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Volumn 29, Issue 6, 2009, Pages 318-325

Glucagon receptor mediates calcium signaling by coupling to Gαq/11 and Gαi/o in HEK293 cells

Author keywords

Ca2+ i; Calcium ignaling; G q 11 protein; G i o protein; Glucagon receptor

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; CYCLIC AMP; FORSKOLIN; GLUCAGON RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PERTUSSIS TOXIN; PHOSPHOLIPASE C; THAPSIGARGIN;

EID: 71049165532     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799890903295150     Document Type: Article
Times cited : (23)

References (35)
  • 2
    • 0029840285 scopus 로고    scopus 로고
    • Molecular and cellular aspects of the glucagon receptor: Role in diabetes and metabolism
    • Burcelin R, Katz EB, Charron MJ. Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism. Diabetes Metab 1996;22:373-396
    • (1996) Diabetes Metab , vol.22 , pp. 373-396
    • Burcelin, R.1    Katz, E.B.2    Charron, M.J.3
  • 3
    • 0030469432 scopus 로고    scopus 로고
    • Glucagon and its receptor in various tissues
    • discussion 42-43
    • Christophe J. Glucagon and its receptor in various tissues. Ann N Y Acad Sci 1996;805:31-42; discussion 42-43
    • (1996) Ann N y Acad Sci , vol.805 , pp. 31-42
    • Christophe, J.1
  • 4
    • 0029120207 scopus 로고
    • Glucagon receptor mRNA distribution in rat tissues
    • Hansen LH, Abrahamsen N, Nishimura E. Glucagon receptor mRNA distribution in rat tissues. Peptides 1995;16:1163-1166
    • (1995) Peptides , vol.16 , pp. 1163-1166
    • Hansen, L.H.1    Abrahamsen, N.2    Nishimura, E.3
  • 5
    • 0027531638 scopus 로고
    • Expression cloning and signaling properties of the rat glucagon receptor
    • Jelinek LJ, Lok S, Rosenberg GB, Smith RA, et al. Expression cloning and signaling properties of the rat glucagon receptor. Science 1993;259:1614-1616
    • (1993) Science , vol.259 , pp. 1614-1616
    • Jelinek, L.J.1    Lok, S.2    Rosenberg, G.B.3    Smith, R.A.4
  • 6
    • 0027180424 scopus 로고
    • Role of calcium fluxes in the action of glucagon on glucose metabolism in rat hepatocytes
    • Mine T. Kojima I. Ogata E. Role of calcium fluxes in the action of glucagon on glucose metabolism in rat hepatocytes Am J Physiol 1993 265 G35-G42
    • (1993) Am J Physiol , vol.265
    • Mine, T.1    Kojima, I.2    Ogata, E.3
  • 7
    • 0032063414 scopus 로고    scopus 로고
    • 2+ on the effects of glucagon on hepatic glycolysis
    • DOI 10.1016/S0306-3623(97)00381-9, PII S0306362397003819
    • Mine T, Kojima I, Ogata E. Role of calcium fluxes in the action of glucagon on glucose metabolism in rat hepatocytes. Am J Physiol 1993;265:G35-42. 7. da Silva AC, Kelmer-Bracht AM, Constantin J, Ishii-Iwamoto EL, et al. The influence of Ca2+ on the effects of glucagon on hepatic glycolysis. Gen Pharmacol 1998;30:655-662 (Pubitemid 28167767)
    • (1998) General Pharmacology , vol.30 , Issue.5 , pp. 655-662
    • Silva, A.C.M.D.1    Kelmer-Bracht, A.M.2    Constantin, J.3    Ishii-Iwamoto, E.L.4    Yamamoto, N.S.5    Bracht, A.6
  • 8
    • 2442555002 scopus 로고    scopus 로고
    • Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans
    • Dalle S, Longuet C, Costes S, Broca C, et al. Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans. J Biol Chem 2004;279:20345-20355
    • (2004) J Biol Chem , vol.279 , pp. 20345-20355
    • Dalle, S.1    Longuet, C.2    Costes, S.3    Broca, C.4
  • 9
