-
1
-
-
0000639869
-
Oxidative phosphorylation and photophosphorylation
-
Boyer, P.D. et al. Oxidative phosphorylation and photophosphorylation. Annu. Rev. Biochem. 46, 955-966 (1977
-
(1977)
Annu. Rev. Biochem.
, vol.46
, pp. 955-966
-
-
Boyer, P.D.1
-
2
-
-
0023642627
-
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
-
Carling, D., Zammit, V.A. & Hardie, D.G. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett. 223, 217-222 (1987
-
(1987)
FEBS Lett.
, vol.223
, pp. 217-222
-
-
Carling, D.1
Zammit, V.A.2
Hardie, D.G.3
-
3
-
-
0024546378
-
The AMP-activated protein kinase: A multisubstrate regulator of lipid metabolism
-
Hardie, D.G., Carling, D. & Sim, A.T.R. The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism. Trends Biochem. Sci. 14, 20-23 (1989 (Pubitemid 19031701)
-
(1989)
Trends in Biochemical Sciences
, vol.14
, Issue.1
, pp. 20-23
-
-
Hardie, D.G.1
Carling, D.2
Sim, A.T.R.3
-
4
-
-
0015918822
-
Regulation of hepatic acetyl-CoA carboxylase by phosphorylation and dephosphorylation
-
Carlson, C.A. & Kim, K.H. Regulation of hepatic acetyl-CoA carboxylase by phosphorylation and dephosphorylation. J. Biol. Chem. 248, 378-380 (1973
-
(1973)
J. Biol. Chem.
, vol.248
, pp. 378-380
-
-
Carlson, C.A.1
Kim, K.H.2
-
5
-
-
0018963044
-
Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge
-
Yeh, L.A., Lee, K. & Kim, K. Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by adenylate energy charge. J. Biol. Chem. 255, 2308-2314 (1980 (Pubitemid 10036033)
-
(1980)
Journal of Biological Chemistry
, vol.255
, Issue.6
, pp. 2308-2314
-
-
Yeh, L.A.1
Lee, K.H.2
Kim, K.H.3
-
6
-
-
0015864346
-
Modulation of 3-hydroxy-3- methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol
-
Beg, Z.H., Allmann, D.W. & Gibson, D.M. Modulation of 3-hydroxy-3- methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol. Biochem. Biophys. Res. Commun. 54, 1362-1369 (1973
-
(1973)
Biochem. Biophys. Res. Commun.
, vol.54
, pp. 1362-1369
-
-
Beg, Z.H.1
Allmann, D.W.2
Gibson, D.M.3
-
7
-
-
0021140780
-
Allosteric activation of rat liver cytosylic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by nucleoside diphosphates
-
Harwood, H.J. Jr., Brandt, K.G. & Rodwell, V.W. Allosteric activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by nucleoside diphosphates. J. Biol. Chem. 259, 2810-2815 (1984 (Pubitemid 14127910)
-
(1984)
Journal of Biological Chemistry
, vol.259
, Issue.5
, pp. 2810-2815
-
-
Harwood Jr., H.J.1
Brandt, K.G.2
Rodwell, V.W.3
-
8
-
-
0019459227
-
Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system
-
Ingebritsen, T.S., Parker, R.A. & Gibson, D.M. Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system. J. Biol. Chem. 256, 1138-1144 (1981 (Pubitemid 11157213)
-
(1981)
Journal of Biological Chemistry
, vol.256
, Issue.3
, pp. 1138-1144
-
-
Ingebritsen, T.S.1
Parker, R.A.2
Gibson, D.M.3
-
9
-
-
0031717105
-
The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
-
DOI 10.1146/annurev.biochem.67.1.821
-
Hardie, D.G., Carling, D. & Carlson, M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67, 821-855 (1998 (Pubitemid 28411146)
-
(1998)
Annual Review of Biochemistry
, vol.67
, pp. 821-855
-
-
Hardie, D.G.1
Carling, D.2
Carlson, M.3
-
10
-
-
0023789884
-
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase
-
Munday, M.R., Campbell, D.G., Carling, D. & Hardie, D.G. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur. J. Biochem. 175, 331-338 (1988
-
(1988)
Eur. J. Biochem.
