메뉴 건너뛰기




Volumn 12, Issue 10, 2012, Pages 2588-2600

The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells

Author keywords

Alloreactive T cells; costimulatory molecules; T cell development

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

EID: 84867098819     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04180.x     Document Type: Review
Times cited : (45)

References (136)
  • 1
    • 65349104572 scopus 로고    scopus 로고
    • Mechanisms of costimulation
    • Sharpe AH,. Mechanisms of costimulation. Immunol Rev 2009; 229: 5-11.
    • (2009) Immunol Rev , vol.229 , pp. 5-11
    • Sharpe, A.H.1
  • 2
    • 65349189555 scopus 로고    scopus 로고
    • Costimulatory pathways in transplantation: Challenges and new developments
    • Li XC, Rothstein DM, Sayegh MH,. Costimulatory pathways in transplantation: Challenges and new developments. Immunol Rev 2009; 229: 271-293.
    • (2009) Immunol Rev , vol.229 , pp. 271-293
    • Li, X.C.1    Rothstein, D.M.2    Sayegh, M.H.3
  • 3
    • 79956125257 scopus 로고    scopus 로고
    • Origins of CD4(+) effector and central memory T cells
    • Pepper M, Jenkins MK,. Origins of CD4(+) effector and central memory T cells. Nat Immunol 2011; 12: 467-471.
    • (2011) Nat Immunol , vol.12 , pp. 467-471
    • Pepper, M.1    Jenkins, M.K.2
  • 5
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of CD4+ T cell lineage differentiation
    • Zhou L, Chong MM, Littman DR,. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009; 30: 646-655.
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1    Chong, M.M.2    Littman, D.R.3
  • 6
    • 56349093347 scopus 로고    scopus 로고
    • IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9 +IL-10 +Foxp3(-) effector T cells
    • Dardalhon V, Awasthi A, Kwon H, et al,. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9 +IL-10 +Foxp3(-) effector T cells. Nat Immunol 2008; 9: 1347-1355.
    • (2008) Nat Immunol , vol.9 , pp. 1347-1355
    • Dardalhon, V.1    Awasthi, A.2    Kwon, H.3
  • 7
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, et al,. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 9
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen M, Uyttenhove C, van Snick J, et al,. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008; 9: 1341-1346.
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    Van Snick, J.3
  • 10
    • 0031573660 scopus 로고    scopus 로고
    • Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation
    • Tao X, Constant S, Jorritsma P, Bottomly K,. Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J Immunol 1997; 159: 5956-5963.
    • (1997) J Immunol , vol.159 , pp. 5956-5963
    • Tao, X.1    Constant, S.2    Jorritsma, P.3    Bottomly, K.4
  • 11
    • 0036839081 scopus 로고    scopus 로고
    • Is selection for TCR affinity a factor in cytokine polarization?
    • Boyton RJ, Altmann DM,. Is selection for TCR affinity a factor in cytokine polarization? Trends Immunol 2002; 23: 526-529.
    • (2002) Trends Immunol , vol.23 , pp. 526-529
    • Boyton, R.J.1    Altmann, D.M.2
  • 12
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea JJ, Paul WE,. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010; 327: 1098-1102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 14
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, Bailey-Bucktrout SL, Jeker LT, et al,. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009; 10: 1000-1007.
    • (2009) Nat Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 15
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL,. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-2357.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 16
    • 58149382715 scopus 로고    scopus 로고
    • Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway
    • Mariotti J, Foley J, Ryan K, et al,. Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway. Blood 2008; 112: 4765-4775.
    • (2008) Blood , vol.112 , pp. 4765-4775
    • Mariotti, J.1    Foley, J.2    Ryan, K.3
  • 17
    • 68049146006 scopus 로고    scopus 로고
    • Recently discovered T cell subsets cannot keep their commitments
    • Strom TB, Koulmanda M,. Recently discovered T cell subsets cannot keep their commitments. J Am Soc Nephrol 2009; 20: 1677-1680.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1677-1680
    • Strom, T.B.1    Koulmanda, M.2
  • 18
    • 79955730734 scopus 로고    scopus 로고
    • T helper cell differentiation more than just cytokines
    • Zygmunt B, Veldhoen M,. T helper cell differentiation more than just cytokines. Adv Immunol 2011; 109: 159-196.
    • (2011) Adv Immunol , vol.109 , pp. 159-196
    • Zygmunt, B.1    Veldhoen, M.2
  • 19
    • 65349188127 scopus 로고    scopus 로고
    • Translating costimulation blockade to the clinic: Lessons learned from three pathways
    • Ford ML, Larsen CP,. Translating costimulation blockade to the clinic: Lessons learned from three pathways. Immunol Rev 2009; 229: 294-306.
    • (2009) Immunol Rev , vol.229 , pp. 294-306
    • Ford, M.L.1    Larsen, C.P.2
  • 20
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al,. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434-438.
    • (1996) Nature , vol.381 , pp. 434-438
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 21
    • 0030046808 scopus 로고    scopus 로고
    • CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway
    • Larsen CP, Alexander DZ, Hollenbaugh D, et al,. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996; 61: 4-9.
