The regulatory role of Vα14 NKT cells in innate and acquired immune response

Annual Review of Immunology

Volumn 21, Issue , 2003, Pages 483-513

  Taniguchi, Masaru ^a   Harada, Michishige ^a   Kojo, Satoshi ^a   Nakayama, Toshinori ^a   Wakao, Hiroshi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

galactosylceramide; Gene rearrangement; GM CSF receptor; Innate immunity; Regulation of immune response; V 14 NKT cell deficient mice

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD1D ANTIGEN; CIRCULAR DNA; CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 18; LIGAND; LIPOPOLYSACCHARIDE; LYMPHOCYTE ANTIGEN RECEPTOR; UNCLASSIFIED DRUG;

ABORTION; ALLERGIC ENCEPHALITIS; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; AUTOIMMUNE DISEASE; CANCER IMMUNOTHERAPY; CELL LINEAGE; CELL LOSS; CELL MATURATION; COMPARATIVE STUDY; CRYPTOCOCCUS NEOFORMANS; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG POTENCY; EMBRYO DEVELOPMENT; GENE REARRANGEMENT; GENETIC SELECTION; GENETIC TRANSCRIPTION; GRANULOMA; HEPATITIS B; HEPATITIS B VIRUS; HOMEOSTASIS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INFECTION; INFECTION PREVENTION; INJECTION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALARIA; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MULTIGENE FAMILY; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SPECIES COMPARISON; SPLEEN; STEM CELL; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE; TRANSPLANTATION TOLERANCE; TRYPANOSOMA CRUZI; TUMOR IMMUNITY; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; EVOLUTION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MOUSE; MOUSE MUTANT; NEOPLASM; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; EVOLUTION; HUMANS; IMMUNE TOLERANCE; IMMUNITY, NATURAL; INFECTION; KILLER CELLS, NATURAL; LIGANDS; MICE; MICE, KNOCKOUT; MULTIGENE FAMILY; NEOPLASMS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SELECTION (GENETICS); T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS;

EID: 0038228956     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.21.120601.141057     Document Type: Review

References (144)

