edmonds, A.N.4    Lee, A.W.5    Kell, D.B.6
  • 26
    • 0034794242 scopus 로고    scopus 로고
    • Microbial physiology, fermentation kinetics, and process engineering of heteropolysaccharide production by lactic acid bacteria. First international symposium on exopolysaccharides from lactic acid bacteria: From fundamentals to applications
    • doi:10.1016/S0958-6946(01) 00118-2
    • Degeest B, Vaningelgem F, Vuyst LD (2001) Microbial physiology, fermentation kinetics, and process engineering of heteropolysaccharide production by lactic acid bacteria. First international symposium on exopolysaccharides from lactic acid bacteria: from fundamentals to applications. Int Dairy J 11(9):747-757. doi:10.1016/S0958-6946(01) 00118-2. http://www.sciencedirect.com/science/article/pii/S0958694601001182
    • (2001) Int Dairy J , vol.11 , Issue.9 , pp. 747-757
    • Degeest, B.1    Vaningelgem, F.2    Vuyst, L.D.3
  • 27
    • 61349178501 scopus 로고    scopus 로고
    • Production of recombinant proteins by microbes and higher organisms
    • doi:10.1016/j.biotechadv.2009. 01.008
    • Demain AL, Vaishnav P (2009) Production of recombinant proteins by microbes and higher organisms. Biotechnol Adv 27(3):297-306. doi:10.1016/j.biotechadv.2009. 01.008. http://www.sciencedirect.com/science/ article/pii/S0734975009000202
    • (2009) Biotechnol Adv , vol.27 , Issue.3 , pp. 297-306
    • Demain, A.L.1    Vaishnav, P.2
  • 28
    • 13844299345 scopus 로고    scopus 로고
    • Use of an artificial neural network in modeling yeast biomass and yield of beta-glucan
    • doi:10.1016/j.procbio.2004.06.015
    • Desai KM, Vaidya BK, Singhal RS, Bhagwat SS (2005) Use of an artificial neural network in modeling yeast biomass and yield of beta-glucan. Process Biochem 40(5):1617-1626. doi:10.1016/j.procbio.2004.06.015. http://www. sciencedirect. com/science/article/pii/S0032959204002419
    • (2005) Process Biochem , vol.40 , Issue.5 , pp. 1617-1626
    • Desai, K.M.1    Vaidya, B.K.2    Singhal, R.S.3    Bhagwat, S.S.4
  • 29
    • 52949129443 scopus 로고    scopus 로고
    • Biomass estimation in batch biotechnological processes by bayesian gaussian process regression
    • doi:10.1016/j.compchemeng.2008.05.015
    • di Sciascio F, Amicarelli AN (2008) Biomass estimation in batch biotechnological processes by Bayesian Gaussian process regression. Comput Chem Eng 32(12):3264-3273. doi:10.1016/j.compchemeng.2008.05.015. http://www.sciencedirect.com/science/article/B6TFT-4SNWW3H-4/2/ e7ecbc19b6e8b778e9ee21d8f77c46f6
    • (2008) Comput Chem Eng , vol.32 , Issue.12 , pp. 3264-3273
    • Di Sciascio, F.1    Amicarelli, A.N.2
  • 31
    • 0021052008 scopus 로고
    • Theory and applications of unstructured growth models: Kinetic and energetic aspects
    • doi:10.1002/bit.260251202
    • Esener AA, Roels JA, Kossen NWF (1983) Theory and applications of unstructured growth models: kinetic and energetic aspects. Biotechnol Bioeng 25(12):2803-2841. doi:10.1002/bit.260251202
    • (1983) Biotechnol Bioeng , vol.25 , Issue.12 , pp. 2803-2841
    • Esener, A.A.1    Roels, J.A.2    Kossen, N.W.F.3
  • 32
    • 72649086203 scopus 로고    scopus 로고
    • Application of a model using the phenomenological approach for prediction of growth and xanthan gum production with sugar cane broth in a batch process
    • Faria S, Angelica VP, Maria RM, Julio RE, Luiz CV (2010) Application of a model using the phenomenological approach for prediction of growth and xanthan gum production with sugar cane broth in a batch process. LWT -Food Sci Technol 43:498-506
    • (2010) LWT -Food Sci Technol , vol.43 , pp. 498-506
    • Faria, S.1    Angelica, V.P.2    Maria, R.M.3    Julio, R.E.4    Luiz, C.V.5
  • 33
    • 0031457353 scopus 로고    scopus 로고
    • Nonlinear observers for parameter estimation in bioprocesses
    • doi:10.1016/S0009-2509(97) 00190-5
    • Farza M, Hammouri H, Othman S, Busawon K (1997) Nonlinear observers for parameter estimation in bioprocesses. Chem Eng Sci 52(23):4251-4267. doi:10.1016/S0009-2509(97) 00190-5. http://www.sciencedirect.com/science/ article/pii/S0009250997001905
    • (1997) Chem Eng Sci , vol.52 , Issue.23 , pp. 4251-4267
    • Farza, M.1    Hammouri, H.2    Othman, S.3    Busawon, K.4
  • 35
    • 20044375357 scopus 로고    scopus 로고
    • Evaluation of a new annular capacitance probe for biomass monitoring in industrial pilot-scale fermentations
    • doi:10.1016/j.jbiotec.2004. 12.006
    • Ferreira AP, Vieira LM, Cardoso JP, Menezes JC (2005) Evaluation of a new annular capacitance probe for biomass monitoring in industrial pilot-scale fermentations. J Biotechnol 116(4):403-409. doi:10.1016/j.jbiotec.2004. 12.006. http://www.sciencedirect.com/science/article/pii/S016816560400611X
    • (2005) J Biotechnol , vol.116 , Issue.4 , pp. 403-409
    • Ferreira, A.P.1    Vieira, L.M.2    Cardoso, J.P.3    Menezes, J.C.4
  • 36
    • 33745211674 scopus 로고    scopus 로고
    • Near-infrared spectroscopic monitoring of biomass, glucose, ethanol and protein content in a high cell density baker's yeast fedbatch bioprocess
    • doi:10.1002/yea. 1371
    • Finn B, Harvey LM, McNeil B (2006) Near-infrared spectroscopic monitoring of biomass, glucose, ethanol and protein content in a high cell density baker's yeast fedbatch bioprocess. Yeast 23(7):507-517. doi:10.1002/yea. 1371
    • (2006) Yeast , vol.23 , Issue.7 , pp. 507-517
    • Finn, B.1    Harvey, L.M.2    McNeil, B.3
  • 37
    • 37249066180 scopus 로고    scopus 로고
    • Control of cultivation processes for recombinant protein production: A review
    • doi:10.1007/s00449-007-0163-7