    • 33644987298 scopus 로고    scopus 로고
    • Glucagon receptor- mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: Role of protein kinase A and phospholipase C
    • Li XC, Carretero OA, Shao Y, Zhuo JL. Glucagon receptor- mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: role of protein kinase A and phospholipase C. Hypertension 2006;47:580-585
    • (2006) Hypertension , vol.47 , pp. 580-585
    • Li, X.C.1    Carretero, O.A.2    Shao, Y.3    Zhuo, J.L.4
  • 10
    • 0023768499 scopus 로고
    • Glucagon receptor-mediated activation of Gs is accompanied by subunit dissociation
    • Iyengar R, Rich KA, Herberg JT, Premont RT, et al. Glucagon receptor-mediated activation of Gs is accompanied by subunit dissociation. J Biol Chem 1988;263:15348-15353
    • (1988) J Biol Chem , vol.263 , pp. 15348-15353
    • Iyengar, R.1    Rich, K.A.2    Herberg, J.T.3    Premont, R.T.4
  • 11
    • 0034647923 scopus 로고    scopus 로고
    • Selective stabilization of the high affinity binding conformation of glucagon receptor by the long splice variant of Galpha(s)
    • Unson CG, Wu CR, Sakmar TP, Merrifield RB. Selective stabilization of the high affinity binding conformation of glucagon receptor by the long splice variant of Galpha(s). J Biol Chem 2000;275:21631-21638
    • (2000) J Biol Chem , vol.275 , pp. 21631-21638
    • Unson, C.G.1    Wu, C.R.2    Sakmar, T.P.3    Merrifield, R.B.4
  • 12
    • 0023664159 scopus 로고
    • A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)- cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3′,5′-phosphorothioate
    • Connelly PA, Botelho LH, Sisk RB, Garrison JC. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)- cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem 1987;262:4324-4332
    • (1987) J Biol Chem , vol.262 , pp. 4324-4332
    • Connelly, P.A.1    Botelho, L.H.2    Sisk, R.B.3    Garrison, J.C.4
  • 13
    • 0024565413 scopus 로고
    • Evidence indicating that the glucagon- induced increase in cytoplasmic free Ca2+ concentration in hepatocytes is mediated by an increase in cyclic AMP concentration
    • Staddon JM, Hansford RG. Evidence indicating that the glucagon- induced increase in cytoplasmic free Ca2+ concentration in hepatocytes is mediated by an increase in cyclic AMP concentration. Eur J Biochem 1989;179:47-52.
    • (1989) Eur J Biochem , vol.179 , pp. 47-52
    • Staddon, J.M.1    Hansford, R.G.2
  • 14
    • 0023906862 scopus 로고
    • Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes
    • Mine T, Kojima I, Ogata E. Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes. Biochim Biophys Acta 1988;970:166-171
    • (1988) Biochim Biophys Acta , vol.970 , pp. 166-171
    • Mine, T.1    Kojima, I.2    Ogata, E.3
  • 15
    • 0023041534 scopus 로고
    • Activation of two signal-transduction systems in hepatocytes by glucagon
    • Wakelam MJ, Murphy GJ, Hruby VJ, Houslay MD. Activation of two signal-transduction systems in hepatocytes by glucagon. Nature 1986;323:68-71.
    • (1986) Nature , vol.323 , pp. 68-71
    • Wakelam, M.J.1    Murphy, G.J.2    Hruby, V.J.3    Houslay, M.D.4
  • 16
    • 0031799045 scopus 로고    scopus 로고
    • Glucagon-mediated Ca2+ signaling in BHK cells expressing cloned human glucagon receptors
    • Hansen LH, Gromada J, Bouchelouche P, Whitmore T, et al. Glucagon-mediated Ca2+ signaling in BHK cells expressing cloned human glucagon receptors. Am J Physiol 1998;274:C1552-62.
    • (1998) Am J Physiol , vol.274