, vol.175
, pp. 331-338
-
-
Munday, M.R.1
Campbell, D.G.2
Carling, D.3
Hardie, D.G.4
-
11
-
-
77957349477
-
AMP-activated protein kinase and its downstream transcriptional pathways
-
Cantó, C. & Auwerx, J. AMP-activated protein kinase and its downstream transcriptional pathways. Cell. Mol. Life Sci. 67, 3407-3423 (2010
-
(2010)
Cell. Mol. Life Sci.
, vol.67
, pp. 3407-3423
-
-
Cantó, C.1
Auwerx, J.2
-
12
-
-
67650898228
-
LKB1 and AMPK family signaling: The intimate link between cell polarity and energy metabolism
-
Jansen, M., Ten Klooster, J.P., Offerhaus, G.J. & Clevers, H. LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol. Rev. 89, 777-798 (2009
-
(2009)
Physiol. Rev.
, vol.89
, pp. 777-798
-
-
Jansen, M.1
Ten Klooster, J.P.2
Offerhaus, G.J.3
Clevers, H.4
-
13
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
-
Kahn, B.B., Alquier, T., Carling, D. & Hardie, D.G. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25 (2005 (Pubitemid 43960587)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
14
-
-
56449117024
-
AMPK: A metabolic gauge regulating whole-body energy homeostasis
-
Lage, R., Diéguez, C., Vidal-Puig, A. & López, M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol. Med. 14, 539-549 (2008
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 539-549
-
-
Lage, R.1
Diéguez, C.2
Vidal-Puig, A.3
López, M.4
-
15
-
-
67650914230
-
AMPK in health and disease
-
Steinberg, G.R. & Kemp, B.E. AMPK in health and disease. Physiol. Rev. 89, 1025-1078 (2009
-
(2009)
Physiol. Rev.
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
16
-
-
77954589064
-
AMPK inhibition in health and disease
-
Viollet, B. et al. AMPK inhibition in health and disease. Crit. Rev. Biochem. Mol. Biol. 45, 276-295 (2010
-
(2010)
Crit. Rev. Biochem. Mol. Biol.
, vol.45
, pp. 276-295
-
-
Viollet, B.1
-
17
-
-
65349177200
-
AMPK: An emerging drug target for diabetes and the metabolic syndrome
-
Zhang, B.B., Zhou, G. & Li, C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 9, 407-416 (2009
-
(2009)
Cell Metab.
, vol.9
, pp. 407-416
-
-
Zhang, B.B.1
Zhou, G.2
Li, C.3
-
18
-
-
0028310837
-
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism
-
Carling, D. et al. Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. J. Biol. Chem. 269, 11442-11448 (1994 (Pubitemid 24200360)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.15
, pp. 11442-11448
-
-
Carling, D.1
Aguan, K.2
Woods, A.3
Verhoeven, A.J.M.4
Beri, R.K.5
Brennan, C.H.6
Sidebottom, C.7
Davison, M.D.8
Scott, J.9
-
19
-
-
0027932717
-
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
-
Mitchelhill, K.I. et al. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J. Biol. Chem. 269, 2361-2364 (1994 (Pubitemid 24235720)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.4
, pp. 2361-2364
-
-
Mitchelhill, K.I.1
Stapleton, D.2
Gao, G.3
House, C.4
Michell, B.5
Katsis, F.6
Witters, L.A.7
Kemp, B.E.8
-
20
-
-
13344285343
-
Mammalian AMP-activated protein kinase subfamily
-
DOI 10.1074/jbc.271.2.611
-
Stapleton, D. et al. Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271, 611-614 (1996 (Pubitemid 26034902)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.2
, pp. 611-614
-
-
Stapleton, D.1
Mitchelhill, K.I.2
Gao, G.3
Widmer, J.4
Michell, B.J.5
Teh, T.6
House, C.M.7
Fernandez, C.S.8
Cox, T.9
Witters, L.A.10
Kemp, B.E.11
-
21
-
-
0019566797
-
Mutants of yeast defective in sucrose utilization
-
Carlson, M., Osmond, B. & Botstein, D. Mutants of yeast defective in sucrose utilization. Genetics 98, 25-40 (1981
-
(1981)
Genetics
, vol.98
, pp. 25-40
-
-
Carlson, M.1
Osmond, B.2
Botstein, D.3
-
22
-
-
0021432459
-
A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast
-
Carlson, M., Osmond, B., Neigeborn, L. & Botstein, D. A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics 107, 19-32 (1984
-
(1984)
Genetics
, vol.107
, pp. 19-32
-
-
Carlson, M.1
Osmond, B.2
Neigeborn, L.3
Botstein, D.4
-
23
-
-
0022534202
-
A yeast gene that is essential for release from glucose repression encodes a protein kinase
-
Celenza, J.L. & Carlson, M. A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science 233, 1175-1180 (1986 (Pubitemid 16032170)
-
(1986)
Science
, vol.233
, Issue.4769
, pp. 1175-1180
-
-
Celenza, J.L.1
Carlson, M.2
-
24
-
-
0028126820
-
Mammalian 5′-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase
-
Stapleton, D. et al. Mammalian 5′-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase. J. Biol. Chem. 269, 29343-29346 (1994
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 29343-29346
-
-
Stapleton, D.1
-
25
-
-
0029925785
-
Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro
-
Woods, A. et al. Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. J. Biol. Chem. 271, 10282-10290 (1996
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10282-10290
-
-
Woods, A.1
-
26
-
-
0033118209
-
Glucose repression in yeast
-
Carlson M.
