Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 26, 2009, Pages 10734-10739

  Yuan, Xueli ^a   Ansari, M Javeed ^a,c   D'Addio, Francesca ^a   Paez Cortez, Jesus ^a   Schmitt, Isabella ^a   Donnarumma, Michela ^a   Boenisch, Olaf ^a   Zhao, Xiaozhi ^a   Popoola, Joyce ^a   Clarkson, Michael R ^a   Yagita, Hideo ^d   Akiba, Hisaya ^d   Freeman, Gordon J ^b   Iacomini, John ^a   Turka, Laurence A ^e   Glimcher, Laurie H ^f   Sayegh, Mohamed H ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Costimulation; IL 17; Immunosuppression; Rejection

Indexed keywords

INTERLEUKIN 17; KIDNEY INJURY MOLECULE 1; TRANSCRIPTION FACTOR T BET;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; GRAFT SURVIVAL; HEART TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TRANSPLANTATION TOLERANCE;

ACUTE DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FLUORESCENT ANTIBODY TECHNIQUE; GRAFT REJECTION; HEART TRANSPLANTATION; INTERLEUKIN-17; KAPLAN-MEIERS ESTIMATE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; T-BOX DOMAIN PROTEINS; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 67649784846     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812538106     Document Type: Article

References (39)

1. Ansari MJ, Sayegh MH (2007) The arduous road to achieving an immunosuppression-free state in kidney transplant recipients. Nature Clinical Practice 3:464-465. (Pubitemid 47313023)
2. Newell KA, et al. (1999) Cutting edge: Blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells. J Immunol 163:2358-2362. (Pubitemid 29399150)
3. Jones ND, et al. (2000) CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection. J Immunol 165:1111-1118. (Pubitemid 30484783)
4. Bishop DK, Chan Wood S, Eichwald EJ, Orosz CG (2001) Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions. J Immunol 166:3248-3255. (Pubitemid 33117324)
5. Valujskikh A, Pantenburg B, Heeger PS (2002) Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. Am J Transplant 2:501-509. (Pubitemid 36306868)
6. Zhai Y, Meng L, Gao F, Busuttil RW, Kupiec-Weglinski JW (2002) Allograft rejection by primed/memory CD8+T cells is CD154 blockade resistant: Therapeutic implications for sensitized transplant recipients. J Immunol 169:4667-4673. (Pubitemid 35178248)
7. Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008) Th17 cells in human disease. Immunol Rev 223:87-113.
8. Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821-852. (Pubitemid 46697925)
9. Lafaille JJ (1998) The role of helper T cell subsets in autoimmune diseases. Cytokine Growth Factor Rev 9:139-151. (Pubitemid 28376450)
10. Piccotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK (1997) Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation 63:619-624.
11. Goriely S, Goldman M (2007) The interleukin-12 family: New players in transplantation immunity? Am J Transplant 7:278-284.
12. Yuan X, et al. (2008) A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 205:3133-3144.
13. Burrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK (2008) CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol 181:3906-3914.
14. Xiao S, et al. (2007) Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 204:1691-1702. (Pubitemid 47048034)
15. Degauque N, et al. (2008) Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest 118:735-741. (Pubitemid 351206561)
16. Ueno T, et al. (2008) The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 118:742-751. (Pubitemid 351206562)
17. Larsen CP, et al. (1996) Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434-438. (Pubitemid 26162734)
18. Park H, et al. (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6):1133-1141. (Pubitemid 41541791)
19. Shin HC, Benbernou N, Fekkar H, Esnault S, Guenounou M (1998) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine 10):841-850.
20. Stark MA, et al. (2005) Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22:285-294. (Pubitemid 40387471)
21. Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A (2003) IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide- induced airway neutrophilia: IL-15 as a possible trigger. J Immunol 170:2106-2112. (Pubitemid 36197433)
22. Turka LA, Walsh PT (2008) IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci 13:1440-1446.
23. Meyers JH, et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 6:455-464. (Pubitemid 41716758)
24. Szabo SJ, et al. (2002) Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295:338-342. (Pubitemid 34074366)
25. Intlekofer AM, et al. (2008) Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science 321:408-411. (Pubitemid 352029977)
26. Rangachari M, et al. (2006) T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med 203:2009-2019. (Pubitemid 44188474)
27. Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK (2006) Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med 203:2785-2791. (Pubitemid 46026156)
28. Nakae S, et al. (2002) Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17:375-387. (Pubitemid 35279557)
29. Sayegh MH, et al. (1995) CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 181:1869-1874.
30. Nathan MJ, et al. (2004) Requirement for donor and recipient CD40 expression in cardiac allograft rejection: Induction of Th1 responses and influence of donor-derived dendritic cells. J Immunol 172:6626-6633. (Pubitemid 38669097)
31. Liu Z, et al. (2009) Evaluating the effects of immunosuppressants on human immunity using cytokine profiles of whole blood. Cytokine 45:141-147.
32. Yang K, et al. (2009) Inhibitory effect of rapamycin and dexamethasone on production of IL-17 and IFN-gamma in Vogt-Koyanagi-Harada patients. Br J Ophthalmol 93:249-253.
33. Furukawa Y, Yoshikawa H, Iwasa K, Yamada M Clinical efficacy and cytokine network modulating effects of tacrolimus in myasthenia gravis. J neuroimmunol 195:108-115, 2008.
34. Fossiez F, et al. (1996) T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183:2593-2603. (Pubitemid 26193037)
35. Zhang C, Zhang J, Yang B, Wu C (2008) Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis. Cytokine 42:345-352.
36. Umetsu SE, et al. (2005) TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol 6:447-454. (Pubitemid 41716757)
37. Radhakrishnan S, et al. (2008) Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J Immunol 181:3137-3147.
38. Numasaki M, et al. (2003) Interleukin-17 promotes angiogenesis and tumor growth. Blood 101:2620-2627. (Pubitemid 36857622)
39. Nam JS, et al. (2008) Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res 68:3915-3923.