    • Hansen, L.H.1    Gromada, J.2    Bouchelouche, P.3    Whitmore, T.4
  • 17
    • 0022976869 scopus 로고
    • Exton JH.Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate
    • Blackmore PF, Exton JH.Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate. J Biol Chem 1986;261:11056-11063
    • (1986) J Biol Chem , vol.261 , pp. 11056-11063
    • Blackmore, P.F.1
  • 19
    • 0034927336 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase C
    • Rhee SG. Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 2001;70:281-312.
    • (2001) Annu Rev Biochem , vol.70 , pp. 281-312
    • Rhee, S.G.1
  • 20
    • 27444440633 scopus 로고    scopus 로고
    • Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins
    • Hubbard KB, Hepler JR. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cell Signal 2006;18:135-150
    • (2006) Cell Signal , vol.18 , pp. 135-150
    • Hubbard, K.B.1    Hepler, J.R.2
  • 21
    • 0038394476 scopus 로고    scopus 로고
    • A new mode of Ca2+ signaling by G protein-coupled receptors: Gating of IP3 receptor Ca2+ release channels by Gbetagamma
    • Zeng W, Mak DO, Li Q, Shin DM, et al. A new mode of Ca2+ signaling by G protein-coupled receptors: gating of IP3 receptor Ca2+ release channels by Gbetagamma. Curr Biol 2003;13:872-876
    • (2003) Curr Biol , vol.13 , pp. 872-876
    • Zeng, W.1    Mak, D.O.2    Li, Q.3    Shin, D.M.4
  • 22
    • 0030950672 scopus 로고    scopus 로고
    • Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C
    • Dorn GW II, Oswald KJ, McCluskey TS, Kuhel DG, et al. Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C. Biochemistry 1997;36:6415-6423
    • (1997) Biochemistry , vol.36 , pp. 6415-6423
    • Dorn Gw, I.I.1    Oswald, K.J.2    McCluskey, T.S.3    Kuhel, D.G.4
  • 23
    • 4544363653 scopus 로고    scopus 로고
    • Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: Study using the Xenopus oocyte expression system
    • Uezono Y, Kaibara M, Murasaki O, Taniyama K. Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system. Am J Physiol Cell Physiol 2004;287:C885-94.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Uezono, Y.1    Kaibara, M.2    Murasaki, O.3    Taniyama, K.4
  • 24
    • 14844338481 scopus 로고    scopus 로고
    • Beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    • Barnes WG, Reiter E, Violin JD, Ren XR, et al. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem 2005; 280:8041-8050
    • (2005) J Biol Chem , vol.280 , pp. 8041-8050
    • Barnes, W.G.1    Reiter, E.2    Violin, J.D.3    Ren, X.R.4
  • 25
    • 30044445078 scopus 로고    scopus 로고
    • Altered expression of G(q/11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1, 4,5-trisphosphate and Ca(2+) signaling
    • Atkinson PJ, Young KW, Ennion SJ, Kew JN, et al. Altered expression of G(q/11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1,4,5-trisphosphate and Ca(2+) signaling. Mol Pharmacol 2006;69:174-184
    • (2006) Mol Pharmacol , vol.69 , pp. 174-184
    • Atkinson, P.J.1    Young, K.W.2    Ennion, S.J.3    Kew, J.N.4    Al, E.5
  • 26
    • 0031960313 scopus 로고    scopus 로고
    • A tool coming of age: Thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca (2+)-ATPases
    • Treiman M, Caspersen C, Christensen SB. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca (2+)-ATPases. Trends Pharmacol Sci 1998;19:131-135
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 131-135
    • Treiman, M.1    Caspersen, C.2    Christensen, S.B.3
