메뉴 건너뛰기




Volumn 295, Issue 1, 2008, Pages

Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: Involvement of PI3K but not cAMP

Author keywords

Cyclic adenosine monophosphate; Glycolysis; Insulin; Phosphoinositide 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADENYLATE CYCLASE; CYCLIC AMP; ENZYME INHIBITOR; GLUCAGON; INSULIN; NKY 80; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; GLUCOSE; MORPHOLINE DERIVATIVE; PALMITIC ACID DERIVATIVE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE INHIBITOR;

EID: 50349088761     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90228.2008     Document Type: Article
Times cited : (21)

References (43)
  • 1
    • 0021269073 scopus 로고
    • Regulation of peripheral insulin/glucagon levels by rat liver
    • Balks HJ, Jungermann K. Regulation of peripheral insulin/glucagon levels by rat liver. Eur J Biochem 141: 645-650, 1984.
    • (1984) Eur J Biochem , vol.141 , pp. 645-650
    • Balks, H.J.1    Jungermann, K.2
  • 2
    • 0017582072 scopus 로고
    • Activation of protein kinase and glycogen phosphorylase in isolated rat liver cells by glucagon and catecholamines
    • Birnbaum M, Fain JN. Activation of protein kinase and glycogen phosphorylase in isolated rat liver cells by glucagon and catecholamines. J Biol Chem 252: 528-535, 1977.
    • (1977) J Biol Chem , vol.252 , pp. 528-535
    • Birnbaum, M.1    Fain, J.N.2
  • 7
    • 9944222737 scopus 로고    scopus 로고
    • Quantitation of the large polypeptide glucagon by protein precipitation and LC/MS
    • Delinsky D, Hill KT, White CA, Bartlett MG. Quantitation of the large polypeptide glucagon by protein precipitation and LC/MS. Biomed Chromatogr 18: 700-705, 2004.
    • (2004) Biomed Chromatogr , vol.18 , pp. 700-705
    • Delinsky, D.1    Hill, K.T.2    White, C.A.3    Bartlett, M.G.4
  • 8
    • 2342519996 scopus 로고    scopus 로고
    • Alanine infusion during hypoglycaemia partly supports cognitive performance in healthy human subjects
    • Evans M, Hopkins D, Macdonald IA, Amiel SA. Alanine infusion during hypoglycaemia partly supports cognitive performance in healthy human subjects. Diabet Med 21: 440-446, 2004.
    • (2004) Diabet Med , vol.21 , pp. 440-446
    • Evans, M.1    Hopkins, D.2    Macdonald, I.A.3    Amiel, S.A.4
  • 9
    • 0015240282 scopus 로고
    • Studies on the role of adenosine 3′,5′-monophosphate in the hepatic actions of glucagon and catecholamines
    • Exton J, Robison GA, Sutherland EW, Park CR. Studies on the role of adenosine 3′,5′-monophosphate in the hepatic actions of glucagon and catecholamines. J Biol Chem 246: 6166-6177, 1971.
    • (1971) J Biol Chem , vol.246 , pp. 6166-6177
    • Exton, J.1    Robison, G.A.2    Sutherland, E.W.3    Park, C.R.4
  • 11
    • 0019347265 scopus 로고
    • Physiology of glucagon
    • Gerich J. Physiology of glucagon. Int Rev Physiol 24: 243-275, 1981.
    • (1981) Int Rev Physiol , vol.24 , pp. 243-275
    • Gerich, J.1
  • 12
    • 33846856711 scopus 로고    scopus 로고
    • Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains
    • Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28: 84-116, 2007.
    • (2007) Endocr Rev , vol.28 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 13
    • 0024406131 scopus 로고
    • Age-dependent effects of phorbol ester on adenylate cyclase stimulation by glucagon in liver of female rats
    • Hermsdorf T, Dettmer D, Hofmann E. Age-dependent effects of phorbol ester on adenylate cyclase stimulation by glucagon in liver of female rats. Biomed Biochim Acta 48: 255-260, 1989.
    • (1989) Biomed Biochim Acta , vol.48 , pp. 255-260
    • Hermsdorf, T.1    Dettmer, D.2    Hofmann, E.3
  • 14
    • 0029178019 scopus 로고
    • Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP
    • Houslay M. Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP. Adv Enzyme Regul 35: 303-338, 1995.
    • (1995) Adv Enzyme Regul , vol.35 , pp. 303-338
    • Houslay, M.1
  • 15
    • 0032387694 scopus 로고    scopus 로고
    • Effects of glucagon on glycogenolysis and gluconeogenesis are region-specific in periportal and perivenous hepatocytes
    • Ikezawa Y, Yamatani K, Ogawa A, Ohnuma H, Igarashi M, Daimon M, Manaka H, Sasaki H. Effects of glucagon on glycogenolysis and gluconeogenesis are region-specific in periportal and perivenous hepatocytes. J Lab Clin Med 132: 547-555, 1998.
