메뉴 건너뛰기




Volumn 60, Issue 5, 2012, Pages 315-329

Hepatitis C virus-mediated modulation of cellular immunity

Author keywords

Adaptive immune response; Dendritic cells; HCV; Kupffer cells; NK cells; NKT cells

Indexed keywords

DNA VACCINE; HEPATITIS C VACCINE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4A; NONSTRUCTURAL PROTEIN 5A; PEGINTERFERON ALPHA; RIBAVIRIN;

EID: 84866599314     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-012-0184-z     Document Type: Review
Times cited : (20)

References (179)
  • 1
    • 33845650186 scopus 로고    scopus 로고
    • Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection
    • DOI 10.1002/hep.21438
    • Abel M, Sene D, Pol S et al (2006) Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection. Hepatology 44:1607-1616 (Pubitemid 44953666)
    • (2006) Hepatology , vol.44 , Issue.6 , pp. 1607-1616
    • Abel, M.1    Sene, D.2    Pol, S.3    Bourliere, M.4    Poynard, T.5    Charlotte, F.6    Cacoub, P.7    Caillat-Zucman, S.8
  • 2
    • 40549084319 scopus 로고    scopus 로고
    • Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses
    • DOI 10.1172/JCI32400
    • Ahlenstiel G, Martin MP, Gao X et al (2008) Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses. J Clin Invest 118:1017-1026 (Pubitemid 351364609)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.3 , pp. 1017-1026
    • Ahlenstiel, G.1    Martin, M.P.2    Gao, X.3    Carrington, M.4    Rehermann, B.5
  • 3
    • 72549104093 scopus 로고    scopus 로고
    • Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner
    • Ahlenstiel G, Titerence RH, Koh C et al (2010) Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa- dependent manner. Gastroenterology 138(325-335):e1-e2
    • (2010) Gastroenterology , vol.138 , Issue.325-335
    • Ahlenstiel, G.1    Titerence, R.H.2    Koh, C.3
  • 4
    • 34249787349 scopus 로고    scopus 로고
    • + cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses
    • DOI 10.1128/JVI.02202-06
    • Alatrakchi N, Graham CS, van der Vliet HJ et al (2007) Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses. J Virol 81:5882-5892 (Pubitemid 46847025)
    • (2007) Journal of Virology , vol.81 , Issue.11 , pp. 5882-5892
    • Alatrakchi, N.1    Graham, C.S.2    Van Der Vliet, H.J.J.3    Sherman, K.E.4    Exley, M.A.5    Koziel, M.J.6
  • 5
    • 77949816250 scopus 로고    scopus 로고
    • Activation of natural killer cells during acute infection with hepatitis C virus
    • Amadei B, Urbani S, Cazaly A et al (2010) Activation of natural killer cells during acute infection with hepatitis C virus. Gastroenterology 138:1536-1545
    • (2010) Gastroenterology , vol.138 , pp. 1536-1545
    • Amadei, B.1    Urbani, S.2    Cazaly, A.3
  • 6
    • 33750719589 scopus 로고    scopus 로고
    • Natural killer cells in viral infection: More than just killers
    • DOI 10.1111/j.1600-065X.2006.00465.x
    • Andoniou CE, Andrews DM, Degli-Esposti MA (2006) Natural killer cells in viral infection: more than just killers. Immunol Rev 214:239-250 (Pubitemid 44707915)
    • (2006) Immunological Reviews , vol.214 , Issue.1 , pp. 239-250
    • Andoniou, C.E.1    Andrews, D.M.2    Degli-Esposti, M.A.3
  • 8
    • 0035874506 scopus 로고    scopus 로고
    • Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection
    • Auffermann-Gretzinger S, Keeffe EB, Levy S (2001) Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 97:3171-3176
    • (2001) Blood , vol.97 , pp. 3171-3176
    • Auffermann-Gretzinger, S.1    Keeffe, E.B.2    Levy, S.3
  • 9
    • 33947139667 scopus 로고    scopus 로고
    • Differential dysfunction in dendritic cell subsets during chronic HCV infection
    • DOI 10.1016/j.clim.2006.12.001, PII S1521661606009661
    • Averill L, Lee WM, Karandikar NJ (2007) Differential dysfunction in dendritic cell subsets during chronic HCV infection. Clin Immunol 123:40-49 (Pubitemid 46401508)
    • (2007) Clinical Immunology , vol.123 , Issue.1 , pp. 40-49
    • Averill, L.1    Lee, W.M.2    Karandikar, N.J.3
  • 10
    • 0035121503 scopus 로고    scopus 로고
    • Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection
    • Bain C, Fatmi A, Zoulim F et al (2001) Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 120:512-524 (Pubitemid 32147649)
    • (2001) Gastroenterology , vol.120 , Issue.2 , pp. 512-524
    • Bain, C.1    Fatmi, A.2    Zoulim, F.3    Zarski, J.-P.4    Trepo, C.5    Inchauspe, G.6
  • 11
    • 84855388574 scopus 로고    scopus 로고
    • Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man
    • Barnes E, Folgori A, Capone S et al (2012) Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man. Sci Transl Med 4(115):115ra1
    • (2012) Sci Transl Med , vol.4 , Issue.115
    • Barnes, E.1    Folgori, A.2    Capone, S.3
  • 13
    • 0034985916 scopus 로고    scopus 로고
    • Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection
    • DOI 10.1053/jhep.2001.24371
    • Bassett SE, Guerra B, Brasky K et al (2001) Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection. Hepatology 33:1479-1487 (Pubitemid 32496985)
    • (2001) Hepatology , vol.33 , Issue.6 , pp. 1479-1487
    • Bassett, S.E.1    Guerra, B.2    Brasky, K.3    Miskovsky, E.4    Houghton, M.5    Klimpel, G.R.6    Lanford, R.E.7
  • 14
    • 0842300376 scopus 로고    scopus 로고
    • Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells
    • DOI 10.1053/j.gastro.2003.11.018
    • Bataller R, Paik YH, Lindquist JN et al (2004) Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 126:529-540 (Pubitemid 38182310)
