PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

Journal of Hepatology

Volumn 45, Issue 4, 2006, Pages 520-528

  Mühlbauer, Marcus ^a   Fleck, Martin ^a   Schütz, Christian ^a   Weiss, Thomas ^a   Froh, Matthias ^a   Blank, Christian ^a   Schölmerich, Jürgen ^a   Hellerbrand, Claus ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Apoptosis; B7 H1; Hepatocytes; Liver; PD 1; PD L1; Tolerance

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; PROTEIN; PROTEIN PD L1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL INTERACTION; CELL STIMULATION; COCULTURE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HEPATOMA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIVER CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE; VIRUS INFECTION;

ADENOVIRUS INFECTIONS, HUMAN; ANTIGENS, CD; APOPTOSIS; CELL COMMUNICATION; COCULTURE TECHNIQUES; GENE EXPRESSION; HEPATOCYTES; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; JURKAT CELLS; LIVER; LYMPHOCYTE ACTIVATION; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 33748098860     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2006.05.007     Document Type: Article

References (46)

1. Knolle P.A., and Gerken G. Local control of the immune response in the liver. Immunol Rev 174 (2000) 21-34
2. Knolle P.A., and Limmer A. Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells. Trends Immunol 22 (2001) 432-437
3. Griffith T.S., Brunner T., Fletcher S.M., Green D.R., and Ferguson T.A. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270 (1995) 1189-1192
4. Dong H., Zhu G., Tamada K., and Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5 (1999) 1365-1369
5. Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192 (2000) 1027-1034
6. Latchman Y., Wood C.R., Chernova T., Chaudhary D., Borde M., Chernova I., et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2 (2001) 261-268
7. Herold K.C., Montag A.G., and Buckingham F. Induction of tolerance to autoimmune diabetes with islet antigens. J Exp Med 176 (1992) 1107-1114
8. Youngnak-Piboonratanakit P., Tsushima F., Otsuki N., Igarashi H., Machida U., Iwai H., et al. The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role. Immunol Lett 94 (2004) 215-222
9. Ruddle N.H., Picarella D., Kratz A., Li C.B., and Flavell R.A. Probing the mechanism of TNF-alpha(cachectin)- and TNF-beta(lymphotoxin)-induced pancreatic inflammation with transgenic mice. Res Immunol 144 (1993) 336-342
10. Guerder S., Picarella D.E., Linsley P.S., and Flavell R.A. Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. Proc Natl Acad Sci USA 91 (1994) 5138-5142
11. Cuff C.A., Sacca R., and Ruddle N.H. Differential induction of adhesion molecule and chemokine expression by LTalpha3 and LTalphabeta in inflammation elucidates potential mechanisms of mesenteric and peripheral lymph node development. J Immunol 162 (1999) 5965-5972
12. Luther S.A., Lopez T., Bai W., Hanahan D., and Cyster J.G. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12 (2000) 471-481
13. Oei E., Kalb T., Beuria P., Allez M., Nakazawa A., Azuma M., et al. Accessory cell function of airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 287 (2004) L318-L331
14. Subudhi S.K., Alegre M.L., and Fu Y.X. The balance of immune responses: costimulation verse coinhibition. J Mol Med 83 (2005) 193-202
15. Dong H., Zhu G., Tamada K., Flies D.B., van Deursen J.M., and Chen L. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 20 (2004) 327-336
16. Iwai Y., Terawaki S., Ikegawa M., Okazaki T., and Honjo T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J Exp Med 198 (2003) 39-50
17. Yu M.C., Chen C.H., Liang X., Wang L., Gandhi C.R., Fung J.J., et al. Inhibition of T-cell responses by hepatic stellate cells via B7-H1-mediated T-cell apoptosis in mice. Hepatology 40 (2004) 1312-1321
18. Hellerbrand, Wang S.C., Tsukamoto H., Brenner D.A., and Rippe R.A. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology 24 (1996) 670-676
19. Steiling H., Muhlbauer M., Bataille F., Scholmerich J., Werner S., and Hellerbrand C. Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease. Am J Pathol 165 (2004) 1233-1241
