Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes

European Journal of Immunology

Volumn 33, Issue 12, 2003, Pages 3448-3457

  Brady, Miriam T ^a   MacDonald, Angus J ^a,b   Rowan, Aileen G ^a   Mills, Kingston H G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b NEW YORK BLOOD CENTER   (United States)

Author keywords

Hepatitis C virus; IL 10; Immune subversion; Regulatory T cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ARTICLE; CELL ACTIVATION; CELL MATURATION; CELL PROLIFERATION; CELL SEPARATION; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DIFFERENTIATION; MONOCYTE; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SUPERNATANT; T LYMPHOCYTE; TH1 CELL;

ANTIGENS, CD; ANTIGENS, CD86; DENDRITIC CELLS; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNOGLOBULINS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MONOCYTES; TH1 CELLS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0347382454     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324251     Document Type: Article

References (33)

1. + T cells with viral clearance in acute hepatitis C. J. Infect. Dis. 2000. 181: 1528-1536.
2. + T cell responsiveness in hepatitis C virus infection. Hepatology 2001. 33: 267-276.
3. + T-helper-cell responses in resolved hepatitis C virus infection. J. Virol. 2002. 76: 12584-12595.
4. Koziel, M. J., Dudley, D., Wong, J. T., Dienstag, J., Houghton, M., Ralston, R., and Walker, B. D., Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J. Immunol 1992. 149: 3339-3344.
5. Battegay, M., Fikes, J., Di Bisceglie, A. M., Wentworth, P. A., Sette, A., Celis, E., Ching, W. M., Grakoui, A., Rice, C. M., Kurokohchi, K., Berzofsky, J. A., Hoofnagle, J. H., Feinstone, S. M. and Akatsuka, T., Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus encoded peptides binding to HLA-A2.1 molecules. J. Virol. 1995. 69: 2462-2470.
6. Tsai, S.-L., Liaw, Y.-F., Chen, M.-H., Huang, C.-Y. and Kuo, G. C., Detection of Type-2 like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity. Hepatology 1997. 25: 449-458.
7. + T cell response in acute hepatitis C. Gastroenterology 1999. 117: 933-941.
8. Napoli, J., Bishop, G. A., McGuinness, P. H., Painter, D. M. and McCaughan, G. W., Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 1996. 24: 759-765.
9. Quiroga, J. A., Martin, J., Navas, S. and Carreno, V., Induction of interleukin-12 production in chronic hepatitis C virus infection correlates with the hepatocellular damage. J. Infect. Dis. 1998. 178: 247-251.
10. Vossen, M. T., Westerhout, E. M., Soderberg-Naucler, C. and Wiertz, E. J., Viral immune evasion: a masterpiece of evolution. Immunogenetics 2002. 54: 527-542.
11. Taoufik, Y., Lantz, O., Wallon, C., Charles, A., Dussaix, E. and Delfraissy, J. F., Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood 1997. 89: 2842-2848.
12. Stockl, J., Vetr, H., Majdic, O., Ziabinger, G., Kuechler, E. and Knapp, W., Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10. J. Clin. Invest. 1999. 104: 957-965.
13. McGuirk, P., McCann, C. and Mills, K. H. G., Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 2002. 195: 221-231.
14. Barnes, P. F., Chatterjee, D., Abrams, J. S., Lu, S., Wang, E., Yamamura, M., Brennan, P. J. and Modlin, R. L., Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J. Immunol. 1992. 149: 541-547.
15. Woitas, R. P., Lechmann, M., Jung, G., Kaiser, R., Sauerbruch, T. and Spengler, U., CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes. J. Immunol. 1997. 159: 1012-1018.
