-
1
-
-
0029840285
-
Molecular and cellular aspectsof the glucagon receptor: Role in diabetes and metabolism
-
Burcelin R, Katz EB, Charron MJ. Molecular and cellular aspectsof the glucagon receptor: role in diabetes and metabolism. DiabetesMetab (Paris) 1996; 22: 373-96.
-
(1996)
DiabetesMetab (Paris)
, vol.22
, pp. 373-396
-
-
Burcelin, R.1
Katz, E.B.2
Charron, M.J.3
-
2
-
-
0036378574
-
Structure-function of the glucagon receptorfamily of G protein-coupled receptors: The glucagon, GIP, GLP-1, and GLP-2 receptors
-
Brubaker PL, Drucker DJ. Structure-function of the glucagon receptorfamily of G protein-coupled receptors: The glucagon, GIP, GLP-1, and GLP-2 receptors. Receptors Channels 2002; 8: 179-88.
-
(2002)
Receptors Channels
, vol.8
, pp. 179-188
-
-
Brubaker, P.L.1
Drucker, D.J.2
-
3
-
-
0037376913
-
Glucagon and regulation of glucose metabolism
-
Jiang G, Zhang BB. Glucagon and regulation of glucose metabolism. Am J Physiol 2003; 284: E671-8.
-
(2003)
Am J Physiol
, vol.284
-
-
Jiang, G.1
Zhang, B.B.2
-
4
-
-
84965091312
-
The relationship of epinephrineand glucagon to liver phosphorylase. IV. Effect of epinephrine andglucagon on the reactivation of phosphorylase in liver homogenates
-
Rall T, Sutherland EW, Berthet J. The relationship of epinephrineand glucagon to liver phosphorylase. IV. Effect of epinephrine andglucagon on the reactivation of phosphorylase in liver homogenates. J Biol Chem 1957; 224: 463-75.
-
(1957)
J Biol Chem
, vol.224
, pp. 463-475
-
-
Rall, T.1
Sutherland, E.W.2
Berthet, J.3
-
5
-
-
0020131685
-
Evaluation of adenosine or related nucleosides asphysiological regulators of lipolysis in adipose tissue
-
Schechter Y. Evaluation of adenosine or related nucleosides asphysiological regulators of lipolysis in adipose tissue. Endocrinol1982; 110: 1579-83.
-
(1982)
Endocrinol
, vol.110
, pp. 1579-1583
-
-
Schechter, Y.1
-
6
-
-
0001559662
-
Fractionation and characterization of acyclic adenine ribonucleotide formed by tissue particles
-
Sutherland EW, Rall TW. Fractionation and characterization of acyclic adenine ribonucleotide formed by tissue particles. J BiolChem 1958; 232: 1077-91.
-
(1958)
J BiolChem
, vol.232
, pp. 1077-1091
-
-
Sutherland, E.W.1
Rall, T.W.2
-
7
-
-
73849159943
-
Adenyl cylase I. Distribution, preparation, and properties
-
Sutherland EW, Rall TW, Menon T. Adenyl cylase I. Distribution, preparation, and properties. J Biol Chem 1962; 237: 1220-27.
-
(1962)
J Biol Chem
, vol.237
, pp. 1220-1227
-
-
Sutherland, E.W.1
Rall, T.W.2
Menon, T.3
-
8
-
-
0015493877
-
Studies on the mechanism of hormone action
-
Sutherland EW. Studies on the mechanism of hormone action. Science 1972; 177: 401-08.
-
(1972)
Science
, vol.177
, pp. 401-408
-
-
Sutherland, E.W.1
-
9
-
-
0035897590
-
Molecular biologicalapproaches to unravel adenylyl cyclase signaling and function
-
Patel, TB, Du Z, Pierre S, Cartin L, Scholich, K. Molecular biologicalapproaches to unravel adenylyl cyclase signaling and function. Gene 2001; 269: 13-25.
-
(2001)
Gene
, vol.269
, pp. 13-25
-
-
Patel, T.B.1
Du, Z.2
Pierre, S.3
Cartin, L.4
Scholich, K.5
-
10
-
-
79956212666
-
Impact of glycogen phosphorylaseinhibitor and metformin on basal and glucagon-stimulated hepaticglucose flux in conscious dogs
-
Torres TP, Sasaki N, Donahue EP, Lacy B, Printz RL, CherringtonAD, Treadway JL, Shiota M. Impact of glycogen phosphorylaseinhibitor and metformin on basal and glucagon-stimulated hepaticglucose flux in conscious dogs. J Pharmacol Exper Ther 2011; 337:610-620.
-
(2011)
J Pharmacol Exper Ther
, vol.337
, pp. 610-620
-
-
Torres, T.P.1
Sasaki, N.2
Donahue, E.P.3
Lacy, B.4
Printz, R.L.5
Cherrington, A.D.6
Treadway, J.L.7
Shiota, M.8
-
12
-
-
0014670359
-
Adenyl cyclase in fat cells II. Hormonereceptors
-
Birnbaumer L, Rodbell M. Adenyl cyclase in fat cells II. Hormonereceptors. J Biol Chem 1969; 244: 3477-3482.
-
(1969)
J Biol Chem
, vol.244
, pp. 3477-3482
-
-
Birnbaumer, L.1
Rodbell, M.2
-
13
-
-
0017717457
-
Receptor binding of glucagon and adenosine3',5'-monophosphate accumulation in isolated rat fat cells
-
Sonne O, Gliemann J. Receptor binding of glucagon and adenosine3',5'-monophosphate accumulation in isolated rat fat cells. BiochimBiophys Acta 1977; 499: 259-72.
-
(1977)
BiochimBiophys Acta
, vol.499
, pp. 259-272
-
-
Sonne, O.1
Gliemann, J.2
-
14
-
-
0015975951
-
Studies of glucagonresistance in large rat adipocytes: 125I-labeledglucagon binding andlipolytic activity
-
Livingston JN, Cuatrecasas P, Lockwood DH. Studies of glucagonresistance in large rat adipocytes: 125I-labeledglucagon binding andlipolytic activity. J Lipid Res 1974; 15: 26-32.
-
(1974)
J Lipid Res
, vol.15
, pp. 26-32
-
-
Livingston, J.N.1
Cuatrecasas, P.2
Lockwood, D.H.3
-
15
-
-
0019523661
-
Responses of rat andguinea pig hearts to glucagon. Lack of evidence for a dissociationbetween changes in myocardial cyclic 3,5-adenosine monophosphateand contractility
-
Rodgers R, MacLeod KM, McNeill JH. Responses of rat andguinea pig hearts to glucagon. Lack of evidence for a dissociationbetween changes in myocardial cyclic 3,5-adenosine monophosphateand contractility. Circ Res 1981; 49: 216-25.
-
(1981)
Circ Res
, vol.49
, pp. 216-225
-
-
Rodgers, R.1
McLeod, K.M.2
McNeill, J.H.3
-
16
-
-
0015246439
-
The role ofcyclic AMP in the interaction of glucagon and insulin in the controlof liver metabolism
-
Exton JH, Lewis SB, Ho RJ, Robison GA, Park CR. The role ofcyclic AMP in the interaction of glucagon and insulin in the controlof liver metabolism. Ann NY Acad Sci 1971; 185: 85-100.
-
(1971)
Ann NY Acad Sci
, vol.185
, pp. 85-100
-
-
Exton, J.H.1
Lewis, S.B.2
Ho, R.J.3
Robison, G.A.4
Park, C.R.5
-
17
-
-
0034644638
-
β-2 Adrenergic and several other Gproteinreceptors in human atrial membranes activate both Gs andGi
-
Kilts JD, Gerhardt MA, Richardson MD, Sreeram G, Mackensen B, Grocott HP, White WD, Davis RD, Newman MF, Reves JG, Schwinn DA, Kwatra MM. β-2 Adrenergic and several other Gproteinreceptors in human atrial membranes activate both Gs andGi. Circ Res 2000; 87: 707-9.
-
(2000)
Circ Res
, vol.87
, pp. 707-709
-
-
Kilts, J.D.1
Gerhardt, M.A.2
Richardson, M.D.3
Sreeram, G.4
McKensen, B.5
Grocott, H.P.6
White, W.D.7
Davis, R.D.8
Newman, M.F.9
Reves, J.G.10
Schwinn, D.A.11
Kwatra, M.M.12
-
18
-
-
0023101596
-
Hormonal control of glucose production and pyruvate kinase activityin isolated rat liver cells: Influence of hypothyroidism
-
Laville M, Khalfallah Y, Vidal H, Beylot M, Comte B, Riou JP. Hormonal control of glucose production and pyruvate kinase activityin isolated rat liver cells: influence of hypothyroidism. Mol CellEndocrinol 1987; 50: 247-53.
-
(1987)
Mol CellEndocrinol
, vol.50
, pp. 247-253
-
-
Laville, M.1
Khalfallah, Y.2
Vidal, H.3
Beylot, M.4
Comte, B.5
Riou, J.P.6
-
19
-
-
0343049161
-
Modulation of gluconeogenesis by epinephrine in hepatocytes isolatedfrom genetically obese (fa/fa) Zucker rats
-
Sánchez-Gutiérrez JC, Sánchez-Arias JA, Samper B, Felíu JE. Modulation of gluconeogenesis by epinephrine in hepatocytes isolatedfrom genetically obese (fa/fa) Zucker rats. Arch BiochemBiophys 2000; 373: 249-54.
-
(2000)
Arch BiochemBiophys
, vol.373
, pp. 249-254
-
-
Sánchez-Gutiérrez, J.C.1
Sánchez-Arias, J.A.2
Samper, B.3
Felíu, J.E.4
-
20
-
-
0024195969
-
The role of cyclic AMP inrapid and long-term regulation of gluconeogenesis and glycolysis
-
Pilkis SJ, Claus TH, El-Maghrabi MR. The role of cyclic AMP inrapid and long-term regulation of gluconeogenesis and glycolysis. Adv Sec Mess Phosphoprot Res 1988; 22: 175-91.
-
(1988)
Adv Sec Mess Phosphoprot Res
, vol.22
, pp. 175-191
-
-
Pilkis, S.J.1
Claus, T.H.2
El-Maghrabi, M.R.3
-
21
-
-
0026520193
-
Molecular physiology of the regulation ofhepatic gluconeogenesis and glycolysis
-
Pilkis SJ, Granner DK. Molecular physiology of the regulation ofhepatic gluconeogenesis and glycolysis. Ann Rev Physiol 1992; 54:885-909.
-
(1992)
Ann Rev Physiol
, vol.54
, pp. 885-909
-
-
Pilkis, S.J.1
Granner, D.K.2
-
22
-
-
1542285160
-
Hepatocytes: Critical for glucose homeostasis
-
Klover PJ, Mooney RA. Hepatocytes: Critical for glucose homeostasis. Int J Biochem Cell Biol 2004; 36: 753-58.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 753-758
-
-
Klover, P.J.1
Mooney, R.A.2
-
23
-
-
0020104631
-
Lipolytic and adenylatecyclase-stimulating activity of N trinitrophenyl glucagon: Comparisonwith other glucagon derivatives modified at the amino terminus
-
Jean-Baptiste E, Rizack MA, Epand RM. Lipolytic and adenylatecyclase-stimulating activity of N trinitrophenyl glucagon: comparisonwith other glucagon derivatives modified at the amino terminus. Biosci Rep 2: 1982; 163-67.
-
(1982)
Biosci Rep
, vol.2
, pp. 163-167
-
-
Jean-Baptiste, E.1
Rizack, M.A.2
Epand, R.M.3
-
24
-
-
0021961911
-
Glucagonreceptor of human liver. Studies of its molecular weight andbinding properties, and its ability to activate hepatic adenylyl cyclaseof non-obese and obese subjects
-
Livingston J, Einarsson K, Backman L, Ewerth S, Arner P. Glucagonreceptor of human liver. Studies of its molecular weight andbinding properties, and its ability to activate hepatic adenylyl cyclaseof non-obese and obese subjects. J Clin Invest 1985; 75: 397-403.
-
(1985)
J Clin Invest
, vol.75
, pp. 397-403
-
-
Livingston, J.1
Einarsson, K.2
Backman, L.3
Ewerth, S.4
Arner, P.5
-
25
-
-
0022539041
-
Effects of [1-Nα-trinitrophenylhistidine, 12-homoarginine] glucagonon cyclic AMP levels and free fatty acid release in isolatedrat adipocytes
-
García-Sáinz JA, Sánchez-Sevilla L, Pelton JT, Trivedi D, HrubyDJ. Effects of [1-Nα-trinitrophenylhistidine, 12-homoarginine] glucagonon cyclic AMP levels and free fatty acid release in isolatedrat adipocytes. Biochim Biophys Acta 1986; 886: 310-16.
-
(1986)
Biochim Biophys Acta
, vol.886
, pp. 310-316
-
-
García-Sáinz, J.A.1
Sánchez-Sevilla, L.2
Pelton, J.T.3
Trivedi, D.4
Hruby, D.J.5
-
26
-
-
0024462981
-
Decreased glucagon bindingand glucagon-stimulated lipolysis in adipocytes from streptozotocin-diabetic rats
-
Sato N, Irie M, Kajinuma H, Suzuki K. Decreased glucagon bindingand glucagon-stimulated lipolysis in adipocytes from streptozotocin-diabetic rats. Acta Endocrinol 1989; 121: 705-13.
-
(1989)
Acta Endocrinol
, vol.121
, pp. 705-713
-
-
Sato, N.1
Irie, M.2
Kajinuma, H.3
Suzuki, K.4
-
27
-
-
0025219445
-
Adrenalectomyinducedalterations in glucagon binding and glycolysis in isolatedrat adipocytes
-
Watanabe K, Irie M, Kajinuma H, Suzuki K. Adrenalectomyinducedalterations in glucagon binding and glycolysis in isolatedrat adipocytes. Horm Metab Res 1990; 22: 215-20.
-
(1990)
Horm Metab Res
, vol.22
, pp. 215-220
-
-
Watanabe, K.1
Irie, M.2
Kajinuma, H.3
Suzuki, K.4
-
28
-
-
0016717794
-
Glucagon and adipose tissue
-
Lefebvre PJ. Glucagon and adipose tissue. Biochem Pharmacol1975; 24: 1261-66.
-
(1975)
Biochem Pharmacol
, vol.24
, pp. 1261-1266
-
-
Lefebvre, P.J.1
-
29
-
-
0029320699
-
Signal transduction: Evolution of an idea
-
Rodbell M. Signal transduction: evolution of an idea. Biosci Rep1995; 15: 117-33.
-
(1995)
Biosci Rep
, vol.15
, pp. 117-133
-
-
Rodbell, M.1
-
31
-
-
0021269073
-
Regulation of peripheral insulin/glucagonlevels by rat liver
-
Balks HJ, Jungermann K. Regulation of peripheral insulin/glucagonlevels by rat liver. Eur J Biochem 1984; 141: 645-50.
-
(1984)
Eur J Biochem
, vol.141
, pp. 645-650
-
-
Balks, H.J.1
Jungermann, K.2
-
32
-
-
0024245370
-
Glucagon binding and lipolytic response in isolatedadipocytes from streptozotocin-diabetic rats
-
Mayor P, Calle C. Glucagon binding and lipolytic response in isolatedadipocytes from streptozotocin-diabetic rats. Endocrinol Japon1988; 35: 207-15.
-
(1988)
Endocrinol Japon
, vol.35
, pp. 207-215
-
-
Mayor, P.1
Calle, C.2
-
34
-
-
0027131998
-
Impaired hormonal responseto hypoglycemia in spontaneously and recurrently hypoglycemicrats
-
Powell AM, Sherwin RS, Shulman GI. Impaired hormonal responseto hypoglycemia in spontaneously and recurrently hypoglycemicrats. J Clin Invest 1993; 92: 2667-74.
-
(1993)
J Clin Invest
, vol.92
, pp. 2667-2674
-
-
Powell, A.M.1
Sherwin, R.S.2
Shulman, G.I.3
-
35
-
-
0036084145
-
Effects of recurrent hyperinsulinemia with and without hypoglycemiaon counterregulation in diabetic rats
-
2002
-
Inouye K, Shum K, Chan O, Mathoo J, Matthews SG, Vranic M. Effects of recurrent hyperinsulinemia with and without hypoglycemiaon counterregulation in diabetic rats. Am J Physiol 2002; 282:E1369-79, 2002.
-
(2002)
Am J Physiol
, vol.282
-
-
Inouye, K.1
Shum, K.2
Chan, O.3
Mathoo, J.4
Matthews, S.G.5
Vranic, M.6
-
36
-
-
0038015596
-
The daily rhythm in plasma glucagon concentrationsin the rat is modulated by the biological clock and by feeding behavior
-
Ruiter M, LaFleur SE, van Heijningen C, van der Vliet J, KalsbeekA, Buijs RM. The daily rhythm in plasma glucagon concentrationsin the rat is modulated by the biological clock and by feeding behavior. Diabetes 2003; 52: 1709-15.
-
(2003)
Diabetes
, vol.52
, pp. 1709-1715
-
-
Ruiter, M.1
la Fleur, S.E.2
van Heijningen, C.3
van der Vliet, J.4
Kalsbeek, A.5
Buijs, R.M.6
-
37
-
-
0842331573
-
Exercise induces hypoglycemia in rats with islettransplantation
-
Omer A, Duvivier-Kali VF, Aschenbach W, Tchipashvili V, GoodyearLJ, Weir GC. Exercise induces hypoglycemia in rats with islettransplantation. Diabetes 2004; 53: 360-65.