-
Carlson, M. Glucose repression in yeast. Curr. Opin. Microbiol. 2, 202-207 (1999
-
(1999)
Curr. Opin. Microbiol.
, vol.2
, pp. 202-207
-
-
-
27
-
-
37349041710
-
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease
-
DOI 10.1016/j.febslet.2007.11.018, PII S0014579307011623
-
Hardie, D.G. Role of the AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Lett. 582, 81-89 (2008 (Pubitemid 350297243)
-
(2008)
FEBS Letters
, vol.582
, Issue.1
, pp. 81-89
-
-
Hardie, D.G.1
-
28
-
-
0024786438
-
Purification and characterisation of the AMP-activated protein kinase
-
Carling, D., Clarke, P.R., Zammit, V.A. & Hardie, D.G. Purification and characterisation of the AMP-activated protein kinase. Eur. J. Biochem. 186, 129-136 (1989
-
(1989)
Eur. J. Biochem.
, vol.186
, pp. 129-136
-
-
Carling, D.1
Clarke, P.R.2
Zammit, V.A.3
Hardie, D.G.4
-
29
-
-
0043071497
-
Mammalian AMP-activated protein kinase: Functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli
-
DOI 10.1016/S1046-5928(03)00126-8
-
Neumann, D., Woods, A., Carling, D., Wallimann, T. & Schlattner, U. Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr. Purif. 30, 230-237 (2003 (Pubitemid 36990336)
-
(2003)
Protein Expression and Purification
, vol.30
, Issue.2
, pp. 230-237
-
-
Neumann, D.1
Woods, A.2
Carling, D.3
Wallimann, T.4
Schlattner, U.5
-
30
-
-
0018308131
-
Characterization and regulation of reductase kinase, a protein kinase that modulates the enzyme activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
Beg, Z.H., Stonik, J.A. & Brewer, H.B. Jr. Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc. Natl. Acad. Sci. USA 76, 4375-4379 (1979 (Pubitemid 9256564)
-
(1979)
Proceedings of the National Academy of Sciences of the United States of America
, vol.76
, Issue.9
, pp. 4375-4379
-
-
Beg, Z.H.1
Stonik, J.A.2
Brewer Jr., H.B.3
-
31
-
-
0029561919
-
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2Cα and native bovine protein phosphatase-2A(C)
-
DOI 10.1016/0014-5793(95)01368-7
-
Davies, S.P., Helps, N.R., Cohen, P.T. & Hardie, D.G. 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C ? and native bovine protein phosphatase-2AC. FEBS Lett. 377, 421-425 (1995 (Pubitemid 26027159)
-
(1995)
FEBS Letters
, vol.377
, Issue.3
, pp. 421-425
-
-
Davies, S.P.1
Helps, N.R.2
Cohen, P.T.W.3
Hardie, D.G.4
-
32
-
-
0028845251
-
5′-AMP activates the AMP-activated protein kinase cascade and Ca2+/calmodulin activates the calmodulin-dependent protein kinase-I cascade, via 3 independent mechanisms
-
Hawley, S.A. et al. 5′-AMP activates the AMP-activated protein kinase cascade and Ca2+/calmodulin activates the calmodulin-dependent protein kinase-I cascade, via 3 independent mechanisms. J. Biol. Chem. 270, 27186-27191 (1995
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27186-27191
-
-
Hawley, S.A.1
-
33
-
-
0031007065
-
The AMP-activated protein kinase. Fuel gauge of the mammalian cell?