    • (1996) Transplantation , vol.61 , pp. 4-9
    • Larsen, C.P.1    Alexander, D.Z.2    Hollenbaugh, D.3
  • 22
    • 0033529235 scopus 로고    scopus 로고
    • Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
    • Kenyon NS, Chatzipetrou M, Masetti M, et al,. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc Natl Acad Sci U S A 1999; 96: 8132-8137.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8132-8137
    • Kenyon, N.S.1    Chatzipetrou, M.2    Masetti, M.3
  • 23
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk AD, Burkly LC, Batty DS, et al,. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686-693.
    • (1999) Nat Med , vol.5 , pp. 686-693
    • Kirk, A.D.1    Burkly, L.C.2    Batty, D.S.3
  • 24
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    • Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA,. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A 1996; 93: 13967-13972.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13967-13972
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.G.3    Peach, R.4    Linsley, P.S.5    Turka, L.A.6
  • 25
    • 0034235458 scopus 로고    scopus 로고
    • Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
    • Durham MM, Bingaman AW, Adams AB, et al,. Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol 2000; 165: 1-4.
    • (2000) J Immunol , vol.165 , pp. 1-4
    • Durham, M.M.1    Bingaman, A.W.2    Adams, A.B.3
  • 26
    • 0034663755 scopus 로고    scopus 로고
    • Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: Implications for tolerance induction
    • Smiley ST, Csizmadia V, Gao W, Turka LA, Hancock WW,. Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: Implications for tolerance induction. Transplantation 2000; 70: 415-419.
    • (2000) Transplantation , vol.70 , pp. 415-419
    • Smiley, S.T.1    Csizmadia, V.2    Gao, W.3    Turka, L.A.4    Hancock, W.W.5
  • 27
    • 0036829074 scopus 로고    scopus 로고
    • New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs
    • Sho M, Sandner SE, Najafian N, et al,. New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. Ann Surg 2002; 236: 667-675.
    • (2002) Ann Surg , vol.236 , pp. 667-675
    • Sho, M.1    Sandner, S.E.2    Najafian, N.3
  • 28
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
    • Kawai T, Andrews D, Colvin RB, Sachs DH, Cosimi AB,. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med 2000; 6: 114.
    • (2000) Nat Med , vol.6 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3    Sachs, D.H.4    Cosimi, A.B.5
  • 29
    • 0036130828 scopus 로고    scopus 로고
    • CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism
    • Andre P, Prasad KS, Denis CV, et al,. CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med 2002; 8: 247-252.
    • (2002) Nat Med , vol.8 , pp. 247-252
    • Andre, P.1    Prasad, K.S.2    Denis, C.V.3
  • 30
    • 19944412462 scopus 로고    scopus 로고
    • Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival
    • Adams AB, Shirasugi N, Jones TR, et al,. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 2005; 174: 542-550.
    • (2005) J Immunol , vol.174 , pp. 542-550
    • Adams, A.B.1    Shirasugi, N.2    Jones, T.R.3
  • 31
    • 0035204919 scopus 로고    scopus 로고
    • Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
    • McIntire JJ, Umetsu SE, Akbari O, et al,. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2001; 2: 1109-1116.
    • (2001) Nat Immunol , vol.2 , pp. 1109-1116
    • McIntire, J.J.1    Umetsu, S.E.2    Akbari, O.3
  • 32
    • 18244365585 scopus 로고    scopus 로고
    • TIM-1 induces T cell activation and inhibits the development of peripheral tolerance
    • Umetsu SE, Lee WL, McIntire JJ, et al,. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol 2005; 6: 447-454.
    • (2005) Nat Immunol , vol.6 , pp. 447-454
    • Umetsu, S.E.1    Lee, W.L.2    McIntire, J.J.3
  • 33
    • 34447273787 scopus 로고    scopus 로고
    • Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
    • Xiao S, Najafian N, Reddy J, et al,. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 2007; 204: 1691-1702.
    • (2007) J Exp Med , vol.204 , pp. 1691-1702
    • Xiao, S.1    Najafian, N.2    Reddy, J.3
  • 34
    • 38849120861 scopus 로고    scopus 로고
    • Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice
    • Degauque N, Mariat C, Kenny J, et al,. Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest 2008; 118: 735-741.
    • (2008) J Clin Invest , vol.118 , pp. 735-741
    • Degauque, N.1    Mariat, C.2    Kenny, J.3
  • 36
    • 38849166163 scopus 로고    scopus 로고
    • The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model
    • Ueno T, Habicht A, Clarkson MR, et al,. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 2008; 118: 742-751.
    • (2008) J Clin Invest , vol.118 , pp. 742-751
    • Ueno, T.1    Habicht, A.2    Clarkson, M.R.3
  • 37
    • 79959988692 scopus 로고    scopus 로고
    • Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells
    • Xiao L, Fu ZR, Liu F, et al,. Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells. PLoS One 2011; 6: e21697.