-
(2004)
Diabetes
, vol.53
, pp. 360-365
-
-
Omer, A.1
Duvivier-Kali, V.F.2
Aschenbach, W.3
Tchipashvili, V.4
Goodyear, L.J.5
Weir, G.C.6
-
38
-
-
1442350003
-
The effects ofdehydroepiandrosterone sulfate on counterregulatory responses duringrepeated hypoglycemia in conscious normal rats
-
Sandoval D, Ping L, Neill RA, Morrey S, Davis SN. The effects ofdehydroepiandrosterone sulfate on counterregulatory responses duringrepeated hypoglycemia in conscious normal rats. Diabetes2004; 53: 679-86.
-
(2004)
Diabetes
, vol.53
, pp. 679-686
-
-
Sandoval, D.1
Ping, L.2
Neill, R.A.3
Morrey, S.4
Davis, S.N.5
-
39
-
-
21044434666
-
Alterations inhepatic glucagon receptor density and in Gs α and Gi α2 proteincontent with diet-induced hepatic steatosis: Effects of acute exercise
-
Charbonneau A, Melancon A, Lavoie C, Lavoie J-M. Alterations inhepatic glucagon receptor density and in Gs α and Gi α2 proteincontent with diet-induced hepatic steatosis: effects of acute exercise. Am J Physiol 2005; 289: E8-14.
-
(2005)
Am J Physiol
, vol.289
-
-
Charbonneau, A.1
Melancon, A.2
Lavoie, C.3
Lavoie, J-M.4
-
40
-
-
0014899070
-
Glucagonlevels and metabolic effects in fasting man
-
Marliss E, Aoki TT, Unger RH, Soeldner JS, Cahill GF Jr. Glucagonlevels and metabolic effects in fasting man. J Clin Invest 1970;49: 2256-70.
-
(1970)
J Clin Invest
, vol.49
, pp. 2256-2270
-
-
Marliss, E.1
Aoki, T.T.2
Unger, R.H.3
Soeldner, J.S.4
Cahill Jr., G.F.5
-
41
-
-
0018340297
-
Hyperglycemiaand glucagon suppression: Possible importance of the vagus andenteric humoral factors
-
Findlay DM, Omond S, Alford FP, Chisholm DJ. Hyperglycemiaand glucagon suppression: Possible importance of the vagus andenteric humoral factors. J Clin Endocrinol Metab 1979; 48: 13-16.
-
(1979)
J Clin Endocrinol Metab
, vol.48
, pp. 13-16
-
-
Findlay, D.M.1
Omond, S.2
Alford, F.P.3
Chisholm, D.J.4
-
42
-
-
0021343484
-
Transhepatic glucagon gradients inman: Evidence for glucagon extraction by human liver
-
Jaspan J, Ruddick J, Rayfield E. Transhepatic glucagon gradients inman: evidence for glucagon extraction by human liver. J Clin EndocrinolMetab 1984; 58: 287-92.
-
(1984)
J Clin EndocrinolMetab
, vol.58
, pp. 287-292
-
-
Jaspan, J.1
Ruddick, J.2
Rayfield, E.3
-
43
-
-
0021263283
-
Defectiveglucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus
-
Bolli GB, Tsalikian E, Haymond MW, Cryer PE, Gerich JE. Defectiveglucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. J Clin Invest 1984; 73: 1532-41.
-
(1984)
J Clin Invest
, vol.73
, pp. 1532-1541
-
-
Bolli, G.B.1
Tsalikian, E.2
Haymond, M.W.3
Cryer, P.E.4
Gerich, J.E.5
-
44
-
-
0031720736
-
Effects ofglucagon on renal and hepatic glutamine gluconeogenesis in normalpostabsorptive humans
-
Stumvoll M, Meyer C, Kreider M, Perriello G, Gerich J. Effects ofglucagon on renal and hepatic glutamine gluconeogenesis in normalpostabsorptive humans. Metabolism 1998; 47: 1227-32.
-
(1998)
Metabolism
, vol.47
, pp. 1227-1232
-
-
Stumvoll, M.1
Meyer, C.2
Kreider, M.3
Perriello, G.4
Gerich, J.5
-
45
-
-
2342519996
-
Alanine infusionduring hypoglycaemia partly supports cognitive performance inhealthy human subjects
-
Evans M, Hopkins D, Macdonald IA, Amiel SA. Alanine infusionduring hypoglycaemia partly supports cognitive performance inhealthy human subjects. Diabet Med 2004; 21: 440-46.
-
(2004)
Diabet Med
, vol.21
, pp. 440-446
-
-
Evans, M.1
Hopkins, D.2
McDonald, I.A.3
Amiel, S.A.4
-
46
-
-
18144396132
-
Role of the decrement in intraislet insulin for the glucagonresponse to hypoglycemia in humans
-
Gosmanov NR, Szoke E, Israelian Z, Smith T, Cryer PE, Gerich JE, Meyer C. Role of the decrement in intraislet insulin for the glucagonresponse to hypoglycemia in humans. Diabetes Care 2005; 28:1124-31.
-
(2005)
Diabetes Care
, vol.28
, pp. 1124-1131
-
-
Gosmanov, N.R.1
Szoke, E.2
Israelian, Z.3
Smith, T.4
Cryer, P.E.5
Gerich, J.E.6
Meyer, C.7
-
47
-
-
23944516266
-
Impact of glucagon response on postprandial hyperglycemia inmen with impaired glucose tolerance and type 2 diabetes mellitus
-
Henkel E, Menschikowski M, Koehler C, Leonhardt W, HanefeldM. Impact of glucagon response on postprandial hyperglycemia inmen with impaired glucose tolerance and type 2 diabetes mellitus. Metabolism 2005; 54: 1168-73.
-
(2005)
Metabolism
, vol.54
, pp. 1168-1173
-
-
Henkel, E.1
Menschikowski, M.2
Koehler, C.3
Leonhardt, W.4
Hanefeld, M.5
-
48
-
-
0015267906
-
Different effects of lipolytic hormones andphosphodiesterase inhibitors on cyclic 3',5'-AMP levels in isolatedadipocytes
-
Schwabe U, Ebert R. Different effects of lipolytic hormones andphosphodiesterase inhibitors on cyclic 3',5'-AMP levels in isolatedadipocytes. Naunyn-Schmiedeberg's Arch Pharmacol 1972; 274:287-98.
-
(1972)
Naunyn-Schmiedeberg's Arch Pharmacol
, vol.274
, pp. 287-298
-
-
Schwabe, U.1
Ebert, R.2
-
49
-
-
0018934104
-
Altered lipolytic response to glucagonand adenosine deaminase in adipocytes from starved rats
-
Honnor RC, Saggerson ED. Altered lipolytic response to glucagonand adenosine deaminase in adipocytes from starved rats. BiochemJ 1980; 188: 757-61.
-
(1980)
BiochemJ
, vol.188
, pp. 757-761
-
-
Honnor, R.C.1
Saggerson, E.D.2
-
50
-
-
0025878245
-
Alterations inG-protein expression and the hormonal regulation of adenylate cyclasein the adipocytes of obese (fa/fa) Zucker rats
-
Strassheim D, Palmer T, Milligan G, Houslay MD. Alterations inG-protein expression and the hormonal regulation of adenylate cyclasein the adipocytes of obese (fa/fa) Zucker rats. Biochem J1991; 276: 197-202.
-
(1991)
Biochem J
, vol.276
, pp. 197-202
-
-
Strassheim, D.1
Palmer, T.2
Milligan, G.3
Houslay, M.D.4
-
51
-
-
0020131685
-
Evaluation of adenosine or related nucleosides asphysiological regulators of lipolysis in adipose tissue
-
Schechter Y. Evaluation of adenosine or related nucleosides asphysiological regulators of lipolysis in adipose tissue. Endocrinol1982; 110: 1579-83.
-
(1982)
Endocrinol
, vol.110
, pp. 1579-1583
-
-
Schechter, Y.1
-
52
-
-
0027141309
-
Presence of glucagon and glucagon-like peptide-1-(7-36) amide receptors in solubilized membranes of human adiposetissue
-
Mérida E, Delgado E, Molina LM, Villanueva-Peñacarillo ML, Valverde I. Presence of glucagon and glucagon-like peptide-1-(7-36) amide receptors in solubilized membranes of human adiposetissue. J Clin Endocrinol Metab 1993; 77: 1654-1657.
-
(1993)
J Clin Endocrinol Metab
, vol.77
, pp. 1654-1657
-
-
Mérida, E.1
Delgado, E.2
Molina, L.M.3
Villanueva-Peñacarillo, M.L.4
Valverde, I.5
-
53
-
-
0021826713
-
Glycerol release from incubated humanadipocytes is not affected by gastrointestinal peptides
-
Richter WO, Schwandt P. Glycerol release from incubated humanadipocytes is not affected by gastrointestinal peptides. In J Obes1985; 9: 25-27.
-
(1985)
In J Obes
, vol.9
, pp. 25-27
-
-
Richter, W.O.1
Schwandt, P.2
-
54
-
-
0024369773
-
Human glucagon and vasoactiveintestinal polypeptide (VIP) stimulate free fatty acid release fromhuman adipose tissue in vitro
-
Richter WO, Robl H, Schwandt P. Human glucagon and vasoactiveintestinal polypeptide (VIP) stimulate free fatty acid release fromhuman adipose tissue in vitro. Peptides 1989; 10: 333-35.
-
(1989)
Peptides
, vol.10
, pp. 333-335
-
-
Richter, W.O.1
Robl, H.2
Schwandt, P.3
-
55
-
-
0027378372
-
Identificationof glucagon receptors in human adipocytes from a liposarcoma
-
Carranza MC, Simón MA, Torres A, Romero B, Calle C. Identificationof glucagon receptors in human adipocytes from a liposarcoma. J Endocrinol Invest 1993; 16: 439-42.
-
(1993)
J Endocrinol Invest
, vol.16
, pp. 439-442
-
-
Carranza, M.C.1
Simón, M.A.2
Torres, A.3
Romero, B.4
Calle, C.5
-
56
-
-
0029086454
-
Physiological effect of glucagon in human isolated adipocytes
-
Perea A, Clemente F, Martinell J, Villanueva-Peñacarillo ML, Valverde I. Physiological effect of glucagon in human isolated adipocytes. Horm Metab Res 1995; 27: 372-75.
-
(1995)
Horm Metab Res
, vol.27
, pp. 372-375
-
-
Perea, A.1
Clemente, F.2
Martinell, J.3
Villanueva-Peñacarillo, M.L.4
Valverde, I.5
-
58
-
-
0023943604
-
Somatostatin-induced inhibition of lipolysis: In vitro studies
-
Endröczi E, Kovács Z, Lévay G, Sasváry M, Korányi L. Somatostatin-induced inhibition of lipolysis: in vitro studies. ActaPhysiol Hung 1988; 71: 77-82.
-
(1988)
ActaPhysiol Hung
, vol.71
, pp. 77-82
-
-
Endröczi, E.1
Kovács, Z.2
Lévay, G.3
Sasváry, M.4
Korányi, L.5
-
59
-
-
0031046709
-
Direct andindirect effects of insulin in suppressing glucose production indepancreatized dogs: Role of glucagon
-
Giacca A, Fisher SJ, McCall RH, Shi ZQ, Vranic M. Direct andindirect effects of insulin in suppressing glucose production indepancreatized dogs: Role of glucagon. Endocrinology 1997; 138:999-1007.
-
(1997)
Endocrinology
, vol.138
, pp. 999-1007
-
-
Giacca, A.1
Fisher, S.J.2
McCall, R.H.3
Shi, Z.Q.4
Vranic, M.5
-
60
-
-
54849431792
-
The glucagon receptor is required for the adaptivemetabolic response to fasting
-
Longuet C, Sinclair EM, Maida A, Baggio LL, Maziarz M, CharronMJ, Drucker DJ. The glucagon receptor is required for the adaptivemetabolic response to fasting. Cell Metab. 2008; 8: 359-71.
-
(2008)
Cell Metab.
, vol.8
, pp. 359-371
-
-
Longuet, C.1
Sinclair, E.M.2
Maida, A.3
Baggio, L.L.4
Maziarz, M.5
Charron, M.J.6
Drucker, D.J.7
-
61
-
-
79551600048
-
Glucagonreceptor knockout prevents insulin-deficient type 1 diabetes inmice
-
Lee Y, Wang M-Y, Du XQ, Charron MJ, Unger RH. Glucagonreceptor knockout prevents insulin-deficient type 1 diabetes inmice. Diabetes 2011; 60: 391-97.
-
(2011)
Diabetes
, vol.60
, pp. 391-397
-
-
Lee, Y.1
Wang, M-Y.2
Du, X.Q.3
Charron, M.J.4
Unger, R.H.5
-
62
-
-
57049128398
-
Metabolic effects of glucagon in theperfused rat heart
-
Kreisberg R, Williamson JR. Metabolic effects of glucagon in theperfused rat heart. Am J Physiol 1964; 207: 721-27.
-
(1964)
Am J Physiol
, vol.207
, pp. 721-727
-
-
Kreisberg, R.1
Williamson, J.R.2
-
63
-
-
0014511498
-
Effect of glucagon on rat heart adenyl cyclase
-
Murad F, Vaughan M. Effect of glucagon on rat heart adenyl cyclase. Biochem Pharmacol 1969; 18: 1053-59.
-
(1969)
Biochem Pharmacol
, vol.18
, pp. 1053-1059
-
-
Murad, F.1
Vaughan, M.2
-
64
-
-
0016734460
-
Regulation of adenosine 3':5'-monophosphate-dependent protein kinase. Regulation of the heartenzyme by epinephrine, glucagon, insulin, and 1-methyl-3-isobutylxanthine
-
Keely SL, Corbin JD, Park CR. Regulation of adenosine 3':5'-monophosphate-dependent protein kinase. Regulation of the heartenzyme by epinephrine, glucagon, insulin, and 1-methyl-3-isobutylxanthine. J Biol Chem 1975; 250: 4832-40.
-
(1975)
J Biol Chem
, vol.250
, pp. 4832-4840
-
-
Keely, S.L.1
Corbin, J.D.2
Park, C.R.3
-
65
-
-
0016606352
-
Dissociations between changes inmyocardial cyclic adenosine monophosphate and contractility
-
Henry PD, Dobson JG, Sobel BE. Dissociations between changes inmyocardial cyclic adenosine monophosphate and contractility. CircRes 1975; 36: 392-400.
-
(1975)
CircRes
, vol.36
, pp. 392-400
-
-
Henry, P.D.1
Dobson, J.G.2
Sobel, B.E.3
-
66
-
-
0019494198
-
Characterization of glucagon-induced changes in rate, contractility and cyclic AMP levelsin isolated cardiac preparations of the rat and guinea pig
-
MacLeod KM, Rodgers RL, McNeill JH. Characterization of glucagon-induced changes in rate, contractility and cyclic AMP levelsin isolated cardiac preparations of the rat and guinea pig. J PharmacolExper Ther 1981; 217: 798-804.
-
(1981)
J PharmacolExper Ther
, vol.217
, pp. 798-804
-
-
MacLeod, K.M.1
Rodgers, R.L.2
McNeill, J.H.3
-
67
-
-
0020074103
-
Cyclic AMP-dependentand cyclic AMP-independent antagonism of insulin activation ofcardiac glycogen synthase
-
Ramachandran C, Angelos KL, Walsh DA. Cyclic AMP-dependentand cyclic AMP-independent antagonism of insulin activation ofcardiac glycogen synthase. J Biol Chem 1982; 257: 1448-57.
-
(1982)
J Biol Chem
, vol.257
, pp. 1448-1457
-
-
Ramachandran, C.1
Angelos, K.L.2
Walsh, D.A.3
-
68
-
-
0022921469
-
Alterations of rat cardiac adenylate cyclase activitywith age
-
Robberecht P, Gillard M, Waelboeck M, Camus J-C, DeNeef P, Christophe J. Alterations of rat cardiac adenylate cyclase activitywith age. Eur J Pharmacol 1986; 126: 91-95.
-
(1986)
Eur J Pharmacol
, vol.126
, pp. 91-95
-
-
Robberecht, P.1
Gillard, M.2
Waelboeck, M.3
Camus, J-C.4
de Neef, P.5
Christophe, J.6
-
69
-
-
0023904381
-
Receptor occupancy and adenylate cyclase activation in ratliver and heart membranes by 10 glucagon analogs modified in position2, 3, 4, 25, 27, and/or 29
-
Robberecht P, Damien C, Moroder L, Coy DH, Wünsch E, ChristopheJ. Receptor occupancy and adenylate cyclase activation in ratliver and heart membranes by 10 glucagon analogs modified in position2, 3, 4, 25, 27, and/or 29. Regulat Pept 1988; 21: 117-28.
-
(1988)
Regulat Pept
, vol.21
, pp. 117-128
-
-
Robberecht, P.1
Damien, C.2
Moroder, L.3
Coy, D.H.4
Wünsch, E.5
Christophe, J.6
-
70
-
-
0023912592
-
Altered responsiveness of adenylate cyclaseto adenosine and other agents in the myocardial sarcolemma andaorta of spontaneously-hypertensive rats
-
Anand-Srivastava MB. Altered responsiveness of adenylate cyclaseto adenosine and other agents in the myocardial sarcolemma andaorta of spontaneously-hypertensive rats. Biochem Pharmacol1988; 37: 3017-22.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 3017-3022
-
-
Anand-Srivastava, M.B.1
-
71
-
-
0025270818
-
Glucagon stimulates thecardiac Ca2+ current by activation of adenylyl cyclase and inhibitionof phosphodiesterase
-
Méry P, Brechler V, Pavoine C, Pecke F. Glucagon stimulates thecardiac Ca2+ current by activation of adenylyl cyclase and inhibitionof phosphodiesterase. Nature 1990; 345: 158-61.
