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Volumn 289, Issue 1 52-1, 2005, Pages

Alterations in hepatic glucagon receptor density and in G sα and Giα2 protein content with diet-induced hepatic steatosis: Effects of acute exercise

Author keywords

Fat deposits; Glucagon receptor affinity; High fat diet; Liver; Liver lipid infiltration

Indexed keywords

FATTY ACID; GLUCAGON; GLUCAGON RECEPTOR; GLUCOSE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TRIACYLGLYCEROL;

EID: 21044434666     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00570.2004     Document Type: Article
Times cited : (27)

References (38)
  • 1
    • 0029019227 scopus 로고
    • Regulation of glucagon receptor mRNA in cultured primary rat hepatocytes by glucose and cAMP
    • Abrahamsen N, Lundgren K, and Nishimura E. Regulation of glucagon receptor mRNA in cultured primary rat hepatocytes by glucose and cAMP. J Biol Chem 270: 15853-15857, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 15853-15857
    • Abrahamsen, N.1    Lundgren, K.2    Nishimura, E.3
  • 2
    • 0028222256 scopus 로고
    • Liver beta-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes
    • Begin-Heick N. Liver beta-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes. Am J Physiol Cell Physiol 266: C1664-C1672, 1994.
    • (1994) Am J Physiol Cell Physiol , vol.266
    • Begin-Heick, N.1
  • 3
    • 0017889089 scopus 로고
    • Decreased glucagon receptors in diabetic rat hepatocytes. Evidence for regulation of glucagon receptors by hyperglucagonemia
    • Bhathena SJ, Voyles NR, Smith S, and Recant L. Decreased glucagon receptors in diabetic rat hepatocytes. Evidence for regulation of glucagon receptors by hyperglucagonemia. J Clin Invest 61: 1488-1497, 1978.
    • (1978) J Clin Invest , vol.61 , pp. 1488-1497
    • Bhathena, S.J.1    Voyles, N.R.2    Smith, S.3    Recant, L.4
  • 5
    • 0032478631 scopus 로고    scopus 로고
    • In vivo and in vitro regulation of hepatic glucagon receptor mRNA concentration by glucose metabolism
    • Burcelin R, Mrejen C, Decaux JF, De Mouzon SH, Girard J, and Charron MJ. In vivo and in vitro regulation of hepatic glucagon receptor mRNA concentration by glucose metabolism. J Biol Chem 273: 8088-8093, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 8088-8093
    • Burcelin, R.1    Mrejen, C.2    Decaux, J.F.3    De Mouzon, S.H.4    Girard, J.5    Charron, M.J.6
  • 6
    • 0028258752 scopus 로고
    • Guanine nucleotide binding regulatory proteins in liver from obese humans with and without type II diabetes: Evidence for altered "cross-talk" between the insulin receptor and Gi-proteins
    • Caro JF, Raju MS, Caro M, Lynch CJ, Poulos J, Exton JH, and Thakkar JK. Guanine nucleotide binding regulatory proteins in liver from obese humans with and without type II diabetes: evidence for altered "cross-talk" between the insulin receptor and Gi-proteins. J Cell Biochem 54: 309-319, 1994.
    • (1994) J Cell Biochem , vol.54 , pp. 309-319
    • Caro, J.F.1    Raju, M.S.2    Caro, M.3    Lynch, C.J.4    Poulos, J.5    Exton, J.H.6    Thakkar, J.K.7
  • 7
    • 23644442053 scopus 로고    scopus 로고
    • Evidence of hepatic glucagon resistance associated with hepatic steatosis: Reversal effect of training
    • doi:10.1055/s-2004-821225
    • Charbonneau A, Couturier K, Gauthier MS, and Lavoie JM. Evidence of hepatic glucagon resistance associated with hepatic steatosis: reversal effect of training. Int. J Sports Med doi:10.1055/s-2004-821225.
    • Int J Sports Med
    • Charbonneau, A.1    Couturier, K.2    Gauthier, M.S.3    Lavoie, J.M.4
  • 8
    • 0029788099 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits
    • DebBurman SK, Ptasienski J, Benovic JL, and Hosey MM. G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits. J Biol Chem 271: 22552-22562, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 22552-22562
    • Debburman, S.K.1    Ptasienski, J.2    Benovic, J.L.3    Hosey, M.M.4
  • 9
    • 0021253305 scopus 로고
    • Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus
    • Dighe RR, Rojas FJ, Birnbaumer L, and Garber AJ. Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus. J Clin Invest 73: 1013-10123, 1984.
    • (1984) J Clin Invest , vol.73 , pp. 1013-10123
    • Dighe, R.R.1    Rojas, F.J.2    Birnbaumer, L.3    Garber, A.J.4
  • 11
    • 3342951967 scopus 로고    scopus 로고
    • Swim training increases glucose output from liver perfused in situ with glucagon in fed and fasted rats
    • Drouin R, Robert G, Milot M, Massicotte D, Péronnet F, and Lavoie C. Swim training increases glucose output from liver perfused in situ with glucagon in fed and fasted rats. Metabolism 53: 1027-1031, 2004.