    • (2011) PLoS One , vol.6
    • Xiao, L.1    Fu, Z.R.2    Liu, F.3
  • 38
    • 0030443168 scopus 로고    scopus 로고
    • Regulation of surface and intracellular expression of CTLA4 on mouse T cells
    • Alegre ML, Noel PJ, Eisfelder BJ, et al,. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol 1996; 157: 4762-4770.
    • (1996) J Immunol , vol.157 , pp. 4762-4770
    • Alegre, M.L.1    Noel, P.J.2    Eisfelder, B.J.3
  • 39
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • Walunas TL, Bakker CY, Bluestone JA,. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 1996; 183: 2541-2550.
    • (1996) J Exp Med , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 40
    • 65849174780 scopus 로고    scopus 로고
    • SnapShot: B7/CD28 costimulation
    • e1
    • Paterson AM, Vanguri VK, Sharpe AH,. SnapShot: B7/CD28 costimulation. Cell 2009; 137: 974-4 e1.
    • (2009) Cell , vol.137 , pp. 974-984
    • Paterson, A.M.1    Vanguri, V.K.2    Sharpe, A.H.3
  • 41
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al,. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008; 322: 271-275.
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 42
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, et al,. Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4. Science 2011; 332: 600-603.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3
  • 43
    • 0028135078 scopus 로고
    • CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity
    • Baliga P, Chavin KD, Qin L, et al,. CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity. Transplantation. 1994; 58: 1082-1090.
    • (1994) Transplantation , vol.58 , pp. 1082-1090
    • Baliga, P.1    Chavin, K.D.2    Qin, L.3
  • 44
    • 0029864501 scopus 로고    scopus 로고
    • Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection
    • Azuma H, Chandraker A, Nadeau K, et al,. Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection. Proc Natl Acad Sci U S A 1996; 93: 12439-12444.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12439-12444
    • Azuma, H.1    Chandraker, A.2    Nadeau, K.3
  • 45
    • 0031464292 scopus 로고    scopus 로고
    • Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients
    • Sayegh MH, Zheng XG, Magee C, Hancock WW, Turka LA,. Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients. Transplantation 1997; 64: 1646-1650.
    • (1997) Transplantation , vol.64 , pp. 1646-1650
    • Sayegh, M.H.1    Zheng, X.G.2    Magee, C.3    Hancock, W.W.4    Turka, L.A.5
  • 46
    • 76949101581 scopus 로고    scopus 로고
    • A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
    • Vincenti F, Charpentier B, Vanrenterghem Y, et al,. A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am J Transplant 2010; 10: 535-546.
    • (2010) Am J Transplant , vol.10 , pp. 535-546
    • Vincenti, F.1    Charpentier, B.2    Vanrenterghem, Y.3
  • 47
    • 0242539820 scopus 로고    scopus 로고
    • Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    • Sabatos CA, Chakravarti S, Cha E, et al,. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 2003; 4: 1102-1110.
    • (2003) Nat Immunol , vol.4 , pp. 1102-1110
    • Sabatos, C.A.1    Chakravarti, S.2    Cha, E.3
  • 48
    • 77951673268 scopus 로고    scopus 로고
    • TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
    • Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH,. TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 2010; 235: 172-189.
    • (2010) Immunol Rev , vol.235 , pp. 172-189
    • Freeman, G.J.1    Casasnovas, J.M.2    Umetsu, D.T.3    Dekruyff, R.H.4
  • 49
    • 30044434075 scopus 로고    scopus 로고
    • The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    • Zhu C, Anderson AC, Schubart A, et al,. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 2005; 6: 1245-1252.
    • (2005) Nat Immunol , vol.6 , pp. 1245-1252
    • Zhu, C.1    Anderson, A.C.2    Schubart, A.3
  • 50
    • 0242708767 scopus 로고    scopus 로고
    • Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    • Sanchez-Fueyo A, Tian J, Picarella D, et al,. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol 2003; 4: 1093-1101.
    • (2003) Nat Immunol , vol.4 , pp. 1093-1101
    • Sanchez-Fueyo, A.1    Tian, J.2    Picarella, D.3
  • 51
    • 70349248367 scopus 로고    scopus 로고
    • TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
    • Hastings WD, Anderson DE, Kassam N, et al,. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol 2009; 39: 2492-2501.
    • (2009) Eur J Immunol , vol.39 , pp. 2492-2501
    • Hastings, W.D.1    Anderson, D.E.2    Kassam, N.3
  • 52
    • 78650635632 scopus 로고    scopus 로고
    • TIM-3: A novel regulatory molecule of alloimmune activation
    • Boenisch O, D'Addio F, Watanabe T, et al,. TIM-3: A novel regulatory molecule of alloimmune activation. J Immunol 2010; 185: 5806-5819.
    • (2010) J Immunol , vol.185 , pp. 5806-5819
    • Boenisch, O.1    D'Addio, F.2    Watanabe, T.3
  • 53
    • 80051621113 scopus 로고    scopus 로고
    • The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo
    • Yang J, Riella LV, Chock S, et al,. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol 2011; 187: 1113-1119.