-
(1990)
Nature
, vol.345
, pp. 158-161
-
-
Méry, P.1
Brechler, V.2
Pavoine, C.3
Pecke, F.4
-
72
-
-
17444419736
-
The phosphodiesterase 3inhibitor cilostamide enhances inotropic responses to glucagon butnot to dobutamine in rat ventricular myocardium
-
Juan-Fita MJ, Vargas ML, Hernández J. The phosphodiesterase 3inhibitor cilostamide enhances inotropic responses to glucagon butnot to dobutamine in rat ventricular myocardium. Eur J Pharmacol2005; 512: 207-13.
-
(2005)
Eur J Pharmacol
, vol.512
, pp. 207-213
-
-
Juan-Fita, M.J.1
Vargas, M.L.2
Hernández, J.3
-
73
-
-
0031792161
-
cAMP-mediated signal transduction and sarcoplasmicreticular function in heart failure
-
Movsesian MA. cAMP-mediated signal transduction and sarcoplasmicreticular function in heart failure. Ann NY Acad Sci 1998;853: 231-39.
-
(1998)
Ann NY Acad Sci
, vol.853
, pp. 231-239
-
-
Movsesian, M.A.1
-
74
-
-
23044517378
-
Maintenance of the postabsorptive plasma glucoseconcentration: Insulin or insulin plus glucagon?
-
Raju B, Cryer PE. Maintenance of the postabsorptive plasma glucoseconcentration: insulin or insulin plus glucagon? Am J PhysiolEndocrinol Metab 2005; 289: E181-86.
-
(2005)
Am J PhysiolEndocrinol Metab
, vol.289
-
-
Raju, B.1
Cryer, P.E.2
-
75
-
-
50349088761
-
Insulin-like stimulation of cardiac fuelmetabolism by physiological levels of glucagon: Involvement ofPI3K but not cAMP
-
Harney JA, Rodgers RL. Insulin-like stimulation of cardiac fuelmetabolism by physiological levels of glucagon: involvement ofPI3K but not cAMP. Am J Physiol 2008; 295: E155-61.
-
(2008)
Am J Physiol
, vol.295
-
-
Harney, J.A.1
Rodgers, R.L.2
-
76
-
-
0035201478
-
Insulin like effects of a physiologic concentration of carnitine oncardiac metabolism
-
Rodgers R, Christe ME, Tremblay GC, Babson JR, Daniels T. Insulin like effects of a physiologic concentration of carnitine oncardiac metabolism. Mol Cell Biochem 2001; 226: 97-105.
-
(2001)
Mol Cell Biochem
, vol.226
, pp. 97-105
-
-
Rodgers, R.1
Christe, M.E.2
Tremblay, G.C.3
Babson, J.R.4
Daniels, T.5
-
77
-
-
0032401577
-
Mechanisms of control of heart glycolysis
-
Depré C, Rider MH, Hue L. Mechanisms of control of heart glycolysis. Eur J Biochem 1998; 258: 277-90.
-
(1998)
Eur J Biochem
, vol.258
, pp. 277-290
-
-
Depré, C.1
Rider, M.H.2
Hue, L.3
-
79
-
-
0032881288
-
AKT/PKB and other D3phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
-
Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation. Ann Rev Biochem 1999; 68:965-1014.
-
(1999)
Ann Rev Biochem
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
80
-
-
0031037296
-
Linkage of G-protein-coupled receptors to the MAPK signalingpathway through PI 3-kinase γ
-
Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. Linkage of G-protein-coupled receptors to the MAPK signalingpathway through PI 3-kinase γ. Science 1997; 275: 394-97.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
Gutkind, J.S.4
Wetzker, R.5
-
81
-
-
11144253483
-
Convergent signal transduction pathwayscontrolling cardiomyocyte survival and function: The role of PI 3-kinase and Akt
-
Matsui T, Rosenzweig A. Convergent signal transduction pathwayscontrolling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol 2005; 38: 63-71.
-
(2005)
J Mol Cell Cardiol
, vol.38
, pp. 63-71
-
-
Matsui, T.1
Rosenzweig, A.2
-
82
-
-
0036172306
-
Chemokine signalling: Pivotingaround multiple phosphoinositide 3-kinases
-
Curnock AP, Logan MK, Ward SG. Chemokine signalling: pivotingaround multiple phosphoinositide 3-kinases. Immunol 2002;105: 125-36.
-
(2002)
Immunol
, vol.105
, pp. 125-136
-
-
Curnock, A.P.1
Logan, M.K.2
Ward, S.G.3
-
84
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-7.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
85
-
-
3242698804
-
The role of phosphoinositide-3 kinase and PTEN in cardiovascularphysiology and disease
-
Oudit G, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH. The role of phosphoinositide-3 kinase and PTEN in cardiovascularphysiology and disease. J Mol Cell Cardiol 2004; 37:449-71.
-
(2004)
J Mol Cell Cardiol
, vol.37
, pp. 449-471
-
-
Oudit, G.1
Sun, H.2
Kerfant, B.G.3
Crackower, M.A.4
Penninger, J.M.5
Backx, P.H.6
-
86
-
-
79959525534
-
Pharmacological targeting of glucagon and glucagon-like peptide1 receptors has different effects on energy state and glucosehomeostasis in diet-induced obese mice
-
GuW, Lloyd DJ, Chinookswong N, Komorowski R, Sivits Jr G, Graham M, Winters KA, Yan H, Boros LG, Lindberg RA, VéniantMM. Pharmacological targeting of glucagon and glucagon-like peptide1 receptors has different effects on energy state and glucosehomeostasis in diet-induced obese mice. J Pharmacol Exper Ther2011; 338: 70-81.
-
(2011)
J Pharmacol Exper Ther
, vol.338
, pp. 70-81
-
-
Gu, W.1
Lloyd, D.J.2
Chinookswong, N.3
Komorowski, R.4
Sivits Jr, G.5
Graham, M.6
Winters, K.A.7
Yan, H.8
Boros, L.G.9
Lindberg, R.A.10
Véniant, M.M.11
-
87
-
-
0015978018
-
Effects of glucagon oncyclic AMP and carbohydrate metabolism in livers from diabeticrats
-
Pilkis SJ, Exton JH, Johnson RA, Park CR. Effects of glucagon oncyclic AMP and carbohydrate metabolism in livers from diabeticrats. Biochim Biophys Acta 1974; 343: 250-67.
-
(1974)
Biochim Biophys Acta
, vol.343
, pp. 250-267
-
-
Pilkis, S.J.1
Exton, J.H.2
Johnson, R.A.3
Park, C.R.4
-
88
-
-
0017640595
-
Studies onalpha-adrenergic activation of hepatic glucose output. Studies onrole of calcium in α-adrenergic activation of phosphorylase
-
Assimacopoulos-Jeannet FD, Blackmore PF, Exton JH. Studies onalpha-adrenergic activation of hepatic glucose output. Studies onrole of calcium in α-adrenergic activation of phosphorylase. J BiolChem 1977; 252: 2662-69.
-
(1977)
J BiolChem
, vol.252
, pp. 2662-2669
-
-
Assimacopoulos-Jeannet, F.D.1
Blackmore, P.F.2
Exton, J.H.3
-
89
-
-
0019934974
-
AngiotensinII inhibits the accumulation of cyclic AMP produced by glucagonbut not its metabolic effects
-
Cárdenas-Tanús RJ, Huerta-Bahena J, Garcia-Sáinz JA. AngiotensinII inhibits the accumulation of cyclic AMP produced by glucagonbut not its metabolic effects. FEBS Lett 1982; 143: 1-4.
-
(1982)
FEBS Lett
, vol.143
, pp. 1-4
-
-
Cárdenas-Tanús, R.J.1
Huerta-Bahena, J.2
Garcia-Sáinz, J.A.3
-
90
-
-
0018256261
-
Responsiveness to glucagon by isolated rathepatocytes controlled by the redox state of the cytosolic nicotinamide-adenine dinucleotide couple acting on adenosine 3':5'-cyclicmonophosphate phosphodiesterase
-
Clark MG, Jarrett IG. Responsiveness to glucagon by isolated rathepatocytes controlled by the redox state of the cytosolic nicotinamide-adenine dinucleotide couple acting on adenosine 3':5'-cyclicmonophosphate phosphodiesterase. Biochem J 1978; 176: 805-16.
-
(1978)
Biochem J
, vol.176
, pp. 805-816
-
-
Clark, M.G.1
Jarrett, I.G.2
-
91
-
-
0021135757
-
Metabolic effects and cyclic AMP levels produced byglucagon, (1-Nα-trinitrophenylhistidine12-homoarginine) glucagonand forskolin in isolated rat hepatocytes
-
Corvera S, Huerta-Bahena J, Pelton JT, Hruby VJ, Trivedi D, García-Sáinz JA. Metabolic effects and cyclic AMP levels produced byglucagon, (1-Nα-trinitrophenylhistidine12-homoarginine) glucagonand forskolin in isolated rat hepatocytes. Biochim Biophys Acta1984; 804: 434-41.
-
(1984)
Biochim Biophys Acta
, vol.804
, pp. 434-441
-
-
Corvera, S.1
Huerta-Bahena, J.2
Pelton, J.T.3
Hruby, V.J.4
Trivedi, D.5
García-Sáinz, J.A.6
-
92
-
-
0015240282
-
Studies on the roleof adenosine 3,5-monophosphate in the hepatic actions of glucagonand catecholamines
-
Exton J, Robison GA, Sutherland EW, Park CR. Studies on the roleof adenosine 3,5-monophosphate in the hepatic actions of glucagonand catecholamines. J Biol Chem 1971; 246: 6166-77.
-
(1971)
J Biol Chem
, vol.246
, pp. 6166-6177
-
-
Exton, J.1
Robison, G.A.2
Sutherland, E.W.3
Park, C.R.4
-
93
-
-
2442733778
-
Hormonal control of pyruvate kinaseactivity and of gluconeogenesis in isolated hepatocytes
-
Felíu JE, Hue L, Hers H-G. Hormonal control of pyruvate kinaseactivity and of gluconeogenesis in isolated hepatocytes. Proc NatAcad Sci USA 1976; 73: 2762-66.
-
(1976)
Proc NatAcad Sci USA
, vol.73
, pp. 2762-2766
-
-
Felíu, J.E.1
Hue, L.2
Hers, H-G.3
-
94
-
-
0024406131
-
Age-dependent effects ofphorbol ester on adenylate cyclase stimulation by glucagon in liverof female rats
-
Hermsdorf T, Dettmer D, Hofmann E. Age-dependent effects ofphorbol ester on adenylate cyclase stimulation by glucagon in liverof female rats. Biomed Biochim Acta 1989; 48: 255-60.
-
(1989)
Biomed Biochim Acta
, vol.48
, pp. 255-260
-
-
Hermsdorf, T.1
Dettmer, D.2
Hofmann, E.3
-
95
-
-
0032387694
-
Effects of glucagon on glycogenolysisand gluconeogenesis are region-specific in periportal andperivenous hepatocytes
-
Ikezawa Y, Yamatani K, Ogawa A, Ohnuma H, Igarashi M, DaimonM, Manaka H, Sasaki H. Effects of glucagon on glycogenolysisand gluconeogenesis are region-specific in periportal andperivenous hepatocytes. J Lab Clin Med 1998; 132: 547-55.
-
(1998)
J Lab Clin Med
, vol.132
, pp. 547-555
-
-
Ikezawa, Y.1
Yamatani, K.2
Ogawa, A.3
Ohnuma, H.4
Igarashi, M.5
Daimon, M.6
Manaka, H.7
Sasaki, H.8
-
96
-
-
0018947495
-
(Des-Histidine1) (Nεphenylthiocarbamoyllysine)-glucagon: Effects onglycogenolysis in perfused rat liver
-
Khan BA, Bregman MD, Nugent CA, Hruby VJ, Brendel K. (Des-Histidine1) (Nεphenylthiocarbamoyllysine)-glucagon: Effects onglycogenolysis in perfused rat liver. Biochem Biopys Res Commun1980; 93: 729-36.
-
(1980)
Biochem Biopys Res Commun
, vol.93
, pp. 729-736
-
-
Khan, B.A.1
Bregman, M.D.2
Nugent, C.A.3
Hruby, V.J.4
Brendel, K.5
-
97
-
-
0032696950
-
Dietary fat type alters glucose metabolism inisolated rat hepatocytes
-
Bizeau ME, Hazel JR. Dietary fat type alters glucose metabolism inisolated rat hepatocytes. J Nutrit Biochem 1999; 10: 709-15.
-
(1999)
J Nutrit Biochem
, vol.10
, pp. 709-715
-
-
Bizeau, M.E.1
Hazel, J.R.2
-
98
-
-
0021796390
-
Regulation of gluconeogenesisin hepatocytes from fasted alloxan-diabetic rats
-
Wernette-Hammond ME, Lardy HA. Regulation of gluconeogenesisin hepatocytes from fasted alloxan-diabetic rats. Diabetes 1985;34: 767-73.
-
(1985)
Diabetes
, vol.34
, pp. 767-773
-
-
Wernette-Hammond, M.E.1
Lardy, H.A.2
-
99
-
-
0017105833
-
Effect of glucagon on cyclic AMP, albuminmetabolism and incorporation of 14C-leucine intp proteins in isolatedparenchymal rat liver cells
-
Dich J, Gluud CN. Effect of glucagon on cyclic AMP, albuminmetabolism and incorporation of 14C-leucine intp proteins in isolatedparenchymal rat liver cells. Acta Physiol Scand 1976; 97: 457-69.
-
(1976)
Acta Physiol Scand
, vol.97
, pp. 457-469
-
-
Dich, J.1
Gluud, C.N.2
-
100
-
-
0021253305
-
Glucagon-stimulableadenylyl cyclase in rat liver. The impact of streptozotocin-induceddiabetes mellitus
-
Dighe RR, Roja FJ, Birnbaumer L, Garber AJ. Glucagon-stimulableadenylyl cyclase in rat liver. The impact of streptozotocin-induceddiabetes mellitus. J Clin Invest 1984; 73: 1013-23.
-
(1984)
J Clin Invest
, vol.73
, pp. 1013-1023
-
-
Dighe, R.R.1
Roja, F.J.2
Birnbaumer, L.3
Garber, A.J.4
-
101
-
-
0023028531
-
Synergistic inhibition of glucagon-inducedeffects on hepatic glucose metabolism in the presence of insulin anda cAMP antagonist
-
Marks JS, Botelho LHP. Synergistic inhibition of glucagon-inducedeffects on hepatic glucose metabolism in the presence of insulin anda cAMP antagonist. J Biol Chem 1986; 261: 15895-99.
-
(1986)
J Biol Chem
, vol.261
, pp. 15895-15899
-
-
Marks, J.S.1
Botelho, L.H.P.2
-
102
-
-
0015239241
-
The glucagon-sensitive adenylcyclase system in plasma membranes of rat liver. I. Properties
-
Pohl SL, Birnbaumer L, Rodbell M. The glucagon-sensitive adenylcyclase system in plasma membranes of rat liver. I. Properties. JBiol Chem 1986; 246: 1849-56.
-
(1986)
JBiol Chem
, vol.246
, pp. 1849-1856
-
-
Pohl, S.L.1
Birnbaumer, L.2
Rodbell, M.3
-
103
-
-
0017741944
-
Binding andbiological activity of glucagon in liver cell membranes of chronicallyhyperglucagonemic rats
-
Srikant CB, Freeman D, McKorkle K, Unger RH. Binding andbiological activity of glucagon in liver cell membranes of chronicallyhyperglucagonemic rats. J Biol Chem 1977; 252: 7434-38.
-
(1977)
J Biol Chem
, vol.252
, pp. 7434-7438
-
-
Srikant, C.B.1
Freeman, D.2
McKorkle, K.3
Unger, R.H.4
-
104
-
-
0021505496
-
Pulsatile glucagon deliveryenhances glucose production by perifused rat hepatocytes
-
Weigle DS, Koerker DJ, Goodner CJ. Pulsatile glucagon deliveryenhances glucose production by perifused rat hepatocytes. Am JPhysiol 1984; 247: E564-68.
-
(1984)
Am JPhysiol
, vol.247
-
-
Weigle, D.S.1
Koerker, D.J.2
Goodner, C.J.3
-
105
-
-
33749479524
-
Glucagon-mediated internalization of serine-phosphorylated glucagon receptorand Gsα in rat liver
-
Merlen C, Fabrega S, Desbuquois B, Unson CG, Authier F. Glucagon-mediated internalization of serine-phosphorylated glucagon receptorand Gsα in rat liver. FEBS Lett 2006; 580: 5697-5704.
-
(2006)
FEBS Lett
, vol.580
, pp. 5697-5704
-
-
Merlen, C.1
Fabrega, S.2
Desbuquois, B.3
Unson, C.G.4
Authier, F.5
-
106
-
-
78649882282
-
Insulininducedhypoglycemia increases hepatic sensitivity to glucagon indogs
-
Rivera N, Ramnanan CJ, An Z, Farmer T, Smith M, Farmer B, Irimia JM, Snead W, Lautz M, Roach P, Cherrington AD. Insulininducedhypoglycemia increases hepatic sensitivity to glucagon indogs. J Clin Invest 2010; 120: 4425-35.