    • Gnoth S, Jenzsch M, Simutis R, Luebbert A (2008) Control of cultivation processes for recombinant protein production: a review. Bioprocess Biosyst Eng 31:21-39. doi:10.1007/s00449-007-0163-7
    • (2008) Bioprocess Biosyst Eng , vol.31 , Issue.21-39
    • Gnoth, S.1    Jenzsch, M.2    Simutis, R.3    Luebbert, A.4
  • 38
    • 79953216313 scopus 로고    scopus 로고
    • Modelling and optimization for a switched system in microbial fed-batch culture
    • doi:10.1016/apm. 2011.01.023
    • Gong Z, Liu C, Feng E,Wang L, Yu Y (2011) Modelling and optimization for a switched system in microbial fed-batch culture. Appl Math Modell 35(7):3276-3284. doi:10.1016/apm. 2011.01.023. http://www.sciencedirect.com/ science/article/pii/S0307904X11000369
    • (2011) Appl Math Modell , vol.35 , Issue.7 , pp. 3276-3284
    • Gong, Z.1    Liu, C.2    Feng, E.3    Wang, L.4    Yu, Y.5
  • 39
    • 0000769141 scopus 로고    scopus 로고
    • Near-infrared spectroscopic determination of acetate, ammonium, biomass, and glycerol in an industrial escherichia coli fermentation
    • Hall JW, McNeil B, Rollins MJ, Draper I, Thompson BG, Macaloney G (1996) Near-infrared spectroscopic determination of acetate, ammonium, biomass, and glycerol in an industrial Escherichia coli fermentation. Appl Spectrosc 50(1):102-108. http://as.osa.org/abstract.cfm?URI=as-50-1-102
    • (1996) Appl Spectrosc , vol.50 , Issue.1 , pp. 102-108
    • Hall, J.W.1    McNeil, B.2    Rollins, M.J.3    Draper, I.4    Thompson, B.G.5    Macaloney, G.6
  • 40
    • 84892783660 scopus 로고
    • Advances in biochemical engineering biotechnology
    • In: A. Fiechter et al. (eds), Springer, Berlin
    • Harder A, Roels JA (1982) Advances in biochemical engineering biotechnology. In: A. Fiechter et al. (eds) Microbes and engineering aspects. Springer, Berlin
    • (1982) Microbes and Engineering Aspects
    • Harder, A.1    Roels, J.A.2
  • 41
    • 0035921173 scopus 로고    scopus 로고
    • Analysis of single-chain antibody production in pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations
    • doi:10.1002/bit.1125
    • Hellwig S, Emde F, Raven NPG, Henke M, van der Logt P, Fischer R (2001) Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations. Biotechnol Bioeng 74(4):344-352. doi:10.1002/bit.1125
    • (2001) Biotechnol Bioeng , vol.74 , Issue.4 , pp. 344-352
    • Hellwig, S.1    Emde, F.2    Raven, N.P.G.3    Henke, M.4    Van Der Logt, P.5    Fischer, R.6
  • 42
    • 35348958504 scopus 로고    scopus 로고
    • Controlled fed-batch by tracking the maximal culture capacity
    • Advances in Biochemical Engineering Sciences, doi:10.1016/j.jbiotec.2007. 04.021
    • Henes B, Sonnleitner B (2007) Controlled fed-batch by tracking the maximal culture capacity. J Biotechnol 132(2):118-126. Advances in Biochemical Engineering Sciences doi:10.1016/j.jbiotec.2007.04.021. http://www. sciencedirect.com/science/article/pii/S0168165607003173
    • (2007) J Biotechnol , vol.132 , Issue.2 , pp. 118-126
    • Henes, B.1    Sonnleitner, B.2
  • 43
    • 77950832203 scopus 로고    scopus 로고
    • Prozess analytische technologie in der biotechnologie
    • doi:10.1002/cite. 200900136
    • Herwig C (2010) Prozess analytische technologie in der biotechnologie. Chem Ing Tech 82(4):405-414. doi:10.1002/cite. 200900136
    • (2010) Chem Ing Tech , vol.82 , Issue.4 , pp. 405-414
    • Herwig, C.1
  • 44
    • 77954310993 scopus 로고    scopus 로고
    • Model based control of minimal overflow metabolite in technical scale fed-batch yeast fermentation
    • doi:10.1016/j.bej. 2010.04.014
    • Hocalar A, Tuerker M (2010) Model based control of minimal overflow metabolite in technical scale fed-batch yeast fermentation. Biochem Eng J 51(1-2):64-71. doi:10.1016/j.bej. 2010.04.014. http://www.sciencedirect.com/ science/article/B6V5N-5023KT2-1/2/5939b8a436dc646976572d7d868c681f
    • (2010) Biochem Eng J , vol.51 , Issue.1-2 , pp. 64-71
    • Hocalar, A.1    Tuerker, M.2
  • 45
    • 79952455843 scopus 로고    scopus 로고
    • Comparison of different estimation techniques for biomass concentration in large scale yeast fermentation
    • doi:10.1016/j.isatra.2010.12.003
    • Hocalar A, Trker M, Karakuzu C, Yuezgec U (2011) Comparison of different estimation techniques for biomass concentration in large scale yeast fermentation. ISA Trans 50(2):303-314. doi:10.1016/j.isatra.2010.12.003. http://www.sciencedirect.com/science/article/pii/S0019057810001230
    • (2011) ISA Trans , vol.50 , Issue.2 , pp. 303-314
    • Hocalar, A.1    Trker, M.2    Karakuzu, C.3    Yuezgec, U.4
  • 46
    • 33645736967 scopus 로고    scopus 로고
    • Estimation of biomass concentrations in fermentation processes for recombinant protein production
    • doi:10.1007/s00449-006-0051-6
    • Jenzsch M, Simutis R, Eisbrenner G, Stueckrath I, Luebbert A (2006) Estimation of biomass concentrations in fermentation processes for recombinant protein production. Bioprocess Biosyst Eng 29:19-27. doi:10.1007/s00449-006- 0051-6
    • (2006) Bioprocess Biosyst Eng , vol.29 , pp. 19-27
    • Jenzsch, M.1    Simutis, R.2    Eisbrenner, G.3    Stueckrath, I.4    Luebbert, A.5
  • 47
    • 0037955821 scopus 로고    scopus 로고
    • Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing
    • doi:10.1002/bit. 10610
    • Jobe AM, Herwig C, Surzyn M, Walker B, Marison I, von Stockar U (2003) Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing. Biotechnol Bioeng 82(6):627-639. doi:10.1002/bit. 10610
    • (2003) Biotechnol Bioeng , vol.82 , Issue.6 , pp. 627-639
    • Jobe, A.M.1    Herwig, C.2    Surzyn, M.3    Walker, B.4    Marison, I.5    Von Stockar, U.6
  • 48
    • 34447292394 scopus 로고    scopus 로고