    • (2011) J Immunol , vol.187 , pp. 1113-1119
    • Yang, J.1    Riella, L.V.2    Chock, S.3
  • 54
    • 79953239218 scopus 로고    scopus 로고
    • Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts
    • Riella LV, Watanabe T, Sage PT, et al,. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant 2011; 11: 832-840.
    • (2011) Am J Transplant , vol.11 , pp. 832-840
    • Riella, L.V.1    Watanabe, T.2    Sage, P.T.3
  • 55
    • 0036884356 scopus 로고    scopus 로고
    • Programmed death-1 targeting can promote allograft survival
    • Ozkaynak E, Wang L, Goodearl A, et al,. Programmed death-1 targeting can promote allograft survival. J Immunol. 2002; 169: 6546-6553.
    • (2002) J Immunol. , vol.169 , pp. 6546-6553
    • Ozkaynak, E.1    Wang, L.2    Goodearl, A.3
  • 56
    • 21044441208 scopus 로고    scopus 로고
    • Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo
    • Ito T, Ueno T, Clarkson MR, et al,. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J Immunol 2005; 174: 6648-6656.
    • (2005) J Immunol , vol.174 , pp. 6648-6656
    • Ito, T.1    Ueno, T.2    Clarkson, M.R.3
  • 57
    • 40149110241 scopus 로고    scopus 로고
    • Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy
    • Yang J, Popoola J, Khandwala S, et al,. Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy. Circulation 2008; 117: 660-669.
    • (2008) Circulation , vol.117 , pp. 660-669
    • Yang, J.1    Popoola, J.2    Khandwala, S.3
  • 58
    • 0141433189 scopus 로고    scopus 로고
    • Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival
    • Gao W, Demirci G, Strom TB, Li XC,. Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival. Transplantation 2003; 76: 994-999.
    • (2003) Transplantation , vol.76 , pp. 994-999
    • Gao, W.1    Demirci, G.2    Strom, T.B.3    Li, X.C.4
  • 59
    • 20144376357 scopus 로고    scopus 로고
    • Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo
    • Sandner SE, Clarkson MR, Salama AD, et al,. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol 2005; 174: 3408-3415.
    • (2005) J Immunol , vol.174 , pp. 3408-3415
    • Sandner, S.E.1    Clarkson, M.R.2    Salama, A.D.3
  • 60
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ,. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007; 27: 111-122.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 61
    • 0034677054 scopus 로고    scopus 로고
    • Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells
    • Lane P,. Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells. J Exp Med 2000; 191: 201-206.
    • (2000) J Exp Med , vol.191 , pp. 201-206
    • Lane, P.1
  • 62
    • 0035062434 scopus 로고    scopus 로고
    • Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo
    • Waaga AM, Gasser M, Kist-van Holthe JE, et al,. Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo. J Clin Invest 2001; 107: 909-916.
    • (2001) J Clin Invest , vol.107 , pp. 909-916
    • Waaga, A.M.1    Gasser, M.2    Kist-Van Holthe, J.E.3
  • 63
    • 67649213521 scopus 로고    scopus 로고
    • Role of IL-4 and Th2 responses in allograft rejection and tolerance
    • Tay SS, Plain KM, Bishop GA,. Role of IL-4 and Th2 responses in allograft rejection and tolerance. Curr Opin Organ Transplant 2009; 14: 16-22.
    • (2009) Curr Opin Organ Transplant , vol.14 , pp. 16-22
    • Tay, S.S.1    Plain, K.M.2    Bishop, G.A.3
  • 64
    • 0030951832 scopus 로고    scopus 로고
    • Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?
    • Piccotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK,. Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation 1997; 63: 619-624.
    • (1997) Transplantation , vol.63 , pp. 619-624
    • Piccotti, J.R.1    Chan, S.Y.2    Vanbuskirk, A.M.3    Eichwald, E.J.4    Bishop, D.K.5
  • 66
    • 0345422709 scopus 로고    scopus 로고
    • Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo
    • Rodriguez-Palmero M, Hara T, Thumbs A, Hunig T,. Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo. Eur J Immunol 1999; 29: 3914-3924.
    • (1999) Eur J Immunol , vol.29 , pp. 3914-3924
    • Rodriguez-Palmero, M.1    Hara, T.2    Thumbs, A.3    Hunig, T.4
  • 67
    • 0036156303 scopus 로고    scopus 로고
    • Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats
    • Laskowski IA, Pratschke J, Wilhelm MJ, et al,. Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats. J Am Soc Nephrol 2002; 13: 519-527.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 519-527
    • Laskowski, I.A.1    Pratschke, J.2    Wilhelm, M.J.3
  • 68
    • 77952961806 scopus 로고    scopus 로고
    • Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation
    • Poirier N, Azimzadeh AM, Zhang T, et al,. Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation. Sci Trans Med 2010; 2: 17ra10.
    • (2010) Sci Trans Med , vol.2
    • Poirier, N.1    Azimzadeh, A.M.2    Zhang, T.3
  • 69
    • 33644862359 scopus 로고    scopus 로고
    • Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment
    • So T, Song J, Sugie K, Altman A, Croft M,. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A 2006; 103: 3740-3745.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3740-3745
    • So, T.1    Song, J.2    Sugie, K.3    Altman, A.4    Croft, M.5
  • 70
    • 0032213337 scopus 로고    scopus 로고
    • OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors
    • Ohshima Y, Yang LP, Uchiyama T, et al,. OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood 1998; 92: 3338-3345.