-
(2010)
J Clin Invest
, vol.120
, pp. 4425-4435
-
-
Rivera, N.1
Ramnanan, C.J.2
An, Z.3
Farmer, T.4
Smith, M.5
Farmer, B.6
Irimia, J.M.7
Snead, W.8
Lautz, M.9
Roach, P.10
Cherrington, A.D.11
-
107
-
-
0020558967
-
Glucagon receptors on isolatedhepatocytes and hepatocyte membrane vesicles. Discrete populationswith ligand-and environment-dependent affinities
-
Bonnevie-Nielsen V, Tager HS. Glucagon receptors on isolatedhepatocytes and hepatocyte membrane vesicles. Discrete populationswith ligand-and environment-dependent affinities. J BiolChem 1983; 258: 1313-20.
-
(1983)
J BiolChem
, vol.258
, pp. 1313-1320
-
-
Bonnevie-Nielsen, V.1
Tager, H.S.2
-
108
-
-
0027396096
-
Simultaneoussolubilization of high-affinity receptors for VIP and glucagon andof a low-affinity binding protein for VIP, shown to be identical tocalmodulin
-
Andersson M, Carlquist M, Maletti M, Marie J-C. Simultaneoussolubilization of high-affinity receptors for VIP and glucagon andof a low-affinity binding protein for VIP, shown to be identical tocalmodulin. FEBS Lett 1993; 318: 35-40.
-
(1993)
FEBS Lett
, vol.318
, pp. 35-40
-
-
Andersson, M.1
Carlquist, M.2
Maletti, M.3
Marie, J-C.4
-
109
-
-
0023041534
-
Activation oftwo signal-transduction systems in hepatocytes by glucagon
-
Wakelam M, Murphy GJ, Hruby VJ, Houslay MD. Activation oftwo signal-transduction systems in hepatocytes by glucagon. Nature1986; 323: 68-71.
-
(1986)
Nature
, vol.323
, pp. 68-71
-
-
Wakelam, M.1
Murphy, G.J.2
Hruby, V.J.3
Houslay, M.D.4
-
110
-
-
0027531638
-
Expression cloning and signaling properties of the rat glucagon receptor
-
Jelinek L, Lok S, Rosenberg GB, Smith RA, Grant FJ, Biggs S, Bensch PA, Kuijper JL, Sheppard PO, Sprecher CA, O'Hara PJ, Foster D, Walker KM, Chen LHJ, McKernan PA, Kindsvogel W. Expression cloning and signaling properties of the rat glucagon receptor. Science 1993; 259: 1614-16.
-
(1993)
Science
, vol.259
, pp. 1614-1616
-
-
Jelinek, L.1
Lok, S.2
Rosenberg, G.B.3
Smith, R.A.4
Grant, F.J.5
Biggs, S.6
Bensch, P.A.7
Kuijper, J.L.8
Sheppard, P.O.9
Sprecher, C.A.10
O'Hara, P.J.11
Foster, D.12
Walker, K.M.13
Chen, L.H.J.14
McKernan, P.A.15
Kindsvogel, W.16
-
111
-
-
79951962147
-
CREB and the CRTC co-activators:Sensors for hormonal and metabolic signals
-
Altarejos JY, Montminy M. CREB and the CRTC co-activators:sensors for hormonal and metabolic signals. Nature Rev Mol CellBiol 2011; 12: 141-51.
-
(2011)
Nature Rev Mol CellBiol
, vol.12
, pp. 141-151
-
-
Altarejos, J.Y.1
Montminy, M.2
-
112
-
-
0015169502
-
Characteristics of glucagonaction on the hepatic adenylate cyclase system
-
Rodbell M, Birnbaumer L, Pohl SL. Characteristics of glucagonaction on the hepatic adenylate cyclase system. Biochem J 1971;125: 58P-59P.
-
(1971)
Biochem J
, vol.125
-
-
Rodbell, M.1
Birnbaumer, L.2
Pohl, S.L.3
-
113
-
-
0021356212
-
Hormonal regulation of hepatic gluconeogenesis
-
Kraus-Friedmann N. Hormonal regulation of hepatic gluconeogenesis. Physiol Rev 1984; 64: 170-259.
-
(1984)
Physiol Rev
, vol.64
, pp. 170-259
-
-
Kraus-Friedmann, N.1
-
114
-
-
0029019227
-
Regulation of glucagonreceptor mRNA in cultured primary rat hepatocytes by glucose andcAMP
-
Abrahamsen N, Lundgren K, Nishimura E. Regulation of glucagonreceptor mRNA in cultured primary rat hepatocytes by glucose andcAMP. J Biol Chem 1995; 270: 15853-57.
-
(1995)
J Biol Chem
, vol.270
, pp. 15853-15857
-
-
Abrahamsen, N.1
Lundgren, K.2
Nishimura, E.3
-
115
-
-
0025331424
-
Relative contribution of glycogenolysisand gluconeogenesis to basal, glucagon-and nerve stimulationdependentglucose output in the perfused liver from fed and fastedrats
-
Beuers U, Jungermann K Relative contribution of glycogenolysisand gluconeogenesis to basal, glucagon-and nerve stimulationdependentglucose output in the perfused liver from fed and fastedrats. Biochem Int 1990; 21: 405-15.
-
(1990)
Biochem Int
, vol.21
, pp. 405-415
-
-
Beuers, U.1
Jungermann, K.2
-
116
-
-
0020972416
-
Gluconeogenesis and related aspects of glycolysis
-
Hers HG, Hue L. Gluconeogenesis and related aspects of glycolysis. Ann Rev Biochem 1983; 52: 617-53.
-
(1983)
Ann Rev Biochem
, vol.52
, pp. 617-653
-
-
Hers, H.G.1
Hue, L.2
-
117
-
-
0023099179
-
Mechanisms of hormonal regulation of hepatic glucosemetabolism
-
Exton JH. Mechanisms of hormonal regulation of hepatic glucosemetabolism. Diabet Metab Rev 1987; 3: 163-83.
-
(1987)
Diabet Metab Rev
, vol.3
, pp. 163-183
-
-
Exton, J.H.1
-
118
-
-
78651272137
-
Hormonal regulation of gluconeogenicgene transcription in the liver
-
Yabaluri N, Bashyam MD. Hormonal regulation of gluconeogenicgene transcription in the liver. J Biosci 2010; 35: 473-84.
-
(2010)
J Biosci
, vol.35
, pp. 473-484
-
-
Yabaluri, N.1
Bashyam, M.D.2
-
119
-
-
0025914685
-
Hepatic gluconeogenesis/glycolysis: Regulationand structure/function relationships
-
Pilkis SJ, Claus TH. Hepatic gluconeogenesis/glycolysis: Regulationand structure/function relationships. Ann Rev Nutr 1991; 11:465-515.
-
(1991)
Ann Rev Nutr
, vol.11
, pp. 465-515
-
-
Pilkis, S.J.1
Claus, T.H.2
-
120
-
-
0020613008
-
Inhibition of transcriptionof the phosphoeolpyruvate carboxykinase gene by insulin
-
Granner D, Andreone T, Sasaki K, Beale E. Inhibition of transcriptionof the phosphoeolpyruvate carboxykinase gene by insulin. Nature1983; 305: 549-51.
-
(1983)
Nature
, vol.305
, pp. 549-551
-
-
Granner, D.1
Andreone, T.2
Sasaki, K.3
Beale, E.4
-
121
-
-
0021367985
-
Hormonalregulation of key gluconeogenic enzymes and glucose release incultured hepatocytes: Effects of dexamethasone and gastrointestinalhormones on glucagon action
-
Fleig WE, Noether-Fleig G, Roeben H, Ditchuneit H. Hormonalregulation of key gluconeogenic enzymes and glucose release incultured hepatocytes: Effects of dexamethasone and gastrointestinalhormones on glucagon action. Arch Biochem Biophys 1984; 229:368-78.
-
(1984)
Arch Biochem Biophys
, vol.229
, pp. 368-378
-
-
Fleig, W.E.1
Noether-Fleig, G.2
Roeben, H.3
Ditchuneit, H.4
-
122
-
-
0021679330
-
Multihormonal regulation of phosphoenolpyruvatecarboxykinase gene transcription. The dominant role of insulin
-
Sasaki K, Cripe TP, Koch SR, Andreone TL, Petersen DD, BealeEG, Granner DK. Multihormonal regulation of phosphoenolpyruvatecarboxykinase gene transcription. The dominant role of insulin. J Biol Chem. 1984; 259: 15242-51.
-
(1984)
J Biol Chem.
, vol.259
, pp. 15242-15251
-
-
Sasaki, K.1
Cripe, T.P.2
Koch, S.R.3
Andreone, T.L.4
Petersen, D.D.5
Beale, E.G.6
Granner, D.K.7
-
123
-
-
0024210013
-
Regulation of theexpression of the phosphoenolpyruvate carboxykinase gene in culturedrat hepatocytes by glucagon and insulin
-
Christ B, Nath A, Bastian H, Jungermann K. Regulation of theexpression of the phosphoenolpyruvate carboxykinase gene in culturedrat hepatocytes by glucagon and insulin. Eur J Biochem 1988;178: 373-79.
-
(1988)
Eur J Biochem
, vol.178
, pp. 373-379
-
-
Christ, B.1
Nath, A.2
Bastian, H.3
Jungermann, K.4
-
124
-
-
0025316920
-
Mechanism of the inhibition byinsulin of the glucagon-dependent activation of the phosphoenolpyruvatecarboxykinase gene in rat hepatocyte cultures. Action ongene transcription, mRNA level and-stability as well as hysteresiseffect
-
Christ B, Nath A, Jungermann K. Mechanism of the inhibition byinsulin of the glucagon-dependent activation of the phosphoenolpyruvatecarboxykinase gene in rat hepatocyte cultures. Action ongene transcription, mRNA level and-stability as well as hysteresiseffect. Biol Chem Hoppe-Seyler 1990; 371: 395-402.
-
(1990)
Biol Chem Hoppe-Seyler
, vol.371
, pp. 395-402
-
-
Christ, B.1
Nath, A.2
Jungermann, K.3
-
125
-
-
0036787607
-
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcriptionfactor Fox01
-
Nakae J, Biggs WH 3rd, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D. Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcriptionfactor Fox01. Nat Genet 2002; 32: 245-53.
-
(2002)
Nat Genet
, vol.32
, pp. 245-253
-
-
Nakae, J.1
Biggs III, W.H.2
Kitamura, T.3
Cavenee, W.K.4
Wright, C.V.5
Arden, K.C.6
Accili, D.7
-
126
-
-
0141839103
-
Novel concepts in insulin regulation of hepaticgluconeogenesis
-
Barthel A, Schmoll D. Novel concepts in insulin regulation of hepaticgluconeogenesis. Am J Physiol 2003; 285: E685-92.
-
(2003)
Am J Physiol
, vol.285
-
-
Barthel, A.1
Schmoll, D.2
-
127
-
-
34548831102
-
Insulin modulates gluconeogenesis by inhibitionof the coactivator TORC2
-
Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Herediea J, Yates J3rd, Montminy M. Insulin modulates gluconeogenesis by inhibitionof the coactivator TORC2. Nature 2007; 449: 366-69.
-
(2007)
Nature
, vol.449
, pp. 366-369
-
-
Dentin, R.1
Liu, Y.2
Koo, S.H.3
Hedrick, S.4
Vargas, T.5
Herediea, J.6
Yates III, J.7
Montminy, M.8
-
128
-
-
47249114106
-
How insulin receptorsubstrate proteins regulate the metabolic capacity of the liver-implications for health and disease
-
Fritche L, Weigert C, Häring H-U, Lehmann R. How insulin receptorsubstrate proteins regulate the metabolic capacity of the liver-implications for health and disease. Curr Med Chem 2008; 15:1316-29.
-
(2008)
Curr Med Chem
, vol.15
, pp. 1316-1329
-
-
Fritche, L.1
Weigert, C.2
Häring, H-U.3
Lehmann, R.4
-
129
-
-
58849155132
-
Mechanism and managementof AKT inhibitor-induced hyperglycemia
-
Crouthamel M-C, Kahana JA, Korenchuk S, Zhang S-Y, SundaresanG, Eberwein DJ, Brown KK, Kumar R. Mechanism and managementof AKT inhibitor-induced hyperglycemia. Clin Cancer Res2009; 15: 217-25.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 217-225
-
-
Crouthamel, M-C.1
Kahana, J.A.2
Korenchuk, S.3
Zhang, S-Y.4
Sundaresan, G.5
Eberwein, D.J.6
Brown, K.K.7
Kumar, R.8
-
130
-
-
79251557845
-
Targeting forkhead box 01 from the conceptto metabolic diseases: Lessons from mouse models
-
Cheng Z, White MF. Targeting forkhead box 01 from the conceptto metabolic diseases: Lessons from mouse models. Antioxid RedoxSignal 2011; 14: 649-61.
-
(2011)
Antioxid RedoxSignal
, vol.14
, pp. 649-661
-
-
Cheng, Z.1
White, M.F.2
-
131
-
-
84859735682
-
HMGA1 is a noveldownstream nuclear target of the insulin receptor signaling pathway
-
Chiefari E, Nevolo MT, Arcidiacono B, Maurizio E, Nocera A, Liritano S, Sgarra R, Passidente K, Palmieri C, Paonessa F, BrunettiG, Manfioletti G, Foti D, Brunetti A. HMGA1 is a noveldownstream nuclear target of the insulin receptor signaling pathway. PLoS 1 2012; 6: 1-10.
-
(2012)
PLoS 1
, vol.6
, pp. 1-10
-
-
Chiefari, E.1
Nevolo, M.T.2
Arcidiacono, B.3
Maurizio, E.4
Nocera, A.5
Liritano, S.6
Sgarra, R.7
Passidente, K.8
Palmieri, C.9
Paonessa, F.10
Brunetti, G.11
Manfioletti, G.12
Foti, D.13
Brunetti, A.14
-
132
-
-
0021954753
-
Pretranslationalregulation of tyrosine aminotransferase and phosphoenolpyruvatecarboxykinase (GTP) synthesis by glucagon and dexamethasone inadult rat hepatocytes
-
Iyendjian PB, Auberger P, Guigoz Y, LeCam A. Pretranslationalregulation of tyrosine aminotransferase and phosphoenolpyruvatecarboxykinase (GTP) synthesis by glucagon and dexamethasone inadult rat hepatocytes. Biochem J year 225: 77-84, 1985.
-
(1985)
Biochem J year
, vol.225
, pp. 77-84
-
-
Iyendjian, P.B.1
Auberger, P.2
Guigoz, Y.3
LeCam, A.4
-
133
-
-
0030998776
-
Regulation of phosphoenolpyruvate carboxykinase(GTP) gene expression
-
Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase(GTP) gene expression. Annu Rev Biochem 1997; 66:581-611.
-
(1997)
Annu Rev Biochem
, vol.66
, pp. 581-611
-
-
Hanson, R.W.1
Reshef, L.2
-
134
-
-
0041756347
-
cAMP stimulates transcriptionof the gene for cytosolic phosphoenolpyruvate carboxykinasein rat liver nuclei
-
Lamers WH, Hanson RW, Meisner HM. cAMP stimulates transcriptionof the gene for cytosolic phosphoenolpyruvate carboxykinasein rat liver nuclei. Proc Natl Acad Sci (USA) 1982; 79:5137-41.
-
(1982)
Proc Natl Acad Sci (USA)
, vol.79
, pp. 5137-5141
-
-
Lamers, W.H.1
Hanson, R.W.2
Meisner, H.M.3
-
135
-
-
0035430282
-
Transcriptional regulation by the phosphorylation-dependent factor CREB
-
Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Mol Cell Biol 2001; 2: 599-609.
-
(2001)
Mol Cell Biol
, vol.2
, pp. 599-609
-
-
Mayr, B.1
Montminy, M.2
-
136
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivatorPCG-1
-
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, RudolphD, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivatorPCG-1. Nature 2001; 413: 179-83.
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Puigserver, P.10
Spiegelman, B.11
Montminy, M.12
-
137
-
-
20644460348
-
Factors thatcontrol the tissue-specific transcription of the gene for phosphoenolpyruvatecarboxykinase
-
Chakravarty K, Cassuto H, Reshef L, Hanson RW. Factors thatcontrol the tissue-specific transcription of the gene for phosphoenolpyruvatecarboxykinase. Crit Rev Biochem Mol Biol 2005; 40:129-154.
-
(2005)
Crit Rev Biochem Mol Biol
, vol.40
, pp. 129-154
-
-
Chakravarty, K.1
Cassuto, H.2
Reshef, L.3
Hanson, R.W.4
-
138
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucosemetabolism
-
Koo S-H, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar S, Brindle P, Takemori H, MontminyM. The CREB coactivator TORC2 is a key regulator of fasting glucosemetabolism. Nature 2005; 437:1109-14.
-
(2005)
Nature
, vol.437
, pp. 1109-1114
-
-
Koo, S-H.1
Flechner, L.2
Qi, L.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, S.9
Brindle, P.10
Takemori, H.11
Montminy, M.12
-
139
-
-
33645055091
-
Dual role of the coactivator TORC2 in modulatinghepatic glucose output and insulin signaling
-
Canettieri G, Koo S-H, Berdeaux R, Heredia J, Hedrick S, ZhangX, Montminy M. Dual role of the coactivator TORC2 in modulatinghepatic glucose output and insulin signaling. Cell Metab 2005;2: 331-38.