  • 27
    • 1842728354 scopus 로고    scopus 로고
    • Pro-nucleotide inhibitors of adenylyl cyclases in intact cells
    • Laux WH, Pande P, Shoshani I, GAO J, et al. Pro-nucleotide inhibitors of adenylyl cyclases in intact cells. J Biol Chem 2004;279:13317-13332
    • (2004) J Biol Chem , vol.279 , pp. 13317-13332
    • Laux, W.H.1    Pande, P.2    Shoshani, I.3    Gao, J.4
  • 28
    • 0015239327 scopus 로고
    • The glucagonsensitive adenyl cyclase system in plasma membranes of rat liver. 3. Binding of glucagon: Method of assay and specificity
    • Rodbell M, Krans HM, Pohl SL, Birnbaumer L.The glucagonsensitive adenyl cyclase system in plasma membranes of rat liver. 3. Binding of glucagon: method of assay and specificity. J Biol Chem 1971;246:1861-1871.
    • (1971) J Biol Chem , vol.246 , pp. 1861-1871
    • Rodbell, M.1    Krans, H.M.2    Pohl, S.L.3    Birnbaumer, L.4
  • 29
    • 62149101953 scopus 로고    scopus 로고
    • Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling
    • Gutknecht E,Van der Linden I, Van Kolen K,Verhoeven KF, et al. Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling. Mol Pharmacol 2009; 75:648-657
    • (2009) Mol Pharmacol , vol.75 , pp. 648-657
    • Gutknecht, E.1    Van Der Linden, I.2    Van Kolen, K.3    Verhoeven, K.F.4
  • 30
    • 34248393065 scopus 로고    scopus 로고
    • An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations
    • Makita N, Sato J, Manaka K, Shoji Y, et al. An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations. Proc Natl Acad Sci U S A 2007;104:5443-5448
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5443-5448
    • Makita, N.1    Sato, J.2    Manaka, K.3    Shoji, Y.4
  • 31
    • 0023682777 scopus 로고
    • Sources of calcium mobilized by glucagon in isolated rat hepatocytes
    • Mine T, Kojima I, Ogata E. Sources of calcium mobilized by glucagon in isolated rat hepatocytes. Acta Endocrinol (Copenh) 1988;119:301-306
    • (1988) Acta Endocrinol (Copenh) , vol.119 , pp. 301-306
    • Mine, T.1    Kojima, I.2    Ogata, E.3
  • 32
    • 0028224822 scopus 로고
    • Inositol 1, 4, 5-trisphosphate activates receptor-mediated calcium entry by two different pathways in hepatocytes
    • Striggow F, Bohnensack R. Inositol 1, 4, 5-trisphosphate activates receptor-mediated calcium entry by two different pathways in hepatocytes. Eur J Biochem 1994;222:229-234
    • (1994) Eur J Biochem , Issue.222 , pp. 229-234
    • Striggow, F.1    Bohnensack, R.2
  • 33
    • 0032489421 scopus 로고    scopus 로고
    • Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes
    • Cao Y, Chatton JY. Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes. FEBS Lett 1998;424:33-36
    • (1998) FEBS Lett , vol.424 , pp. 33-36
    • Cao, Y.1    Chatton, J.Y.2
  • 34
    • 0034745218 scopus 로고    scopus 로고
    • Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells
    • Rychkov G, Brereton HM, Harland ML, Barritt GJ. Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells. Hepatology 2001;33:938-947
    • (2001) Hepatology , vol.33 , pp. 938-947
    • Rychkov, G.1    Brereton, H.M.2    Harland, M.L.3    Barritt, G.J.4
  • 35
    • 0027397544 scopus 로고
    • Inositol trisphosphate and calcium signalling
    • Berridge MJ. Inositol trisphosphate and calcium signalling. Nature 1993;361:315-325
    • (1993) Nature , vol.361 , pp. 315-325
    • Berridge, M.J.1


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