Effect of RQ and pre-seed conditions on biomass and galactosyl transferase production during fed-batch culture of S. cerevisiae BT150

Journal of Biotechnology

Volumn 80, Issue 1, 2000, Pages 55-62

  Zigová, Jana ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Fed batch cultivation; Feedback control; Glycosyltransferase; Pre seed culture; Respiratory quotient (RQ); Saccharomyces cerevisiae

Indexed keywords

GALACTOSYLTRANSFERASE; RECOMBINANT ENZYME;

ARTICLE; BIOMASS; BIOREACTOR; DRUG MANUFACTURE; FEEDBACK SYSTEM; FERMENTATION; PRIORITY JOURNAL; RESPIRATORY QUOTIENT; SACCHAROMYCES CEREVISIAE; TECHNIQUE;

BIOMASS; BIOREACTORS; FERMENTATION; GLYCOSYLATION; HUMANS; N-ACETYLLACTOSAMINE SYNTHASE; OXYGEN CONSUMPTION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0034625520     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(00)00231-5     Document Type: Article

References (16)

1. Alfafara G.C., Miura K., Shimizu H. et al. Fuzzy control of ethanol concentration and its application to maximum glutathione production in yeast fed-batch culture. Biotechnol. Bioeng. 41:1993;493-501.
2. Bishop B.F., Lorbert S.J. The needs for sensors in bacterial and yeast fermentations. Courtney McGregor W. Sensors in Bioprocess Control, vol 6, Bioprocess Technology. 1990;1-16 Marcel Dekker, New York.
3. Dantigny P., Ninow J.L., Lakrori M. A new control strategy for yeast production based on the L/A* approach. Appl. Microbiol. Biotechnol. 36:1991;352-357.
4. Elling L. Enzymes for the synthesis of nucleotide sugars. Adv. Biochem. Eng. Biotechnol. 58:1997;89-144.
5. th International Carbohydrate Symposium, July 21-26, Milano, Italy, BP135, pp. 390-391.
6. Hensing M.C.M., Ruowenhorst R.J., Heijnen J.J., van Dijken J.P., Pronk J.T. Physiological and technological aspects of large-scale heterologous-protein production with yeast. Antonie van Leeuwenhoek. 67:1995;261-279.
7. Herrmann G.F., Krezdorn C., Malissard M. et al. Large-scale production of a soluble human β-1,4-galactosyltransferase using a Saccharomyces cerevisiae expression system. Prot. Expr. Pur. 6:1995;72-78.
8. Jin S., Ye K., Shimizu K., Nikawa J. Application of artificial neural network and fuzzy control for fed-batch cultivation of recombinant Saccharomyces cerevisiae. J. Ferm. Bioeng. 81:1996;412-421.
9. Kleene R., Krezdorn C.H., Watzele G. et al. Expression of soluble active human β-1,4-galactosyltransferase in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 201:1994;160-167.
10. Larsson C., Lidén G., Niklasson C., Gustafsson L. Calorimetric control of fed-batch cultures of Saccharomyces cerevisiae. Bioproc. Eng. 7:1991;151-155.
11. Malissard M., Borsig L., Di Marco S. et al. Recombinant soluble β-1,4-galactosyltransferases expressed in Saccharomyces cerevisiae: purification, characterization and comparison with human enzyme. Eur. J. Biochem. 239:1996;340-348.
12. Mendoza-Vega O., Sabatié J., Brown S.W. Industrial production of heterologous proteins by fed-batch cultures of the yeast Saccharomyces cerevisiae. FEMS Microbiol. Rev. 15:1994;369-410.
13. O'Connor G.M., Sanchez-Riera F., Cooney C.L. Design and evaluation of control strategies for high cell density fermentations. Biotechnol. Bioeng. 39:1992;293-304.
14. Paulson J.C., Ujita-Lee E., Colley K.J., Adler B., Browne J.K. Method for producing secretable glycosyltransferases and other Golgi processing enzymes. US Patent. 5:1991;519.
15. Schwientek T., Ernst J.F. Efficient intra and extracellular production of human β-1,4-galactosyltransferase in Saccharomyces cerevisiae is mediated by yeast secretion leaders. Gene. 145:1994;299-303.
16. Weuster-Botz D., Paschold H., Striegel B. et al. Continuous computer controlled production of formiate dehydrogenase (FDH) and isolation on a pilot scale. Chem. Eng. Technol. 17:1994;131-137.