-
(2005)
Cell Metab
, vol.2
, pp. 331-338
-
-
Canettieri, G.1
Koo, S-H.2
Berdeaux, R.3
Heredia, J.4
Hedrick, S.5
Zhang, X.6
Montminy, M.7
-
141
-
-
47249114106
-
How insulin receptorsubstrate proteins regulate the metabolic capacity of the liver-implications for health and disease
-
Fritsche L, Weigert C, Häring H-U, Lehmann R. How insulin receptorsubstrate proteins regulate the metabolic capacity of the liver-implications for health and disease. Curr Med Chem 2008; 15:1316-29.
-
(2008)
Curr Med Chem
, vol.15
, pp. 1316-1329
-
-
Fritsche, L.1
Weigert, C.2
Häring, H-U.3
Lehmann, R.4
-
142
-
-
63849206613
-
AMP-activated protein kinase in the regulationof hepatic energy metabolism: From physiology to therapeuticperspectives
-
Viollet B, Guigas B, Leclerc J, Hébrard S, Lantier L, Mounier R, Andreelli F, Foretz M. AMP-activated protein kinase in the regulationof hepatic energy metabolism: from physiology to therapeuticperspectives. Acta Physiol (Oxf) 2009; 196: 81-98.
-
(2009)
Acta Physiol (Oxf)
, vol.196
, pp. 81-98
-
-
Viollet, B.1
Guigas, B.2
Leclerc, J.3
Hébrard, S.4
Lantier, L.5
Mounier, R.6
Andreelli, F.7
Foretz, M.8
-
143
-
-
11244335844
-
A distal region involvinghepatocyte nuclear factor 4α and CAAT/Enhancer binding proteinmarkedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter
-
Gautier-Stein A, Mithieux G, Rajas F. A distal region involvinghepatocyte nuclear factor 4α and CAAT/Enhancer binding proteinmarkedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter. Mol Endocrinol 2005; 19: 163-74.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 163-174
-
-
Gautier-Stein, A.1
Mithieux, G.2
Rajas, F.3
-
144
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through thecoactivator PGC-1
-
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Pulgserver P, Splegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through thecoactivator PGC-1. Nature 2001; 413: 179-83.
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Pulgserver, P.10
Splegelman, B.11
Montminy, M.12
-
145
-
-
0035808330
-
Mice with a deletion in the gene for CCAAT/Enhancerbindingprotein β have an attenuated response to cAMP and impairedcarbohydrate metabolism
-
Croniger CM, Millward C, Yang J, Kawai Y, Arinze IJ, Liu S, Harada-Shiba M, Chakravarty K, Friedman JE, Poli V, HansonRW. Mice with a deletion in the gene for CCAAT/Enhancerbindingprotein β have an attenuated response to cAMP and impairedcarbohydrate metabolism. J Biol Chem 2001; 276: 629-38.
-
(2001)
J Biol Chem
, vol.276
, pp. 629-638
-
-
Croniger, C.M.1
Millward, C.2
Yang, J.3
Kawai, Y.4
Arinze, I.J.5
Liu, S.6
Harada-Shiba, M.7
Chakravarty, K.8
Friedman, J.E.9
Poli, V.10
Hanson, R.W.11
-
146
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptionalcoactivator PGC-1
-
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, AdelmantG, Stafford J, Kahn CR, Granner DK, Newgard CB, SpiegelmanBM. Control of hepatic gluconeogenesis through the transcriptionalcoactivator PGC-1. Nature 2001; 413: 131-38.
-
(2001)
Nature
, vol.413
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
147
-
-
2442701392
-
PGC-1 promotes insulin resistancein liver through PPAR-α-dependent induction of TRB-3
-
Koo S-H, Satoh H, Herzig S, Lee C-H, Hedrick S, Kuldarni R, Evans RM, Olefsky J, Montminy M. PGC-1 promotes insulin resistancein liver through PPAR-α-dependent induction of TRB-3. NatureMed 2004; 10: 530-34.
-
(2004)
NatureMed
, vol.10
, pp. 530-534
-
-
Koo, S-H.1
Satoh, H.2
Herzig, S.3
Lee, C-H.4
Hedrick, S.5
Kuldarni, R.6
Evans, R.M.7
Olefsky, J.8
Montminy, M.9
-
148
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucosemetabolism
-
Koo S-H, Flechner L, Ling Q, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, MontminyM. The CREB coactivator TORC2 is a key regulator of fasting glucosemetabolism. Nature 2005; 437: 1109-14.
-
(2005)
Nature
, vol.437
, pp. 1109-1114
-
-
Koo, S-H.1
Flechner, L.2
Ling, Q.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, F.9
Brindle, P.10
Takemori, H.11
Montminy, M.12
-
149
-
-
67649657842
-
CRTC2 (TORC2) contributes to the transcriptional respons to fastingin the liver but is not required for the maintenance of glucosehomeostasis
-
Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. CRTC2 (TORC2) contributes to the transcriptional respons to fastingin the liver but is not required for the maintenance of glucosehomeostasis. Cell Metab 2009; 10: 55-62.
-
(2009)
Cell Metab
, vol.10
, pp. 55-62
-
-
Le Lay, J.1
Tuteja, G.2
White, P.3
Dhir, R.4
Ahima, R.5
Kaestner, K.H.6
-
150
-
-
0347988171
-
Regulation of hepatic glucosemetabolism by leptin in pig and rat primary hepatocytes
-
Raman P, Donkin SS, Spurlock ME. Regulation of hepatic glucosemetabolism by leptin in pig and rat primary hepatocytes. Am JPhysiol 2004; 286: R206-16.
-
(2004)
Am JPhysiol
, vol.286
-
-
Raman, P.1
Donkin, S.S.2
Spurlock, M.E.3
-
151
-
-
5344228270
-
The CREB coactivator TORC2 functions as acalcium-and cAMP-sensitive conincindence detector
-
Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, JeffriesS, Guzman E, Niessen S, Yates JR 3rd, Takemori H, OkamotoM, Montminy M. The CREB coactivator TORC2 functions as acalcium-and cAMP-sensitive conincindence detector. Cell 2004;119: 61-74.
-
(2004)
Cell
, vol.119
, pp. 61-74
-
-
Screaton, R.A.1
Conkright, M.D.2
Katoh, Y.3
Best, J.L.4
Canettieri, G.5
Jeffries, S.6
Guzman, E.7
Niessen, S.8
Yates III, J.R.9
Takemori, H.10
Okamoto, M.11
Montminy, M.12
-
152
-
-
0017227895
-
Effects of physiological levels of glucagon andgrowth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone duringsuppression of endogenous hormone secretion with somatostatin
-
Gerich JE, Lorenzi M, Bier DM, Tsalifian E, Schneider V, KaramJH, Forsham PH. Effects of physiological levels of glucagon andgrowth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone duringsuppression of endogenous hormone secretion with somatostatin. JClin Invest 1976; 57: 875-84.
-
(1976)
JClin Invest
, vol.57
, pp. 875-884
-
-
Gerich, J.E.1
Lorenzi, M.2
Bier, D.M.3
Tsalifian, E.4
Schneider, V.5
Karam, J.H.6
Forsham, P.H.7
-
153
-
-
70350447639
-
Novel Liver-specific TORC2 siRNA corrects hyperglycemiain rodent models of type 2 diabetes
-
Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, LiP, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, PoliskyB, Olefsky JM. Novel Liver-specific TORC2 siRNA corrects hyperglycemiain rodent models of type 2 diabetes. Am J Physiol2009; 297: E1137-46.
-
(2009)
Am J Physiol
, vol.297
-
-
Saberi, M.1
Bjelica, D.2
Schenk, S.3
Imamura, T.4
Bandyopadhyay, G.5
Li, P.6
Jadhar, V.7
Vargeese, C.8
Wang, W.9
Bowman, K.10
Zhang, Y.11
Polisky, B.12
Olefsky, J.M.13
-
154
-
-
77954980506
-
Glucagon deficiencyreduces hepatic glucose production and improves glucose tolerancein adult mice
-
Hancock AS, Du A, Liu J, Miller M, May CL. Glucagon deficiencyreduces hepatic glucose production and improves glucose tolerancein adult mice. Mol Endocrinol 2010; 24: 1605-14.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1605-1614
-
-
Hancock, A.S.1
du, A.2
Liu, J.3
Miller, M.4
May, C.L.5
-
155
-
-
0032947501
-
Hypoglycemia and impaired hepaticglucose production in mice with a deletion of the C/EBPbeta gene
-
Liu S, Croniger C, Arizmendi C, Garada-Shiba M, Ren J, Poli V, Hanson RW, Friedman JE. Hypoglycemia and impaired hepaticglucose production in mice with a deletion of the C/EBPbeta gene. J Clin Invest 1999; 103: 207-13.
-
(1999)
J Clin Invest
, vol.103
, pp. 207-213
-
-
Liu, S.1
Croniger, C.2
Arizmendi, C.3
Garada-Shiba, M.4
Ren, J.5
Poli, V.6
Hanson, R.W.7
Friedman, J.E.8
-
156
-
-
0030989153
-
Differential regulation of the mitogen-activated protein andstress-activated protein kinase cascades by adrenergic agonists inquiescent and regenerating adult rat hepatocytes
-
Spector MS, Auer K, Jarvis WD, Ishac EJN, Gao B, Kunos G, DentP. Differential regulation of the mitogen-activated protein andstress-activated protein kinase cascades by adrenergic agonists inquiescent and regenerating adult rat hepatocytes. Mol Cell Biol1997; 17: 3556-65.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 3556-3565
-
-
Spector, M.S.1
Auer, K.2
Jarvis, W.D.3
Ishac, E.J.N.4
Gao, B.5
Kunos, G.6
Dent, P.7
-
157
-
-
11144219992
-
Glucagon represses signalingthrough the mammalian target of rapamycin in rat liver byactivating AMP-activated protein kinase
-
Kimball SR, Siegfried BA, Jefferson LS. Glucagon represses signalingthrough the mammalian target of rapamycin in rat liver byactivating AMP-activated protein kinase. J Biol Chem 2004; 279:54103-09.
-
(2004)
J Biol Chem
, vol.279
, pp. 54103-54109
-
-
Kimball, S.R.1
Siegfried, B.A.2
Jefferson, L.S.3
-
158
-
-
30044436829
-
p38 Mitogen-activated proteinkinase plays a stimulatory role in hepatic gluconeogenesis
-
Cao W, Collins QF, Becker TC, Robidoux J, Lupo EG, Xiong Y, Daniel KW, Floering L, Collins S. p38 Mitogen-activated proteinkinase plays a stimulatory role in hepatic gluconeogenesis. J BiolChem 2005; 280: 42731-37.
-
(2005)
J BiolChem
, vol.280
, pp. 42731-42737
-
-
Cao, W.1
Collins, Q.F.2
Becker, T.C.3
Robidoux, J.4
Lupo, E.G.5
Xiong, Y.6
Daniel, K.W.7
Floering, L.8
Collins, S.9
-
159
-
-
2442555002
-
Glucagon promotes cAMP-response elementbindingprotein phosphorylation via activation of ERK1/2 in MIN6cell line and isolated islets of Langerhans
-
Dalle S, Longuet C, Costes S, Broca C, Faruque O, Fontés G, HaniEH, Bataille D. Glucagon promotes cAMP-response elementbindingprotein phosphorylation via activation of ERK1/2 in MIN6cell line and isolated islets of Langerhans. J Biol Chem 2004; 279:20345-55.
-
(2004)
J Biol Chem
, vol.279
, pp. 20345-20355
-
-
Dalle, S.1
Longuet, C.2
Costes, S.3
Broca, C.4
Faruque, O.5
Fontés, G.6
Hani, E.H.7
Bataille, D.8
-
160
-
-
33748463364
-
NR4A orphan nuclear receptors are transcriptional regulators of hepaticglucose metabolism
-
Pei L, Waki H, Vaitheesvaran B, Wilpitz D, Kurland I, Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepaticglucose metabolism. Nature Med 2006; 12: 1048-55.
-
(2006)
Nature Med
, vol.12
, pp. 1048-1055
-
-
Pei, L.1
Waki, H.2
Vaitheesvaran, B.3
Wilpitz, D.4
Kurland, I.5
Tontonoz, P.6
-
161
-
-
33646525394
-
Cross-talk between angiotensin IIand glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangialcells
-
Li XC, Carretero OA, Zhuo JL. Cross-talk between angiotensin IIand glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangialcells. Biochem Pharmacol 2006; 71: 1711-19.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1711-1719
-
-
Li, X.C.1
Carretero, O.A.2
Zhuo, J.L.3
-
162
-
-
33644987298
-
Glucagon receptormediatedextracellular signal-regulated kinase 1/2 phosphorylationin rat mesangial cells: Role of protein kinase A and phospholipaseC
-
Li XC, Carretero OA, Shao Y, Zhuo JL. Glucagon receptormediatedextracellular signal-regulated kinase 1/2 phosphorylationin rat mesangial cells: role of protein kinase A and phospholipaseC. Hypertension 2006; 47: 580-85.
-
(2006)
Hypertension
, vol.47
, pp. 580-585
-
-
Li, X.C.1
Carretero, O.A.2
Shao, Y.3
Zhuo, J.L.4
-
163
-
-
77957768686
-
AMPK-dependent repression of hepatic gluconeogenesisvia disruption of CREB·CRTC2 complex by orphan nuclear receptorsmall heterodimer partner
-
Lee J-M. Seo W-Y, Song K-H, Chanda D, Kim YD, Kim D-K, LeeM-W, Ryu D, Kim Y-H, Noh J-R, Lee C-H, Chiang JYL, Koo S-H, Choi H-S. AMPK-dependent repression of hepatic gluconeogenesisvia disruption of CREB·CRTC2 complex by orphan nuclear receptorsmall heterodimer partner. J Biol Chem 2010; 285: 32182-91.
-
(2010)
J Biol Chem
, vol.285
, pp. 32182-32191
-
-
Lee, J-M.1
Seo, W.-Y.2
Song, K.-H.3
Chanda, D.4
Kim, Y.D.5
Kim, D.-K.6
Lee, M.-W.7
Ryu, D.8
Kim, Y.-H.9
Noh, J.-R.10
Lee, C.-H.11
Chiang, J.Y.L.12
Koo, S.-H.13
Choi, H.-S.14
-
164
-
-
84872619882
-
Inhibition of rat hepatocyteproliferation by transforming growth factor β and glucagon isassociated with inhibition of ERK2 and p70 S6 kinase
-
Dixon M, Agius L, Yeaman SJ, Day CP. Inhibition of rat hepatocyteproliferation by transforming growth factor β and glucagon isassociated with inhibition of ERK2 and p70 S6 kinase. Hepatology1999; 29: 8-24.
-
(1999)
Hepatology
, vol.29
, pp. 8-24
-
-
Dixon, M.1
Agius, L.2
Yeaman, S.J.3
Day, C.P.4
-
166
-
-
79961202907
-
Metabolic impact of glucagon deficiency
-
Hayashi Y. Metabolic impact of glucagon deficiency. DiabetesObesity Metab 2011; 13 (Suppl 1): 151-157.
-
(2011)
DiabetesObesity Metab
, vol.13
, Issue.SUPPL. 1
, pp. 151-157
-
-
Hayashi, Y.1
-
167
-
-
0023896220
-
The low activity of acetyl-CoA carboxylase inbasal and glucagon-stimulated hepatocytes is due to phosphorylationby the AMP-activated protein kinase and not cyclic AMP dependentprotein kinase
-
Sim AT, Hardie DG. The low activity of acetyl-CoA carboxylase inbasal and glucagon-stimulated hepatocytes is due to phosphorylationby the AMP-activated protein kinase and not cyclic AMP dependentprotein kinase. FEBS Lett 2008; 233:294-8.
-
(2008)
FEBS Lett
, vol.233
, pp. 294-298
-
-
Sim, A.T.1
Hardie, D.G.2
-
168
-
-
68849090270
-
Hepatic energy state is regulated by glucagon receptorsignaling in mice
-
Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, WassermanDH. Hepatic energy state is regulated by glucagon receptorsignaling in mice. J Clin Invest 2009; 119: 2412-2422.
-
(2009)
J Clin Invest
, vol.119
, pp. 2412-2422
-
-
Berglund, E.D.1
Lee-Young, R.S.2
Lustig, D.G.3
Lynes, S.E.4
Donahue, E.P.5
Camacho, R.C.6
Meredith, M.E.7
Magnuson, M.A.8
Charron, M.J.9
Wasserman, D.H.10
-
169
-
-
77957556136
-
Glucagon and lipid interactions in the regulation of hepatic AMPKsignaling and expression of PPARalpha and FGF21 transcripts invivo
-
Berglund ED, Kang L, Lee-Young RS, Hasenour CM, Lustig DG, Lynes SE, Donahue EP, Swift LL, Charron MJ, Wasserman DH. Glucagon and lipid interactions in the regulation of hepatic AMPKsignaling and expression of PPARalpha and FGF21 transcripts invivo. Am J Physiol 2010; 299: E607-E614.