-
Hardie, D.G. & Carling, D. The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur. J. Biochem. 246, 259-273 (1997 (Pubitemid 27232500)
-
(1997)
European Journal of Biochemistry
, vol.246
, Issue.2
, pp. 259-273
-
-
Hardie, D.G.1
Carling, D.2
-
34
-
-
0029910018
-
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
-
DOI 10.1074/jbc.271.44.27879
-
Hawley, S.A. et al. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J. Biol. Chem. 271, 27879-27887 (1996 (Pubitemid 26367365)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.44
, pp. 27879-27887
-
-
Hawley, S.A.1
Davison, M.2
Woods, A.3
Davies, S.P.4
Beri, R.K.5
Carling, D.6
Hardie, D.G.7
-
35
-
-
34147152841
-
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
-
DOI 10.1042/BJ20061520
-
Sanders, M.J., Grondin, P.O., Hegarty, B.D., Snowden, M.A. & Carling, D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem. J. 403, 139-148 (2007 (Pubitemid 46569875)
-
(2007)
Biochemical Journal
, vol.403
, Issue.1
, pp. 139-148
-
-
Sanders, M.J.1
Grondin, P.O.2
Hegarty, B.D.3
Snowden, M.A.4
Carling, D.5
-
36
-
-
33845949733
-
Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
-
DOI 10.1074/jbc.M606357200
-
Suter, M. et al. Dissecting the role of AMP for allosteric stimulation, activation and deactivation of AMP-activated protein kinase. J. Biol. Chem. 281, 32207-32216 (2006 (Pubitemid 46036775)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.43
, pp. 32207-32216
-
-
Suter, M.1
Riek, U.2
Tuerk, R.3
Schlattner, U.4
Wallimann, T.5
Neumann, D.6
-
37
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
DOI 10.1073/pnas.1533136100
-
Hong, S.P., Leiper, F.C., Woods, A., Carling, D. & Carlson, M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. USA 100, 8839-8843 (2003 (Pubitemid 36899185)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.15
, pp. 8839-8843
-
-
Hong, S.-P.1
Leiper, F.C.2
Woods, A.3
Carling, D.4
Carlson, M.5
-
38
-
-
0041700137
-
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex
-
DOI 10.1016/S0960-9822(03)00459-7
-
Sutherland, C.M. et al. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr. Biol. 13, 1299-1305 (2003 (Pubitemid 36953302)
-
(2003)
Current Biology
, vol.13
, Issue.15
, pp. 1299-1305
-
-
Sutherland, C.M.1
Hawley, S.A.2
McCartney, R.R.3
Leech, A.4
Stark, M.J.R.5
Schmidt, M.C.6
Hardie, D.G.7
-
39
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD ?/β and MO25 ?/β are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley, S.A. et al. Complexes between the LKB1 tumor suppressor, STRAD ?/β and MO25 ?/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2, 28 (2003
-
(2003)