    • (1998) Blood , vol.92 , pp. 3338-3345
    • Ohshima, Y.1    Yang, L.P.2    Uchiyama, T.3
  • 71
    • 59849096875 scopus 로고    scopus 로고
    • OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade
    • Burrell BE, Lu G, Li XC, Bishop DK,. OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade. J Immunol 2009; 182: 379-390.
    • (2009) J Immunol , vol.182 , pp. 379-390
    • Burrell, B.E.1    Lu, G.2    Li, X.C.3    Bishop, D.K.4
  • 72
    • 0037443415 scopus 로고    scopus 로고
    • The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo
    • Yuan X, Salama AD, Dong V, et al,. The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo. J Immunol 2003; 170: 2949-2955.
    • (2003) J Immunol , vol.170 , pp. 2949-2955
    • Yuan, X.1    Salama, A.D.2    Dong, V.3
  • 73
    • 1642485023 scopus 로고    scopus 로고
    • Critical role of OX40 in CD28 and CD154-independent rejection
    • Demirci G, Amanullah F, Kewalaramani R, et al,. Critical role of OX40 in CD28 and CD154-independent rejection. J Immunol 2004; 172: 1691-1698.
    • (2004) J Immunol , vol.172 , pp. 1691-1698
    • Demirci, G.1    Amanullah, F.2    Kewalaramani, R.3
  • 74
    • 0038752607 scopus 로고    scopus 로고
    • Interaction between ICOS-B7RP1 and B7-CD28 costimulatory pathways in alloimmune responses in vivo
    • Salama AD, Yuan X, Nayer A, et al,. Interaction between ICOS-B7RP1 and B7-CD28 costimulatory pathways in alloimmune responses in vivo. Am J Transplant 2003; 3: 390-395.
    • (2003) Am J Transplant , vol.3 , pp. 390-395
    • Salama, A.D.1    Yuan, X.2    Nayer, A.3
  • 75
    • 0043245118 scopus 로고    scopus 로고
    • The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity
    • Harada H, Salama AD, Sho M, et al,. The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. J Clin Invest 2003; 112: 234-243.
    • (2003) J Clin Invest , vol.112 , pp. 234-243
    • Harada, H.1    Salama, A.D.2    Sho, M.3
  • 76
    • 0034917195 scopus 로고    scopus 로고
    • Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
    • Ozkaynak E, Gao W, Shemmeri N, et al,. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat Immunol 2001; 2: 591-596.
    • (2001) Nat Immunol , vol.2 , pp. 591-596
    • Ozkaynak, E.1    Gao, W.2    Shemmeri, N.3
  • 77
    • 0034912508 scopus 로고    scopus 로고
    • ICOS costimulation: It's not just for TH2 cells anymore
    • Sperling AI, Bluestone JA,. ICOS costimulation: It's not just for TH2 cells anymore. Nat Immunol 2001; 2: 573-574.
    • (2001) Nat Immunol , vol.2 , pp. 573-574
    • Sperling, A.I.1    Bluestone, J.A.2
  • 78
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, Li Z, Yang XO, et al,. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6: 1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3
  • 79
    • 13544277680 scopus 로고    scopus 로고
    • ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling
    • Watanabe M, Watanabe S, Hara Y, et al,. ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling. J Immunol 2005; 174: 1989-1996.
    • (2005) J Immunol , vol.174 , pp. 1989-1996
    • Watanabe, M.1    Watanabe, S.2    Hara, Y.3
  • 80
    • 66949171812 scopus 로고    scopus 로고
    • Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients
    • Takahashi N, Matsumoto K, Saito H, et al,. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol 2009; 182: 5515-5527.
    • (2009) J Immunol , vol.182 , pp. 5515-5527
    • Takahashi, N.1    Matsumoto, K.2    Saito, H.3
  • 81
    • 35648938123 scopus 로고    scopus 로고
    • TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen-specific Th2 differentiation and intestinal allergy
    • Yang PC, Xing Z, Berin CM, et al,. TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen-specific Th2 differentiation and intestinal allergy. Gastroenterology 2007; 133: 1522-1533.
    • (2007) Gastroenterology , vol.133 , pp. 1522-1533
    • Yang, P.C.1    Xing, Z.2    Berin, C.M.3
  • 82
    • 46049095214 scopus 로고    scopus 로고
    • Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model
    • e1-e7.
    • Feng BS, Chen X, He SH, et al,. Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model. J Allergy Clin Immunol 2008; 122: 55-61, e1-e7.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 55-61
    • Feng, B.S.1    Chen, X.2    He, S.H.3
  • 83
    • 23744437449 scopus 로고    scopus 로고
    • Tim-2 regulates T helper type 2 responses and autoimmunity
    • Chakravarti S, Sabatos CA, Xiao S, et al,. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med 2005; 202: 437-444.