    • (2004) Metabolism , vol.53 , pp. 1027-1031
    • Drouin, R.1    Robert, G.2    Milot, M.3    Massicotte, D.4    Péronnet, F.5    Lavoie, C.6
  • 12
    • 0021799816 scopus 로고
    • Structure-function relationships in glucagon. Re-evaluation of glucagon-(1-21)
    • Frandsen EK, Thim L, Moody AJ, and Markussen J. Structure-function relationships in glucagon. Re-evaluation of glucagon-(1-21). J Biol Chem 260: 7581-7584, 1985.
    • (1985) J Biol Chem , vol.260 , pp. 7581-7584
    • Frandsen, E.K.1    Thim, L.2    Moody, A.J.3    Markussen, J.4
  • 13
    • 3242888007 scopus 로고    scopus 로고
    • Effects of introducing physical training in the course of a 16-wk high-fat diet regimen on hepatic steatosis, adipose tissue fat accumulation, and plasma lipid profile
    • Gauthier MS, Couturier K, Charbonneau A, and Lavoie JM. Effects of introducing physical training in the course of a 16-wk high-fat diet regimen on hepatic steatosis, adipose tissue fat accumulation, and plasma lipid profile. Int J Obes 28: 1064-1071, 2004.
    • (2004) Int J Obes , vol.28 , pp. 1064-1071
    • Gauthier, M.S.1    Couturier, K.2    Charbonneau, A.3    Lavoie, J.M.4
  • 14
    • 0038517194 scopus 로고    scopus 로고
    • Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis
    • Gauthier MS, Couturier K, Latour JG, and Lavoie JM. Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis. J Appl Physiol 94: 2127-2134, 2003.
    • (2003) J Appl Physiol , vol.94 , pp. 2127-2134
    • Gauthier, M.S.1    Couturier, K.2    Latour, J.G.3    Lavoie, J.M.4
  • 15
    • 0029076885 scopus 로고
    • Tissue-specific alterations in G protein expression in genetic vs. diet-induced models of noninsulin-dependent diabetes mellitus in the mouse
    • Gettys TW, Ramkumar V, Surwit RS, and Taylor IL. Tissue-specific alterations in G protein expression in genetic vs. diet-induced models of noninsulin-dependent diabetes mellitus in the mouse. Metabolism 44: 771-778, 1995.
    • (1995) Metabolism , vol.44 , pp. 771-778
    • Gettys, T.W.1    Ramkumar, V.2    Surwit, R.S.3    Taylor, I.L.4
  • 16
    • 0025204639 scopus 로고
    • Receptor and postreceptor effects of free fatty acids on hepatocyte insulin dynamics
    • Hennes MM, Shrago E, and Kissebah AH. Receptor and postreceptor effects of free fatty acids on hepatocyte insulin dynamics. Int J Obes 14: 829-830, 1990.
    • (1990) Int J Obes , vol.14 , pp. 829-830
    • Hennes, M.M.1    Shrago, E.2    Kissebah, A.H.3
  • 17
    • 0027139319 scopus 로고
    • Regional myocardial down-regulation of the inhibitory GTP-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model for chronic episodic myocardial ischemia
    • Hammond HK, Roth DA, McKirnan MD, and Ping P. Regional myocardial down-regulation of the inhibitory GTP-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model for chronic episodic myocardial ischemia. J Clin Invest 92: 2644-2652, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 2644-2652
    • Hammond, H.K.1    Roth, D.A.2    McKirnan, M.D.3    Ping, P.4
  • 19
    • 0015918902 scopus 로고
    • Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance
    • Kahn CR, Neville DM, and Roth J. Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J Biol Chem 248: 244-250, 1973.
    • (1973) J Biol Chem , vol.248 , pp. 244-250
    • Kahn, C.R.1    Neville, D.M.2    Roth, J.3
  • 20
    • 0020421971 scopus 로고
    • Evidence for an augmented glucagon dependence of hepatic glucose production in cirrhosis of the liver
    • Keller U, Sonnenberg GE, Burckhardt D, and Perruchoud A. Evidence for an augmented glucagon dependence of hepatic glucose production in cirrhosis of the liver. J Clin Endocrinol Metab 54: 961-968, 1982.
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 961-968
    • Keller, U.1    Sonnenberg, G.E.2    Burckhardt, D.3    Perruchoud, A.4
  • 21
    • 0032498122 scopus 로고    scopus 로고
    • Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures
    • Krones A, Kietzmann T, and Jungermann K. Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures. FEBS Lett 421: 136-140, 1998.
    • (1998) FEBS Lett , vol.421 , pp. 136-140
    • Krones, A.1    Kietzmann, T.2    Jungermann, K.3
  • 23
    • 0032563291 scopus 로고    scopus 로고
    • G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
    • Lefkowitz RJ. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem 273: 18677-18680, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 18677-18680
    • Lefkowitz, R.J.1
  • 24
    • 0344310763 scopus 로고    scopus 로고
    • Mechanisms of beta-adrenergic receptor desensitization and resensitization