20. Hoves S., Krause S.W., Halbritter D., Zhang H.G., Mountz J.D., Scholmerich J., et al. Mature but not immature Fas ligand (CD95L)-transduced human monocyte-derived dendritic cells are protected from Fas-mediated apoptosis and can be used as killer APC. J Immunol 170 (2003) 5406-5413
21. Brown J.A., Dorfman D.M., Ma F.R., Sullivan E.L., Munoz O., Wood C.R., et al. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 170 (2003) 1257-1266
22. Bennett F., Luxenberg D., Ling V., Wang I.M., Marquette K., Lowe D., et al. Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. J Immunol 170 (2003) 711-718
23. Mazanet M.M., and Hughes C.C. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J Immunol 169 (2002) 3581-3588
24. Rodig N., Ryan T., Allen J.A., Pang H., Grabie N., Chernova T., et al. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol 33 (2003) 3117-3126
25. Yamazaki T., Akiba H., Iwai H., Matsuda H., Aoki M., Tanno Y., et al. Expression of programmed death 1 ligands by murine T cells and APC. J Immunol 169 (2002) 5538-5545
26. Liang S.C., Latchman Y.E., Buhlmann J.E., Tomczak M.F., Horwitz B.H., Freeman G.J., et al. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur J Immunol 33 (2003) 2706-2716
27. Eriksson U., Kurrer M.O., Sebald W., Brombacher F., and Kopf M. Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol 167 (2001) 464-469
28. Nagano H., Mitchell R.N., Taylor M.K., Hasegawa S., Tilney N.L., and Libby P. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 100 (1997) 550-557
29. Pewe L., Haring J., and Perlman S. CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus. J Virol 76 (2002) 7329-7333
30. Napoli J., Bishop G.A., McGuinness P.H., Painter D.M., and McCaughan G.W. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 24 (1996) 759-765
31. Fukuda R., Ishimura N., Nguyen T.X., Chowdhury A., Ishihara S., Kohge N., et al. The expression of IL-2, IL-4 and interferon-gamma (IFN-gamma) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B. Clin Exp Immunol 100 (1995) 446-451
32. Dumoulin F.L., Wennrich U., Nischalke H.D., Leifeld L., Fischer H.P., Sauerbruch T., et al. Intrahepatic mRNA levels of interferon gamma and tumor necrosis factor alpha and response to antiviral treatment of chronic hepatitis C. J Hum Virol 4 (2001) 195-199
33. Bogdan C. The function of type I interferons in antimicrobial immunity. Curr Opin Immunol 12 (2000) 419-424
34. Woo M.H., and Kale-Pradhan P.B. Fludrocortisone in the treatment of subarachnoid hemorrhage-induced hyponatremia. Ann Pharmacother 31 (1997) 637-639
35. Hoofnagle J.H. Management of hepatitis C: current and future perspectives. J Hepatol 31 (1999) 264-268
36. Shoukry N.H., Cawthon A.G., and Walker C.M. Cell-mediated immunity and the outcome of hepatitis C virus infection. Annu Rev Microbiol 58 (2004) 391-424
37. Pol S., Carnot F., Nalpas B., Lagneau J.L., Fontaine H., Serpaggi J., et al. Reversibility of hepatitis C virus-related cirrhosis. Hum Pathol 35 (2004) 107-112
38. Boettler T., Spangenberg H.C., Neumann-Haefelin C., Panther E., Urbani S., Ferrari C., et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 79 (2005) 7860-7867
39. Tsuda M., Matsumoto K., Inoue H., Matsumura M., Nakano T., Mori A., et al. Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA. Biochem Biophys Res Commun 330 (2005) 263-270
40. Vossen M.T., Westerhout E.M., Soderberg-Naucler C., and Wiertz E.J. Viral immune evasion: a masterpiece of evolution. Immunogenetics 54 (2002) 527-542
41. Hewitt E.W. The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110 (2003) 163-169
42. Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439 (2006) 682-687
43. Wang S., Bajorath J., Flies D.B., Dong H., Honjo T., and Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med 197 (2003) 1083-1091
44. Tseng S.Y., Otsuji M., Gorski K., Huang X., Slansky J.E., Pai S.I., et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med 193 (2001) 839-846
45. Liu X., Gao J.X., Wen J., Yin L., Li O., Zuo T., et al. B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J Exp Med 197 (2003) 1721-1730
46. Lee S.K., Seo S.H., Kim B.S., Kim C.D., Lee J.H., Kang J.S., et al. IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells. J Dermatol Sci 40 (2005) 95-103