    • (2004) Gastroenterology , vol.126 , Issue.2 , pp. 529-540
    • Bataller, R.1    Paik, Y.-H.2    Lindquist, J.N.3    Lemasters, J.J.4    Brenner, D.A.5
  • 15
    • 77954674575 scopus 로고    scopus 로고
    • Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
    • Bengsch B, Seigel B, Ruhl M et al (2010) Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 6:e1000947
    • (2010) PLoS Pathog , vol.6
    • Bengsch, B.1    Seigel, B.2    Ruhl, M.3
  • 17
    • 54049155697 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response
    • Bode JG, Brenndorfer ED, Haussinger D (2008) Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response. Biol Chem 389:1283-1298
    • (2008) Biol Chem , vol.389 , pp. 1283-1298
    • Bode, J.G.1    Brenndorfer, E.D.2    Haussinger, D.3
  • 18
    • 70349306569 scopus 로고    scopus 로고
    • Interplay between host cell and hepatitis C virus in regulating viral replication
    • Bode JG, Brenndorfer ED, Karthe J et al (2009) Interplay between host cell and hepatitis C virus in regulating viral replication. Biol Chem 390:1013-1032
    • (2009) Biol Chem , vol.390 , pp. 1013-1032
    • Bode, J.G.1    Brenndorfer, E.D.2    Karthe, J.3
  • 20
    • 0347382454 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes
    • DOI 10.1002/eji.200324251
    • Brady MT, MacDonald AJ, Rowan AG et al (2003) Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur J Immunol 33:3448-3457 (Pubitemid 37541123)
    • (2003) European Journal of Immunology , vol.33 , Issue.12 , pp. 3448-3457
    • Brady, M.T.1    MacDonald, A.J.2    Rowan, A.G.3    Mills, K.H.G.4
  • 21
    • 68949105585 scopus 로고    scopus 로고
    • Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factorinduced signal transduction by cleavage of the T-cell protein tyrosine phosphatase
    • Brenndorfer ED, Karthe J, Frelin L et al (2009) Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factorinduced signal transduction by cleavage of the T-cell protein tyrosine phosphatase. Hepatology 49:1810-1820
    • (2009) Hepatology , vol.49 , pp. 1810-1820
    • Brenndorfer, E.D.1    Karthe, J.2    Frelin, L.3
  • 22
    • 78049506154 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor alpha treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C
    • Brenndorfer ED, Weiland M, Frelin L et al (2010) Anti-tumor necrosis factor alpha treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C. Hepatology 52:1553-1563
    • (2010) Hepatology , vol.52 , pp. 1553-1563
    • Brenndorfer, E.D.1    Weiland, M.2    Frelin, L.3
  • 23
    • 84857797219 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-gamma production
    • Brenndorfer ED, Brass A, Soderholm J et al (2012) Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-gamma production. Gut 61:589-596
    • (2012) Gut , vol.61 , pp. 589-596
    • Brenndorfer, E.D.1    Brass, A.2    Soderholm, J.3
  • 25
  • 26
    • 7044247947 scopus 로고    scopus 로고
    • + regulatory T lymphocytes in hepatitis C virus infection
    • DOI 10.1002/hep.20454
    • Cabrera R, Tu Z, Xu Y et al (2004) An immunomodulatory role for CD4 (+) CD25 (+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 40:1062-1071 (Pubitemid 39425561)
    • (2004) Hepatology , vol.40 , Issue.5 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6    Nelson, D.R.7
  • 27
    • 0029949897 scopus 로고    scopus 로고
    • Immunoregulatory cytokines in chronic hepatitis C virus infection: Pre- and posttreatment with interferon alfa
    • DOI 10.1053/jhep.1996.v24.pm0008707283
    • Cacciarelli TV, Martinez OM, Gish RG et al (1996) Immunoregulatory cytokines in chronic hepatitis C virus infection: pre-and posttreatment with interferon alfa. Hepatology 24:6-9 (Pubitemid 26249404)
    • (1996) Hepatology , vol.24 , Issue.1 , pp. 6-9
    • Cacciarelli, T.V.1    Martinez, O.M.2    Gish, R.G.3    Villanueva, J.C.4    Krams, S.M.5
  • 30
    • 79955527858 scopus 로고    scopus 로고
    • Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination
    • Chen A, Ahlen G, Brenndorfer ED et al (2011) Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination. J Immunol 186:5107-5118
    • (2011) J Immunol , vol.186 , pp. 5107-5118
    • Chen, A.1    Ahlen, G.2    Brenndorfer, E.D.3
  • 33
    • 21344442371 scopus 로고    scopus 로고
    • Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    • DOI 10.1002/hep.20749
    • Cox AL, Mosbruger T, Lauer GM et al (2005) Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. Hepatology 42:104-112 (Pubitemid 40911317)
    • (2005) Hepatology , vol.42 , Issue.1 , pp. 104-112
    • Cox, A.L.1    Mosbruger, T.2    Lauer, G.M.3    Pardoll, D.4    Thomas, D.L.5    Ray, S.C.6
  • 35
    • 75549090719 scopus 로고    scopus 로고
    • Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection
    • Crotta S, Brazzoli M, Piccioli D et al (2010) Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection. J Hepatol 52:183-190
    • (2010) J Hepatol , vol.52 , pp. 183-190
    • Crotta, S.1    Brazzoli, M.2    Piccioli, D.3
  • 44
    • 34247487768 scopus 로고    scopus 로고
    • + T-cell proliferation in patients with hepatitis C virus infection
    • DOI 10.1111/j.1365-2567.2007.02577.x
    • Della Bella S, Crosignani A, Riva A et al (2007) Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection. Immunology 121:283-292 (Pubitemid 46663097)
    • (2007) Immunology , vol.121 , Issue.2 , pp. 283-292
    • Della Bella, S.1    Crosignani, A.2    Riva, A.3    Presicce, P.4    Benetti, A.5    Longhi, R.6    Podda, M.7    Villa, M.L.8
  • 46
