메뉴 건너뛰기




Volumn 138, Issue 3, 1997, Pages 999-1007

Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: Role of glucagon

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN;

EID: 0031046709     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.3.5025     Document Type: Article
Times cited : (37)

References (46)
  • 1
    • 0023546855 scopus 로고
    • Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects
    • Prager R, Wallace P, Olefsky JM 1987 Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36:607-611
    • (1987) Diabetes , vol.36 , pp. 607-611
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3
  • 2
    • 0025297310 scopus 로고
    • Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
    • Ader M, Bergman RN 1990 Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 245:E1020-E1032
    • (1990) Am J Physiol , vol.245
    • Ader, M.1    Bergman, R.N.2
  • 3
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin K, Steil GM, Getty L, Bergman RN 1995 Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44:1038-1045
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 4
    • 0029969117 scopus 로고    scopus 로고
    • A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
    • Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD 1996 A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45:1594-1604
    • (1996) Diabetes , vol.45 , pp. 1594-1604
    • Sindelar, D.K.1    Balcom, J.H.2    Chu, C.A.3    Neal, D.W.4    Cherrington, A.D.5
  • 5
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca A, Fisher S, Shi ZQ, Gupta R, Lickley L, Vranic M 1992 Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90:1769-1777
    • (1992) J Clin Invest , vol.90 , pp. 1769-1777
    • Giacca, A.1    Fisher, S.2    Shi, Z.Q.3    Gupta, R.4    Lickley, L.5    Vranic, M.6
  • 6
    • 0029936779 scopus 로고    scopus 로고
    • Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans
    • Lewis GF, Zinman B, Groenewoud Y, Vranic M, Giacca A 1996 Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes 45:454-462
    • (1996) Diabetes , vol.45 , pp. 454-462
    • Lewis, G.F.1    Zinman, B.2    Groenewoud, Y.3    Vranic, M.4    Giacca, A.5
  • 7
    • 8044223985 scopus 로고
    • The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production
    • Abstract
    • Sindelar D, Chu C, Hastings J, Venson P, Cherrington A 1995 The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production. Diabetes 44:55A (Abstract)
    • (1995) Diabetes , vol.44
    • Sindelar, D.1    Chu, C.2    Hastings, J.3    Venson, P.4    Cherrington, A.5
  • 8
    • 0029861999 scopus 로고    scopus 로고
    • Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
    • Rebrin K, Steil GM, Mittelman SD, Bergman RN 1996 Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98:741-749
    • (1996) J Clin Invest , vol.98 , pp. 741-749
    • Rebrin, K.1    Steil, G.M.2    Mittelman, S.D.3    Bergman, R.N.4
  • 9
    • 0021678714 scopus 로고
    • Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise
    • Wasserman DH, Lickley HLA, Vranic M 1984 Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise. J Clin Invest 74:1404-1413
    • (1984) J Clin Invest , vol.74 , pp. 1404-1413
    • Wasserman, D.H.1    Lickley, H.L.A.2    Vranic, M.3
  • 10
    • 0027990802 scopus 로고
    • Intracerebroventricular administration of somatostatin octapeptide counteracts the hormonal and metabolic responses to stress in normal and diabetic dogs
    • Miles PDG, Yamatani K, Brown MR, Lickley HLA, Vranic M 1994 Intracerebroventricular administration of somatostatin octapeptide counteracts the hormonal and metabolic responses to stress in normal and diabetic dogs. Metabolism 43:1-11
    • (1994) Metabolism , vol.43 , pp. 1-11
    • Miles, P.D.G.1    Yamatani, K.2    Brown, M.R.3    Lickley, H.L.A.4    Vranic, M.5