    • (1998) J Lab Clin Med , vol.132 , pp. 547-555
    • Ikezawa, Y.1    Yamatani, K.2    Ogawa, A.3    Ohnuma, H.4    Igarashi, M.5    Daimon, M.6    Manaka, H.7    Sasaki, H.8
  • 16
    • 0036084145 scopus 로고    scopus 로고
    • Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats
    • Inouye K, Shum K, Chan O, Mathoo J, Matthews SG, Vranic M. Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats. Am J Physiol Endocrinol Metab 282: E1369-E1379, 2002.
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Inouye, K.1    Shum, K.2    Chan, O.3    Mathoo, J.4    Matthews, S.G.5    Vranic, M.6
  • 17
    • 0021343484 scopus 로고
    • Transhepatic glucagon gradients in man: Evidence for glucagon extraction by human liver
    • Jaspan J, Ruddick J, Rayfield E. Transhepatic glucagon gradients in man: evidence for glucagon extraction by human liver. J Clin Endocrinol Metab 58: 287-292, 1984.
    • (1984) J Clin Endocrinol Metab , vol.58 , pp. 287-292
    • Jaspan, J.1    Ruddick, J.2    Rayfield, E.3
  • 20
    • 57049128398 scopus 로고
    • Metabolic effects of glucagon in the perfused rat heart
    • Kreisberg R, Williamson JR. Metabolic effects of glucagon in the perfused rat heart. Am J Physiol 207: 721-727, 1964.
    • (1964) Am J Physiol , vol.207 , pp. 721-727
    • Kreisberg, R.1    Williamson, J.R.2
  • 21
    • 0029808270 scopus 로고    scopus 로고
    • Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin
    • Lefebvre V, Mechin MC, Louckx MP, Rider MH, Hue L. Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin. J Biol Chem 271: 22289-22292, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 22289-22292
    • Lefebvre, V.1    Mechin, M.C.2    Louckx, M.P.3    Rider, M.H.4    Hue, L.5
  • 22
    • 33644987298 scopus 로고    scopus 로고
    • Glucagon receptor-mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: Role of protein kinase A and phospholipase C
    • Li X, Carretero OA, Shao Y, Zhuo JL. Glucagon receptor-mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: role of protein kinase A and phospholipase C. Hypertension 47: 580-585, 2006.
    • (2006) Hypertension , vol.47 , pp. 580-585
    • Li, X.1    Carretero, O.A.2    Shao, Y.3    Zhuo, J.L.4
  • 23
    • 0021961911 scopus 로고
    • Glucagon receptor of human liver. Studies of its molecular weight and binding properties, and its ability to activate hepatic adenylyl cyclase of non-obese and obese subjects
    • Livingston J, Einarsson K, Backman L, Ewerth S, Arner P. Glucagon receptor of human liver. Studies of its molecular weight and binding properties, and its ability to activate hepatic adenylyl cyclase of non-obese and obese subjects. J Clin Invest 75: 397-403, 1985.
    • (1985) J Clin Invest , vol.75 , pp. 397-403
    • Livingston, J.1    Einarsson, K.2    Backman, L.3    Ewerth, S.4    Arner, P.5
  • 25
    • 11144253483 scopus 로고    scopus 로고
    • Convergent signal transduction pathways controlling cardiomyocyte survival and function: The role of PI 3-kinase and Akt
    • Matsui T, Rosenzweig A. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol 38: 63-71, 2005.
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 63-71
    • Matsui, T.1    Rosenzweig, A.2
  • 26
    • 0025270818 scopus 로고
    • Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase
    • Méry P, Brechler V, Pavoine C, Pecke F. Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase. Nature 345: 158-161, 1990.
    • (1990) Nature , vol.345 , pp. 158-161
    • Méry, P.1    Brechler, V.2    Pavoine, C.3    Pecke, F.4
  • 27
    • 0014511498 scopus 로고
    • Effect of glucagon on rat heart adenyl cyclase
    • Murad F, Vaughan M. Effect of glucagon on rat heart adenyl cyclase. Biochem Pharmacol 18: 1053-1059, 1969.
    • (1969) Biochem Pharmacol , vol.18 , pp. 1053-1059
    • Murad, F.1    Vaughan, M.2
  • 28
    • 0023127427 scopus 로고
    • The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism
    • Murphy G, Hruby VJ, Trivedi D, Wakelam MJ, Houslay MD. The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism. Biochem J 243: 39-46, 1987.
    • (1987) Biochem J , vol.243 , pp. 39-46
    • Murphy, G.1    Hruby, V.J.2    Trivedi, D.3    Wakelam, M.J.4    Houslay, M.D.5
  • 31
    • 23044517378 scopus 로고    scopus 로고