    • 7644226241 scopus 로고    scopus 로고
    • Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    • DOI 10.1053/j.gastro.2004.08.067, PII S0016508504015689
    • Dolganiuc A, Oak S, Kodys K et al (2004) Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology 127:1513-1524 (Pubitemid 39457776)
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 1513-1524
    • Dolganiuc, A.1    Oak, S.2    Kodys, K.3    Golenbock, D.T.4    Finberg, R.W.5    Kurt-Jones, E.6    Szabo, G.7
  • 47
    • 33750826035 scopus 로고    scopus 로고
    • Hepatitis C Virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection
    • Dolganiuc A, Chang S, Kodys K et al (2006) Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol 177:6758-6768 (Pubitemid 44715040)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6758-6768
    • Dolganiuc, A.1    Chang, S.2    Kodys, K.3    Mandrekar, P.4    Bakis, G.5    Cormier, M.6    Szabo, G.7
  • 48
    • 35649007401 scopus 로고    scopus 로고
    • Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    • DOI 10.1053/j.gastro.2007.08.003, PII S0016508507014497
    • Dolganiuc A, Norkina O, Kodys K et al (2007) Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology 133:1627-1636 (Pubitemid 350029734)
    • (2007) Gastroenterology , vol.133 , Issue.5 , pp. 1627-1636
    • Dolganiuc, A.1    Norkina, O.2    Kodys, K.3    Catalano, D.4    Bakis, G.5    Marshall, C.6    Mandrekar, P.7    Szabo, G.8
  • 49
    • 57249086246 scopus 로고    scopus 로고
    • Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes
    • Dolganiuc A, Paek E, Kodys K et al (2008) Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes. Gastroenterology 135:2119-2127
    • (2008) Gastroenterology , vol.135 , pp. 2119-2127
    • Dolganiuc, A.1    Paek, E.2    Kodys, K.3
  • 50
    • 34548660561 scopus 로고    scopus 로고
    • Antibodies and B cell memory in viral immunity
    • DOI 10.1016/j.immuni.2007.09.002, PII S1074761307004207
    • Dorner T, Radbruch A (2007) Antibodies and B cell memory in viral immunity. Immunity 27:384-392 (Pubitemid 47418684)
    • (2007) Immunity , vol.27 , Issue.3 , pp. 384-392
    • Dorner, T.1    Radbruch, A.2
  • 51
    • 79959563982 scopus 로고    scopus 로고
    • Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells
    • Echeverria I, Pereboev A, Silva L et al (2011) Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells. Hepatology 54:28-37
    • (2011) Hepatology , vol.54 , pp. 28-37
    • Echeverria, I.1    Pereboev, A.2    Silva, L.3
  • 55
    • 77549085401 scopus 로고    scopus 로고
    • Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine
    • Firbas C, Boehm T, Buerger V et al (2010) Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine. Vaccine 28:2397-2407
    • (2010) Vaccine , vol.28 , pp. 2397-2407
    • Firbas, C.1    Boehm, T.2    Buerger, V.3
  • 58
    • 77955661037 scopus 로고    scopus 로고
    • Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59administered to healthy adults
    • Frey SE, Houghton M, Coates S et al (2010) Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59administered to healthy adults. Vaccine 28:6367-6373
    • (2010) Vaccine , vol.28 , pp. 6367-6373
    • Frey, S.E.1    Houghton, M.2    Coates, S.3
  • 59
    • 19344371631 scopus 로고    scopus 로고
    • Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids
    • Geissmann F, Cameron TO, Sidobre S et al (2005) Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol 3:e113
    • (2005) PLoS Biol , vol.3
    • Geissmann, F.1    Cameron, T.O.2    Sidobre, S.3
  • 61
    • 77953479878 scopus 로고    scopus 로고
    • Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine
    • Gill HS, Soderholm J, Prausnitz MR, Sallberg M (2010) Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine. Gene Ther 17:811-814
    • (2010) Gene Ther , vol.17 , pp. 811-814
    • Gill, H.S.1    Soderholm, J.2    Prausnitz, M.R.3    Sallberg, M.4
  • 63
    • 44849113503 scopus 로고    scopus 로고
    • Cutting edge: Programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: Race-dependent differences
    • Golden-Mason L, Klarquist J, Wahed AS et al (2008a) Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences. J Immunol 180:3637-3641
    • (2008) J Immunol , vol.180 , pp. 3637-3641
    • Golden-Mason, L.1    Klarquist, J.2    Wahed, A.S.3
  • 64
    • 48249137638 scopus 로고    scopus 로고
    • Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure
    • Golden-Mason L, Madrigal-Estebas L, McGrath E et al (2008b) Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Gut 57:1121-1128
    • (2008) Gut , vol.57 , pp. 1121-1128
    • Golden-Mason, L.1    Madrigal-Estebas, L.2    McGrath, E.3
  • 65
    • 69449091993 scopus 로고    scopus 로고
    • Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
    • Golden-Mason L, Palmer BE, Kassam N et al (2009) Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol 83:9122-9130
    • (2009) J Virol , vol.83 , pp. 9122-9130
    • Golden-Mason, L.1    Palmer, B.E.2    Kassam, N.3
  • 66
    • 77957756030 scopus 로고    scopus 로고
    • A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals
    • Gowans EJ, Roberts S, Jones K et al (2010) A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals. J Hepatol 53:599-607
    • (2010) J Hepatol , vol.53 , pp. 599-607
    • Gowans, E.J.1    Roberts, S.2    Jones, K.3
  • 69
    • 80051490030 scopus 로고    scopus 로고
    • A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C
    • Habersetzer F, Honnet G, Bain C et al (2011) A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C. Gastroenterology 141:890-899