  • 12
    • 0019443073 scopus 로고
    • in vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose
    • Boyd ME, Albright EB, Foster DW, McGarry JD 1981 in vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose. J Clin Invest 68:142-152
    • (1981) J Clin Invest , vol.68 , pp. 142-152
    • Boyd, M.E.1    Albright, E.B.2    Foster, D.W.3    McGarry, J.D.4
  • 13
    • 2142684733 scopus 로고
    • Interaction of insulin and glucagon in the control of liver metabolism
    • Exton JH, Park CR 1972 Interaction of insulin and glucagon in the control of liver metabolism. Handb Physiol 1:437-455
    • (1972) Handb Physiol , vol.1 , pp. 437-455
    • Exton, J.H.1    Park, C.R.2
  • 14
    • 0017259545 scopus 로고
    • The essentiality of insulin and the role of glucagon in regulating glucose utilization and production during strenuous exercise in dogs
    • Vranic M, Kawamori R, Pek S, Kovacevic N, Wrenshall G 1976 The essentiality of insulin and the role of glucagon in regulating glucose utilization and production during strenuous exercise in dogs. J Clin Invest 57:245-256
    • (1976) J Clin Invest , vol.57 , pp. 245-256
    • Vranic, M.1    Kawamori, R.2    Pek, S.3    Kovacevic, N.4    Wrenshall, G.5
  • 15
    • 0023105357 scopus 로고
    • Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs
    • Lickley HLA, Kemmer FW, El-Tayeb KMA, Vranic M 1987 Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs. Diabetologia 30:175-182
    • (1987) Diabetologia , vol.30 , pp. 175-182
    • Lickley, H.L.A.1    Kemmer, F.W.2    El-Tayeb, K.M.A.3    Vranic, M.4
  • 17
    • 0024265025 scopus 로고
    • Modelling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps
    • Finegood DT, Bergman RN, Vranic M 1988 Modelling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37:1025-1034
    • (1988) Diabetes , vol.37 , pp. 1025-1034
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 18
    • 0023882359 scopus 로고
    • Regulation of glucose turnover during exercise in pancreatectomized, totally insulin deficient dogs: Effects of beta-adrenergic blockade
    • Bjorkman O, Miles P, Wasserman D, Lickley L, Vranic M 1988 Regulation of glucose turnover during exercise in pancreatectomized, totally insulin deficient dogs: effects of beta-adrenergic blockade. J Clin Invest 81:1759-1767
    • (1988) J Clin Invest , vol.81 , pp. 1759-1767
    • Bjorkman, O.1    Miles, P.2    Wasserman, D.3    Lickley, L.4    Vranic, M.5
  • 21
    • 0014809458 scopus 로고
    • 63Ni as tracer
    • 63Ni as tracer. Anal Biochem 36:105-113
    • (1970) Anal Biochem , vol.36 , pp. 105-113
    • Ho, R.J.1
  • 22
    • 0018087782 scopus 로고
    • Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-OH-butyrate
    • Lloyd B, Burrin J, Smythe P, Alberti KGMM 1978 Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-OH-butyrate. Clin Chem 24:1724-1729
    • (1978) Clin Chem , vol.24 , pp. 1724-1729
    • Lloyd, B.1    Burrin, J.2    Smythe, P.3    Alberti, K.G.M.M.4
  • 24
    • 0027223164 scopus 로고
    • Quantitation of measurement error with optimal segments: Basis for adaptive time course smoothing
    • Bradley DC, Steil GM, Bergman RN 1993 Quantitation of measurement error with optimal segments: basis for adaptive time course smoothing. Am J Physiol 264:E902-E911
    • (1993) Am J Physiol , vol.264
    • Bradley, D.C.1    Steil, G.M.2    Bergman, R.N.3
  • 25
    • 0025761375 scopus 로고
    • Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration
    • Myers SR, McGuinness OP, Neal DW, Cherrington AD 1991 Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest 87:930-939
    • (1991) J Clin Invest , vol.87 , pp. 930-939
    • Myers, S.R.1    McGuinness, O.P.2    Neal, D.W.3    Cherrington, A.D.4
  • 26
    • 8044258950 scopus 로고