    • (2005) J Exp Med , vol.202 , pp. 437-444
    • Chakravarti, S.1    Sabatos, C.A.2    Xiao, S.3
  • 84
    • 59649110032 scopus 로고    scopus 로고
    • A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy
    • Yuan X, Paez-Cortez J, Schmitt-Knosalla I, et al,. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 2008; 205: 3133-3144.
    • (2008) J Exp Med , vol.205 , pp. 3133-3144
    • Yuan, X.1    Paez-Cortez, J.2    Schmitt-Knosalla, I.3
  • 86
    • 85027958582 scopus 로고    scopus 로고
    • Th17: Contributors to allograft rejection and a barrier to the induction of transplantation tolerance?
    • Chadha R, Heidt S, Jones ND, Wood KJ,. Th17: Contributors to allograft rejection and a barrier to the induction of transplantation tolerance? Transplantation 2011; 91: 939-945.
    • (2011) Transplantation , vol.91 , pp. 939-945
    • Chadha, R.1    Heidt, S.2    Jones, N.D.3    Wood, K.J.4
  • 87
    • 77956399884 scopus 로고    scopus 로고
    • Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation
    • Ying H, Yang L, Qiao G, et al,. Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation. J Immunol 2010; 185: 1375-1378.
    • (2010) J Immunol , vol.185 , pp. 1375-1378
    • Ying, H.1    Yang, L.2    Qiao, G.3
  • 89
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, et al,. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2009; 10: 167-175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3
  • 90
    • 78049518331 scopus 로고    scopus 로고
    • The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells
    • Paulos CM, Carpenito C, Plesa G, et al,. The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells. Sci Trans Med 2010; 2: 55ra78.
    • (2010) Sci Trans Med , vol.2
    • Paulos, C.M.1    Carpenito, C.2    Plesa, G.3
  • 91
    • 67649784846 scopus 로고    scopus 로고
    • Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells
    • Yuan X, Ansari MJ, D'Addio F, et al,. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 2009; 106: 10734-10739.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 10734-10739
    • Yuan, X.1    Ansari, M.J.2    D'Addio, F.3
  • 92
    • 79954994382 scopus 로고    scopus 로고
    • Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin v and mucin domains and occurs via the mitogen-activated protein kinase pathway
    • Cao W, Ryan M, Buckley D, O'Connor R, Clarkson MR,. Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway. Immunology 2011; 133: 179-189.
    • (2011) Immunology , vol.133 , pp. 179-189
    • Cao, W.1    Ryan, M.2    Buckley, D.3    O'Connor, R.4    Clarkson, M.R.5
  • 93
    • 58849137203 scopus 로고    scopus 로고
    • CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells
    • Iezzi G, Sonderegger I, Ampenberger F, Schmitz N, Marsland BJ, Kopf M,. CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells. Proc Natl Acad Sci U S A 2009; 106: 876-881.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 876-881
    • Iezzi, G.1    Sonderegger, I.2    Ampenberger, F.3    Schmitz, N.4    Marsland, B.J.5    Kopf, M.6
  • 94
    • 51449124534 scopus 로고    scopus 로고
    • Negative regulation of IL-17 production by OX40/OX40L interaction
    • Li J, Li L, Shang X, et al,. Negative regulation of IL-17 production by OX40/OX40L interaction. Cell Immunol 2008; 253: 31-37.
    • (2008) Cell Immunol , vol.253 , pp. 31-37
    • Li, J.1    Li, L.2    Shang, X.3
  • 95
    • 0033083303 scopus 로고    scopus 로고
    • Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
    • Weinberg AD, Wegmann KW, Funatake C, Whitham RH,. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J Immunol 1999; 162: 1818-1826.
    • (1999) J Immunol , vol.162 , pp. 1818-1826
    • Weinberg, A.D.1    Wegmann, K.W.2    Funatake, C.3    Whitham, R.H.4
  • 96
    • 0033785481 scopus 로고    scopus 로고
    • Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis
    • Yoshioka T, Nakajima A, Akiba H, et al,. Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur J Immunol 2000; 30: 2815-2823.
    • (2000) Eur J Immunol , vol.30 , pp. 2815-2823
    • Yoshioka, T.1    Nakajima, A.2    Akiba, H.3
  • 97
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai X, Cowan M, Feigenbaum L, Singer A,. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 2005; 6: 152-162.
    • (2005) Nat Immunol , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 98
    • 0141920662 scopus 로고    scopus 로고
    • Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells
    • Tang Q, Henriksen KJ, Boden EK, et al,. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol 2003; 171: 3348-3352.
    • (2003) J Immunol , vol.171 , pp. 3348-3352
    • Tang, Q.1    Henriksen, K.J.2    Boden, E.K.3
  • 99
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25 +immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, et al,. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25 +immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12: 431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 100
    • 72449172451 scopus 로고    scopus 로고
    • Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model
    • Yang J, Riella LV, Boenisch O, et al,. Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model. Am J Transplant 2009; 9: 2837-2844.
