Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation

Science Translational Medicine

Volumn 2, Issue 17, 2010, Pages

  Poirier, Nicolas ^a   Azimzadeh, Agnes M ^b   Zhang, Tianshu ^b   Dilek, Nahzli ^a   Mary, Caroline ^c   Nguyen, Bao ^b   Tillou, Xavier ^a   Wu, Guosheng ^b   Reneaudin, Karine ^d   Hervouet, Jeremy ^a   Martinet, Bernard ^a   Coulon, Flora ^a   Allain Launay, Emma ^a   Karam, Georges ^a   Soulillou, Jean Paul ^a   Pierson III, Richard N ^b   Blancho, Gilles ^a   Vanhove, Bernard ^a  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c TcL Pharma SAS   (France)

^d UNIVERSITÉ DE NANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOSUPPRESSIVE AGENT; INDOLEAMINE 2,3 DIOXYGENASE; METHYLPREDNISOLONE SODIUM SUCCINATE; SC28AT; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BABOON; CARDIAC ALLOGRAFT VASCULOPATHY; CARDIAC GRAFT REJECTION; CELL PROLIFERATION; CHRONIC GRAFT REJECTION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME INHIBITION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT REJECTION; LYMPHOCYTE FUNCTION; MACACA FASCICULARIS; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VASCULAR DISEASE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, CD86; CALCINEURIN; GRAFT SURVIVAL; HUMANS; IMMUNE SYSTEM; LYMPHOCYTES; MACACA FASCICULARIS; ORGAN TRANSPLANTATION; PAPIO; T-LYMPHOCYTES, REGULATORY;

EID: 77952961806     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3000116     Document Type: Article

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