Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5264-5272

  Yao, Z Q ^a   Nguyen, D T ^a   Hiotellis, A I ^a   Hahn, Y S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT RECEPTOR; CORE PROTEIN; INTERLEUKIN 2 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY;

ARTICLE; BINDING AFFINITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; VIRUS IMMUNITY; VIRUS INFECTION;

EID: 0035500651     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5264     Document Type: Article

References (49)

1. Complement component C1 and the collectins: Parallels between routes of acquired and innate immunity
2. Molecular organization and function of the complement system
3. T cell-dependent immune response in Clq-deficient mice: Defective interferon-γ production by antigen-specific T cells
4. Homozygous Clq deficiency causes glomerulonephritis associated with multiple apoptotic bodies
5. Evidence that the two Clq binding membrane proteins. gCIq-R and cClq-R, associate to form a complex
6. Human T cells express specific binding sites for Clq: Role in T cell activation and proliferation
7. Interaction of CIq with its receptor on cultured cell lines induces an anti-proliferative response
8. Hepatitis C viruses
9. Hepatitis C virus: Pathogenesis and immune regulation
10. Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis
11. Hepatitis C virus and autoimmunity: Fortuitous association or reality?
12. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLAA2.1 binding motif
13. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV
14. Analysis of successful immune responses infected with hepatitis C virus
15. + T lymphocyte responses are induced during acute hepatitis C virus infection but not sustained
16. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
17. Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C
18. Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity
19. Non-enveloped nucleocapsids of hepatitis C virus in the serum of infected patients
20. Suppression of host immune response by the core protein of hepatitis C virus: Possible implications for hepatitis C virus persistence
21. Interaction between complement receptor gClqR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
22. Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs
23. T-lymphocyte response to hepatitis C virus in different clinical courses of infection
24. Hepatitis C virus core protein: Possible roles in viral pathogenesis
25. Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates
26. Detection of hepatitis C virus core protein circulating within different virus particle populations
27. The HCV core protein acts as a positive regulator of Fas-mediated apoptosis in a human lymphoblastoid T cell line: Possible implications for HCV pathogenesis
28. Long term culture of tumor-specific cytotoxic T cells
29. Biology of the interleukin-2 receptor
30. Structure and function of gClq-R: A multiligand binding cellular protein
31. Parallel signal processing among mammalian MAPKs
32. Activation of the MAP kinase pathway by the protein kinase raf
33. Signal transmission between the plasma membrane and nucleus of T lymphocytes
34. How MAP kinases are regulated
35. Analysis of a successful immune response against hepatitis C virus
36. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
37. Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C
38. Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
39. Buoyant density of hepatitis C virus recovered from infected hosts: Two different features in sucrose equilibrium density-gradient centrifugation related to degree of liver inflammation
40. Development of a simple and highly sensitive enzyme immunoassay for hepatitis C virus core antigen
41. Changes in antibody titers to hepatitis C virus following interferon therapy for chronic infection
42. gCIqR/p32, a Clq-binding protein, is a receptor for the In1B invasion protein of Listeria monocytogenes
43. Protein kinase Cμ is regulated by the multifunctional chaperon protein p32
44. Raf-I activates MAP kinase-kinase
45. Complexes of Ras: GTP with Raf-I and mitogen-activated protein kinase kinase
46. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
47. Mechanism of HIV-1 Tat-induced inhibition of antigen-specific T cell responsiveness
48. Human immunodeficiency virus I Tat binds to dipeptidyl aminopeptidase IV (CD26): A possible mechanism for Tat's immunosuppressive activity
49. Human immunodeficiency virus Tat induces functional unresponsiveness in T cells