    • (2011) Gastroenterology , vol.141 , pp. 890-899
    • Habersetzer, F.1    Honnet, G.2    Bain, C.3
  • 71
    • 0038108598 scopus 로고    scopus 로고
    • Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity
    • DOI 10.1128/JVI.77.15.8299-8309.2003
    • Herzer K, Falk CS, Encke J et al (2003) Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity. J Virol 77:8299-8309 (Pubitemid 36871458)
    • (2003) Journal of Virology , vol.77 , Issue.15 , pp. 8299-8309
    • Herzer, K.1    Falk, C.S.2    Encke, J.3    Eichhorst, S.T.4    Ulsenheimer, A.5    Seliger, B.6    Krammer, P.H.7
  • 72
    • 51449107778 scopus 로고    scopus 로고
    • Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death
    • Holz LE, Benseler V, Bowen DG et al (2008) Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death. Gastroenterology 135:989-997
    • (2008) Gastroenterology , vol.135 , pp. 989-997
    • Holz, L.E.1    Benseler, V.2    Bowen, D.G.3
  • 73
    • 0028674991 scopus 로고
    • The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo
    • Huang L, Soldevila G, Leeker M et al (1994) The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity 1:741-749
    • (1994) Immunity , vol.1 , pp. 741-749
    • Huang, L.1    Soldevila, G.2    Leeker, M.3
  • 74
    • 0031663638 scopus 로고    scopus 로고
    • The antiviral compound ribavirin modulates the T helper (Th)1/Th2 subset balance in hepatitis B and C virus-specific immune responses
    • Hultgren C, Milich DR, Weiland O et al (1998) The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses. J Gen Virol 79(Pt 10):2381-2391 (Pubitemid 28464295)
    • (1998) Journal of General Virology , vol.79 , Issue.10 , pp. 2381-2391
    • Hultgren, C.1    Milich, D.R.2    Weiland, O.3    Sallberg, M.4
  • 76
    • 8444242871 scopus 로고    scopus 로고
    • Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection
    • Jinushi M, Takehara T, Tatsumi T et al (2004) Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection. J Immunol 173:6072-6081 (Pubitemid 39487763)
    • (2004) Journal of Immunology , vol.173 , Issue.10 , pp. 6072-6081
    • Jinushi, M.1    Takehara, T.2    Tatsumi, T.3    Kanto, T.4    Miyagi, T.5    Suzuki, T.6    Kanazawa, Y.7    Hiramatsu, N.8    Hayashi, N.9
  • 77
    • 0032418812 scopus 로고    scopus 로고
    • The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
    • DOI 10.1084/jem.188.12.2199
    • Kalams SA, Walker BD (1998) The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 188:2199-2204 (Pubitemid 29028492)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.12 , pp. 2199-2204
    • Kalams, S.A.1    Walker, B.D.2
  • 81
    • 43049175169 scopus 로고    scopus 로고
    • Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis
    • Kaplan DE, Ikeda F, Li Y et al (2008) Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48:903-913
    • (2008) J Hepatol , vol.48 , pp. 903-913
    • Kaplan, D.E.1    Ikeda, F.2    Li, Y.3
  • 82
    • 0033759170 scopus 로고    scopus 로고
    • Decrease of CD56 (+) T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma
    • Kawarabayashi N, Seki S, Hatsuse K et al (2000) Decrease of CD56 (+) T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma. Hepatology 32:962-969
    • (2000) Hepatology , vol.32 , pp. 962-969
    • Kawarabayashi, N.1    Seki, S.2    Hatsuse, K.3
  • 85
    • 0033690901 scopus 로고    scopus 로고
    • Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
    • Kittlesen DJ, Chianese-Bullock KA, Yao ZQ et al (2000) Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J Clin Invest 106:1239-1249
    • (2000) J Clin Invest , vol.106 , pp. 1239-1249
    • Kittlesen, D.J.1    Chianese-Bullock, K.A.2    Yao, Z.Q.3
  • 86
    • 42949111104 scopus 로고    scopus 로고
    • Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41
    • Klade CS, Wedemeyer H, Berg T et al (2008) Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41. Gastroenterology 134:1385-1395
    • (2008) Gastroenterology , vol.134 , pp. 1385-1395
    • Klade, C.S.1    Wedemeyer, H.2    Berg, T.3
  • 88
    • 77950626070 scopus 로고    scopus 로고
    • Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus
    • Knapp S, Warshow U, Hegazy D et al (2010) Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus. Hepatology 51:1168-1175
    • (2010) Hepatology , vol.51 , pp. 1168-1175
    • Knapp, S.1    Warshow, U.2    Hegazy, D.3
  • 89
    • 70350493684 scopus 로고    scopus 로고
    • The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo
    • Kriegs M, Burckstummer T, Himmelsbach K et al (2009) The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo. J Biol Chem 284:28343-28351
    • (2009) J Biol Chem , vol.284 , pp. 28343-28351
    • Kriegs, M.1    Burckstummer, T.2    Himmelsbach, K.3
  • 91
    • 79954756911 scopus 로고    scopus 로고
    • Interferonlambda serum levels in hepatitis C
    • Langhans B, Kupfer B, Braunschweiger I et al (2011) Interferonlambda serum levels in hepatitis C. J Hepatol 54:859-865
    • (2011) J Hepatol , vol.54 , pp. 859-865
    • Langhans, B.1    Kupfer, B.2    Braunschweiger, I.3
  • 98
    • 66149098224 scopus 로고    scopus 로고
    • Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells
    • Liang H, Russell RS, Yonkers NL et al (2009) Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells. J Virol 83:5693-5707
    • (2009) J Virol , vol.83 , pp. 5693-5707
    • Liang, H.1    Russell, R.S.2    Yonkers, N.L.3
  • 99
    • 0037097766 scopus 로고    scopus 로고
    • Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection
    • DOI 10.1086/340829
    • Lichterfeld M, Leifeld L, Nischalke HD et al (2002) Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection. J Infect Dis 185:1803-1807 (Pubitemid 34615477)
    • (2002) Journal of Infectious Diseases , vol.185 , Issue.12 , pp. 1803-1807
    • Lichterfeld, M.1    Leifeld, L.2    Nischalke, H.D.3    Rockstroh, J.K.4    Hess, L.5    Sauerbruch, T.6    Spengler, U.7
  • 101
    • 77952722154 scopus 로고    scopus 로고
    • Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaBdependent manner
    • 2518e1
    • Lin W, Tsai WL, Shao RX et al (2010) Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaBdependent manner. Gastroenterology 138:2509-2518 2518.e1
    • (2010) Gastroenterology , vol.138 , pp. 2509-2518
    • Lin, W.1    Tsai, W.L.2    Shao, R.X.3
  • 105
    • 58149386478 scopus 로고    scopus 로고
    • Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells
    • Marukian S, Jones CT, Andrus L et al (2008) Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells. Hepatology 48:1843-1850
    • (2008) Hepatology , vol.48 , pp. 1843-1850
    • Marukian, S.1    Jones, C.T.2    Andrus, L.3
  • 106
    • 0027971622 scopus 로고
    • + cytotoxic T-cell responses during chronic viral infection
    • Matloubian M, Concepcion RJ, Ahmed R (1994) CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol 68:8056-8063 (Pubitemid 24362694)
    • (1994) Journal of Virology , vol.68 , Issue.12 , pp. 8056-8063
    • Matloubian, M.1    Concepcion, R.J.2    Ahmed, R.3
  • 107
    • 0037345674 scopus 로고    scopus 로고
    • Extrahepatic manifestations of hepatitis C infection
    • DOI 10.1097/00000441-200303000-00006
    • Mayo MJ (2003) Extrahepatic manifestations of hepatitis C infection. Am J Med Sci 325:135-148 (Pubitemid 36348619)
    • (2003) American Journal of the Medical Sciences , vol.325 , Issue.3 , pp. 135-148
    • Mayo, M.J.1
  • 109
    • 67649637825 scopus 로고    scopus 로고
    • Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: Associations with antiviral treatment outcomes
    • Mengshol JA, Golden-Mason L, Castelblanco N et al (2009) Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes. Gut 58:964-973
    • (2009) Gut , vol.58 , pp. 964-973
    • Mengshol, J.A.1    Golden-Mason, L.2    Castelblanco, N.3
  • 110
    • 77949793555 scopus 로고    scopus 로고
    • A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection
    • Mengshol JA, Golden-Mason L, Arikawa T et al (2010) A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS ONE 5:e9504
    • (2010) PLoS ONE , vol.5
    • Mengshol, J.A.1    Golden-Mason, L.2    Arikawa, T.3
  • 111
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • DOI 10.1038/nature04193, PII N04193
    • Meylan E, Curran J, Hofmann K et al (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437:1167-1172 (Pubitemid 41509355)
    • (2005) Nature , vol.437 , Issue.7062 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 112
    • 33645231470 scopus 로고    scopus 로고
    • Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing
    • Morishima C, Paschal DM, Wang CC et al (2006) Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing. Hepatology 43:573-580
    • (2006) Hepatology , vol.43 , pp. 573-580
    • Morishima, C.1    Paschal, D.M.2    Wang, C.C.3
  • 113
  • 114
    • 4344713084 scopus 로고    scopus 로고
    • Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C
    • DOI 10.1111/j.1365-2249.2004.02550.x
    • Murakami H, Akbar SM, Matsui H et al (2004) Decreased interferonalpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C. Clin Exp Immunol 137:559-565 (Pubitemid 39128083)
    • (2004) Clinical and Experimental Immunology , vol.137 , Issue.3 , pp. 559-565
    • Murakami, H.1    Akbar, S.M.F.2    Matsui, H.3    Horiike, N.4    Onji, M.5
  • 115
    • 44649188658 scopus 로고    scopus 로고
    • Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    • 1937.e1-e2
    • Nakamoto N, Kaplan DE, Coleclough J et al (2008) Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134:1927-1937 1937.e1-e2
    • (2008) Gastroenterology , vol.134 , pp. 1927-1937
    • Nakamoto, N.1    Kaplan, D.E.2    Coleclough, J.3
  • 116
    • 61449181280 scopus 로고    scopus 로고
    • Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
    • Nakamoto N, Cho H, Shaked A et al (2009) Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog 5:e1000313
    • (2009) PLoS Pathog , vol.5
    • Nakamoto, N.1    Cho, H.2    Shaked, A.3
  • 118
    • 33646810822 scopus 로고    scopus 로고
    • Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C
    • DOI 10.1136/gut.2005.076463
    • Nattermann J, Feldmann G, Ahlenstiel G et al (2006) Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut 55:869-877 (Pubitemid 43764560)
    • (2006) Gut , vol.55 , Issue.6 , pp. 869-877
    • Nattermann, J.1    Feldmann, G.2    Ahlenstiel, G.3    Langhans, B.4    Sauerbruch, T.5    Spengler, U.6
  • 119
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • DOI 10.1126/science.282.5386.103
    • Neumann AU, Lam NP, Dahari H et al (1998) Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 282:103-107 (Pubitemid 28471138)
    • (1998) Science , vol.282 , Issue.5386 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6    Perelson, A.S.7
  • 121
    • 0032933394 scopus 로고    scopus 로고
    • Natural T cells in the human liver: Cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammaDelta T cell receptor bearing cells
    • DOI 10.1016/S0198-8859(98)00098-6