    • (2009) Am J Transplant , vol.9 , pp. 2837-2844
    • Yang, J.1    Riella, L.V.2    Boenisch, O.3
  • 101
    • 53149114893 scopus 로고    scopus 로고
    • CD28 controls differentiation of regulatory T cells from naive CD4 T cells
    • Guo F, Iclozan C, Suh WK, Anasetti C, Yu XZ,. CD28 controls differentiation of regulatory T cells from naive CD4 T cells. J Immunol 2008; 181: 2285-2291.
    • (2008) J Immunol , vol.181 , pp. 2285-2291
    • Guo, F.1    Iclozan, C.2    Suh, W.K.3    Anasetti, C.4    Yu, X.Z.5
  • 102
    • 65349151316 scopus 로고    scopus 로고
    • Regulating the regulators: Costimulatory signals control the homeostasis and function of regulatory T cells
    • Bour-Jordan H, Bluestone JA,. Regulating the regulators: Costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev 2009; 229: 41-66.
    • (2009) Immunol Rev , vol.229 , pp. 41-66
    • Bour-Jordan, H.1    Bluestone, J.A.2
  • 103
    • 79953073879 scopus 로고    scopus 로고
    • Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
    • Semple K, Nguyen A, Yu Y, Wang H, Anasetti C, Yu XZ,. Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling. Blood 2011; 117: 3096-3103.
    • (2011) Blood , vol.117 , pp. 3096-3103
    • Semple, K.1    Nguyen, A.2    Yu, Y.3    Wang, H.4    Anasetti, C.5    Yu, X.Z.6
  • 104
    • 0031091771 scopus 로고    scopus 로고
    • Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4
    • Lakkis FG, Konieczny BT, Saleem S, et al,. Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4. J Immunol 1997; 158: 2443-2448.
    • (1997) J Immunol , vol.158 , pp. 2443-2448
    • Lakkis, F.G.1    Konieczny, B.T.2    Saleem, S.3
  • 105
    • 23744517125 scopus 로고    scopus 로고
    • Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
    • Beyersdorf N, Gaupp S, Balbach K, et al,. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med 2005; 202: 445-455.
    • (2005) J Exp Med , vol.202 , pp. 445-455
    • Beyersdorf, N.1    Gaupp, S.2    Balbach, K.3
  • 106
    • 34548488466 scopus 로고    scopus 로고
    • Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies
    • Hunig T,. Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies. Adv Immunol 2007; 95: 111-148.
    • (2007) Adv Immunol , vol.95 , pp. 111-148
    • Hunig, T.1
  • 107
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G, Perry MR, Ward S, et al,. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006; 355: 1018-1028.
    • (2006) N Engl J Med , vol.355 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 108
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: Tolerance and tryptophan catabolism
    • Mellor AL, Munn DH,. IDO expression by dendritic cells: Tolerance and tryptophan catabolism. Nat Rev Immunol 2004; 4: 762-774.
    • (2004) Nat Rev Immunol , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 109
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Larsen CP, Pearson TC, Adams AB, et al,. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005; 5: 443-453.
    • (2005) Am J Transplant , vol.5 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 110
    • 84862784932 scopus 로고    scopus 로고
    • Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model
    • Riella LV, Liu T, Yang J, et al,. Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model. Am J Transplant 2012; 12: 846-855.
    • (2012) Am J Transplant , vol.12 , pp. 846-855
    • Riella, L.V.1    Liu, T.2    Yang, J.3
  • 111
    • 51849108540 scopus 로고    scopus 로고
    • The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation
    • Bluestone JA, Liu W, Yabu JM, et al,. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am J Transplant 2008; 8: 2086-2096.
    • (2008) Am J Transplant , vol.8 , pp. 2086-2096
    • Bluestone, J.A.1    Liu, W.2    Yabu, J.M.3
  • 112
  • 113
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco LM, Salinas VH, Brown KE, et al,. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009; 206: 3015-3029.
    • (2009) J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3
  • 114
    • 0041845131 scopus 로고    scopus 로고
    • Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    • Blazar BR, Carreno BM, Panoskaltsis-Mortari A, et al,. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 2003; 171: 1272-1277.
    • (2003) J Immunol , vol.171 , pp. 1272-1277
    • Blazar, B.R.1    Carreno, B.M.2    Panoskaltsis-Mortari, A.3
  • 115
    • 40849083349 scopus 로고    scopus 로고
    • Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts
    • Wang F, He W, Yuan J, et al,. Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts. Transpl Immunol 2008; 19: 12-19.
    • (2008) Transpl Immunol , vol.19 , pp. 12-19
    • Wang, F.1    He, W.2    Yuan, J.3
  • 116
    • 70350552096 scopus 로고    scopus 로고
    • Galectin-9 significantly prolongs the survival of fully mismatched cardiac allografts in mice
    • He W, Fang Z, Wang F, et al,. Galectin-9 significantly prolongs the survival of fully mismatched cardiac allografts in mice. Transplantation 2009; 88: 782-790.
    • (2009) Transplantation , vol.88 , pp. 782-790
    • He, W.1    Fang, Z.2    Wang, F.3
  • 117
    • 33947667952 scopus 로고    scopus 로고
    • GITR ligation blocks allograft protection by induced CD25+CD4 +regulatory T cells without enhancing effector T-cell function
    • Bushell A, Wood K,. GITR ligation blocks allograft protection by induced CD25+CD4 +regulatory T cells without enhancing effector T-cell function. Am J Transplant 2007; 7: 759-768.