J. Biol.
, vol.2
, pp. 28
-
-
Hawley, S.A.1
-
40
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
DOI 10.1016/j.cub.2003.10.031
-
Woods, A. et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13, 2004-2008 (2003 (Pubitemid 37425212)
-
(2003)
Current Biology
, vol.13
, Issue.22
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.D.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
41
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
-
DOI 10.1016/j.cmet.2005.05.009, PII S155041310500166X
-
Hawley, S.A. et al. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2, 9-19 (2005 (Pubitemid 43239821)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
42
-
-
23044437445
-
2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
-
DOI 10.1016/j.cmet.2005.06.005, PII S1550413105001701
-
Woods, A. et al. Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2, 21-33 (2005 (Pubitemid 43239822)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.-P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
43
-
-
33746979242
-
2+/calmodulin-dependent protein kinase kinase β
-
DOI 10.1128/MCB.00383-06
-
Stahmann, N., Woods, A., Carling, D. & Heller, R. Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase β. Mol. Cell. Biol. 26, 5933-5945 (2006 (Pubitemid 44204514)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.16
, pp. 5933-5945
-
-
Stahmann, N.1
Woods, A.2
Carling, D.3
Heller, R.4
-
44
-
-
33745823168
-
2+ in T lymphocytes
-
DOI 10.1084/jem.20052469
-
Tamás, P. et al. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J. Exp. Med. 203, 1665-1670 (2006 (Pubitemid 44036271)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1665-1670
-
-
Tamas, P.1
Hawley, S.A.2
Clarke, R.G.3
Mustard, K.J.4
Green, K.5
Hardie, D.G.6
Cantrell, D.A.7
-
45
-
-
47749103323
-
Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression
-
Thornton, C., Sardini, A. & Carling, D. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. J. Biol. Chem. 283, 17116-17122 (2008
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 17116-17122
-
-
Thornton, C.1
Sardini, A.2
Carling, D.3
-
46
-
-
20444468520
-
2+/calmodulin-dependent protein kinase kinase α as Snf1-activating kinases in yeast
-
DOI 10.1074/jbc.M501887200
-
Hong, S.P., Momcilovic, M. & Carlson, M. Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase ? as Snf1-activating kinases in yeast. J. Biol. Chem. 28, 21804-21809 (2005 (Pubitemid 40827830)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 21804-21809
-
-
Hong, S.-P.1
Momcilovic, M.2
Carlson, M.3
-
47
-
-
0033974002
-
Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snfl protein kinase
-
DOI 10.1128/MCB.20.4.1321-1328.2000
-
Sanz, P., Alms, G.R., Haystead, T.A. & Carlson, M. Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase. Mol. Cell. Biol. 20, 1321-1328 (2000 (Pubitemid 30069253)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.4
, pp. 1321-1328
-
-
Sanz, P.1
Alms, G.R.2
Haystead, T.A.J.3
Carlson, M.4
-
48
-
-
0024592297
-
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
-
DOI 10.1038/337078a0
-
Haystead, T.A.J. et al. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337, 78-81 (1989 (Pubitemid 19022553)
-
(1989)
Nature
, vol.337
, Issue.6202
, pp. 78-81
-
-
Haystead, T.A.J.1
Sim, A.T.R.2
Carling, D.3
Honnor, R.C.4
Tsukitani, Y.5
Cohen, P.6
Hardie, D.G.7
-
49
-
-
0025915269
-
Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion
-
Moore, F., Weekes, J. & Hardie, D.G. Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion. Eur. J. Biochem. 199, 691-697 (1991
-
(1991)
Eur. J. Biochem.
, vol.199
, pp. 691-697
-
-
Moore, F.1
Weekes, J.2
Hardie, D.G.3
-
50
-
-
77957763018
-
Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
-
Voss, M. et al. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Cell. Signal. 23, 114-124 (2011
-
(2011)
Cell. Signal.
, vol.23
, pp. 114-124
-
-
Voss, M.1
-
51
-
-
79952114408
-
The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 cells
-
Garcia-Haro, L. et al. The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 cells. FASEB J. 24, 5080-5091 (2010
-
(2010)
FASEB J.