    • A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with pichia pastoris
    • doi:10.1016/j.jbiotec.2007.05.019
    • Jungo C, Schenk J, Pasquier M, Marison IW, von Stockar U (2007) A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with Pichia pastoris. J Biotechnol 131(1):57-66. doi:10.1016/j.jbiotec.2007.05.019. http://www.sciencedirect. com/science/article/pii/S0168165607003689
    • (2007) J Biotechnol , vol.131 , Issue.1 , pp. 57-66
    • Jungo, C.1    Schenk, J.2    Pasquier, M.3    Marison, I.W.4    Von Stockar, U.5
  • 49
    • 42649126394 scopus 로고    scopus 로고
    • Applications of pat-process analytical technology in recombinant protein processes with escherichia coli
    • doi:10.1002/elsc.200720232
    • Kaiser C, Pototzki T, Ellert A, Luttmann R (2008) Applications of PAT-process analytical technology in recombinant protein processes with Escherichia coli. Eng Life Sci 8(2):132-138. doi:10.1002/elsc.200720232
    • (2008) Eng Life Sci , vol.8 , Issue.2 , pp. 132-138
    • Kaiser, C.1    Pototzki, T.2    Ellert, A.3    Luttmann, R.4
  • 50
    • 33645127855 scopus 로고    scopus 로고
    • Modelling, on-line state estimation and fuzzy control of production scale fedbatch baker's yeast fermentation
    • Karakuzu C, Tuerker M, Oeztuerk S (2006) Modelling, on-line state estimation and fuzzy control of production scale fedbatch baker's yeast fermentation. Control Eng Pract 14:959-974
    • (2006) Control Eng Pract , vol.14 , pp. 959-974
    • Karakuzu, C.1    Tuerker, M.2    Oeztuerk, S.3
  • 51
    • 0035813391 scopus 로고    scopus 로고
    • Statistical reconciliation of the elemental and molecular biomass composition of saccharomyces cerevisiae
    • doi:10.1002/bit.10054
    • Lange HC, Heijnen JJ (2001) Statistical reconciliation of the elemental and molecular biomass composition of Saccharomyces cerevisiae. Biotechnol Bioeng 75(3):334-344. doi:10.1002/bit.10054
    • (2001) Biotechnol Bioeng , vol.75 , Issue.3 , pp. 334-344
    • Lange, H.C.1    Heijnen, J.J.2
  • 52
    • 0032678154 scopus 로고    scopus 로고
    • Control of fedbatch fermentations
    • doi:10. 1016/S0734-9750(98)00015-9
    • Lee J, Lee SY, Park S, Middelberg APJ (1999) Control of fedbatch fermentations. Biotechnol Adv 17(1):29-48. doi:10. 1016/S0734-9750(98)00015-9. http://www.sciencedirect.com/science/article/B6T4X-3Y0R8HP-3/2/ e463a8f8587f04348630 f403748eb252
    • (1999) Biotechnol Adv , vol.17 , Issue.1 , pp. 29-48
    • Lee, J.1    Lee, S.Y.2    Park, S.3    Middelberg, A.P.J.4
  • 53
    • 0034849822 scopus 로고    scopus 로고
    • Inferential control of the specific growth rate in fed-batch cultivation processes
    • doi:10.1023/A:1010528915228
    • Levisauskas D (2001) Inferential control of the specific growth rate in fed-batch cultivation processes. Biotechnol Lett 23:1189-1195. doi:10.1023/A:1010528915228
    • (2001) Biotechnol Lett , vol.23 , pp. 1189-1195
    • Levisauskas, D.1
  • 54
    • 68349144695 scopus 로고    scopus 로고
    • Optimal control for nonlinear dynamical system of microbial fed-batch culture
    • doi:10.1016/j.cam.2009.06.006
    • Liu C (2009) Optimal control for nonlinear dynamical system of microbial fed-batch culture. J Comput Appl Math 232(2):252-261. doi:10.1016/j.cam.2009.06. 006. http://www.sciencedirect.com/science/article/pii/S0377042709003483
    • (2009) J Comput Appl Math , vol.232 , Issue.2 , pp. 252-261
    • Liu, C.1
  • 55
    • 0030010731 scopus 로고    scopus 로고
    • On-line estimation of biomass concentration and non stationary parameters for aerobic bioprocesses
    • doi:10.1016/0168-1656(95)00197-2
    • Lubenova V (1996) On-line estimation of biomass concentration and non stationary parameters for aerobic bioprocesses. J Biotechnol 46(3):197-207. doi:10.1016/0168-1656(95)00197-2. http://www.sciencedirect.com/science/article/ pii/0168165695001972
    • (1996) J Biotechnol , vol.46 , Issue.3 , pp. 197-207
    • Lubenova, V.1
  • 56
    • 33846008413 scopus 로고    scopus 로고
    • Microcalorimetric study on the growth and metabolism of microencapsulated microbial cell culture
    • doi:10.1016/j.mimet.2006.07.007
    • Ma J, Qi W, Yang L, Yu W, Xie Y, Wang W, Ma X, Xu F, Sun L (2007) Microcalorimetric study on the growth and metabolism of microencapsulated microbial cell culture. J Microbiol Methods 68(1):172-177. doi:10.1016/j.mimet. 2006.07.007. http://www.sciencedirect.com/science/article/pii/S0167701206002211
    • (2007) J Microbiol Methods , vol.68 , Issue.1 , pp. 172-177
    • Ma, J.1    Qi, W.2    Yang, L.3    Yu, W.4    Xie, Y.5    Wang, W.6    Ma, X.7    Xu, F.8    Sun, L.9
  • 57
    • 0001004977 scopus 로고    scopus 로고
    • High-sensitive heat-flow calorimetry
    • doi:10.1016/S0040-6031(97)00383-3
    • Marison I, Linder M, Schenker B (1998) High-sensitive heat-flow calorimetry. Thermochim Acta 310(1-2):43-46. doi:10.1016/S0040-6031(97)00383-3. http://www.sciencedirect. com/science/article/pii/S0040603197003833
    • (1998) Thermochim Acta , vol.310 , Issue.1-2 , pp. 43-46
    • Marison, I.1    Linder, M.2    Schenker, B.3
  • 58
    • 1442303172 scopus 로고    scopus 로고
    • Flow calorimetry and dielectric spectroscopy to control the bacterial conversion of toxic substrates into polyhydroxyalcanoates
    • doi:10.1002/bit.10903
    • Maskow T, Olomolaiye D, Breuer U, Kemp R (2004) Flow calorimetry and dielectric spectroscopy to control the bacterial conversion of toxic substrates into polyhydroxyalcanoates. Biotechnol Bioeng 85(5):547-552. doi:10.1002/bit.10903
    • (2004) Biotechnol Bioeng , vol.85 , Issue.5 , pp. 547-552
    • Maskow, T.1    Olomolaiye, D.2    Breuer, U.3    Kemp, R.4
  • 59
    • 33645366995 scopus 로고    scopus 로고