    • Basal insulin levels suppress hepatic glucose production (HGP) in diabetic dogs by peripheral effects
    • Abstract
    • McCall RH, Shi ZQ, Lam L, Giacca A 1995 Basal insulin levels suppress hepatic glucose production (HGP) in diabetic dogs by peripheral effects. Diabetes [Suppl 1] 44:193A (Abstract)
    • (1995) Diabetes [Suppl 1] , vol.44
    • McCall, R.H.1    Shi, Z.Q.2    Lam, L.3    Giacca, A.4
  • 27
    • 0028586027 scopus 로고
    • Importance of substrate changes in the decrease of hepatic glucose cycling during insulin infusion and declining glycemia in the depancreatized dog
    • Shi ZQ, Giacca A, Fisher S, Vidal H, van de Werve G, Vranic M 1994 Importance of substrate changes in the decrease of hepatic glucose cycling during insulin infusion and declining glycemia in the depancreatized dog. Diabetes 43:1284-1290
    • (1994) Diabetes , vol.43 , pp. 1284-1290
    • Shi, Z.Q.1    Giacca, A.2    Fisher, S.3    Vidal, H.4    Van De Werve, G.5    Vranic, M.6
  • 28
    • 0020712528 scopus 로고
    • Effect of intraportal and peripheral insulin on glucose turnover and recycling in diabetic dogs
    • Stevenson RW, Parsons JA, Alberti KGMM 1983 Effect of intraportal and peripheral insulin on glucose turnover and recycling in diabetic dogs. Am J Physiol 244:E190-E195
    • (1983) Am J Physiol , vol.244
    • Stevenson, R.W.1    Parsons, J.A.2    Alberti, K.G.M.M.3
  • 30
    • 0023201029 scopus 로고
    • Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog
    • Stevenson RW, Williams PE, Cherrington AD 1987 Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Diabetologia 30:782-790
    • (1987) Diabetologia , vol.30 , pp. 782-790
    • Stevenson, R.W.1    Williams, P.E.2    Cherrington, A.D.3
  • 31
    • 0018343294 scopus 로고
    • Identical biological effects of pancreatic glucagon and a purified moiety of canine gastric glucagon
    • Doi K, Prentki M, Yip C, Muller W, Jeanrenaud B, Vranic M 1979 Identical biological effects of pancreatic glucagon and a purified moiety of canine gastric glucagon. J Clin Invest 63:525-531
    • (1979) J Clin Invest , vol.63 , pp. 525-531
    • Doi, K.1    Prentki, M.2    Yip, C.3    Muller, W.4    Jeanrenaud, B.5    Vranic, M.6
  • 32
    • 0022886240 scopus 로고
    • The effect of insulin-induced hypoglycaemia on the secretion of glucagon and hepatic glucose production in pancreatectomized dogs
    • Lussier B, Hetenyi G, Jr 1986 The effect of insulin-induced hypoglycaemia on the secretion of glucagon and hepatic glucose production in pancreatectomized dogs. Can J Physiol Pharmacol 64:1440-1442
    • (1986) Can J Physiol Pharmacol , vol.64 , pp. 1440-1442
    • Lussier, B.1    Hetenyi Jr., G.2
  • 33
    • 0016303760 scopus 로고
    • Increased "glucagon immunoreactivity" in plasma of totally depancreatized dogs
    • Vranic M, Pek S, Kawamori B 1974 Increased "glucagon immunoreactivity" in plasma of totally depancreatized dogs. Diabetes 23:905-912
    • (1974) Diabetes , vol.23 , pp. 905-912
    • Vranic, M.1    Pek, S.2    Kawamori, B.3
  • 34
    • 0025933936 scopus 로고
    • Intra-islet insulin permits glucose to directly suppress pancreatic A cell function
    • Greenbaum CJ, Havel PJ, Taborsky GJ, Klaff LJ 1991 Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. J Clin Invest 88:767-773
    • (1991) J Clin Invest , vol.88 , pp. 767-773
    • Greenbaum, C.J.1    Havel, P.J.2    Taborsky, G.J.3    Klaff, L.J.4
  • 35
    • 0019918172 scopus 로고
    • New perspectives on the microvasculature of the islets of Langerhans in the rat
    • Bonner-Weir S, Orci L 1982 New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31:883-889
    • (1982) Diabetes , vol.31 , pp. 883-889
    • Bonner-Weir, S.1    Orci, L.2
  • 37
    • 0020567342 scopus 로고
    • Minimal increase in glucagon level enhance glucose production in man with partial hypoinsulinemia