-
(2010)
Am J Physiol
, vol.299
-
-
Berglund, E.D.1
Kang, L.2
Lee-Young, R.S.3
Hasenour, C.M.4
Lustig, D.G.5
Lynes, S.E.6
Donahue, E.P.7
Swift, L.L.8
Charron, M.J.9
Wasserman, D.H.10
-
170
-
-
0027514976
-
Calcium-mobilizing effectors inhibitP-enolpyruvate carboxykinase gene expression in cultured rat hepatocytes
-
Valera A, Solanes G, Bosch F. Calcium-mobilizing effectors inhibitP-enolpyruvate carboxykinase gene expression in cultured rat hepatocytes. FEBS Lett. 1993; 333: 319-24.
-
(1993)
FEBS Lett
, vol.333
, pp. 319-324
-
-
Valera, A.1
Solanes, G.2
Bosch, F.3
-
171
-
-
0027943988
-
Differential activation ofCREB by Ca2+/calmodulin-dependent protein kinase type II andtype IV involves phosphorylation of a site that negatively regulatesactivity
-
Sun, P., Enslen, H., Myung, P. Maurer, R. Differential activation ofCREB by Ca2+/calmodulin-dependent protein kinase type II andtype IV involves phosphorylation of a site that negatively regulatesactivity. Genes Dev. 1994; 8: 2527-39.
-
(1994)
Genes Dev.
, vol.8
, pp. 2527-2539
-
-
Sun, P.1
Enslen, H.2
Myung, P.3
Maurer, R.4
-
172
-
-
33947530431
-
p-38 mitogen-activated protein kinase plays an inhibitoryrole in hepatic lipogenesis
-
Xiong Y, Collins QF, An J, Lupo Jr. E, Liu H-Y, Liu D, RobidouxJ, Liu Z, Cao W. p-38 mitogen-activated protein kinase plays an inhibitoryrole in hepatic lipogenesis. J Biol Chem 2007; 282: 12056-63.
-
(2007)
J Biol Chem
, vol.282
, pp. 12056-12063
-
-
Xiong, Y.1
Collins, Q.F.2
An, J.3
Lupo Jr., E.4
Liu, H.-Y.5
Liu, D.6
Robidoux, J.7
Liu, Z.8
Cao, W.9
-
174
-
-
0019823948
-
Glucagonstimulation of fructose 1,6-bisphosphatase phosphorylationin rat hepatocytes
-
Claus TH, Schlumpf J, Maghrabi MR, McGrane M, Pilkis SJ. Glucagonstimulation of fructose 1,6-bisphosphatase phosphorylationin rat hepatocytes. Biochem Biophys Res Commun 1981; 100: 716-23.
-
(1981)
Biochem Biophys Res Commun
, vol.100
, pp. 716-723
-
-
Claus, T.H.1
Schlumpf, J.2
Maghrabi, M.R.3
McGrane, M.4
Pilkis, S.J.5
-
175
-
-
0024565413
-
Evidence indicating that glucagoninducedincrease in cytoplasmic free Ca2+concentration in hepatocytesis mediated by an increase in cyclic AMP concentration
-
Staddon JM, Hansford RG. Evidence indicating that glucagoninducedincrease in cytoplasmic free Ca2+concentration in hepatocytesis mediated by an increase in cyclic AMP concentration. Eur JBiochem 1989; 179: 47-52.
-
(1989)
Eur JBiochem
, vol.179
, pp. 47-52
-
-
Staddon, J.M.1
Hansford, R.G.2
-
176
-
-
0023664159
-
A study ofthe mechanism of glucagon-induced protein phosphorylation in isolatedrat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, thestimulatory and inhibitory diastereomers of adenosine cyclic 3'-5'-phosphorothioate
-
Connelly PA, Parker Botelho LH, Sisk RB, Garrison JC. A study ofthe mechanism of glucagon-induced protein phosphorylation in isolatedrat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, thestimulatory and inhibitory diastereomers of adenosine cyclic 3'-5'-phosphorothioate. J Biol Chem 1987; 262: 4324-32.
-
(1987)
J Biol Chem
, vol.262
, pp. 4324-4332
-
-
Connelly, P.A.1
Parker Botelho, L.H.2
Sisk, R.B.3
Garrison, J.C.4
-
177
-
-
0029562538
-
Glucagon stimulates phosphorylationof different peptides in isolated periportal andperivenous hepatocytes
-
Aggarwal SR, Lindros KO, Palmer TN. Glucagon stimulates phosphorylationof different peptides in isolated periportal andperivenous hepatocytes. FEBS Lett 1995; 377: 439-43.
-
(1995)
FEBS Lett
, vol.377
, pp. 439-443
-
-
Aggarwal, S.R.1
Lindros, K.O.2
Palmer, T.N.3
-
178
-
-
0017154247
-
Hepatic pyruvatekinase. Regulation by glucagon, cyclic adenosine 3':5'-monophosphate, and insulin in the perfused rat liver
-
Blair JB, Cimbala A, Foster JL, Morgan RA. Hepatic pyruvatekinase. Regulation by glucagon, cyclic adenosine 3':5'-monophosphate, and insulin in the perfused rat liver. J Biol Chem1976; 251: 3756-62.
-
(1976)
J Biol Chem
, vol.251
, pp. 3756-3762
-
-
Blair, J.B.1
Cimbala, A.2
Foster, J.L.3
Morgan, R.A.4
-
179
-
-
33749569720
-
Participation of β-adrenergic activity in modulationof GLUT4 expression during fasting and refeeding in rats
-
Zanquetta MM, Nascimento EC, Mori RCT, Schaan BD, YoungME, Machado UF. Participation of β-adrenergic activity in modulationof GLUT4 expression during fasting and refeeding in rats. MetabClin Exper 2006; 55: 1538-45.
-
(2006)
MetabClin Exper
, vol.55
, pp. 1538-1545
-
-
Zanquetta, M.M.1
Nascimento, E.C.2
Mori, R.C.T.3
Schaan, B.D.4
Young, M.E.5
McHado, U.F.6
-
180
-
-
0023606651
-
Inhibition ofglycogenolysis and glycogen phosphorylase by insulin and proinsulinin rat hepatocyte cultures
-
Hartmann H, Probst I, Jungermann K, Creutzfeldt W. Inhibition ofglycogenolysis and glycogen phosphorylase by insulin and proinsulinin rat hepatocyte cultures. Diabetes 1987; 36: 551-55.
-
(1987)
Diabetes
, vol.36
, pp. 551-555
-
-
Hartmann, H.1
Probst, I.2
Jungermann, K.3
Creutzfeldt, W.4
-
181
-
-
0035089880
-
Involvement ofboth phosphatidylinositol 3-kinase and p44/p42 mitogen-activatedprotein kinase pathways in the short-term regulation of pyruvatekinase L by insulin
-
Carrillo JJ, Ibares B, Esteban-Gamboa A, Felíu JE. Involvement ofboth phosphatidylinositol 3-kinase and p44/p42 mitogen-activatedprotein kinase pathways in the short-term regulation of pyruvatekinase L by insulin. Endocrinology 2001; 142: 1057-64.
-
(2001)
Endocrinology
, vol.142
, pp. 1057-1064
-
-
Carrillo, J.J.1
Ibares, B.2
Esteban-Gamboa, A.3
Felíu, J.E.4
-
182
-
-
0034646633
-
Leptin induces insulin-likesignaling that antagonizes cAMP elevation by glucagon in hepatocytes
-
Zhao A, Shinohara MM, Huang D, Shimizu M, Eldar-Finkelman H, Krebs EG, Beavo JA, Bornfeldt KE. Leptin induces insulin-likesignaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 2000; 275: 11348-54.
-
(2000)
J Biol Chem
, vol.275
, pp. 11348-11354
-
-
Zhao, A.1
Shinohara, M.M.2
Huang, D.3
Shimizu, M.4
Eldar-Finkelman, H.5
Krebs, E.G.6
Beavo, J.A.7
Bornfeldt, K.E.8
-
183
-
-
0035996595
-
Phosphatidylinositol-3-kinase regulates glycosylphosphatidylinositolhydrolysis through PLC-2 activation inerythropoietin-stimulated cells. Cell
-
Boudot C, Kadre Z, Petitfrère E, Lambert E, Chrétien S, Mayeux P, Haye B, Billat C. Phosphatidylinositol-3-kinase regulates glycosylphosphatidylinositolhydrolysis through PLC-2 activation inerythropoietin-stimulated cells. Cell. Sign. 2002; 14: 869-78.
-
(2002)
Sign.
, vol.14
, pp. 869-878
-
-
Boudot, C.1
Kadre, Z.2
Petitfrère, E.3
Lambert, E.4
Chrétien, S.5
Mayeux, P.6
Haye, B.7
Billat, C.8
-
184
-
-
0019934974
-
AngiotensinII inhibits the accumulation of cyclic AMP produced by glucagonbut not its metabolic effects
-
Cárdenas-Tanús RJ, Huerta-Bahena J, Carcía-Sáinz JA. AngiotensinII inhibits the accumulation of cyclic AMP produced by glucagonbut not its metabolic effects. FEBS Lett 1982; 143: 1-4.
-
(1982)
FEBS Lett
, vol.143
, pp. 1-4
-
-
Cárdenas-Tanús, R.J.1
Huerta-Bahena, J.2
Carcía-Sáinz, J.A.3
-
185
-
-
0023127427
-
Therapid desensitization of glucagon-stimulated adenylate cyclase is acyclic AMP-independent process that can be mimicked by hormoneswhich stimulate inositol phospholipid metabolism
-
Murphy G, Hruby VJ, Trivedi D, Wakelam MJ, Houslay MD. Therapid desensitization of glucagon-stimulated adenylate cyclase is acyclic AMP-independent process that can be mimicked by hormoneswhich stimulate inositol phospholipid metabolism. BiochemJ 1987; 243: 39-46.
-
(1987)
BiochemJ
, vol.243
, pp. 39-46
-
-
Murphy, G.1
Hruby, V.J.2
Trivedi, D.3
Wakelam, M.J.4
Houslay, M.D.5
-
186
-
-
0024842752
-
Biological activities ofdes-His1[Glu9]glucagon amide, a glucagon antagonist
-
Unson CG, Gurzenda EM, Merrifield RB. Biological activities ofdes-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides1989; 10: 1171-77.
-
(1989)
Peptides
, vol.10
, pp. 1171-1177
-
-
Unson, C.G.1
Gurzenda, E.M.2
Merrifield, R.B.3
-
187
-
-
0022930587
-
Hormonal modulation of key hepatic regulatory enzymesin the gluconeogenic/glycolytic pathway
-
Pilkis SJ, Fox E, Wolfe L, Rothbarth L, Colosia A, Stewart HB, el-Maghrabi MR. Hormonal modulation of key hepatic regulatory enzymesin the gluconeogenic/glycolytic pathway. Ann NY Acad Sci1986; 478: 1-19.
-
(1986)
Ann NY Acad Sci
, vol.478
, pp. 1-19
-
-
Pilkis, S.J.1
Fox, E.2
Wolfe, L.3
Rothbarth, L.4
Colosia, A.5
Stewart, H.B.6
el-Maghrabi, M.R.7
-
188
-
-
0018694584
-
Adrenergic control of glycolysisand pyruvate kinase activity in hepatocytes from young and oldrats
-
Blair JB, James ME, Foster JL. Adrenergic control of glycolysisand pyruvate kinase activity in hepatocytes from young and oldrats. J Biol Chem 1979; 254: 7585-90.
-
(1979)
J Biol Chem
, vol.254
, pp. 7585-7590
-
-
Blair, J.B.1
James, M.E.2
Foster, J.L.3
-
189
-
-
0022381814
-
Sensitivity of the responseof cytosolic calcium in quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides
-
Sistare FD, Picking RA, Haynes RC Jr. Sensitivity of the responseof cytosolic calcium in quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides. J Biol Chem 1985;260: 12744-747.
-
(1985)
J Biol Chem
, vol.260
, pp. 12744-12747
-
-
Sistare, F.D.1
Picking, R.A.2
Haynes Jr., R.C.3
-
190
-
-
0023277313
-
Evidence for theactivation of the multifunctional Ca2+/calmodulin-dependent proteinkinase in response to hormones that increase intracellular Ca2+
-
Connelly PA, Sisk RB, Schulman H, Garrison JC. Evidence for theactivation of the multifunctional Ca2+/calmodulin-dependent proteinkinase in response to hormones that increase intracellular Ca2+. JBiol Chem 1987; 262: 10154-63.
-
(1987)
JBiol Chem
, vol.262
, pp. 10154-10163
-
-
Connelly, P.A.1
Sisk, R.B.2
Schulman, H.3
Garrison, J.C.4
-
191
-
-
0022468947
-
Glucagon and vasopressininteractions on Ca2+ movements in isolated hepatocytes
-
Combettes L, Berthon B, Binet A, Claret M. Glucagon and vasopressininteractions on Ca2+ movements in isolated hepatocytes. Biochem J 1986; 237: 675-83.
-
(1986)
Biochem J
, vol.237
, pp. 675-683
-
-
Combettes, L.1
Berthon, B.2
Binet, A.3
Claret, M.4
-
192
-
-
0022367145
-
Phosphorylationof L-type pyruvate kinase by a Ca2+ /calmodulindependentprotein kinase
-
Schworer CM, EI-Maghrabi MR, Pilkis SJ, Soderling T. Phosphorylationof L-type pyruvate kinase by a Ca2+ /calmodulindependentprotein kinase. J Biol Chern 1985; 260: 3018-22.
-
(1985)
J Biol Chern
, vol.260
, pp. 3018-3022
-
-
Schworer, C.M.1
EI-Maghrabi, M.R.2
Pilkis, S.J.3
Soderling, T.4
-
193
-
-
0023037086
-
Phosphorylationof liver phosphorylase kinase by Ca++/calmodulindependentprotein kinase: Characterization of two phosphorylationsites
-
Soderling TR, Schworer CM, el-Maghrabi MR, Pilkis SJ. Phosphorylationof liver phosphorylase kinase by Ca++/calmodulindependentprotein kinase: characterization of two phosphorylationsites. Biochem Biophys Res Commun 1986; 139: 1017-23.
-
(1986)
Biochem Biophys Res Commun
, vol.139
, pp. 1017-1023
-
-
Soderling, T.R.1
Schworer, C.M.2
el-Maghrabi, M.R.3
Pilkis, S.J.4
-
194
-
-
0022973993
-
Regulation of pyruvate kinase incultured rat hepatocytes. Influence of glucose, ethanol, glucagon, and dexamethasone
-
Blair JB, Sattsangi S, Hartwell R. Regulation of pyruvate kinase incultured rat hepatocytes. Influence of glucose, ethanol, glucagon, and dexamethasone. J Biol Chem 1986; 261, 2425-33.
-
(1986)
J Biol Chem
, vol.261
, pp. 2425-2433
-
-
Blair, J.B.1
Sattsangi, S.2
Hartwell, R.3
-
195
-
-
2442733778
-
Hormonal control of pyruvate kinaseactivity and of gluconeogenesis in isolated hepatocytes
-
Felíu JE, Hue L, Hers H-G. Hormonal control of pyruvate kinaseactivity and of gluconeogenesis in isolated hepatocytes. Proc NatlAcad Sci (USA) 1976; 73: 2762-66.
-
(1976)
Proc NatlAcad Sci (USA)
, vol.73
, pp. 2762-2766
-
-
Felíu, J.E.1
Hue, L.2
Hers, H-G.3
-
196
-
-
0021712405
-
Hormonal regulation of L-typepyruvate kinase in hepatocytes from phosphorylase kinase-deficient(gsd/gsd) rats
-
Clark MG, Patten GS, Clark DG. Hormonal regulation of L-typepyruvate kinase in hepatocytes from phosphorylase kinase-deficient(gsd/gsd) rats. Biochem J 1984; 224: 863-69.
-
(1984)
Biochem J
, vol.224
, pp. 863-869
-
-
Clark, M.G.1
Patten, G.S.2
Clark, D.G.3
-
197
-
-
0023551599
-
Studies on the regulation of rat liver pyruvate kinaseand fructose-1,6-bisphosphatase
-
Ekdahl KN. Studies on the regulation of rat liver pyruvate kinaseand fructose-1,6-bisphosphatase. Upsala J Med Sci 1987; 92: 217-32.
-
(1987)
Upsala J Med Sci
, vol.92
, pp. 217-232
-
-
Ekdahl, K.N.1
-
198
-
-
0027398672
-
Insulin-mimetic actions of phorbol ester in cultured rat hepatocytes. Lack of phorbol-ester-elicited inhibition of the insulinsignal
-
Quentmeier A, Daneschmand H, Klein H, Unthan-Fechner K, Probst I. Insulin-mimetic actions of phorbol ester in cultured rat hepatocytes. Lack of phorbol-ester-elicited inhibition of the insulinsignal. Biochem J 1993; 289: 549-55.
-
(1993)
Biochem J
, vol.289
, pp. 549-555
-
-
Quentmeier, A.1
Daneschmand, H.2
Klein, H.3
Unthan-Fechner, K.4
Probst, I.5
-
199
-
-
0034984029
-
Insulin-sensitive phospholipid signaling systems andglucose transport. Update II
-
Farese RV. Insulin-sensitive phospholipid signaling systems andglucose transport. Update II. Exp Biol Med 2001; 226: 283-95.
-
(2001)
Exp Biol Med
, vol.226
, pp. 283-295
-
-
Farese, R.V.1
-
200
-
-
0344393570
-
Thediacylglycerol and protein kinase C pathways are not involved ininsulin signaling in primary rat hepatocytes
-
Probst I, Beuers U, Drabent B, Unthan-Fechner K, Bütkofer P. Thediacylglycerol and protein kinase C pathways are not involved ininsulin signaling in primary rat hepatocytes. Eur J Biochem 2003;270, 4635-46.