    • Chip calorimetry for the monitoring of whole cell biotransformation
    • doi:10.1016/j.jbiotec.2005.10.008
    • Maskow T, Lerchner J, Peitzsch M, Harms H, Wolf G (2006) Chip calorimetry for the monitoring of whole cell biotransformation. J Biotechnol 122(4):431-442. doi:10.1016/j.jbiotec.2005.10.008. http://www.sciencedirect. com/science/article/pii/S0168165605006450
    • (2006) J Biotechnol , vol.122 , Issue.4 , pp. 431-442
    • Maskow, T.1    Lerchner, J.2    Peitzsch, M.3    Harms, H.4    Wolf, G.5
  • 60
    • 77955337355 scopus 로고    scopus 로고
    • Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant pichia pastoris
    • doi:10.1016/j.jbiosc.2010.03.013
    • Min CK, Lee JW, Chung KH, ParkHW(2010) Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant Pichia pastoris. J Biosci Bioeng 110(3):314-319. doi:10.1016/j.jbiosc.2010.03.013. http://www.sciencedirect.com/science/article/pii/S1389172310001143
    • (2010) J Biosci Bioeng , vol.110 , Issue.3 , pp. 314-319
    • Min, C.K.1    Lee, J.W.2    Chung, K.H.3    Park, H.W.4
  • 61
    • 0034765490 scopus 로고    scopus 로고
    • Estimation of specific growth rate from cell density measurements
    • doi:10.1007/s004490100249
    • Neeleman R, Boxtel L (2001) Estimation of specific growth rate from cell density measurements. Bioprocess Biosyst Eng 24:179-185. doi:10.1007/ s004490100249
    • (2001) Bioprocess Biosyst Eng , vol.24 , pp. 179-185
    • Neeleman, R.1    Boxtel, L.2
  • 62
    • 0032796420 scopus 로고    scopus 로고
    • Bacterial growth: Constant obsession with dn/dt
    • Neidhardt FC (1999) Bacterial growth: constant obsession with dN/dt. J Bacteriol 181:7405-7408
    • (1999) J Bacteriol , vol.181 , pp. 7405-7408
    • Neidhardt, F.C.1
  • 63
    • 0030111123 scopus 로고    scopus 로고
    • Deconvolution of the dielectric spectra of microbial cell suspensions using multivariate calibration and artificial neural networks
    • doi:10.1016/0302-4598(95)01890-5
    • Nicholson DJ, Kell DB, Davey CL (1996) Deconvolution of the dielectric spectra of microbial cell suspensions using multivariate calibration and artificial neural networks. Bioelectrochem Bioenerg 39(2):185-193. doi:10.1016/0302-4598(95)01890-5. http://www.sciencedirect.com/science/article/ pii/0302459895018905
    • (1996) Bioelectrochem Bioenerg , vol.39 , Issue.2 , pp. 185-193
    • Nicholson, D.J.1    Kell, D.B.2    Davey, C.L.3
  • 64
    • 13344260704 scopus 로고    scopus 로고
    • Classification, error detection, and reconciliation of process information in complex biochemical systems
    • Noorman HJ, Romein B, Luyben KC, Heijnen JJ (1996) Classification, error detection, and reconciliation of process information in complex biochemical systems. Biotechnol Bioeng 49:364-376
    • (1996) Biotechnol Bioeng , vol.49 , pp. 364-376
    • Noorman, H.J.1    Romein, B.2    Luyben, K.C.3    Heijnen, J.J.4
  • 65
    • 0035666392 scopus 로고    scopus 로고
    • Automated fed-batch culture of kluyveromyces fragilis based on a novel method for on-line estimation of cell specific growth rate
    • doi:10.1016/S1369-703X(01)00147-4
    • Nor ZM, Tamer MI, Scharer JM, Moo-Young M, Jervis EJ (2001) Automated fed-batch culture of Kluyveromyces fragilis based on a novel method for on-line estimation of cell specific growth rate. Biochem Eng J 9(3): 221-231. doi:10.1016/S1369-703X(01)00147-4. http://www.sciencedirect.com/science/article/ pii/S1369703X01001474
    • (2001) Biochem Eng J , vol.9 , Issue.3 , pp. 221-231
    • Nor, Z.M.1    Tamer, M.I.2    Scharer, J.M.3    Moo-Young, M.4    Jervis, E.J.5
  • 66
    • 0033675439 scopus 로고    scopus 로고
    • Evaluation of online viable biomass measurements during fermentations of candida utilis
    • doi:10.1007/s004499900179
    • November EJ, Van Impe JF (2000) Evaluation of online viable biomass measurements during fermentations of Candida utilis. Bioprocess Biosyst Eng 23:473-477. doi:10.1007/s004499900179
    • (2000) Bioprocess Biosyst Eng , vol.23 , pp. 473-477
    • November, E.J.1    Van Impe, J.F.2
  • 67
    • 0036215136 scopus 로고    scopus 로고
    • The tuning of a model-based estimator for the specific growth rate of candida utilis
    • doi:10.1007/s004490100239
    • November E, Van Impe J (2002) The tuning of a model-based estimator for the specific growth rate of Candida utilis. Bioprocess Biosyst Eng 25:1-12. doi:10.1007/s004490100239
    • (2002) Bioprocess Biosyst Eng , vol.25 , pp. 1-12
    • November, E.1    Van Impe, J.2
  • 68
    • 70350247465 scopus 로고    scopus 로고
    • On-line estimation of biomass, glucose and ethanol in saccharomyces cerevisiae cultivations using in-situ multiwavelength fluorescence and software sensors
    • doi:10.1016/j.jbiotec.2009.08.018
    • Oedman P, Johansen CL, Olsson L, Gernaey KV, Lantz AE (2009) On-line estimation of biomass, glucose and ethanol in Saccharomyces cerevisiae cultivations using in-situ multiwavelength fluorescence and software sensors. J Biotechnol 144(2):102-112. doi:10.1016/j.jbiotec.2009.08.018. http://www.sciencedirect.com/science/article/pii/S016816560900385X
    • (2009) J Biotechnol , vol.144 , Issue.2 , pp. 102-112
    • Oedman, P.1    Johansen, C.L.2    Olsson, L.3    Gernaey, K.V.4    Lantz, A.E.5
  • 69
    • 0030525783 scopus 로고    scopus 로고
    • A study on the convergence of observer-based kinetics estimators in stirred tank bioreactors
    • doi:10.1016/0959-1524(95)00037-2
    • Oliveira R, Ferreira E, Oliveira F, de Azevedo SF (1996) A study on the convergence of observer-based kinetics estimators in stirred tank bioreactors. J Process Control 6(6):367-371. doi:10.1016/0959-1524(95)00037-2. http://www.sciencedirect.com/science/article/pii/0959152495000372