, vol.24
, pp. 5080-5091
-
-
Garcia-Haro, L.1
-
52
-
-
0034654362
-
Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
-
DOI 10.1042/0264-6021:3460659
-
Cheung, P.C., Salt, I.P., Davies, S.P., Hardie, D.G. & Carling, D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem. J. 346, 659-669 (2000 (Pubitemid 30171026)
-
(2000)
Biochemical Journal
, vol.346
, Issue.3
, pp. 659-669
-
-
Cheung, P.C.F.1
Salt, I.P.2
Davies, S.P.3
Hardie, D.G.4
Carling, D.5
-
53
-
-
0031016272
-
The structure of a domain common to archaebacteria and the homocystinuria disease protein
-
DOI 10.1016/S0968-0004(96)30046-7, PII S0968000496300467
-
Bateman, A. The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem. Sci. 22, 12-13 (1997 (Pubitemid 27056090)
-
(1997)
Trends in Biochemical Sciences
, vol.22
, Issue.1
, pp. 12-13
-
-
Bateman, A.1
-
54
-
-
1342332128
-
Bateman domains and adenosine derivatives form a binding contract
-
DOI 10.1172/JCI200420846
-
Kemp, B.E. Bateman domains and adenosine derivatives form a binding contract. J. Clin. Invest. 113, 182-184 (2004 (Pubitemid 38544202)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.2
, pp. 182-184
-
-
Kemp, B.E.1
-
55
-
-
85047691317
-
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
-
DOI 10.1172/JCI200419874
-
Scott, J.W. et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. 113, 274-284 (2004 (Pubitemid 38544212)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.2
, pp. 274-284
-
-
Scott, J.W.1
Hawley, S.A.2
Green, K.A.3
Anis, M.4
Stewart, G.5
Scullion, G.A.6
Norman, D.G.7
Hardie, D.G.8
-
56
-
-
0034685949
-
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
-
DOI 10.1126/science.288.5469.1248
-
Milan, D. et al. A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science 288, 1248-1251 (2000 (Pubitemid 30367203)
-
(2000)
Science
, vol.288
, Issue.5469
, pp. 1248-1251
-
-
Milan, D.1
Jeon, J.-T.2
Looft, C.3
Amarger, V.4
Robic, A.5
Thelander, M.6
Rogel-Gaillard, C.7
Paul, S.8
Iannuccelli, N.9
Rask, L.10
Ronne, H.11
Lundstrom, K.12
Reinsch, N.13
Gellin, J.14
Kalm, E.15
Le Roy, P.16
Chardon, P.17
Andersson, L.18
-
57
-
-
0035872209
-
2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis
-
Blair, E., Redwood, C., Ashrafian, H., Ostman-Smith, I. & Watkins, H. Mutations in the ?2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. Hum. Mol. Genet. 10, 1215-1220 (2001 (Pubitemid 32487544)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.11
, pp. 1215-1220
-
-
Blair, E.1
Redwood, C.2
Ashrafian, H.3
Oliveira, M.4
Broxholme, J.5
Kerr, B.6
Salmon, A.7
Ostman-Smith, I.8
Watkins, H.9
-
58
-
-
0035859215
-
Identification of a gene responsible for familial Wolff-Parkinson-White syndrome
-
DOI 10.1056/NEJM200106143442403
-
Gollob, M.H. et al. Identification of a gene responsible for familial Wolff- Parkinson-White syndrome. N. Engl. J. Med. 344, 1823-1831 (2001); erratum 345, 552 (2001 (Pubitemid 32538695)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.24
, pp. 1823-1831
-
-
Gollob, M.H.1
Green, M.S.2
Tang, A.S.-L.3
Gollob, T.4
Karibe, A.5
Hassan, A.-S.6
Ahmad, F.7
Lozado, R.8
Shah, G.9
Fananapazir, L.10
Bachinski, L.L.11
Roberts, R.12
-
59
-
-
33947526130
-
AMP-activated protein kinase in the heart: Role during health and disease
-
DOI 10.1161/01.RES.0000258446.23525.37, PII 0000301220070302000007
-
Arad, M., Seidman, C.E. & Seidman, J.G. AMP-activated protein kinase in the heart: role during health and disease. Circ. Res. 100, 474-488 (2007 (Pubitemid 46673257)
-
(2007)
Circulation Research
, vol.100
, Issue.4
, pp. 474-488
-
-
Arad, M.1
Seidman, C.E.2
Seidman, J.G.3
-
60
-
-
34047161436
-
Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase
-
DOI 10.1126/science.1137503
-
Townley, R. & Shapiro, L. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315, 1726-1729 (2007 (Pubitemid 46515629)