-
(2003)
Eur J Biochem
, vol.270
, pp. 4635-4646
-
-
Probst, I.1
Beuers, U.2
Drabent, B.3
Unthan-Fechner, K.4
Bütkofer, P.5
-
201
-
-
0025369049
-
Modulation of glucagon actionsby phorbol myristate acetate in isolated hepatocytes. Effect ofhypothyroidism
-
García-Sáinz JA, Macías-Silva M, Hernández-Sotomaor SM, Torres-Márquez ME, Trivedi D, Hruby VJ. Modulation of glucagon actionsby phorbol myristate acetate in isolated hepatocytes. Effect ofhypothyroidism. Cell Signal 1990; 2: 235-43.
-
(1990)
Cell Signal
, vol.2
, pp. 235-243
-
-
García-Sáinz, J.A.1
Macías-Silva, M.2
Hernández-Sotomaor, S.M.3
Torres-Márquez, M.E.4
Trivedi, D.5
Hruby, V.J.6
-
203
-
-
0018252097
-
Control of gluconeogenesis and ofenzymes of glycogen metabolism in isolated rat hepatocytes
-
Hue L, Felíu JE, Hers H-G. Control of gluconeogenesis and ofenzymes of glycogen metabolism in isolated rat hepatocytes. BiochemJ 1978; 176: 791-97.
-
(1978)
BiochemJ
, vol.176
, pp. 791-797
-
-
Hue, L.1
Felíu, J.E.2
Hers, H-G.3
-
204
-
-
0020521860
-
Rapid breakdown of phosphatidylinositol 4-phosphateand phosphpatidylinositol 4,5-bisphosphate in rat hepatocytesstimulated by vasopressin and other Ca2+-mobilizing hormones
-
Creba JA, Downes CP, Hawkins PT, Brewster G, Michell RH, KirkCJ. Rapid breakdown of phosphatidylinositol 4-phosphateand phosphpatidylinositol 4,5-bisphosphate in rat hepatocytesstimulated by vasopressin and other Ca2+-mobilizing hormones. Biochem. J. 1983; 212: 733-47.
-
(1983)
Biochem. J.
, vol.212
, pp. 733-747
-
-
Creba, J.A.1
Downes, C.P.2
Hawkins, P.T.3
Brewster, G.4
Michell, R.H.5
Kirk, C.J.6
-
205
-
-
0020967565
-
Changes in freecytosolic Ca2+ in hepatocytes following α1-adrenergic stimulation. Studies on quin-2-loaded hepatocytes
-
Charest R, Blackmore, PF, Berthon B, Exton JH. Changes in freecytosolic Ca2+ in hepatocytes following α1-adrenergic stimulation. Studies on quin-2-loaded hepatocytes. J Biol Chem 1983; 258:8769-73.
-
(1983)
J Biol Chem
, vol.258
, pp. 8769-8773
-
-
Charest, R.1
Blackmore, P.F.2
Berthon, B.3
Exton, J.H.4
-
206
-
-
0022445402
-
Effect of cyclic AMP-dependenthormones and Ca2+-mobilizing hormones on the Ca2+ influx andphosphoinositide metabolism in isolated rat hepatocytes
-
Poggioli J, Mauger J-P, Claret M. Effect of cyclic AMP-dependenthormones and Ca2+-mobilizing hormones on the Ca2+ influx andphosphoinositide metabolism in isolated rat hepatocytes. Biochem J1986; 235: 663-69.
-
(1986)
Biochem J
, vol.235
, pp. 663-669
-
-
Poggioli, J.1
Mauger, J-P.2
Claret, M.3
-
207
-
-
0021993764
-
Inhibition of hepatic α1-adrenergic effects and binding by phorbolmyristate acetate
-
Lynch CJ, Charest R, Bocckino SB, Exton JH, Blackmore PF. Inhibition of hepatic α1-adrenergic effects and binding by phorbolmyristate acetate. J Biol Chem 1985; 260: 2844-51.
-
(1985)
J Biol Chem
, vol.260
, pp. 2844-2851
-
-
Lynch, C.J.1
Charest, R.2
Bocckino, S.B.3
Exton, J.H.4
Blackmore, P.F.5
-
208
-
-
0023764824
-
The molecular heterogeneity of protein kinase C andits implications for cellular regulation
-
Nishizuka Y. The molecular heterogeneity of protein kinase C andits implications for cellular regulation. Nature (Lond.) 1988; 334:661-64.
-
(1988)
Nature (Lond.)
, vol.334
, pp. 661-664
-
-
Nishizuka, Y.1
-
209
-
-
0018638201
-
The role ofcalcium ions as a mediator of the effects of angiotensin II, catecholamines, and vasopressin on the phosphorylation and activity of enzymesin isolated hepatocytes. J Biol
-
Garrison, J C, Borland M K, Florio VA, Twible DA. The role ofcalcium ions as a mediator of the effects of angiotensin II, catecholamines, and vasopressin on the phosphorylation and activity of enzymesin isolated hepatocytes. J Biol. Chern 1979; 254: 147-56.
-
(1979)
Chern
, vol.254
, pp. 147-156
-
-
Garrison, J.C.1
Borland, M.K.2
Florio, V.A.3
Twible, D.A.4
-
210
-
-
1642352463
-
Ca2+-dependent protein kinase C isoforms inducecholestasis in rat liver
-
Kubitz R, Saha N, Kühlkamp T, Dutta S, Dahl S vom, Wettstein M, Häussinger D. Ca2+-dependent protein kinase C isoforms inducecholestasis in rat liver. J Biol Chem 2004; 279: 10323-30.
-
(2004)
J Biol Chem
, vol.279
, pp. 10323-10330
-
-
Kubitz, R.1
Saha, N.2
Kühlkamp, T.3
Dutta, S.4
vom Dahl, S.5
Wettstein, M.6
Häussinger, D.7
-
211
-
-
0018104767
-
Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of calcium from an exchangeablepool in isolated rat hepatocytes
-
Chen J-LJ, Babcock DF, Lardy HA. Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of calcium from an exchangeablepool in isolated rat hepatocytes. Proc Nat Acad Sci USA 1978;75: 2234-38.
-
(1978)
Proc Nat Acad Sci USA
, vol.75
, pp. 2234-2238
-
-
Chen, J-L.J.1
Babcock, D.F.2
Lardy, H.A.3
-
212
-
-
0029258699
-
Hormonal regulation of cytosolic calciumlevels in liver
-
Kraus-Friedmann N. Hormonal regulation of cytosolic calciumlevels in liver. Braz J Med Biol Res 1995; 28: 275-84.
-
(1995)
Braz J Med Biol Res
, vol.28
, pp. 275-284
-
-
Kraus-Friedmann, N.1
-
214
-
-
0029826073
-
Impairment by interleukin 1 and tumour necrosisfactor of the glucagon-induced increase in phosphoenolpyruvatecarboxykinase gene expression and gluconeogenesis incultured hepatocytes
-
Christ B, Nath A. Impairment by interleukin 1 and tumour necrosisfactor of the glucagon-induced increase in phosphoenolpyruvatecarboxykinase gene expression and gluconeogenesis incultured hepatocytes. Biochem. J. 1996: 320; 161-66.
-
(1996)
Biochem. J.
, vol.320
, pp. 161-166
-
-
Christ, B.1
Nath, A.2
-
215
-
-
0017582072
-
Activation of protein kinase and glycogenphosphorylase in isolated rat liver cells by glucagon and catecholamines
-
Birnbaum M, Fain JN. Activation of protein kinase and glycogenphosphorylase in isolated rat liver cells by glucagon and catecholamines. J Biol Chem 1977; 252: 528-35.
-
(1977)
J Biol Chem
, vol.252
, pp. 528-535
-
-
Birnbaum, M.1
Fain, J.N.2
-
216
-
-
0015935331
-
Relation of glucagon-specific binding sitesto glucagon-dependent stimulation of adenylyl cyclase activity inplasma membranes of rat liver
-
Birnbaumer L, Pohl SL. Relation of glucagon-specific binding sitesto glucagon-dependent stimulation of adenylyl cyclase activity inplasma membranes of rat liver. J Biol Chem 1973; 248: 2056-61.
-
(1973)
J Biol Chem
, vol.248
, pp. 2056-2061
-
-
Birnbaumer, L.1
Pohl, S.L.2
-
217
-
-
0029054042
-
Glucagon receptors: From genetic structure and expressionto effector coupling and biological responses
-
Christophe J. Glucagon receptors: from genetic structure and expressionto effector coupling and biological responses. BiochimBiophys Acta 1995; 1241: 45-57.
-
(1995)
BiochimBiophys Acta
, vol.1241
, pp. 45-57
-
-
Christophe, J.1
-
218
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesisvia activator-coactivator exchange
-
Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates III J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesisvia activator-coactivator exchange. Nature 2008; 456: 269-73.
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
Dentin, R.2
Chen, D.3
Hedrick, S.4
Ravnskjaer, K.5
Schenk, S.6
Milne, J.7
Meyers, D.J.8
Cole, P.9
Yates III, J.10
Olefsky, J.11
Guarente, L.12
Montminy, M.13
-
219
-
-
0017123050
-
Lack of correlation between hormonal effects oncyclic AMP and glycogenolysis in rat liver
-
Okajima F, Ui M. Lack of correlation between hormonal effects oncyclic AMP and glycogenolysis in rat liver. Arch Biochem Biophys1976; 175: 549-57.
-
(1976)
Arch Biochem Biophys
, vol.175
, pp. 549-557
-
-
Okajima, F.1
Ui, M.2
-
220
-
-
0019521739
-
Regulation of fructose 2,6-P2concentration in isolated hepatocytes
-
Richards CS, Furuya E, Uyeda K. Regulation of fructose 2,6-P2concentration in isolated hepatocytes. Biochem Biophys Res Commun1981; 100: 1673-79.
-
(1981)
Biochem Biophys Res Commun
, vol.100
, pp. 1673-1679
-
-
Richards, C.S.1
Furuya, E.2
Uyeda, K.3
-
221
-
-
0019783166
-
Insulin binding and action inisolated hepatocytes: Evidence for spare receptors
-
Frank HJL, Davidson MB, Serbin PA. Insulin binding and action inisolated hepatocytes: Evidence for spare receptors. Metabolism1981; 30: 1159-64.
-
(1981)
Metabolism
, vol.30
, pp. 1159-1164
-
-
Frank, H.J.L.1
Davidson, M.B.2
Serbin, P.A.3
-
222
-
-
71049165532
-
Glucagon receptor mediates calcium signaling bycoupling to G alpha q/11 and G alpha i/o in HEK293 cells
-
Xu Y, Xie X. Glucagon receptor mediates calcium signaling bycoupling to G alpha q/11 and G alpha i/o in HEK293 cells. J ReceptSignal Transduct Res 2009; 29: 318-25. 213.
-
(2009)
J ReceptSignal Transduct Res
, vol.29
-
-
Xu, Y.1
Xie, X.2
-
223
-
-
80052072913
-
Albiglutide, a long lasting glucagon-like peptide analog, protects therat heart against ischemia/reperfusion injury: Evidence for improvingcardiac metabolic efficiency
-
Epub2011 Aug 26
-
Bao W, Aravindhan K, Alsaid H, Chendrimada T, Szapacs M, Citerone DR, Harpel MR, Willette RN, Lepore JJ, Jucker BM. Albiglutide, a long lasting glucagon-like peptide analog, protects therat heart against ischemia/reperfusion injury: Evidence for improvingcardiac metabolic efficiency. PLoS One. 2011; 6:e23570. Epub2011 Aug 26.
-
(2011)
PLoS One
, vol.6
-
-
Bao, W.1
Aravindhan, K.2
Alsaid, H.3
Chendrimada, T.4
Szapacs, M.5
Citerone, D.R.6
Harpel, M.R.7
Willette, R.N.8
Lepore, J.J.9
Jucker, B.M.10
-
224
-
-
0029120207
-
Glucagon receptormRNA distribution in rat tissues
-
Hansen LH, Abrahamsen N, Nishimura E. Glucagon receptormRNA distribution in rat tissues. Peptides 1995; 16: 1163-66.
-
(1995)
Peptides
, vol.16
, pp. 1163-1166
-
-
Hansen, L.H.1
Abrahamsen, N.2
Nishimura, E.3
-
226
-
-
82255185902
-
Control of blood glucose in the absence of hepatic glucoseproduction during prolonged fasting in mice. Induction of renal andintestinal gluconeogenesis by glucagon
-
Mutel E, Gautier-Stein A, Abdul-Wahed A, Amigó-Correig M, Zitoun C, Stefanutti A, Houberdon E, Tourette J-A, Mithieux G, Rajas F. Control of blood glucose in the absence of hepatic glucoseproduction during prolonged fasting in mice. Induction of renal andintestinal gluconeogenesis by glucagon. Diabetes 2011; 60: 3121-31.
-
(2011)
Diabetes
, vol.60
, pp. 3121-3131
-
-
Mutel, E.1
Gautier-Stein, A.2
Abdul-Wahed, A.3
Amigó-Correig, M.4
Zitoun, C.5
Stefanutti, A.6
Houberdon, E.7
Tourette, J-A.8
Mithieux, G.9
Rajas, F.10
-
227
-
-
0015471813
-
Studiesof the development of diabetic ketosis in the rat
-
Meier JM, McGarry D, Faloona GR, Unger RH, Foster DW. Studiesof the development of diabetic ketosis in the rat. J Lipid Res1972; 13: 228-33.
-
(1972)
J Lipid Res
, vol.13
, pp. 228-233
-
-
Meier, J.M.1
McGarry, D.2
Faloona, G.R.3
Unger, R.H.4
Foster, D.W.5
-
228
-
-
0023109225
-
Documentationof hyperglucagonemia throughout the day in nonobeseand obese patients with noninsulin-dependent diabetes mellitus
-
Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB. Documentationof hyperglucagonemia throughout the day in nonobeseand obese patients with noninsulin-dependent diabetes mellitus. JClin Endocrinol Metab 1987; 64: 106-10.
-
(1987)
JClin Endocrinol Metab
, vol.64
, pp. 106-110
-
-
Reaven, G.M.1
Chen, Y.D.2
Golay, A.3
Swislocki, A.L.4
Jaspan, J.B.5
-
229
-
-
0034524938
-
Lack ofsuppression of glucagon contributes to postprandial hyperglycemiain subjects with type 2 diabetes mellitus
-
Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA. Lack ofsuppression of glucagon contributes to postprandial hyperglycemiain subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab2000; 85: 4053-59.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 4053-4059
-
-
Shah, P.1
Vella, A.2
Basu, A.3
Basu, R.4
Schwenk, W.F.5
Rizza, R.A.6
-
230
-
-
78049259220
-
Pathogenesis of fasting and postprandial hyperglycemiain type 2 diabetes: Implications for therapy
-
Rizza RA. Pathogenesis of fasting and postprandial hyperglycemiain type 2 diabetes: Implications for therapy. Diabetes 2010; 59:2697-2707.
-
(2010)
Diabetes
, vol.59
, pp. 2697-2707
-
-
Rizza, R.A.1
-
231
-
-
0018122474
-
Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes
-
Raskin MD, Unger RH. Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes. N Eng J Med1978; 299: 433-36.
-
(1978)
N Eng J Med
, vol.299
, pp. 433-436
-
-
Raskin, M.D.1
Unger, R.H.2
-
232
-
-
0029760864
-
Evidence for amajor role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits
-
Brand CL, Jørgensen PN, Svendsen I, Holst JJ. Evidence for amajor role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits. Diabetes1996; 45: 1076-83.
-
(1996)
Diabetes
, vol.45
, pp. 1076-1083
-
-
Brand, C.L.1
Jørgensen, P.N.2
Svendsen, I.3
Holst, J.J.4
-
233
-
-
36549069114
-
New hepatic targets for glycaemic control in diabetes
-
Agius L. New hepatic targets for glycaemic control in diabetes. Best Pract Res Clin Endocrinol Metab 2007; 21: 587-605.
-
(2007)
Best Pract Res Clin Endocrinol Metab
, vol.21
, pp. 587-605
-
-
Agius, L.1
-
234
-
-
34250854205
-
The role of alpha-cell dysregulation infasting and postprandial hyperglycemia in type-2 diabetes andtherapeutic implications
-
Dunning BE, Gerich JE. The role of alpha-cell dysregulation infasting and postprandial hyperglycemia in type-2 diabetes andtherapeutic implications. Endocrine Reviews 2007; 28: 253-83.
-
(2007)
Endocrine Reviews
, vol.28
, pp. 253-283
-
-
Dunning, B.E.1
Gerich, J.E.2
-
236
-
-
0842288445
-
Reduction in glucagon receptorexpression by antisense oligonucleotide ameliorates diabetic syndromein db/db mice
-
Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT. Reduction in glucagon receptorexpression by antisense oligonucleotide ameliorates diabetic syndromein db/db mice. Diabetes 2004; 53: 410-17.
-
(2004)
Diabetes
, vol.53
, pp. 410-417
-
-
Liang, Y.1
Osborne, M.C.2
Monia, B.P.3
Bhanot, S.4
Gaarde, W.A.5
Reed, C.6
She, P.7
Jetton, T.L.8
Demarest, K.T.9
-
237
-
-
33845522289
-
Glucagon receptor knockout mice displayincreased insulin sensitivity and impaired beta-cell function
-
Sørensen H, Winzell MS, Brand CL, Fosgerau K, Gelling RW, Nishimura E, Ahren B. Glucagon receptor knockout mice displayincreased insulin sensitivity and impaired beta-cell function. Diabetes2006; 55: 3463-69.