    • (1996) J Process Control , vol.6 , Issue.6 , pp. 367-371
    • Oliveira, R.1    Ferreira, E.2    Oliveira, F.3    De Azevedo, S.F.4
  • 70
    • 0022738790 scopus 로고
    • Utilization of spline functions for smoothing fermentation data and for estimation of specific rates
    • doi:10.1002/bit.260280618
    • Oner MD, Erickson LE, Yang SS (1986) Utilization of spline functions for smoothing fermentation data and for estimation of specific rates. Biotechnol Bioeng 28(6):902-918. doi:10.1002/bit.260280618
    • (1986) Biotechnol Bioeng , vol.28 , Issue.6 , pp. 902-918
    • Oner, M.D.1    Erickson, L.E.2    Yang, S.S.3
  • 71
    • 84892780603 scopus 로고    scopus 로고
    • Improved fed-batch fermentation through maintenance of specific productivity by indexing the glucose feed rate to capacitance-measured biomass in pichia pastoris
    • O'Reilly BT, Hilton MD (2006) Improved fed-batch fermentation through maintenance of specific productivity by indexing the glucose feed rate to capacitance-measured biomass in Pichia pastoris. Eli Lilly & Co. Indiapolis
    • (2006) Eli Lilly & Co. Indiapolis
    • O'Reilly, B.T.1    Hilton, M.D.2
  • 72
    • 0032874214 scopus 로고    scopus 로고
    • Kinetics of inclusion body production in batch and high cell density fedbatch culture of escherichia coli expressing ovine growth hormone
    • doi:10.1016/S0168-1656(99)00157-1
    • Panda AK, Khan R, Rao KA, Totey S (1999) Kinetics of inclusion body production in batch and high cell density fedbatch culture of Escherichia coli expressing ovine growth hormone. J Biotechnol 75(2-3):161-172. doi:10.1016/S0168-1656(99)00157-1. http://www.sciencedirect.com/science/article/ pii/S0168165699001571
    • (1999) J Biotechnol , vol.75 , Issue.2-3 , pp. 161-172
    • Panda, A.K.1    Khan, R.2    Rao, K.A.3    Totey, S.4
  • 73
    • 0017265276 scopus 로고
    • Influence of specific growth rate on biomass yield, productivity, and compostion of candida utilis in batch and continuous culture
    • Paredes-Lopez O, Camargo-Rubio E, Ornelas-Vale A (1976) Influence of specific growth rate on biomass yield, productivity, and compostion of Candida utilis in batch and continuous culture. Appl Environ Microbiol 4:487-491
    • (1976) Appl Environ Microbiol , vol.4 , pp. 487-491
    • Paredes-Lopez, O.1    Camargo-Rubio, E.2    Ornelas-Vale, A.3
  • 74
    • 27744479847 scopus 로고    scopus 로고
    • Sliding mode scheme for adaptive specific growth rate control in biotechnological fed-batch processes
    • Pico-Marco E, Pico J, Battista HD (2005) Sliding mode scheme for adaptive specific growth rate control in biotechnological fed-batch processes. Int J Control 78:128-141. http://www.informaworld.com/10.1080/002071705000073772ER
    • (2005) Int J Control , vol.78 , pp. 128-141
    • Pico-Marco, E.1    Pico, J.2    Battista, H.D.3
  • 75
    • 33646185901 scopus 로고    scopus 로고
    • A simple feedback control of escherichia coli growth for recombinant aldolase production in fed-batch mode
    • doi:10.1016/j.bej.2006.01.001
    • Pinsach J, de Mas C, Lopez-Santin J (2006) A simple feedback control of Escherichia coli growth for recombinant aldolase production in fed-batch mode. Biochem Eng J 29(3):235-242. doi:10.1016/j.bej.2006.01.001. http://www. sciencedirect. com/science/article/pii/S1369703X06000039
    • (2006) Biochem Eng J , vol.29 , Issue.3 , pp. 235-242
    • Pinsach, J.1    De Mas, C.2    Lopez-Santin, J.3
  • 76
    • 0033865849 scopus 로고    scopus 로고
    • A structured growth model for cynara cardunculus cell suspension
    • doi:10.1007/PL00009122
    • Pires Cabral PMNAC, Lima Costa ME, Cabral JMS (2000) A structured growth model for Cynara cardunculus cell suspension. Bioprocess Biosyst Eng 23:199-203. doi:10.1007/PL00009122
    • (2000) Bioprocess Biosyst Eng , vol.23 , pp. 199-203
    • Pires Cabral, P.M.N.A.C.1    Lima Costa, M.E.2    Cabral, J.M.S.3
  • 77
    • 4043134472 scopus 로고    scopus 로고
    • Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line
    • Poertner R, Schwabe J, Frahm B (2004) Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line. Biotechnol Appl Biochem 40(Pt1):47-55
    • (2004) Biotechnol Appl Biochem , vol.40 , Issue.PART 1 , pp. 47-55
    • Poertner, R.1    Schwabe, J.2    Frahm, B.3
  • 78
    • 23944459546 scopus 로고    scopus 로고
    • Specific growth rate determines the molecular mass of the alginate produced by azotobacter vinelandii
    • doi:10.1016/j.bej.2005.05.003
    • Priego-Jimenez R, Pena C, Ramirez OT, Galindo E (2005) Specific growth rate determines the molecular mass of the alginate produced by Azotobacter vinelandii. Biochem Eng J 25(3):187-193. doi:10.1016/j.bej.2005.05.003. http://www.sciencedirect.com/science/article/pii/S1369703X05001488
    • (2005) Biochem Eng J , vol.25 , Issue.3 , pp. 187-193
    • Priego-Jimenez, R.1    Pena, C.2    Ramirez, O.T.3    Galindo, E.4
  • 79
    • 77954089972 scopus 로고    scopus 로고
    • Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of escherichia coli
    • doi:10.1016/j.procbio. 2010.04.024
    • Puertas JM, Ruiz J, de la Vega MR, Lorenzo J, Caminal G, Gonzalez G (2010) Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of Escherichia coli. Process Biochem 45(8):1334-1341. doi:10.1016/j.procbio. 2010.04.024. http://www.sciencedirect.com/science/article/B6THB-501FPND-2/2/ 1eaa716fad5f24ea8496b4c6bd6d4fc3
    • (2010) Process Biochem , vol.45 , Issue.8 , pp. 1334-1341
    • Puertas, J.M.1    Ruiz, J.2    De La Vega, M.R.3    Lorenzo, J.4    Caminal, G.5    Gonzalez, G.6
  • 80
    • 27744582231 scopus 로고    scopus 로고