    • (2007) Am J Transplant , vol.7 , pp. 759-768
    • Bushell, A.1    Wood, K.2
  • 118
    • 34548646019 scopus 로고    scopus 로고
    • Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells
    • So T, Croft M,. Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells. J Immunol 2007; 179: 1427-1430.
    • (2007) J Immunol , vol.179 , pp. 1427-1430
    • So, T.1    Croft, M.2
  • 119
    • 34948883517 scopus 로고    scopus 로고
    • OX40 costimulation turns off Foxp3 +Tregs
    • Vu MD, Xiao X, Gao W, et al,. OX40 costimulation turns off Foxp3 +Tregs. Blood 2007; 110: 2501-2510.
    • (2007) Blood , vol.110 , pp. 2501-2510
    • Vu, M.D.1    Xiao, X.2    Gao, W.3
  • 120
    • 38449117447 scopus 로고    scopus 로고
    • OX40 controls functionally different T cell subsets and their resistance to depletion therapy
    • Kroemer A, Xiao X, Vu MD, et al,. OX40 controls functionally different T cell subsets and their resistance to depletion therapy. J Immunol 2007; 179: 5584-5591.
    • (2007) J Immunol , vol.179 , pp. 5584-5591
    • Kroemer, A.1    Xiao, X.2    Vu, M.D.3
  • 122
    • 70350492504 scopus 로고    scopus 로고
    • New insights into the differentiation and function of T follicular helper cells
    • King C,. New insights into the differentiation and function of T follicular helper cells. Nat Rev Immunol 2009; 9: 757-766.
    • (2009) Nat Rev Immunol , vol.9 , pp. 757-766
    • King, C.1
  • 123
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T-B cell interactions underlie germinal centre formation
    • Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN,. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 2008; 455: 764-769.
    • (2008) Nature , vol.455 , pp. 764-769
    • Qi, H.1    Cannons, J.L.2    Klauschen, F.3    Schwartzberg, P.L.4    Germain, R.N.5
  • 124
    • 23444434705 scopus 로고    scopus 로고
    • The role of ICOS in the CXCR5 +follicular B helper T cell maintenance in vivo
    • Akiba H, Takeda K, Kojima Y, et al,. The role of ICOS in the CXCR5 +follicular B helper T cell maintenance in vivo. J Immunol 2005; 175: 2340-2348.
    • (2005) J Immunol , vol.175 , pp. 2340-2348
    • Akiba, H.1    Takeda, K.2    Kojima, Y.3
  • 125
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, et al,. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011; 34: 932-946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3
  • 126
    • 33749151018 scopus 로고    scopus 로고
    • ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells
    • Bossaller L, Burger J, Draeger R, et al,. ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J Immunol 2006; 177: 4927-4932.
    • (2006) J Immunol , vol.177 , pp. 4927-4932
    • Bossaller, L.1    Burger, J.2    Draeger, R.3
  • 127
    • 0037340349 scopus 로고    scopus 로고
    • Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
    • Grimbacher B, Hutloff A, Schlesier M, et al,. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol 2003; 4: 261-268.
    • (2003) Nat Immunol , vol.4 , pp. 261-268
    • Grimbacher, B.1    Hutloff, A.2    Schlesier, M.3
  • 128
    • 60149103686 scopus 로고    scopus 로고
    • Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS
    • Linterman MA, Rigby RJ, Wong R, et al,. Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS. Immunity 2009; 30: 228-241.
    • (2009) Immunity , vol.30 , pp. 228-241
    • Linterman, M.A.1    Rigby, R.J.2    Wong, R.3
  • 129
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    • Fazilleau N, McHeyzer-Williams LJ, Rosen H, McHeyzer-Williams MG,. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol 2009; 10: 375-384.
    • (2009) Nat Immunol , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 130
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, Rao S, Tsai LM, et al,. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009; 31: 457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1    Rao, S.2    Tsai, L.M.3
  • 131
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG,. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 2007; 179: 5099-5108.
    • (2007) J Immunol , vol.179 , pp. 5099-5108
    • Haynes, N.M.1    Allen, C.D.2    Lesley, R.3    Ansel, K.M.4    Killeen, N.5    Cyster, J.G.6
  • 132
  • 133
    • 79956198905 scopus 로고    scopus 로고
    • Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells
    • Hams E, McCarron MJ, Amu S, et al,. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J Immunol 2011; 186: 5648-5655.
    • (2011) J Immunol , vol.186 , pp. 5648-5655
    • Hams, E.1    McCarron, M.J.2    Amu, S.3
  • 134
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • Staudt V, Bothur E, Klein M, et al,. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 2010; 33: 192-202.
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1    Bothur, E.2    Klein, M.3
  • 135
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Hutloff A, Dittrich AM, Beier KC, et al,. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 1999; 397: 263-266.
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1    Dittrich, A.M.2    Beier, K.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.