-
(2006)
Diabetes
, vol.55
, pp. 3463-3469
-
-
Sørensen, H.1
Winzell, M.S.2
Brand, C.L.3
Fosgerau, K.4
Gelling, R.W.5
Nishimura, E.6
Ahren, B.7
-
238
-
-
33845919110
-
Glucagon receptorknockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia
-
Conarello S, Jiang G, Mu J, Li Z, Woods J, Zycband E, Ronan J, LiuF, Roy RS, Zhu L, Charron MJ, Zhang BB. Glucagon receptorknockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Diabetologia 2007;50: 142-50.
-
(2007)
Diabetologia
, vol.50
, pp. 142-150
-
-
Conarello, S.1
Jiang, G.2
Mu, J.3
Li, Z.4
Woods, J.5
Zycband, E.6
Ronan, J.7
Liu, F.8
Roy, R.S.9
Zhu, L.10
Charron, M.J.11
Zhang, B.B.12
-
239
-
-
80054699140
-
Chronic treatment with a glucagon receptor antagonist lowers glucoseand moderately raises circulating glucagon and glucagon-likepeptide 1 without severe alpha cell hypertrophy in diet-inducedobese mice
-
Mu J, Jiang G, Brady E, Dallas-Yang Q, Liu F, Woods J, ZycbandE, Wright M, Li Z, Lu K, Zhu L, Shen X, SinhaRoy R, CandeloreML, Qureshi SA, Shem D-M, Zhang F, Parmee ER, Zhang BB. Chronic treatment with a glucagon receptor antagonist lowers glucoseand moderately raises circulating glucagon and glucagon-likepeptide 1 without severe alpha cell hypertrophy in diet-inducedobese mice. Diabetologia 2011; 54: 2381-91.
-
(2011)
Diabetologia
, vol.54
, pp. 2381-2391
-
-
Mu, J.1
Jiang, G.2
Brady, E.3
Dallas-Yang, Q.4
Liu, F.5
Woods, J.6
Zycband, E.7
Wright, M.8
Li, Z.9
Lu, K.10
Zhu, L.11
Shen, X.12
SinhaRoy, R.13
Candelore, M.L.14
Qureshi, S.A.15
Shem, D-M.16
Zhang, F.17
Parmee, E.R.18
Zhang, B.B.19
-
240
-
-
0016614292
-
Glucagon: Role in the hyperglycemia of diabetesmellitus
-
Dobbs R, Sakurai H, Sasaki H, Faloona G, Valverde I, Baetens D, Orci L, Unger R. Glucagon: role in the hyperglycemia of diabetesmellitus. Science 1975; 187: 544-47.
-
(1975)
Science
, vol.187
, pp. 544-547
-
-
Dobbs, R.1
Sakurai, H.2
Sasaki, H.3
Faloona, G.4
Valverde, I.5
Baetens, D.6
Orci, L.7
Unger, R.8
-
241
-
-
0020471569
-
Hyperglycemia of diabetic rats decreased by a glucagon receptorantagonist
-
Johnson DG, Goebel CU, Hruby VJ, Bregman MD, Trivedi D. Hyperglycemia of diabetic rats decreased by a glucagon receptorantagonist. Science 1982; 215: 1115-16.
-
(1982)
Science
, vol.215
, pp. 1115-1116
-
-
Johnson, D.G.1
Goebel, C.U.2
Hruby, V.J.3
Bregman, M.D.4
Trivedi, D.5
-
242
-
-
0035195977
-
Effects of a novel glucagon receptorantagonist (Bay 27-9955) on glucagon-stimulated glucose productionin humans
-
Petersen KF, Sullivan JT. Effects of a novel glucagon receptorantagonist (Bay 27-9955) on glucagon-stimulated glucose productionin humans. Diabetologia 2001; 44: 2018-24.
-
(2001)
Diabetologia
, vol.44
, pp. 2018-2024
-
-
Petersen, K.F.1
Sullivan, J.T.2
-
243
-
-
15444369236
-
Reduction of hepatic glucoseproduction as a therapeutic target in the treatment of diabetes
-
Wu C, Okar DA, Kang J, Lange AL. Reduction of hepatic glucoseproduction as a therapeutic target in the treatment of diabetes. CurrentDrug Targets 2005; 5: 51-59.
-
(2005)
CurrentDrug Targets
, vol.5
, pp. 51-59
-
-
Wu, C.1
Okar, D.A.2
Kang, J.3
Lange, A.L.4
-
244
-
-
33646512858
-
Glucagon and glucagon-like peptide receptorsas drug targets
-
Estall JL, Drucker DJ. Glucagon and glucagon-like peptide receptorsas drug targets. Curr Pharm Des 2006; 12: 1731-50.
-
(2006)
Curr Pharm Des
, vol.12
, pp. 1731-1750
-
-
Estall, J.L.1
Drucker, D.J.2
-
245
-
-
77953939472
-
Molecular pathways underlyingthe pathogenesis of pancreatic alpha-cell dysfunction
-
Kawamori D, Welters HJ, Kulkarni RN. Molecular pathways underlyingthe pathogenesis of pancreatic alpha-cell dysfunction. AdvExp Med Biol 2010; 654: 421-45.
-
(2010)
AdvExp Med Biol
, vol.654
, pp. 421-445
-
-
Kawamori, D.1
Welters, H.J.2
Kulkarni, R.N.3
-
246
-
-
78649444434
-
The metabolic actions of glucagon revisited
-
Habbeger KM, Heppner KM, Geary N, Bartness TJ, DiMarchi R, Tschöp MH. The metabolic actions of glucagon revisited. Nat RevEndocrinol 2010; 6: 689-97.
-
(2010)
Nat RevEndocrinol
, vol.6
, pp. 689-697
-
-
Habbeger, K.M.1
Heppner, K.M.2
Geary, N.3
Bartness, T.J.4
DiMarchi, R.5
Tschöp, M.H.6
-
247
-
-
63849296798
-
Fully humanmonoclonal antibodies antagonizing the glucagon receptor improveglucose homeostasis in mice and monkeys
-
Yan H, Gu W, Yang J, Shen Y, Lee E, Winters KA, KomorowskiR, Zhang C, Patel JJ, Caughy D, Elliott GS, Lau YY, Wang J, LiYS, Boone T, Lindberg RA, Hu S, Véniant MM. Fully humanmonoclonal antibodies antagonizing the glucagon receptor improveglucose homeostasis in mice and monkeys. J Pharmacol Exper Ther2011; 329: 102-11.
-
(2011)
J Pharmacol Exper Ther
, vol.329
, pp. 102-111
-
-
Yan, H.1
Gu, W.2
Yang, J.3
Shen, Y.4
Lee, E.5
Winters, K.A.6
Komorowski, R.7
Zhang, C.8
Patel, J.J.9
Caughy, D.10
Elliott, G.S.11
Lau, Y.Y.12
Wang, J.13
Li, Y.S.14
Boone, T.15
Lindberg, R.A.16
Hu, S.17
Véniant, M.M.18
-
248
-
-
0023630826
-
Hormonal regulation of L-type pyruvatekinase in rat liver cells in culture
-
Miller BC, Cottam GL. Hormonal regulation of L-type pyruvatekinase in rat liver cells in culture. Arch Biochem Biophys 1987;1987; 259: 66-78.
-
(1987)
Arch Biochem Biophys 1987
, vol.259
, pp. 66-78
-
-
Miller, B.C.1
Cottam, G.L.2
-
249
-
-
0024372988
-
Regulation of the expression of theL-type pyruvate kinase gene in adult rat hepatocytes in primary culture
-
Decaux J-F, Antoine B, Kahn A. regulation of the expression of theL-type pyruvate kinase gene in adult rat hepatocytes in primary culture. J Biol Chem 1989; 264: 11584-90.
-
(1989)
J Biol Chem
, vol.264
, pp. 11584-11590
-
-
Decaux, J-F.1
Antoine, B.2
Kahn, A.3
-
250
-
-
0035958976
-
Glucose-6-phosphate hydrolysisis activated by glucagon in a low temperature-sensitivemanner
-
Ichai C, Guignot L, El-Mir MY, Nogueira V, Guigas B, Chauvin C, Fontaine E, Mithieux G, Leverve XM. Glucose-6-phosphate hydrolysisis activated by glucagon in a low temperature-sensitivemanner. J Biol Chem 2001; 276: 28126-33.
-
(2001)
J Biol Chem
, vol.276
, pp. 28126-28133
-
-
Ichai, C.1
Guignot, L.2
El-Mir, M.Y.3
Nogueira, V.4
Guigas, B.5
Chauvin, C.6
Fontaine, E.7
Mithieux, G.8
Leverve, X.M.9
-
251
-
-
11244335844
-
A distal region involvinghepatocyte nuclear factor 4α and CAAT/enhancer binding proteinmarkedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter
-
Gauthiér-Stein A, Mithieux G, Rajas F. A distal region involvinghepatocyte nuclear factor 4α and CAAT/enhancer binding proteinmarkedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter. Mol Endocrinol 2005; 19: 163-74.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 163-174
-
-
Gauthiér-Stein, A.1
Mithieux, G.2
Rajas, F.3
-
252
-
-
73549103338
-
Hormonal regulation ofglycolytic and pyruvate dehydrogenase kinase/phosphatase genetranscription
-
Wang Z, Iwasaki Y, Zhao LF, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y. Hormonal regulation ofglycolytic and pyruvate dehydrogenase kinase/phosphatase genetranscription. Endocrine J 2009; 56: 1019-30.
-
(2009)
Endocrine J
, vol.56
, pp. 1019-1030
-
-
Wang, Z.1
Iwasaki, Y.2
Zhao, L.F.3
Nishiyama, M.4
Taguchi, T.5
Tsugita, M.6
Kambayashi, M.7
Hashimoto, K.8
Terada, Y.9
-
253
-
-
0021918198
-
Glucagon-stimulated phosphorylation of rat liver glycogen synthasein isolated hepatocytes
-
Akatsuka A, Singh TJ, Nakabayashi H, Lin MC, Huyang K-P. Glucagon-stimulated phosphorylation of rat liver glycogen synthasein isolated hepatocytes. J Biol Chem 1985; 260: 3239-42.
-
(1985)
J Biol Chem
, vol.260
, pp. 3239-3242
-
-
Akatsuka, A.1
Singh, T.J.2
Nakabayashi, H.3
Lin, M.C.4
Huyang, K-P.5
-
254
-
-
0021259756
-
Glucagon and glucose as majorregulators of glycogen metabolism in primary cultured hepatocytes
-
Nakamura T, Kato S, Ichihara A. Glucagon and glucose as majorregulators of glycogen metabolism in primary cultured hepatocytes. J Biochem 1984; 95: 1691-96.
-
(1984)
J Biochem
, vol.95
, pp. 1691-1696
-
-
Nakamura, T.1
Kato, S.2
Ichihara, A.3
-
255
-
-
0023988201
-
The role of proteinkinase C in the inactivation of hepatic glycogen synthase by calcium-mobilizing agonists
-
Bouscarel B, Meurer K, Decker C, Exton JH. The role of proteinkinase C in the inactivation of hepatic glycogen synthase by calcium-mobilizing agonists. Biochem J 1988; 251: 47-53.
-
(1988)
Biochem J
, vol.251
, pp. 47-53
-
-
Bouscarel, B.1
Meurer, K.2
Decker, C.3
Exton, J.H.4
-
256
-
-
0343118174
-
Hormonal responsiveness ofhepatocytes after hypothermic preservation in University of Wisconsinsolution
-
García-Sáinz JA, Casas-González P. Hormonal responsiveness ofhepatocytes after hypothermic preservation in University of Wisconsinsolution. Cell Signal 1997; 9: 277-81.
-
(1997)
Cell Signal
, vol.9
, pp. 277-281
-
-
García-Sáinz, J.A.1
Casas-González, P.2
-
257
-
-
0021133316
-
Potentiation of α1-adrenergic responses in rat liver by a cAMP-dependent mechanism
-
Morgan NG, Charest R, Blackmore PF, Exton JH. Potentiation of α1-adrenergic responses in rat liver by a cAMP-dependent mechanism. Proc Nat Acad Sci USA 1984; 81: 4208-12.
-
(1984)
Proc Nat Acad Sci USA
, vol.81
, pp. 4208-4212
-
-
Morgan, N.G.1
Charest, R.2
Blackmore, P.F.3
Exton, J.H.4
-
258
-
-
0021362840
-
Regulation of hepaticglycogenolysis by glucagon in male and female rats
-
Studer RK, Snowdowne KW, Borle AB. Regulation of hepaticglycogenolysis by glucagon in male and female rats. J Biol Chem1984; 259: 3596-3604.
-
(1984)
J Biol Chem
, vol.259
, pp. 3596-3604
-
-
Studer, R.K.1
Snowdowne, K.W.2
Borle, A.B.3
-
259
-
-
0023216457
-
Effects of epinephrine, glucagon and insulinon the activity and degree of phosphorylation of fructose-1,6-bisphosphatase in cultured hepatocytes
-
Ekdahl KN, Ekman P. Effects of epinephrine, glucagon and insulinon the activity and degree of phosphorylation of fructose-1,6-bisphosphatase in cultured hepatocytes. Biochim Biophys Acta1987; 929: 318-26.
-
(1987)
Biochim Biophys Acta
, vol.929
, pp. 318-326
-
-
Ekdahl, K.N.1
Ekman, P.2
-
260
-
-
0025202408
-
Control of glycogen synthase by hierarchal protein phosphorylation
-
Roach PJ. Control of glycogen synthase by hierarchal protein phosphorylation. FASEB J 1990; 4: 2961-68.
-
(1990)
FASEB J
, vol.4
, pp. 2961-2968
-
-
Roach, P.J.1
-
261
-
-
79956212666
-
Impact of glycogen phosphorylase inhibitorand metformin on basal and glucagon-stimulated hepaticglucose flux in conscious dogs
-
Torres TP, Sasaki N, Donahue EP, Lacy B, Printz RL, CherringtonAD, Treadway JL, Shiota M. Impact of glycogen phosphorylase inhibitorand metformin on basal and glucagon-stimulated hepaticglucose flux in conscious dogs. J Pharmacol Exper Ther 2011; 337:610-20.
-
(2011)
J Pharmacol Exper Ther
, vol.337
, pp. 610-620
-
-
Torres, T.P.1
Sasaki, N.2
Donahue, E.P.3
Lacy, B.4
Printz, R.L.5
Cherrington, A.D.6
Treadway, J.L.7
Shiota, M.8
-
262
-
-
0020328983
-
Regulationby glucagon of hepatic pyruvate kinase, 6-phosphofructo-1-kinase, and fructose-1,6-bisphosphatase
-
Pilkis SJ, El-Maghrabi MR, McGrane M, Pilkis J, Claus TH. Regulationby glucagon of hepatic pyruvate kinase, 6-phosphofructo-1-kinase, and fructose-1,6-bisphosphatase. Fed Proc 1982; 41: 2623-28.
-
(1982)
Fed Proc
, vol.41
, pp. 2623-2628
-
-
Pilkis, S.J.1
El-Maghrabi, M.R.2
McGrane, M.3
Pilkis, J.4
Claus, T.H.5
-
263
-
-
0026683464
-
Phorbol esters, bombesin andinsulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-isphosphatase system in primary cultures offoetal and adult rat hepatocytes
-
Cascales M, Martin-Sanz P, Bosca L. Phorbol esters, bombesin andinsulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-isphosphatase system in primary cultures offoetal and adult rat hepatocytes. Eur J Biochem 1992; 207: 391-97.
-
(1992)
Eur J Biochem
, vol.207
, pp. 391-397
-
-
Cascales, M.1
Martin-Sanz, P.2
Bosca, L.3
-
264
-
-
9744257919
-
Regulation of the regulatory enzyme,6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Okar DA, Wu C, Lange AL. Regulation of the regulatory enzyme,6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Adv EnzRegul 2004; 44: 123-54.
-
(2004)
Adv EnzRegul
, vol.44
, pp. 123-154
-
-
Okar, D.A.1
Wu, C.2
Lange, A.L.3
-
265
-
-
0023101596
-
Hormonal control of glucose production and pyruvate kinase activityin isolated rat liver cells: Influence of hypothyroidism
-
Laville M, Khalfallah H, Vidal H, Beylot B, Comte B, Riou JP. Hormonal control of glucose production and pyruvate kinase activityin isolated rat liver cells: influence of hypothyroidism. Mol CellEndocrinol 1987; 50: 247-53.
-
(1987)
Mol CellEndocrinol
, vol.50
, pp. 247-253
-
-
Laville, M.1
Khalfallah, H.2
Vidal, H.3
Beylot, B.4
Comte, B.5
Riou, J.P.6
-
266
-
-
0018717177
-
Modulation of the phosphorylationstate of rat liver pyruvate kinase by allosteric effectors andinsulin
-
Claus TH, El-Maghrabi R, Pilkis SJ. Modulation of the phosphorylationstate of rat liver pyruvate kinase by allosteric effectors andinsulin. J Biol Chem 1979; 254: 7855-64.
-
(1979)
J Biol Chem
, vol.254
, pp. 7855-7864
-
-
Claus, T.H.1
El-Maghrabi, R.2
Pilkis, S.J.3
|