    • Model-based specific growth rate control for pichia pastoris to improve recombinant protein production
    • doi:10.1002/jctb.1321
    • Ren H, Yuan J (2005) Model-based specific growth rate control for Pichia pastoris to improve recombinant protein production. J Chem Technol Biotechnol 80(11):1268-1272. doi:10.1002/jctb.1321
    • (2005) J Chem Technol Biotechnol , vol.80 , Issue.11 , pp. 1268-1272
    • Ren, H.1    Yuan, J.2
  • 82
    • 0344507414 scopus 로고    scopus 로고
    • Measurement of volumetric (our) and determination of specific (qo2) oxygen uptake rates in animal cell cultures
    • doi:10.1016/S0168-1656(98)00046-7
    • Ruffieux PA, von Stockar U, Marison IW (1998) Measurement of volumetric (OUR) and determination of specific (qo2) oxygen uptake rates in animal cell cultures. J Biotechnol 63(2):85-95. doi:10.1016/S0168-1656(98)00046-7. http://www.sciencedirect.com/science/article/pii/S0168165698000467
    • (1998) J Biotechnol , vol.63 , Issue.2 , pp. 85-95
    • Ruffieux, P.A.1    Von Stockar, U.2    Marison, I.W.3
  • 83
    • 80051468876 scopus 로고    scopus 로고
    • Simple control of fed-batch processes for recombinant protein production with
    • doi:10.1007/s10529-011-0648-y
    • Schaepe S, Kuprijanov A, Aehle M, Simutis R, Luebbert A (2011) Simple control of fed-batch processes for recombinant protein production with E. coli. Biotechnol Lett 33:1781-1788. doi:10.1007/s10529-011-0648-y
    • (2011) E. Coli. Biotechnol Lett , vol.33 , pp. 1781-1788
    • Schaepe, S.1    Kuprijanov, A.2    Aehle, M.3    Simutis, R.4    Luebbert, A.5
  • 84
    • 0033526869 scopus 로고    scopus 로고
    • Thermodynamic analysis of growth of methanobacterium thermoautotrophicum
    • doi:10.1002/(SICI)1097-0290(19990705)64:1<74::AID-BIT8>3.0.CO;2-3
    • Schill NA, Liu JS, Stockar Uv (1999) Thermodynamic analysis of growth of Methanobacterium thermoautotrophicum. Biotechnol Bioeng 64(1):74-81. doi:10.1002/(SICI)1097-0290(19990705)64:13.0.CO;2-3
    • (1999) Biotechnol Bioeng , vol.64 , Issue.1 , pp. 74-81
    • Schill, N.A.1    Liu, J.S.2    Stockar, Uv.3
  • 85
    • 84856302972 scopus 로고    scopus 로고
    • Investigation of the potential of biocalorimetry as a process analytical technology (pat) tool for monitoring and control of crabtree-negative yeast cultures
    • doi:10.1007/s00253-011-3507-9
    • Schuler MM, Sivaprakasam S, Freeland B, Hama A, Hughes KM, Marison I (2012) Investigation of the potential of biocalorimetry as a process analytical technology (PAT) tool for monitoring and control of Crabtree-negative yeast cultures. Appl Microbiol Biotechnol 93(2):575-84. doi:10.1007/s00253-011-3507-9
    • (2012) Appl Microbiol Biotechnol , vol.93 , Issue.2 , pp. 575-584
    • Schuler, M.M.1    Sivaprakasam, S.2    Freeland, B.3    Hama, A.4    Hughes, K.M.5    Marison, I.6
  • 86
    • 77953598931 scopus 로고    scopus 로고
    • Rapid monitoring of recombinant antibody production by mammalian cell cultures using fourier transform infrared spectroscopy and chemometrics
    • doi:10.1002/bit.22707
    • Sellick CA, Hansen R, Jarvis RM, Maqsood AR, Stephens GM, Dickson AJ, Goodacre R (2010) Rapid monitoring of recombinant antibody production by mammalian cell cultures using fourier transform infrared spectroscopy and chemometrics. Biotechnol Bioeng 106(3):432-442. doi:10.1002/bit.22707.
    • (2010) Biotechnol Bioeng , vol.106 , Issue.3 , pp. 432-442
    • Sellick, C.A.1    Hansen, R.2    Jarvis, R.M.3    Maqsood, A.R.4    Stephens, G.M.5    Dickson, A.J.6    Goodacre, R.7
  • 88
    • 0342981802 scopus 로고    scopus 로고
    • Exploratory analysis of bioprocesses using artificial neural network-based methods
    • doi:10.1021/bp9700364
    • Simutis R, Luebbert A (1997) Exploratory analysis of bioprocesses using artificial neural network-based methods. Biotechnol Prog 13(4):479-487. doi:10.1021/bp9700364
    • (1997) Biotechnol Prog , vol.13 , Issue.4 , pp. 479-487
    • Simutis, R.1    Luebbert, A.2
  • 89
    • 79953231589 scopus 로고    scopus 로고
    • Biocalorimetry as a process analytical technology process analyser: Robust in-line monitoring and control of aerobic fed-batch cultures of crabtree-negative yeast cells
    • doi:10.1007/s10973-010-1259-x
    • Sivaprakasam S, Schuler MM, Hama A, Hughes KM, Marison I (2011) Biocalorimetry as a process analytical technology process analyser: robust in-line monitoring and control of aerobic fed-batch cultures of Crabtree-negative yeast cells. J Therm Anal Calorim 104(1):75-85. doi:10.1007/s10973-010-1259-x
    • (2011) J Therm Anal Calorim , vol.104 , Issue.1 , pp. 75-85
    • Sivaprakasam, S.1    Schuler, M.M.2    Hama, A.3    Hughes, K.M.4    Marison, I.5
  • 90
    • 2342632477 scopus 로고    scopus 로고
    • Optimal adaptive control of (bio)chemical reactors: Past, present and future
    • Dynamics, Monitoring, Control and Optimization of Biological Systems. doi:10.1016/j.jprocont.2003.12.005
    • Smets IY, Claes JE, November EJ, Bastin GP, Impe JFV (2004) Optimal adaptive control of (bio)chemical reactors: past, present and future. J Process Control 14(7):795-805. Dynamics, Monitoring, Control and Optimization of Biological Systems. doi:10.1016/j.jprocont.2003.12.005. http://www. sciencedirect.com/science/article/pii/S0959152403001380
    • (2004) J Process Control , vol.14 , Issue.7 , pp. 795-805
    • Smets, I.Y.1    Claes, J.E.2    November, E.J.3    Bastin, G.P.4    Impe, J.F.V.5
  • 92
    • 0034042617 scopus 로고    scopus 로고
    • Industrial application of a large-scale dynamic data reconciliation strategy
    • doi:10.1021/ie990798z