    • Norris S, Doherty DG, Collins C et al (1999) Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells. Hum Immunol 60:20-31 (Pubitemid 29057853)
    • (1999) Human Immunology , vol.60 , Issue.1 , pp. 20-31
    • Norris, S.1    Doherty, D.G.2    Collins, C.3    McEntee, G.4    Traynor, O.5    Hegarty, J.E.6    O'Farrelly, C.7
  • 123
    • 77952578945 scopus 로고    scopus 로고
    • Improving on the ability of endogenous hepatitis B core antigen to prime cytotoxic T lymphocytes
    • Nystrom J, Chen A, Frelin L et al (2010) Improving on the ability of endogenous hepatitis B core antigen to prime cytotoxic T lymphocytes. J Infect Dis 201:1867-1879
    • (2010) J Infect Dis , vol.201 , pp. 1867-1879
    • Nystrom, J.1    Chen, A.2    Frelin, L.3
  • 124
    • 69249113887 scopus 로고    scopus 로고
    • Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections
    • 1160.e1-e7
    • Oliviero B, Varchetta S, Paudice E et al (2009) Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Gastroenterology 137:1151-1160 1160.e1-e7
    • (2009) Gastroenterology , vol.137 , pp. 1151-1160
    • Oliviero, B.1    Varchetta, S.2    Paudice, E.3
  • 125
    • 33645974869 scopus 로고    scopus 로고
    • Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: Implications of HCV lymphotropism
    • Pal S, Sullivan DG, Kim S et al (2006) Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism. Gastroenterology 130:1107-1116
    • (2006) Gastroenterology , vol.130 , pp. 1107-1116
    • Pal, S.1    Sullivan, D.G.2    Kim, S.3
  • 127
    • 0035222608 scopus 로고    scopus 로고
    • The antiviral activity of antibodies in vitro and in vivo
    • DOI 10.1016/S0065-2776(01)77018-6
    • Parren PW, Burton DR (2001) The antiviral activity of antibodies in vitro and in vivo. Adv Immunol 77:195-262 (Pubitemid 33703707)
    • (2001) Advances in Immunology , vol.77 , pp. 195-262
    • Parren, P.W.H.I.1    Burton, D.R.2
  • 128
    • 84855954396 scopus 로고    scopus 로고
    • Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus nonstructural protein 3
    • Pasetto A, Frelin L, Brass A et al (2012) Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus nonstructural protein 3. J Gen Virol 93(Pt 2):247-258
    • (2012) J Gen Virol , vol.93 , Issue.PART 2 , pp. 247-258
    • Pasetto, A.1    Frelin, L.2    Brass, A.3
  • 129
    • 77957336301 scopus 로고    scopus 로고
    • Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses
    • Pelletier S, Drouin C, Bedard N et al (2010) Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses. J Hepatol 53:805-816
    • (2010) J Hepatol , vol.53 , pp. 805-816
    • Pelletier, S.1    Drouin, C.2    Bedard, N.3
  • 131
    • 33645101165 scopus 로고    scopus 로고
    • Flow cytometry assay of myeloid dendritic cells (mDCs) in peripheral blood during acute hepatitis C: Possible pathogenetic mechanisms
    • Perrella A, Atripaldi L, Bellopede P et al (2006a) Flow cytometry assay of myeloid dendritic cells (mDCs) in peripheral blood during acute hepatitis C: possible pathogenetic mechanisms. World J Gastroenterol 12:1105-1109
    • (2006) World J Gastroenterol , vol.12 , pp. 1105-1109
    • Perrella, A.1    Atripaldi, L.2    Bellopede, P.3
  • 133
    • 33750491102 scopus 로고    scopus 로고
    • Interleukin-10-1082 GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection
    • DOI 10.1016/j.jhep.2006.07.026, PII S0168827806004569
    • Persico M, Capasso M, Persico E et al (2006) Interleukin-10-1082GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection. J Hepatol 45:779-785 (Pubitemid 44646685)
    • (2006) Journal of Hepatology , vol.45 , Issue.6 , pp. 779-785
    • Persico, M.1    Capasso, M.2    Persico, E.3    Masarone, M.4    Renzo, A.D.5    Spano, D.6    Bruno, S.7    Iolascon, A.8
  • 134
    • 0034087136 scopus 로고    scopus 로고
    • Relationship between interferon-gamma, interleukin-10, and interleukin-12 production in chronic hepatitis C and in vitro effects of interferon-alpha
    • DOI 10.1023/A:1006694627907
    • Piazzolla G, Tortorella C, Schiraldi O, Antonaci S (2000) Relationship between interferon-gamma, interleukin-10, and interleukin-12 production in chronic hepatitis C and in vitro effects of interferon-alpha. J Clin Immunol 20:54-61 (Pubitemid 30210107)
    • (2000) Journal of Clinical Immunology , vol.20 , Issue.1 , pp. 54-61
    • Piazzolla, G.1    Tortorella, C.2    Schiraldi, O.3    Antonaci, S.4
  • 135
    • 0346157289 scopus 로고    scopus 로고
    • Viral hepatitis C
    • DOI 10.1016/S0140-6736(03)15109-4
    • Poynard T, Yuen MF, Ratziu V et al (2003) Viral hepatitis C. Lancet 362:2095-2100 (Pubitemid 38035201)
    • (2003) Lancet , vol.362 , Issue.9401 , pp. 2095-2100
    • Poynard, T.1    Yuen, M.-F.2    Ratziu, V.3    Lung Lai, C.4
  • 138
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
    • Rehermann B (2009) Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 119:1745-1754
    • (2009) J Clin Invest , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 140
    • 79951680384 scopus 로고    scopus 로고
    • Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection
    • Riezu-Boj JI, Larrea E, Aldabe R et al (2011) Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection. J Hepatol 54:422-431
    • (2011) J Hepatol , vol.54 , pp. 422-431
    • Riezu-Boj, J.I.1    Larrea, E.2    Aldabe, R.3
  • 141
    • 27244444359 scopus 로고    scopus 로고
    • Blocking of interleukin-10 receptor - A novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus
    • DOI 10.1016/j.clim.2005.06.003, PII S1521661605001816
    • Rigopoulou EI, Abbott WG, Haigh P et al (2005) Blocking of interleukin-10 receptor-a novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus. Clin Immunol 117:57-64 (Pubitemid 41725470)
    • (2005) Clinical Immunology , vol.117 , Issue.1 , pp. 57-64
    • Rigopoulou, E.I.1    Abbott, W.G.H.2    Haigh, P.3    Naoumov, N.V.4
  • 143
    • 67650558335 scopus 로고    scopus 로고
    • A first clinical trial of therapeutic vaccination using naked DNA delivered by in vivo electroporation shows antiviral effects in patients with chronic hepatitis C
    • Sallberg M, Frelin L, Diepolder H et al (2009) A first clinical trial of therapeutic vaccination using naked DNA delivered by in vivo electroporation shows antiviral effects in patients with chronic hepatitis C. J Hepatol 50:S18-S19
    • (2009) J Hepatol , vol.50
    • Sallberg, M.1    Frelin, L.2    Diepolder, H.3
  • 144
    • 79958076040 scopus 로고    scopus 로고
    • Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCVspecific CD8+ T cells
    • Schlaphoff V, Lunemann S, Suneetha PV et al (2011) Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCVspecific CD8+ T cells. PLoS Pathog 7:e1002045
    • (2011) PLoS Pathog , vol.7
    • Schlaphoff, V.1    Lunemann, S.2    Suneetha, P.V.3
  • 145
    • 72849146748 scopus 로고    scopus 로고
    • The HLA-E (R)/HLAE (R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gammasecreting human CD8 (+) T cells
    • Schulte D, Vogel M, Langhans B et al (2009) The HLA-E (R)/HLAE (R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gammasecreting human CD8 (+) T cells. J Infect Dis 200:1397-1401
    • (2009) J Infect Dis , vol.200 , pp. 1397-1401
    • Schulte, D.1    Vogel, M.2    Langhans, B.3
  • 147
  • 148
    • 77954409827 scopus 로고    scopus 로고
    • Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were associated with impaired dendritic cells function in HCV infection
    • Shen T, Chen X, Chen Y et al (2010) Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were associated with impaired dendritic cells function in HCV infection. J Med Virol 82:1152-1159
    • (2010) J Med Virol , vol.82 , pp. 1152-1159
    • Shen, T.1    Chen, X.2    Chen, Y.3
  • 151
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-Specific T Cells without Differential Hierarchy Demonstrated Ex Vivo in Persistent HCV Infection
    • DOI 10.1016/j.hep.2003.09.026
    • Sugimoto K, Ikeda F, Stadanlick J et al (2003) Suppression of HCVspecific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 38:1437-1448 (Pubitemid 37466970)
    • (2003) Hepatology , vol.38 , Issue.6 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.-M.6
  • 152
    • 77952127743 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection
    • Takahashi K, Asabe S, Wieland S et al (2010) Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci USA 107:7431-7436
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7431-7436
    • Takahashi, K.1    Asabe, S.2    Wieland, S.3
  • 153
    • 0038228956 scopus 로고    scopus 로고
    • The regulatory role of Valpha14 NKT cells in innate and acquired immune response
    • DOI 10.1146/annurev.immunol.21.120601.141057
    • Taniguchi M, Harada M, Kojo S et al (2003) The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol 21:483-513 (Pubitemid 37174539)
    • (2003) Annual Review of Immunology , vol.21 , pp. 483-513
    • Taniguchi, M.1    Harada, M.2    Kojo, S.3    Nakayama, T.4    Wakao, H.5
  • 155
    • 78751545582 scopus 로고    scopus 로고
    • Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models
    • Thomas E, Feld JJ, Li Q et al (2011) Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models. Hepatology 53:32-41
    • (2011) Hepatology , vol.53 , pp. 32-41
    • Thomas, E.1    Feld, J.J.2    Li, Q.3
  • 157
    • 0031026553 scopus 로고    scopus 로고
    • Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity
    • Tsai SL, Liaw YF, Chen MH et al (1997) Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity. Hepatology 25:449-458
    • (1997) Hepatology , vol.25 , pp. 449-458
    • Tsai, S.L.1    Liaw, Y.F.2    Chen, M.H.3
  • 158
    • 0031680261 scopus 로고    scopus 로고
    • Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
    • Tsai SL, Chen YM, Chen MH et al (1998) Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity. Gastroenterology 115:954-965
    • (1998) Gastroenterology , vol.115 , pp. 954-965
    • Tsai, S.L.1    Chen, Y.M.2    Chen, M.H.3
  • 159
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
    • DOI 10.1084/jem.20011145
    • Tseng CT, Klimpel GR (2002) Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med 195:43-49 (Pubitemid 34074495)
    • (2002) Journal of Experimental Medicine , vol.195 , Issue.1 , pp. 43-49
    • Tseng, C.-T.K.1    Klimpel, G.R.2
  • 160
    • 53049094804 scopus 로고    scopus 로고
    • Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness
    • Uebelhoer L, Han JH, Callendret B et al (2008) Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness. PLoS Pathog 4:e1000143
    • (2008) PLoS Pathog , vol.4
    • Uebelhoer, L.1    Han, J.H.2    Callendret, B.3
  • 163
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    • DOI 10.1128/JVI.01177-06
    • Urbani S, Amadei B, Tola D et al (2006b) PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCVspecific CD8 exhaustion. J Virol 80:11398-11403 (Pubitemid 44706581)
    • (2006) Journal of Virology , vol.80 , Issue.22 , pp. 11398-11403
    • Urbani, S.1    Amadei, B.2    Tola, D.3    Massari, M.4    Schivazappa, S.5    Missale, G.6    Ferrari, C.7
  • 164
    • 72849120234 scopus 로고    scopus 로고
    • Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection
    • Vidal-Castineira JR, Lopez-Vazquez A, Diaz-Pena R et al (2010) Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection. J Virol 84:475-481
    • (2010) J Virol , vol.84 , pp. 475-481
    • Vidal-Castineira, J.R.1    Lopez-Vazquez, A.2    Diaz-Pena, R.3
  • 167
    • 4043179185 scopus 로고    scopus 로고
    • Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease
    • DOI 10.1002/hep.20306
    • Wertheimer AM, Bakke A, Rosen HR (2004) Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease. Hepatology 40:335-345 (Pubitemid 39062851)
    • (2004) Hepatology , vol.40 , Issue.2 , pp. 335-345
    • Wertheimer, A.M.1    Bakke, A.2    Rosen, H.R.3
  • 169
    • 0142244871 scopus 로고    scopus 로고
    • Characterization of HCV-Specific Patr Class II Restricted CD4+ T Cell Responses in an Acutely Infected Chimpanzee
    • DOI 10.1053/jhep.2003.50478
    • Woollard DJ, Grakoui A, Shoukry NH et al (2003) Characterization of HCV-specific Patr class II restricted CD4+ T cell responses in an acutely infected chimpanzee. Hepatology 38:1297-1306 (Pubitemid 37314840)
    • (2003) Hepatology , vol.38 , Issue.5 , pp. 1297-1306
    • Woollard, D.J.1    Grakoui, A.2    Shoukry, N.H.3    Murthy, K.K.4    Campbell, K.J.5    Walker, C.M.6
  • 170
    • 0035876913 scopus 로고    scopus 로고
    • + regulatory t cells from human peripheral blood
    • Yamagiwa S, Gray JD, Hashimoto S et al (2001) A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 166:7282-7289 (Pubitemid 32525603)
    • (2001) Journal of Immunology , vol.166 , Issue.12 , pp. 7282-7289
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 171
    • 44649145310 scopus 로고    scopus 로고
    • Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells
    • DOI 10.1111/j.1872-034X.2008.00317.x
    • Yamagiwa S, Matsuda Y, Ichida T et al (2008) Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells. Hepatol Res 38:664-672 (Pubitemid 351784979)
    • (2008) Hepatology Research , vol.38 , Issue.7 , pp. 664-672
    • Yamagiwa, S.1    Matsuda, Y.2    Ichida, T.3    Honda, Y.4    Takamura, M.5    Sugahara, S.6    Ishikawa, T.7    Ohkoshi, S.8    Sato, Y.9    Aoyagi, Y.10
  • 172
    • 0035500651 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway
    • Yao ZQ, Nguyen DT, Hiotellis AI et al (2001) Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway. J Immunol 167:5264-5272 (Pubitemid 33009764)
    • (2001) Journal of Immunology , vol.167 , Issue.9 , pp. 5264-5272
    • Yao, Z.Q.1    Nguyen, D.T.2    Hiotellis, A.I.3    Hahn, Y.S.4
  • 173
    • 2642546429 scopus 로고    scopus 로고
    • + T cells leads to impaired activation of Lck and Akt
    • DOI 10.1128/JVI.78.12.6409-6419.2004
    • Yao ZQ, Eisen-Vandervelde A, Waggoner SN et al (2004) Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J Virol 78:6409-6419 (Pubitemid 38715939)
    • (2004) Journal of Virology , vol.78 , Issue.12 , pp. 6409-6419
    • Yao, Z.Q.1    Eisen-Vandervelde, A.2    Waggoner, S.N.3    Cale, E.M.4    Hahn, Y.S.5
  • 174
    • 58949091314 scopus 로고    scopus 로고
    • Natural killer cell function is intact after direct exposure to infectious hepatitis C virions
    • Yoon JC, Shiina M, Ahlenstiel G et al (2009) Natural killer cell function is intact after direct exposure to infectious hepatitis C virions. Hepatology 49:12-21
    • (2009) Hepatology , vol.49 , pp. 12-21
    • Yoon, J.C.1    Shiina, M.2    Ahlenstiel, G.3
  • 175
    • 34347336666 scopus 로고    scopus 로고
    • The role of chemokines as inflammatory mediators in chronic hepatitis C virus infection
    • DOI 10.1111/j.1365-2893.2006.00838.x
    • Zeremski M, Petrovic LM, Talal AH (2007) The role of chemokines as inflammatory mediators in chronic hepatitis C virus infection. J Viral Hepat 14:675-687 (Pubitemid 47414927)
    • (2007) Journal of Viral Hepatitis , vol.14 , Issue.10 , pp. 675-687
    • Zeremski, M.1    Petrovic, L.M.2    Talal, A.H.3
  • 176
    • 77957671100 scopus 로고    scopus 로고
    • Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity
    • Zhang Y, Liu Y, Moxley KM et al (2010) Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity. PLoS Pathog 6:e1001018
    • (2010) PLoS Pathog , vol.6
    • Zhang, Y.1    Liu, Y.2    Moxley, K.M.3
  • 177
    • 79952761607 scopus 로고    scopus 로고
    • Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
    • Zhang Y, Ma CJ, Ni L et al (2011a) Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection. J Immunol 186:3093-3103
    • (2011) J Immunol , vol.186 , pp. 3093-3103
    • Zhang, Y.1    Ma, C.J.2    Ni, L.3
  • 178
    • 79957569297 scopus 로고    scopus 로고
    • Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection
    • Zhang Y, Ma CJ, Wang JM et al (2011b) Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection. PLoS ONE 6:e19664
    • (2011) PLoS ONE , vol.6
    • Zhang, Y.1    Ma, C.J.2    Wang, J.M.3
  • 179
    • 36549060584 scopus 로고    scopus 로고
    • Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes
    • DOI 10.1016/j.jhep.2007.08.008, PII S0168827807005302
    • Zimmermann M, Flechsig C, La Monica N et al (2008) Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes. J Hepatol 48:51-60 (Pubitemid 350191988)
    • (2008) Journal of Hepatology , vol.48 , Issue.1 , pp. 51-60
    • Zimmermann, M.1    Flechsig, C.2    Monica, N.L.3    Tripodi, M.4    Adler, G.5    Dikopoulos, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.