-
(2007)
Science
, vol.315
, Issue.5819
, pp. 1726-1729
-
-
Townley, R.1
Shapiro, L.2
-
61
-
-
34848840368
-
Structural basis for AMP binding to mammalian AMP-activated protein kinase
-
DOI 10.1038/nature06161, PII NATURE06161
-
Xiao, B. et al. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449, 496-500 (2007 (Pubitemid 47509548)
-
(2007)
Nature
, vol.449
, Issue.7161
, pp. 496-500
-
-
Xiao, B.1
Heath, R.2
Saiu, P.3
Leiper, F.C.4
Leone, P.5
Jing, C.6
Walker, P.A.7
Haire, L.8
Eccleston, J.F.9
Davis, C.T.10
Martin, S.R.11
Carling, D.12
Gamblin, S.J.13
-
62
-
-
34848843526
-
Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
-
DOI 10.1038/nature06127, PII NATURE06127
-
Amodeo, G.A., Rudolph, M.J. & Tong, L. Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature 449, 492-495 (2007 (Pubitemid 47509541)
-
(2007)
Nature
, vol.449
, Issue.7161
, pp. 492-495
-
-
Amodeo, G.A.1
Rudolph, M.J.2
Tong, L.3
-
63
-
-
35148867829
-
AMPK structure and regulation from three angles
-
DOI 10.1016/j.str.2007.09.006, PII S0969212607003310
-
Kemp, B.E., Oakhill, J.S. & Scott, J.W. AMPK structure and regulation from three angles. Structure 15, 1161-1163 (2007 (Pubitemid 47539170)
-
(2007)
Structure
, vol.15
, Issue.10
, pp. 1161-1163
-
-
Kemp, B.E.1
Oakhill, J.S.2
Scott, J.W.3
-
64
-
-
35148850705
-
Structural insight into AMPK regulation: ADP comes into play
-
DOI 10.1016/j.str.2007.07.017, PII S0969212607002936
-
Jin, X., Townley, R. & Shapiro, L. Structural insight into AMPK regulation: ADP comes into play. Structure 15, 1285-1295 (2007 (Pubitemid 47539159)
-
(2007)
Structure
, vol.15
, Issue.10
, pp. 1285-1295
-
-
Jin, X.1
Townley, R.2
Shapiro, L.3
-
65
-
-
0041319433
-
Effect of exercise intensity on skeletal muscle AMPK signaling in humans
-
Chen, Z.P. et al. Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes 52, 2205-2212 (2003
-
(2003)
Diabetes
, vol.52
, pp. 2205-2212
-
-
Chen, Z.P.1
-
66
-
-
0037127203
-
The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart
-
DOI 10.1074/jbc.M107128200
-
Frederich, M. & Balschi, J.A. The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart. J. Biol. Chem. 277, 1928-1932 (2002 (Pubitemid 34968770)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.3
, pp. 1928-1932
-
-
Frederich, M.1
Balschi, J.A.2
-
67
-
-
0033230853
-
AMP deamination and purine exchange in human skeletal muscle during and after intense exercise
-
DOI 10.1111/j.1469-7793.1999.00909.x
-
Hellsten, Y., Richter, E., Kiens, B. & Bangsbo, J. AMP deamination and purine exchange in human skeletal muscle during and after intense exercise. J. Physiol. (Lond.) 520, 909-920 (1999 (Pubitemid 29533045)
-
(1999)
Journal of Physiology
, vol.520
, Issue.3
, pp. 909-920
-
-
Hellsten, Y.1
Richter, E.A.2
Kiens, B.3
Bangsbo, J.4
-
68
-
-
0018801091
-
Cytosolic phosphorylation potential
-
Veech, R.L., Lawson, J.W.R., Cornell, N.W. & Krebs, H.A. Cytosolic phosphorylation potential. J. Biol. Chem. 254, 6538-6547 (1979
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 6538-6547
-
-
Veech, R.L.1
Lawson, J.W.R.2
Cornell, N.W.3
Krebs, H.A.4
-
69
-
-
79954517977
-
Structure of mammalian AMPK and its regulation by ADP
-
Xiao, B. et al. Structure of mammalian AMPK and its regulation by ADP. Nature 472, 230-233 (2011
-
(2011)
Nature
, vol.472
, pp. 230-233
-
-
Xiao, B.1
-
70
-
-
0016705986
-
Inactivation of 3-hyroxy-3- methylglutaryl coenzyme A reductase in vitro
-
Brown, M.S., Brunschede, G.Y. & Goldstein, J.L. Inactivation of 3-hyroxy-3- methylglutaryl coenzyme A reductase in vitro. J. Biol. Chem. 250, 2502-2509 (1975
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 2502-2509
-
-
Brown, M.S.1
Brunschede, G.Y.2
Goldstein, J.L.3
-
71
-
-
0023025490
-
Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria
-
Corkey, B.E., Duszynski, J., Rich, T.L., Matschinsky, B. & Williamson, J.R. Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. J. Biol. Chem. 261, 2567-2574 (1986 (Pubitemid 17218265)
-
(1986)
Journal of Biological Chemistry
, vol.261
, Issue.6
, pp. 2567-2574
-
-
Corkey, B.E.1
Duszynski, J.2
Rich, T.L.3
-
72
-
-
78650606464
-
β subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK
-
Oakhill, J.S. et al. β subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc. Natl. Acad. Sci. U.S.A. 107, 19237-19241 (2010
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 19237-19241
-
-
Oakhill, J.S.1
-
73
-
-
36348998521
-
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
-
DOI 10.1074/jbc.M706536200
-
Göransson, O. et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J. Biol. Chem. 282, 32549-32560 (2007 (Pubitemid 350159310)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.45
, pp. 32549-32560
-
-
Goransson, O.1
McBride, A.2
Hawley, S.A.3
Ross, F.A.4
Shpiro, N.5
Foretz, M.6
Viollet, B.7
Hardie, D.G.8
Sakamoto, K.9
-
74
-
-
33846945033
-
Conserved α-helix acts as autoinhibitory sequence in AMP-activated protein kinase α subunits
-
DOI 10.1074/jbc.M605790200
-
Pang, T. et al. Conserved a-helix acts as autoinhibitory sequence in AMP-activated protein kinase a subunits. J. Biol. Chem. 282, 495-506 (2007 (Pubitemid 47076612)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.1
, pp. 495-506
-
-
Pang, T.1
Xiong, B.2
Li, J.-Y.3
Qiu, B.-Y.4
Jin, G.-Z.5
Shen, J.-K.6
Li, J.7
-
75
-
-
67649484365
-
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
-
Chen, L. et al. Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature 459, 1146-1149 (2009
-
(2009)
Nature
, vol.459
, pp. 1146-1149
-
-
Chen, L.1
-
76
-
-
76549089547
-
Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: Synergistic effects of Ca2+ and AMP
-
Fogarty, S. et al. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP. Biochem. J. 426, 109-118 (2010
-
(2010)
Biochem. J.
, vol.426
, pp. 109-118
-
-
Fogarty, S.1
-
77
-
-
0038814313
-
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
-
DOI 10.1016/S0960-9822(03)00249-5
-
Hudson, E.R. et al. A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr. Biol. 13, 861-866 (2003 (Pubitemid 36573255)
-
(2003)
Current Biology
, vol.13
, Issue.10
, pp. 861-866
-
-
Hudson, E.R.1
Pan, D.A.2
James, J.3
Lucocq, J.M.4
Hawley, S.A.5
Green, K.A.6
Baba, O.7
Terashima, T.8
Hardie, D.G.9
-
78
-
-
0037799908
-
AMPK β subunit targets metabolic stress sensing to glycogen
-
DOI 10.1016/S0960-9822(03)00292-6
-
Polekhina, G. et al. AMPK β subunit targets metabolic stress sensing to glycogen. Curr. Biol. 13, 867-871 (2003 (Pubitemid 36573256)
-
(2003)
Current Biology
, vol.13
, Issue.10
, pp. 867-871
-
-
Polekhina, G.1
Gupta, A.2
Michell, B.J.3
Van Denderen, B.4
Murthy, S.5
Feil, S.C.6
Jennings, I.G.7
Campbell, D.J.8
Witters, L.A.9
Parker, M.W.10
Kemp, B.E.11
Stapleton, D.12
-
79
-
-
57849090443
-
The glycogen-binding domain on the AMPK β subunit allows the kinase to act as a glycogen sensor
-
McBride, A., Ghilagaber, S., Nikolaev, A. & Hardie, D.G. The glycogen-binding domain on the AMPK β subunit allows the kinase to act as a glycogen sensor. Cell Metab. 9, 23-34 (2009
-
(2009)
Cell Metab.
, vol.9
, pp. 23-34
-
-
McBride, A.1
Ghilagaber, S.2
Nikolaev, A.3
Hardie, D.G.4
-
80
-
-
36348978499
-
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
-
DOI 10.1074/jbc.M706543200
-
Sanders, M.J. et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J. Biol. Chem. 282, 32539-32548 (2007 (Pubitemid 350159309)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.45
, pp. 32539-32548
-
-
Sanders, M.J.1
Ali, Z.S.2
Hegarty, B.D.3
Heath, R.4
Snowden, M.A.5
Carling, D.6
|