    • Soderstrom TA, Edgar TF, Russo LP, Young RE (2000) Industrial application of a large-scale dynamic data reconciliation strategy. Ind Eng Chem Res 39(6):1683-1693. doi:10.1021/ie990798z
    • (2000) Ind Eng Chem Res , vol.39 , Issue.6 , pp. 1683-1693
    • Soderstrom, T.A.1    Edgar, T.F.2    Russo, L.P.3    Young, R.E.4
  • 93
    • 33746873756 scopus 로고    scopus 로고
    • Constant specific growth rate in fed-batch cultivation of bordetella pertussis using adaptive control
    • doi:10.1016/j.jbiotec.2006.03.005
    • Soons Z, Voogt J, van Straten G, van Boxtel A (2006) Constant specific growth rate in fed-batch cultivation of Bordetella pertussis using adaptive control. J Biotechnol 125(2):252-268. doi:10.1016/j.jbiotec.2006.03.005. http://www.sciencedirect.com/science/article/B6T3C-4JRVFMT-G/2/ 64ed11bb51668106db9e145220b0fd22
    • (2006) J Biotechnol , vol.125 , Issue.2 , pp. 252-268
    • Soons, Z.1    Voogt, J.2    Van Straten, G.3    Van Boxtel, A.4
  • 94
    • 47349123020 scopus 로고    scopus 로고
    • Online automatic tuning and control for fed-batch cultivation
    • doi:10.1007/s00449-007-0182-4
    • Soons Z, van Straten G, van der Pol L, van Boxtel A (2008a) Online automatic tuning and control for fed-batch cultivation. Bioprocess Biosyst Eng 31:453-467. doi:10.1007/s00449-007-0182-4
    • (2008) Bioprocess Biosyst Eng , vol.31 , pp. 453-467
    • Soons, Z.1    Van Straten, G.2    Van Der Pol, L.3    Van Boxtel, A.4
  • 95
    • 53049096060 scopus 로고    scopus 로고
    • Assessment of near infrared and software sensor for biomass monitoring and control
    • doi:10.1016/j.chemolab.2008.07.009
    • Soons ZI, Streefland M, van Straten G, van Boxtel AJ (2008b) Assessment of near infrared and software sensor for biomass monitoring and control. Chemom Intell Lab Syst 94(2): 166-174. doi:10.1016/j.chemolab.2008.07.009. http://www.sciencedirect.com/science/article/pii/S0169743908001482
    • (2008) Chemom Intell Lab Syst , vol.94 , Issue.2 , pp. 166-174
    • Soons, Z.I.1    Streefland, M.2    Van Straten, G.3    Van Boxtel, A.J.4
  • 97
    • 0015910716 scopus 로고
    • A theoretical study on the amount of atp required for synthesis ofmicrobial cell material
    • doi:10.1007/BF02578899
    • Stouthamer A (1973) A theoretical study on the amount of ATP required for synthesis ofmicrobial cell material.Antonie van Leeuwenhoek 39:545-565. doi:10.1007/BF02578899
    • (1973) Antonie van Leeuwenhoek , vol.39 , pp. 545-565
    • Stouthamer, A.1
  • 98
    • 0025428793 scopus 로고
    • Enhanced antibody production at slowed growth rates: Experimental demonstration and a simple structured model
    • doi:10.1021/bp00003a013
    • Suzuki E, Ollis DF (1990) Enhanced antibody production at slowed growth rates: experimental demonstration and a simple structured model. Biotechnol Prog 6(3):231-236. doi:10.1021/bp00003a013.
    • (1990) Biotechnol Prog , vol.6 , Issue.3 , pp. 231-236
    • Suzuki, E.1    Ollis, D.F.2
  • 99
    • 0012999118 scopus 로고    scopus 로고
    • Using heat-flow measurements for the feed control of a fed batch fermentation of saccharomyces cerevisiae
    • doi:10.1016/S0040-6031(97)00425-5
    • van Kleeff B, Kuenen J, Honderd G, Heijnen J (1998) Using heat-flow measurements for the feed control of a fed batch fermentation of Saccharomyces cerevisiae. Thermochim Acta 309(1-2):175-180. doi:10.1016/S0040-6031(97)00425-5. http://www.sciencedirect.com/science/article/pii/S0040603197004255
    • (1998) Thermochim Acta , vol.309 , Issue.1-2 , pp. 175-180
    • Van Kleeff, B.1    Kuenen, J.2    Honderd, G.3    Heijnen, J.4
  • 101
    • 33749133230 scopus 로고    scopus 로고
    • Metabolic flux distributions in corynebacterium glutamicum during growth and lysine overproduction
    • doi: 10.1002/(SICI)1097-0290(20000320)67:6<872::AID-BIT21> 3.0.CO;2-X
    • Vallino JJ, Stephanopoulos G (2000) Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnol Bioeng 67(6):872-885. doi: 10.1002/(SICI)1097-0290(20000320)67:6 3.0.CO;2-X
    • (2000) Biotechnol Bioeng , vol.67 , Issue.6 , pp. 872-885
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 103
    • 33644820781 scopus 로고    scopus 로고
    • Metabolic engineering under uncertainty. I: Framework development
    • doi:10.1016/j.ymben.2005.11.003
    • Wang L, Hatzimanikatis V (2006) Metabolic engineering under uncertainty. I: framework development. Metab Eng 8(2):133-141. doi:10.1016/j.ymben.2005.11. 003. http://www.sciencedirect.com/science/article/pii/S1096717605000996
    • (2006) Metab Eng , vol.8 , Issue.2 , pp. 133-141
    • Wang, L.1    Hatzimanikatis, V.2
  • 104
    • 77951975693 scopus 로고    scopus 로고
    • Evaluation of software sensors for on-line estimation of culture conditions in an escherichia coli cultivation expressing a recombinant protein
    • doi:10.1016/j.jbiotec. 2010.02.023
    • Warth B, Rajkai G,Mandenius CF (2010) Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein. J Biotechnol 147(1):37-45. doi:10.1016/j.jbiotec. 2010.02.023. http://www.sciencedirect.com/science/ article/pii/S0168165610001100
    • (2010) J Biotechnol , vol.147 , Issue.1 , pp. 37-45
    • Warth, B.1    Rajkai, G.2    Mandenius, C.F.3
  • 105
    • 77957345665 scopus 로고    scopus 로고
    • Pat method to gather bioprocess parameters in real-Time using simple input variables and first principle relationships
    • doi:10.1016/j.ces.2010.05.002
    • Wechselberger P, Seifert A, Herwig C (2010) PAT method to gather bioprocess parameters in real-Time using simple input variables and first principle relationships. Chem Eng Sci 65(21):5734-5746. doi:10.1016/j.ces.2010. 05.002. http://www.sciencedirect.com/science/article/B6TFK-502V6YH-2/2/ dec419f3c392075fe5297951cf012158
