Investigation of the potential of biocalorimetry as a process analytical technology (PAT) tool for monitoring and control of Crabtree-negative yeast cultures

Applied Microbiology and Biotechnology

Volumn 93, Issue 2, 2012, Pages 575-584

  Schuler, Moira Monika ^a   Sivaprakasam, Senthilkumar ^a   Freeland, Brian ^a   Hama, Adel ^a   Hughes, Katie Marie ^a   Marison, Ian W ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Biocalorimetry; Candida utilis; Fed batch; Kluyveromyces marxianus; On line biomass estimation; Pichia pastoris; Specific growth rate

Indexed keywords

BIOCALORIMETRY; CANDIDA UTILIS; FED-BATCH; KLUYVEROMYCES MARXIANUS; ON-LINE BIOMASS ESTIMATION; PICHIA PASTORIS; SPECIFIC GROWTH RATE;

BATCH CELL CULTURE; BIOMASS; CALORIMETRY; CANDIDA; CHEMICAL SENSORS; ECOLOGY; ESTIMATION; GROWTH RATE; ROBUST CONTROL; YEAST;

QUALITY CONTROL;

BIOMASS; CALORIMETRY; CONTROL SYSTEM; GROWTH RATE; HEAT FLOW; SUBSTRATE; YEAST;

ARTICLE; BIOCALORIMETRY; BIOPROCESS; CALORIMETRY; CHEMICAL REACTION; CONTROL STRATEGY; CULTURE MEDIUM; FED BATCH CULTURE; FEEDBACK SYSTEM; FUNGAL STRAIN; FUNGUS CULTURE; GROWTH RATE; KLUYVEROMYCES MARXIANUS; NONHUMAN; PICHIA JADINII; PICHIA PASTORIS; PROCESS ANALYTICAL TECHNOLOGY; PROCESS CONTROL; PROCESS TECHNOLOGY; QUALITY CONTROL; SENSITIVITY ANALYSIS;

AEROBIOSIS; BIOCHEMICAL PHENOMENA; BIOMASS; CALORIMETRY; CULTURE MEDIA; HOT TEMPERATURE; YEASTS;

CALLUNA VULGARIS; KLUYVEROMYCES MARXIANUS; PICHIA JADINII; PICHIA PASTORIS;

EID: 84856302972     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3507-9     Document Type: Article

References (43)

1. Arndt M, Kleist S, Miksch G, Friehs K, Flaschel E, Trierweiler J, Hitzmann B (2005) A feedforward-feedback substrate controller based on a Kalman filter for a fed-batch cultivation of Escherichia coli producing phytase. Comput Chem Eng 29(5):1113-1120 (Pubitemid 40417827)
2. Biener R, Steinkmper A, Hofmann J (2010) Calorimetric control for high cell density cultivation of a recombinant Escherichia coli strain. J Biotechnol 146(1-2):45-53
3. Cannizzaro C, Valentinotti S, von Stockar U (2004) Control of yeast fed-batch process through regulation of extracellular ethanol concentration. Bioprocess Biosyst Eng 26:377-383. doi: 10.1007/s00449-004-0384-y
4. CDER (2004) Guidance for industry pat-a framework for innovative pharmaceutical development, manufacturing and quality assurance. FDA, Silver Spring
5. Chang C-C, Chen W-C, Ho T-F, Wu H-S, Wei Y-H (2011) Development of natural anti-tumor drugs by microorganisms. J Biosci Bioeng 111:501-511
6. Claes JE, Van Impe JF (1999) On-line estimation of the specific growth rate based on viable biomass measurements: experimental validation. Bioprocess Biosyst Eng 21:389-395. doi: 10.1007/s004490050692 (Pubitemid 129645309)
7. Dabros M, Schuler M, Marison I (2010) Simple control of specific growth rate in biotechnological fed-batch processes based on enhanced online measurements of biomass. Bioprocess Biosyst Eng 33:1109-1118 doi: 10.1007/s00449-010-0438-2
8. Duboc P, von Stockar U (1995) Energetic investigation of Saccharomyces cerevisiae during transitions. Part 1. Mass balances. Thermochim Acta 251:119-130. Calorimetric and Thermodynamic Studies in Biology
9. Duboc P, von Stockar U (1998) Systematic errors in data evaluation due to ethanol stripping and water vaporization. Biotechnol Bioeng 58(4):428-439 (Pubitemid 28134342)
10. Guan Y, Evans PM, Kemp RB (1998) Specific heat flow rate: an on-line monitor and potential control variable of specific metabolic rate in animal cell culture that combines microcalorimetry with dielectric spectroscopy. Biotechnol Bioeng 58(5):464-477 (Pubitemid 28178248)
11. Hellmuth K, Korz D, Sanders E, Deckwer W-D (1994) Effect of growth rate on stability and gene expression of recombinant plasmids during continuous and high cell density cultivation of Escherichia coli tg1. J Biotechnol 32(3):289-298 (Pubitemid 24081040)
12. Hocalar A, Tuerker M (2010) Model based control of minimal overflow metabolite in technical scale fed-batch yeast fermentation. Biochem Eng J 51(1-2):64 - 71
13. ICH (2008) Pharmaceutical development qr2. ICH, Geneva
14. Ishikawa Y, Shoda M, (1983) Calorimetric analysis of Escherichia coli in continuous culture. Biotechnol Bioeng 25(7):1817-1827 (Pubitemid 13047786)
15. Kontoravdi C, Asprey SP, Pistikopoulos EN, Mantalaris A (2007) Development of a dynamic model of monoclonal antibody production and glycosylation for product quality monitoring. Comput Chem Eng 31(5-6):392-400. In: ESCAPE-15-selected papers from the 15th European symposium on computer aided process engineering held in Barcelona, Spain, May 29-June 1, 2005 (Pubitemid 46282060)
16. Larsson C, Lidn, G, Niklasson C, Gustafsson L (1991) Calorimetric control of fed-batch cultures of Saccharomyces cerevisiae. Bioprocess Biosyst Eng 7:151-155 doi: 10.1007/BF00387410.
17. Lee J, Lee SY, Park S, Middelberg APJ (1999) Control of fed-batch fermentations. Biotechnol Adv 17(1):29-48
18. Lubenova V (1996) On-line estimation of biomass concentration and non stationary parameters for aerobic bioprocesses. J Biotechnol 46(3):197-207 (Pubitemid 26202241)
19. Ma J, Qi W, Yang L, Yu W, Xie Y, Wang W, Ma X, Xu F, Sun L (2007) Microcalorimetric study on the growth and metabolism of microencapsulated microbial cell culture. J Microbiol Methods 68(1):172-177 (Pubitemid 46054329)
20. Marison I, Birou B, von Stockar U (1985) Use of a novel heat-flux calorimeter for the measurement of heat generated during growth of on lactose. Thermochim Acta 85:497-500
21. Maskow T, Kiesel B, Schubert T, Yong Z, Harms H, Yao J (2010) Calorimetric real time monitoring of lambda prophage induction. J Virol Methods 168(1-2):126-132
22. Maskow T, Olomolaiye D, Breuer U, Kemp R (2004) Flow calorimetry and dielectric spectroscopy to control the bacterial conversion of toxic substrates into polyhydroxyalcanoates. Biotechnol Bioeng 85(5):547-552 (Pubitemid 38268671)