    • Maintenance of the postabsorptive plasma glucose concentration: Insulin or insulin plus glucagon?
    • Raju B, Cryer PE. Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon? Am J Physiol Endocrinol Metab 289: E181-E186, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Raju, B.1    Cryer, P.E.2
  • 32
    • 84965091312 scopus 로고
    • The relationship of epinephrine and glucagon to liver phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates
    • Rall T, Sutherland EW, Berthet J. The relationship of epinephrine and glucagon to liver phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates. J Biol Chem 224: 463-475, 1957.
    • (1957) J Biol Chem , vol.224 , pp. 463-475
    • Rall, T.1    Sutherland, E.W.2    Berthet, J.3
  • 33
    • 0020074103 scopus 로고
    • Cyclic AMP-dependent and cyclic AMP-independent antagonism of insulin activation of cardiac glycogen synthase
    • Ramachandran C, Angelos KL, Walsh DA. Cyclic AMP-dependent and cyclic AMP-independent antagonism of insulin activation of cardiac glycogen synthase. J Biol Chem 257: 1448-1457, 1982.
    • (1982) J Biol Chem , vol.257 , pp. 1448-1457
    • Ramachandran, C.1    Angelos, K.L.2    Walsh, D.A.3
  • 34
    • 0035201478 scopus 로고    scopus 로고
    • Insulin-like effects of a physiologic concentration of carnitine on cardiac metabolism
    • Rodgers R, Christe ME, Tremblay GC, Babson JR, Daniels T. Insulin-like effects of a physiologic concentration of carnitine on cardiac metabolism. Mol Cell Biochem 226: 97-105, 2001.
    • (2001) Mol Cell Biochem , vol.226 , pp. 97-105
    • Rodgers, R.1    Christe, M.E.2    Tremblay, G.C.3    Babson, J.R.4    Daniels, T.5
  • 35
    • 0019523661 scopus 로고
    • Responses of rat and guinea pig hearts to glucagon. Lack of evidence for a dissociation between changes in myocardial cyclic 35-adenosine monophosphate and contractility
    • Rodgers R, MacLeod KM, McNeill JH. Responses of rat and guinea pig hearts to glucagon. Lack of evidence for a dissociation between changes in myocardial cyclic 35-adenosine monophosphate and contractility. Circ Res 49: 216-225, 1981.
    • (1981) Circ Res , vol.49 , pp. 216-225
    • Rodgers, R.1    MacLeod, K.M.2    McNeill, J.H.3
  • 36
    • 1442350003 scopus 로고    scopus 로고
    • The effects of dehydroepiandrosterone sulfate on counterregulatory responses during repeated hypoglycemia in conscious normal rats
    • Sandoval D, Ping L, Neill RA, Morrey S, Davis SN. The effects of dehydroepiandrosterone sulfate on counterregulatory responses during repeated hypoglycemia in conscious normal rats. Diabetes 53: 679-686, 2004.
    • (2004) Diabetes , vol.53 , pp. 679-686
    • Sandoval, D.1    Ping, L.2    Neill, R.A.3    Morrey, S.4    Davis, S.N.5
  • 37
  • 38
    • 0031193750 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: Regulation by insulin, cyclic AMP and pyruvate
    • Sugden M, Orfali KA, Fryer LG, Holness MJ, Priestman DA. Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: regulation by insulin, cyclic AMP and pyruvate. J Mol Cell Cardiol 29: 1867-1875, 1997.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 1867-1875
    • Sugden, M.1    Orfali, K.A.2    Fryer, L.G.3    Holness, M.J.4    Priestman, D.A.5
  • 39
    • 0015493877 scopus 로고
    • Studies on the mechanism of hormone action
    • Sutherland E. Studies on the mechanism of hormone action. Science 177: 401-408, 1972.
    • (1972) Science , vol.177 , pp. 401-408
    • Sutherland, E.1
  • 40
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387: 673-676, 1997.
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 41
    • 0024842752 scopus 로고
    • Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist
    • Unson CG, Gurzenda EM, Merrifield RB. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides 10: 1171-1177, 1989.
    • (1989) Peptides , vol.10 , pp. 1171-1177
    • Unson, C.G.1    Gurzenda, E.M.2    Merrifield, R.B.3
  • 42
    • 0023041534 scopus 로고
    • Activation of two signal-transduction systems in hepatocytes by glucagon
    • Wakelam M, Murphy GJ, Hruby VJ, Houslay MD. Activation of two signal-transduction systems in hepatocytes by glucagon. Nature 323: 68-71, 1986.
    • (1986) Nature , vol.323 , pp. 68-71
    • Wakelam, M.1    Murphy, G.J.2    Hruby, V.J.3    Houslay, M.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.