    • (2010) Chem Eng Sci , vol.65 , Issue.21 , pp. 5734-5746
    • Wechselberger, P.1    Seifert, A.2    Herwig, C.3
  • 106
    • 78049451371 scopus 로고    scopus 로고
    • Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered saccharomyces cerevisiae
    • doi:10.1016/j.ymben.2010.08.003
    • Wisselink HW, Cipollina C, Oud B, Crimi B, Heijnen JJ, Pronk JT, van Maris AJ (2010) Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae. Metab Eng 12(6):537-551. doi:10.1016/j.ymben.2010.08.003. http://www.sciencedirect.com/ science/article/pii/S1096717610000807
    • (2010) Metab Eng , vol.12 , Issue.6 , pp. 537-551
    • Wisselink, H.W.1    Cipollina, C.2    Oud, B.3    Crimi, B.4    Heijnen, J.J.5    Pronk, J.T.6    Van Maris, A.J.7
  • 107
    • 33748504585 scopus 로고    scopus 로고
    • An artificial neural network for biomass estimation from automatic ph control signal
    • doi:10.1007/BF03026252
    • Won H, Yoon-Keun C (2006) An artificial neural network for biomass estimation from automatic ph control signal. Biotechnol Bioprocess Eng 11:351-356. doi:10.1007/BF03026252
    • (2006) Biotechnol Bioprocess Eng , vol.11 , pp. 351-356
    • Won, H.1    Yoon-Keun, C.2
  • 108
    • 79960023556 scopus 로고    scopus 로고
    • High efficient production of recombinant human consensus interferon mutant in high cell density culture of pichia pastoris using two phases methanol control
    • doi:10.1016/j.procbio. 2011.05.015
    • Wu D, Chu J, Hao YY, Wang YH, Zhuang YP, Zhang SL (2011) High efficient production of recombinant human consensus interferon mutant in high cell density culture of Pichia pastoris using two phases methanol control. Process Biochem 46(8):1663-1669. doi:10.1016/j.procbio. 2011.05.015. http://www.sciencedirect. com/science/article/pii/S1359511311001917
    • (2011) Process Biochem , vol.46 , Issue.8 , pp. 1663-1669
    • Wu, D.1    Chu, J.2    Hao, Y.Y.3    Wang, Y.H.4    Zhuang, Y.P.5    Zhang, S.L.6
  • 109
    • 43549087887 scopus 로고    scopus 로고
    • Real-Time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by saccharomyces cerevisiae t65 in industrial complex medium
    • doi:10.1263/jbb.105. 409
    • Xiong ZQ, Guo MJ, Guo YX, Chu J, Zhuang YP, Zhang SL (2008) Real-Time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae T65 in industrial complex medium. J Biosci Bioeng 105(4):409-413. doi:10.1263/jbb.105. 409. http://www. sciencedirect.com/science/article/B6VSD-4SJJ2PM-J/2/ ec54312d1be7ed362d3fc9ba017af047
    • (2008) J Biosci Bioeng , vol.105 , Issue.4 , pp. 409-413
    • Xiong, Z.Q.1    Guo, M.J.2    Guo, Y.X.3    Chu, J.4    Zhuang, Y.P.5    Zhang, S.L.6
  • 110
    • 62949092759 scopus 로고    scopus 로고
    • Stochastic stability of the continuous-Time unscented kalman filter
    • CDC 2008, doi:10.1109/CDC.2008. 4738717
    • Xu J, Wang S, Dimirovski G, Jing Y (2008) Stochastic stability of the continuous-Time unscented Kalman filter. In: 47th IEEE conference on decision and control, 2008. CDC 2008, pp 5110-5115. doi:10.1109/CDC.2008. 4738717
    • (2008) 47th IEEE Conference on Decision and Control , vol.2008 , pp. 5110-5115
    • Xu, J.1    Wang, S.2    Dimirovski, G.3    Jing, Y.4
  • 111
    • 76049106890 scopus 로고    scopus 로고
    • Effects of acetic acid and its assimilation in fed-batch cultures of recombinant escherichia coli containing humanlike collagen cdna
    • doi: 10.1016/j.jbiosc.2009.08.008
    • Xue W, Fan D, Shang L, Zhu C, Ma X, Zhu X, Yu Y (2010) Effects of acetic acid and its assimilation in fed-batch cultures of recombinant Escherichia coli containing humanlike collagen cDNA. J Biosci Bioeng 109(3):257-261. doi: 10.1016/j.jbiosc.2009.08.008. http://www.sciencedirect.com/science/article/ B6VSD-4X7PPTM-1/2/2136a00dc49e7a6a304 fdd1a6f87dfab
    • (2010) J Biosci Bioeng , vol.109 , Issue.3 , pp. 257-261
    • Xue, W.1    Fan, D.2    Shang, L.3    Zhu, C.4    Ma, X.5    Zhu, X.6    Yu, Y.7
  • 112
    • 57549093493 scopus 로고    scopus 로고
    • On-line evolutionary optimization of an industrial fed-batch yeast fermentation process
    • doi:10.1016/j. isatra.2008.09.001
    • Yuezgec U, Tuerker M, Hocalar A (2009) On-line evolutionary optimization of an industrial fed-batch yeast fermentation process. ISA Trans 48(1):79-92. doi:10.1016/j. isatra.2008.09.001. http://www.sciencedirect.com/science/article/ pii/S001905780800061X
    • (2009) ISA Trans , vol.48 , Issue.1 , pp. 79-92
    • Yuezgec, U.1    Tuerker, M.2    Hocalar, A.3
  • 113
    • 0028500651 scopus 로고
    • Functional state modeling and fuzzy control of fed-batch aerobic baker's yeast process
    • doi:10.1016/0168-1656(94)90196-1
    • Zhang XC, Visala A, Halme A, Linko P (1994) Functional state modeling and fuzzy control of fed-batch aerobic baker's yeast process. J Biotechnol 37(1):1-10. doi:10.1016/0168-1656(94)90196-1. http://www.sciencedirect. com/science/article/pii/0168165694901961
    • (1994) J Biotechnol , vol.37 , Issue.1 , pp. 1-10
    • Zhang, X.C.1    Visala, A.2    Halme, A.3    Linko, P.4
  • 114
    • 0034625520 scopus 로고    scopus 로고
    • Effect of rq and pre-seed conditions on biomass and galactosyl transferase production during fed-batch culture ofs. Cerevisiae bt150
    • doi:10.1016/S0168-1656(00)00231-5
    • Zigova J (2000) Effect of RQ and pre-seed conditions on biomass and galactosyl transferase production during fed-batch culture of S. cerevisiae BT150. J Biotechnol 80(1):55-62. doi:10.1016/S0168-1656(00)00231-5. http://www.science direct.com/science/article/B6T3C-40HV09T-4/2/9a584b4244 399c8064999d319134023a
    • (2000) J Biotechnol , vol.80 , Issue.1 , pp. 55-62
    • Zigova, J.1


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