23. McLeod G, Clelland K, Tapp H, Kemsley EK, Wilson RH, Poulter G, Coombs D, Hewitt CJ (2009) A comparison of variate pre- selection methods for use in partial least squares regression: a case study on NIR spectroscopy applied to monitoring beer fermentation. J Food Eng 90(2):300-307
24. Murrill PW (1991) Fundamentals of process control theory. Instrument Society of America, Research Triangle Park
25. Nagai S (1979) Mass and energy balances for microbial growth kinetics. In: Advances in biochemical engineering, volume 11, of advances in biochemical engineering/biotechnology, vol 11. Springer, Berlin, pp 49-83
26. Nahku R, Valgepea K, Lahtvee P-J, Erm S, Abner K, Adamberg K, Vilu R (2010) Specific growth rate dependent transcriptome profiling of Escherichia coli k12 mg1655 in accelerostat cultures. J Biotechnol 145(1):60-65
27. Ogunnaike BA, Ray HW (1994) Process dynamics modeling and control. Oxford University Press, Oxford
28. Puertas J-M, Ruiz J, de la Vega MR, Lorenzo J, Caminal G, Gonzlez G (2010) Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of Escherichia coli. Process Biochem 45(8):1334-1341
29. Randolph T, Marison I, Martens D, von Stockar U (1990) Calorimetric control of fed-batch fermentations. Biotechnol Bioeng 36(7):678-684 (Pubitemid 20360896)
30. Rhiel M, Ducommun P, Bolzonella I, Marison I, von Stockar U (2002) Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements. Biotechnol Bioeng 77(2):174-185 (Pubitemid 34072411)
31. Schenk J, Balazs K, Jungo C, Urfer J, Wegmann C, Zocchi A, Marison IW, von Stockar U (2008) Influence of specific growth rate on specific productivity and glycosylation of a recombinant avidin produced by a Pichia pastoris mut(+) strain. Biotechnol Bioeng 99(2):368-377 (Pubitemid 351158285)
32. Schubert T, Breuer U, Harms H, Maskow T (2007) Calorimetric bioprocess monitoring by small modifications to a standard bench-scale bioreactor. J Biotechnol 130(1):24-31 (Pubitemid 46634645)
33. Senthilkumar S, Surianarayanan M, Swaminathan G (2008) Biocalorimetric and respirometric studies on biological treatment of tannery saline wastewater. Appl Microbiol Biotechnol 78:249-255. doi: 10.1007/s00253-007-1309-x
34. Sivaprakasam S, Schuler M, Hama A, Hughes K-M, Marison I (2011) Biocalorimetry as a process analytical technology process analyser; robust in-line monitoring and control of aerobic fed-batch cultures of Crabtree-negative yeast cells. J Therm Anal Calorim 1-11 doi: 10.1007/s10973-010-1259-x
35. Tomson K, Barber J, Vanatalu K (2006) Adaptastat-a new method for optimising of bacterial growth conditions in continuous culture: interactive substrate limitation based on dissolved oxygen measurement. J Microbiol Methods 64(3):380-390 (Pubitemid 43212813)
36. Tuerker M (2004) Development of biocalorimetry as a technique for process monitoring and control in technical scale fermentations. Thermochim Acta 419(1-2):73-81
37. Verduyn C, Postma E, Scheffers WA, Van Dijken JP (1992) Effect of benzoic acid on metabolic fluxes in yeasts: a continuous-culture study on the regulation of respiration and alcoholic fermentation. Yeast 8(7):501-517
38. Voisard D, Pugeaud P, Kumar AR, Jenny K, Jayaraman K, Marison IW, von Stockar U (2002) Development of a large-scale biocalorimeter to monitor and control bioprocesses. Biotechnol Bioeng 80(2):125-138
39. von Stockar U, Duboc P, Menoud L, Marison IW (1997) On-line calorimetry as a technique for process monitoring and control in biotechnology. Thermochim Acta 300(1-2):225-236. A Collection of Invited Papers in Celebration of Volume 300 (Pubitemid 127348934)
40. von Stockar U, Marison I (1989) The use of calorimetry in biotechnology. In: Bioprocesses and engineering, vol 40 of advances in biochemical engineering/biotechnology. Springer, Berlin, pp 93-136. doi: 10.1007/BFb0009829
41. von Stockar U, van der Wielen LAM (1997) Thermodynamics in biochemical engineering. J Biotechnol 59(1-2):25-37 (Pubitemid 28057024)
42. Wechselberger P, Seifert A, Herwig C (2010) Pat method to gather bioprocess parameters in real-time using simple input variables and first principle relationships. Chem Eng Sci 65(21):5734-5746. Pharmaceutical Engineering Science-A Key for Tomorrow's Drugs
43. Xiong Z-Q, Guo M-J, Guo Y-X, Chu J, Zhuang Y-P, Zhang S-L (2008) Real-time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae t65 in industrial complex medium. J Biosci Bioeng 105(4):409-413 (Pubitemid 351680741)