    • Lins PE, Wajngot A, Adamson U, Vranic M, Efendic S 1983 Minimal increase in glucagon level enhance glucose production in man with partial hypoinsulinemia. Diabetes 32:633-636
    • (1983) Diabetes , vol.32 , pp. 633-636
    • Lins, P.E.1    Wajngot, A.2    Adamson, U.3    Vranic, M.4    Efendic, S.5
  • 39
    • 8044246543 scopus 로고
    • Suppression of hepatic glucose production in normal dogs is mediated both by insulin's direct and indirect effects
    • Abstract
    • McCall RH, Shi ZQ, Vranic M, Giacca A 1995 Suppression of hepatic glucose production in normal dogs is mediated both by insulin's direct and indirect effects. Diabetologia [Suppl 1] 38:A154 (Abstract)
    • (1995) Diabetologia [Suppl 1] , vol.38
    • McCall, R.H.1    Shi, Z.Q.2    Vranic, M.3    Giacca, A.4
  • 40
    • 0002983061 scopus 로고
    • Diabetes mellitus
    • Wilson JD, Foster DW (eds) Saunders, Philadelphia
    • Unger RH, Foster DW 1992 Diabetes mellitus. In: Wilson JD, Foster DW (eds) William's Textbook of Endocrinology. Saunders, Philadelphia, pp 1255-1333
    • (1992) William's Textbook of Endocrinology , pp. 1255-1333
    • Unger, R.H.1    Foster, D.W.2
  • 41
    • 0019287144 scopus 로고
    • The role of calcium in alpha-adrenergic inactivation of glycogen symthase in rat hepatocytes and its inhibition by insulin
    • Strickland GW, Blackmore PF, Exton JH 1980 The role of calcium in alpha-adrenergic inactivation of glycogen symthase in rat hepatocytes and its inhibition by insulin. Diabetes 29:617-622
    • (1980) Diabetes , vol.29 , pp. 617-622
    • Strickland, G.W.1    Blackmore, P.F.2    Exton, J.H.3
  • 42
    • 0014333513 scopus 로고
    • Influence of glucagon and 3′,5′-AMP on insulin responsiveness of the perfused rat liver
    • Glinsmann WH, Mortimore GE 1968 Influence of glucagon and 3′,5′-AMP on insulin responsiveness of the perfused rat liver. Am J Physiol 215:553-559
    • (1968) Am J Physiol , vol.215 , pp. 553-559
    • Glinsmann, W.H.1    Mortimore, G.E.2
  • 43
    • 0014408706 scopus 로고
    • Role of adenosine 3′,5′-monophosphate in the effects of insulin and antinsulin serum on liver metabolism
    • Jefferson LS, Exton JH, Butcher RW, Sutherland EW, Park CR 1968 Role of adenosine 3′,5′-monophosphate in the effects of insulin and antinsulin serum on liver metabolism. J Biol Chem 243:1031-1038
    • (1968) J Biol Chem , vol.243 , pp. 1031-1038
    • Jefferson, L.S.1    Exton, J.H.2    Butcher, R.W.3    Sutherland, E.W.4    Park, C.R.5
  • 44
    • 0025637706 scopus 로고
    • Effects of insulin on glucagon stimulated glucose production in the conscious dog
    • Steiner KE, Williams PE, Lacy WW, Cherrington AD 1991 Effects of insulin on glucagon stimulated glucose production in the conscious dog. Metabolism 39:1325-1333
    • (1991) Metabolism , vol.39 , pp. 1325-1333
    • Steiner, K.E.1    Williams, P.E.2    Lacy, W.W.3    Cherrington, A.D.4
  • 45
    • 8044244173 scopus 로고
    • Peripheral effects of insulin on hepatic glucose production (HGP) in humans. An important role for glucagon
    • Abstract
    • Lewis GF, Zinman B, Steiner G, Vranic M, Giacca A 1995 Peripheral effects of insulin on hepatic glucose production (HGP) in humans. An important role for glucagon. Diabetes [Suppl 1] 44:196A (Abstract)
    • (1995) Diabetes [Suppl 1] , vol.44
    • Lewis, G.F.1    Zinman, B.2    Steiner, G.3    Vranic, M.4    Giacca, A.5
  • 46
    • 8044254591 scopus 로고    scopus 로고
    • Portal effect of insulin to lower HGO requires hyperglucagonemia
    • Abstract
    • Mittelman S, Steil G, Rebrin K 1996 Portal effect of insulin to lower HGO requires hyperglucagonemia. Diabetes [Suppl 2] 00:166A (Abstract)
    • (1996) Diabetes [Suppl 2]
    • Mittelman, S.1    Steil, G.2    Rebrin, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.