Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

Diabetologia

Volumn 44, Issue 11, 2001, Pages 2018-2024

  Petersen, K F ^a   Sullivan, J T ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

Diabetes; Glucagon; Glucagon antagonist; Glucose production

Indexed keywords

3,5 DIISOPROPYL 2 (1 HYDROXYETHYL) 6 PROPYL 4' FLUORO 1,1' BIPHENYL; ANTIDIABETIC AGENT; BAY 27 9955; GLUCAGON; GLUCAGON RECEPTOR ANTAGONIST; GLUCOSE; INSULIN; PLACEBO; SOMATOSTATIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPERGLUCAGONEMIA; INSULIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; BIPHENYL COMPOUNDS; BLOOD GLUCOSE; GLUCAGON; HEMOGLOBIN A, GLYCOSYLATED; HORMONE ANTAGONISTS; HUMANS; INSULIN; KINETICS; MALE; PLACEBOS; RECEPTORS, GLUCAGON; REFERENCE VALUES; SOMATOSTATIN; TIME FACTORS;

EID: 0035195977     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100006     Document Type: Article

References (18)

1. Mechanism by which metformin reduces glucose production in type 2 diabetes
2. Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration
3. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study
4. Hyperglucagonemia anal its suppression. Importance in the metabolic control of diabetes
5. Studies of pancreatic alpha cell function in normal and diabetic subjects
6. Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans
7. Direct analysis of 18 O in glucose by mass spectrometry
8. Experimental validation of measurements of glucose tumover in nonsteady state
9. Glucose uptake and production during the oral glucose tolerance test
10. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
11. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: Contributions of excessive hepatic glucose production and impaired tissue glucose uptake
12. The organ of Langerhans in new perspective
13. Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics
14. The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
15. Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man
16. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog
17. The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog