Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway

Immunology

Volumn 133, Issue 2, 2011, Pages 179-189

  Cao, Wei ^a   Ryan, Michelle ^b   Buckley, Deirdre ^b   O'Connor, Rosemary ^b   Clarkson, Michael R ^c  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b Department of Biochemistry ^*  (Ireland)

^c University College Cork and INFANT Centre   (Ireland)

Author keywords

Alloimmune response; Immune inhibition; T helper type 17; T cell immunoglobulin mucin 4

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING PROTEIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T HELPER CELL TYPE 17; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION TOLERANCE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MUCINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TH17 CELLS;

EID: 79954994382     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03424.x     Document Type: Article

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