    • Lefkowitz RJ, Pitcher J, Krueger K, and Daaka Y. Mechanisms of beta-adrenergic receptor desensitization and resensitization. Adv Pharmacol 42: 416-420, 1998.
    • (1998) Adv Pharmacol , vol.42 , pp. 416-420
    • Lefkowitz, R.J.1    Pitcher, J.2    Krueger, K.3    Daaka, Y.4
  • 26
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, and Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23: 201-229, 2002.
    • (2002) Endocr Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 27
    • 0014738371 scopus 로고
    • Determination of glycogen in small tissue samples
    • Lo S, Russell JC, and Taylor AW. Determination of glycogen in small tissue samples. J Appl Physiol 28: 234-236, 1970.
    • (1970) J Appl Physiol , vol.28 , pp. 234-236
    • Lo, S.1    Russell, J.C.2    Taylor, A.W.3
  • 28
    • 0036092516 scopus 로고    scopus 로고
    • Influence of prior exercise and liver glycogen content on the sensitivity of the liver to glucagon
    • Matas Bonjorn V, Latour MG, Bélanger P, and Lavoie JM. Influence of prior exercise and liver glycogen content on the sensitivity of the liver to glucagon. J Appl Physiol 92: 188-194, 2002.
    • (2002) J Appl Physiol , vol.92 , pp. 188-194
    • Matas Bonjorn, V.1    Latour, M.G.2    Bélanger, P.3    Lavoie, J.M.4
  • 29
    • 0025292641 scopus 로고
    • Age related changes of lipid fractions and total fatty acids in liver lipids and heart lipids of female and male rats aged 37-1200 days (liver) and 331-1200 days (heart)
    • Murawski U, Kriesten K, and Egge H. Age related changes of lipid fractions and total fatty acids in liver lipids and heart lipids of female and male rats aged 37-1200 days (liver) and 331-1200 days (heart). Comp Biochem Physiol B 96: 271-289, 1990.
    • (1990) Comp Biochem Physiol B , vol.96 , pp. 271-289
    • Murawski, U.1    Kriesten, K.2    Egge, H.3
  • 31
    • 0029785214 scopus 로고    scopus 로고
    • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled recepror kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies
    • Pitcher JA, Fredericks ZL, Stone WC, Premont RT, Stoffel RH, Koch WJ, and Lefkowitz RJ. Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled recepror kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J Biol Chem 271: 24907-24913, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 24907-24913
    • Pitcher, J.A.1    Fredericks, Z.L.2    Stone, W.C.3    Premont, R.T.4    Stoffel, R.H.5    Koch, W.J.6    Lefkowitz, R.J.7
  • 33
    • 0017755532 scopus 로고
    • The glucagon receptor and its relationship to adenylate cyclase
    • Pohl SL. The glucagon receptor and its relationship to adenylate cyclase. Fed Proc 36: 2115-2118, 1977.
    • (1977) Fed Proc , vol.36 , pp. 2115-2118
    • Pohl, S.L.1
  • 34
    • 0033583195 scopus 로고    scopus 로고
    • Identification of a glucose response element in the promoter of the rat glucagon receptor gene
    • Portois L, Maget B, Tastenoy M, Perret J, and Svoboda M. Identification of a glucose response element in the promoter of the rat glucagon receptor gene. J Biol Chem 274: 8181-8190, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 8181-8190
    • Portois, L.1    Maget, B.2    Tastenoy, M.3    Perret, J.4    Svoboda, M.5
  • 35
    • 0029052473 scopus 로고
    • Adaptations in glucose homeostasis during chronic nutritional deprivation in rats: Hepatic resistance to both insulin and glucagon
    • Rao RH. Adaptations in glucose homeostasis during chronic nutritional deprivation in rats: hepatic resistance to both insulin and glucagon. Metabolism 44: 817-824, 1995.
    • (1995) Metabolism , vol.44 , pp. 817-824
    • Rao, R.H.1
  • 37
    • 0035096932 scopus 로고    scopus 로고
    • The effect of exercise training on glucose tolerance and skeletal muscle triacylglycerol content in rats fed with a high-fat diet
    • Straczkowski M, Kowalska I, Dzienis-Straczkowska S, Kinalski M, Gorski J, and Kinalska I. The effect of exercise training on glucose tolerance and skeletal muscle triacylglycerol content in rats fed with a high-fat diet. Diabetes Metab 27: 19-23, 2001.
    • (2001) Diabetes Metab , vol.27 , pp. 19-23
    • Straczkowski, M.1    Kowalska, I.2    Dzienis-Straczkowska, S.3    Kinalski, M.4    Gorski, J.5    Kinalska, I.6
  • 38
    • 0032757393 scopus 로고    scopus 로고
    • Glucose regulation of the expression of the glucagon receptor gene
    • Svoboda M, Portois L, and Malaisse WJ. Glucose regulation of the expression of the glucagon receptor gene. Mol Genet Metab 68: 258-267, 1999.
    • (1999) Mol Genet Metab , vol.68 , pp. 258-267
    • Svoboda, M.1    Portois, L.2    Malaisse, W.J.3


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