16. Kakumu, S., Okamura, A., Ishikawa, T., Iwata, K., Yano, M. and Yoshioka, K., Production of interleukins 10 and 12 by peripheral blood mononuclear cells (PBMC) in chronic hepatitis C virus (HCV) infection. Clin. Exp. Immunol. 1997. 108: 138-143.
17. MacDonald, A. J., Duffy, M., Brady, M. T., McKiernan, S., Hall, W., Hegarty, J., Curry, M. and Mills, K. H. G., CD4 T helper type 1 and regulatory T cells induced against the same Epitopes on the core protein in hepatitis C virus infected persons. J. Infect. Dis. 2002. 185: 720-727.
18. Scheiner, P. A., Florman, S. S., Emre, S., Fishbein, T., Schwartz, M. E., Miller,. C. M. and Boros, P., Recurrence of hepatitis C after liver transplantation is associated with increased systemic IL-10 levels. Mediators Inflamm. 2001. 10: 37-41.
19. Yee, L. J., Tang, J., Gibson, A. W., Kimberly, R., Van Leeuwen, D. J. and Kaslow, R. A., Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection. Hepatology 2001. 33: 708-712.
20. Higgins, S. C., McCann, C., Lavelle, E. C., Keogh, B., McNeela, E., Byrne, P., O'Gorman, B., Jarnicki, A., McGuirk, P. and Mills, K. H. G., Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J. Immunol. 2003. 171: 3119-3127.
21. McGuirk, P. and Mills, K. H. G., Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 2002. 23: 450-455.
22. Gale, M. Jr., Blakely, C. M., Kwieciszewski, B., Tan, S. L., Dossett, M., Tang, N. M., Korth, M. J., Polyak, S. J., Gretch, D. R. and Katze, M. G., Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol. Cell. Biol. 1998. 18. 5208-5218.
23. Bode, J. G., Ludwig, S., Ehrhardt, C., Erhardt, A., Albrecht, U., Schaper, F., Heinrich, P. C. and Haussinger, D., IFN-α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3. FASEB J. 2003. 17: 488-490.
24. De Francesco, R. and Steinkuhler, C., Structure and function of the hepatitis C virus NS3-NS4A serine proteinase. Curr. Top. Microbiol. Immunol. 2000. 242: 149-169.
25. Kato, J., Kato, N., Yoshida, H., Ono-Nita, S. K., Shiratori, Y. and Omata, M., Hepatitis C virus NS4A and NS413 proteins suppress translation in vivo. J. Med. Virol. 2002. 66: 187-199.
26. Aoubala, M., Holt, J., Clegg, R. A., Rowlands, O. J. and Harris, M., The inhibition of cAMP-dependent protein kinase by full-length hepatitis C virus NS3/4A complex is due to ATP hydrolysis. J. Gen. Virol. 2001. 82: 1637-1646.
27. Marie, J. C., Kehren, J., Trescol-Biemont, M. C., Evlashev, A., Valentin, H., Walzer, T., Tedone, R., Loveland, B., Nicolas, J. F., Rabourdin-Combe, C. and Horvat, B., Mechanism of measles virus-induced suppression of inflammatory immune responses. Immunity 2001. 14: 69-79.
28. Yao, Z. Q., Nguyen, D. T., Hiotellis, A. I. and Hahn, Y. S., Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway. J. Immunol. 2001. 167: 5264-5272.
29. + T cells by dendritic cells expressing hepatitis C virus core and E1 proteins. J. Virol. 2002. 76: 5062-5070.
30. Bain, C., Fatmi, A., Zoulim, F., Zarski, J. P., Trepo, C. and Inchauspe, G., Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 2001. 120: 512-524.
31. Auffermann-Gretzinger, S., Keeffe, E. S. and Levy, S., Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C infection. Blood. 2001. 97: 3171-3176.
32. Dolganiue, A., Kodys, K., Kopasz, A., Marshall, C., Do, T., Romics, L. Jr., Mandrekar, P., Zapp, M. and Szabo, G., Hepatitis C virus core and non-structural protein 3 proteins induce pro-and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J. Immunol. 2003. 170: 5615-5624.
33. Mills, K. H. G., An indirect rosette technique for the identification and separation of lymphocyte populations by monoclonal antibodies. Methods Enzymol. 1986. 121: 726-737.