1. - T cells in mice and humans. J. Exp. Med. 180:1097-106
2. + T cell populations. Int. Immunol. 7:1157-61
3. Imai K, Kanno M, Kimoto H, Shigemoto K, Yamamoto S, Taniguchi M. 1986. Sequence and expression of transcripts of the T-cell antigen receptor α-chain gene in a functional, antigen-specific suppressor-T-cell hybridoma. Proc. Natl. Acad. Sci. USA 83:8708-12
4. Koseki H, Imai K, Ichikawa T, Hayata I, Taniguchi M. 1989. Predominant use of a particular α-chain in suppressor T cell hybridomas specific for keyhole limpet hemocyanin. Int. Immunol. 1:557-64
5. Cui J, Shin T, Kawano T, Sato H, Kondo E, et al. 1997. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 278:1623-26
6. Arden B, Clark SP, Kabelitz D, Mak TW. 1995. Mouse T-cell receptor variable gene segment families. Immunogenetics 42:501-30
7. + T-cell antigen receptor a chain expanded in unprimed mice. Proc. Natl. Acad. Sci. USA 87:5248-52
8. + cells in the liver of mice. J. Exp. Med. 180:699-704
9. + T cells by non-major histocompatibility complex-encoded class I-like molecules expressed on bone marrow-derived cells. Proc. Natl. Acad. Sci. USA 92:1200-4
10. Makino Y, Yamagata N, Sasho T, Adachi Y, Kanno R, et al. 1993. Extrathymic development of Vα14-positive T cells. J. Exp. Med. 177:1399-408
11. Fowlkes BJ, Kruisbeek AM, Ton-That H, Weston MA, Coligan JE, et al. 1987. A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family. Nature 329:251-54
12. Budd RC, Miescher GC, Howe RC, Lees RK, Bron C, MacDonald HR. 1987. Developmentally regulated expression of T cell receptor β chain variable domains in immature thymocytes. J. Exp. Med. 166:577-82
13. + cells. J. Immunol. 145:3209-15
14. + subset. J. Immunol. 145:1039-45
15. - thymocytes with specific lymphokine secretion. Eur. J. Immunol. 23:307-10
16. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285-95
17. + thymocytes selected by MHC class I molecules. Science 263:1774-78
18. + T lymphocytes. Science 268:863-65
19. + T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182:2091-96
20. + T cells in the bone marrow: divergence from the thymus. J. Immunol. 163:5338-45
21. Eberl G, Lees R, Smiley ST, Taniguchi M, Grusby MJ, MacDonald HR. 1999. Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J. Immunol. 162:6410-19
22. Hammond KJ, Pelikan SB, Crowe NY, Randle-Barrett E, Nakayama T, et al. 1999. NKT cells are phenotypically and functionally diverse. Eur. J. Immunol. 29:3768-81
23. Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG. 2000. NKT cells: facts, functions and fallacies. Immunol. Today 21:573-83
24. Sato K, Ohtsuka K, Hasegawa K, Yamagiwa S, Watanabe H, et al. 1995. Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J. Exp. Med. 182:759-67
25. Terabe M, Matsui S, Noben-Trauth N, Chen H, Watson C, et al. 2000. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat. Immunol. 1:515-20
26. + T cells. J. Immunol. 164:2009-15
27. + natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production. Blood 97:2923-31
28. Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, et al. 2001. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J. Immunol. 167:5531-34
29. Seki S, Abo T, Ohteki T, Sugiura K, Kumagai K. 1991. Unusual αβ-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J. Immunol. 147:1214-21
30. Sato H, Nakayama T, Tanaka Y, Yamashita M, Shibata Y, et al. 1999. Induction of differentiation of pre-NKT cells to mature Vα14 NKT cells by granulocyte/macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 96:7439-44
31. Taniguchi M, Koseki H, Tokuhisa T, Masuda K, Sato H, et al. 1996. Essential requirement of an invariant Vα14 T cell antigen receptor expression in the development of natural killer T cells. Proc. Natl. Acad. Sci. USA 93:11025-28
32. + NK T cells in the early stages of embryogenesis. Proc. Natl. Acad. Sci. USA 93:6516-20
33. Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4, Immunity 6:469-77
34. Smiley ST, Kaplan MH, Grusby MJ. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275:977-79
35. + T cell development and early IL-4 production in CD1-deficient mice. Immunity 6:459-67
36. Groettrup M, Ungewiss K, Azogui O, Palacios R, Owen MJ, et al. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell 75:283-94
37. Saint-Ruf C, Ungewiss K, Groettrup M, Bruno L, Fehling HJ, von Boehmer H. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266:1208-12
38. Di Santo JP, Rodewald HR. 1998. In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development. Curr. Opin. Immunol. 10:196-207
39. Park LS, Friend D, Gillis S, Urdal DL. 1986, Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor. J. Biol. Chem. 261:4177-83
40. Scherer DC, Brockman JA, Bendall HH, Zhang GM, Ballard DW, Oltz EM. 1996. Corepression of RelA and c-rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes. Immunity 5:563-74
41. O'Brien DP, Oltz EM, Van Ness BG. 1997. Coordinate transcription and V(D)J recombination of the kappa immunoglobulin light-chain locus: NF-κB-dependent and -independent pathways of activation. Mol. Cell. Biol. 17:3477-87
42. Ye SK, Maki K, Kitamura T, Sunaga S, Akashi K, et al. 1999. Induction of germline transcription in the TCRγ locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity 11:213-23
43. Gapin L, Matsuda JL, Surh CD, Kronenberg M. 2001. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol. 2:971-78
44. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A. 2002. A thymic precursor to the NK T cell lineage. Science 296:553-55
45. +CD1d-dependent precursor stage. J. Exp. Med. 195:835-44
46. + T-cell antigen receptor a chain in mice. Proc. Natl. Acad. Sci. USA 88:7518-22
47. Lu BZ, Nei M. 1989. Study on molecular evolution for both variable segments of immunoglobulin heavy chain and T cell receptor. Yi Chuan Xue Bao 16:140-50
48. Tanaka T, Nei M. 1989. Positive Darwinian selection observed at the variable-region genes of immunoglobulins. Mol. Biol. Evol. 6:447-59
49. Kimura M. 1983. The neutral theory of molecular evolution. In Evolution of Genes and Proteins, ed. M Nei, RK Koen, 11:208-33. Sunderland, MA: Sinauer
50. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, et al. 1997. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278:1626-29
51. Kamada N, Iijima H, Kimura K, Harada M, Shimizu E, et al. 2001. Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells. Int. Immunol. 13:853-61
52. Burdin N, Brossay L, Degano M, Iijima H, Gui M, et al. 2000. Structural requirements for antigen presentation by mouse CD1. Proc. Natl. Acad. Sci. USA 97:10156-61
53. Naidenko OV, Maher JK, Ernst WA, Sakai T, Modlin RL, Kronenberg M. 1999. Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules. J. Exp. Med. 190:1069-80
54. Husbands SD, Schonrich G, Arnold B, Chandler PR, Simpson E, et al. 1992. Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism. Eur J. Immunol. 22:2655-61
55. Powrie F. 1995. T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 3:171-74
56. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270:1189-92
57. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-64
58. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18-32
59. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212-18
60. Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein J. 1999. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190:1215-26
61. Sonoda KH, Faunce DE, Taniguchi M, Exley M, Balk S, Stein-Streilein J. 2001. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J. Immunol. 166:42-50
62. Sonoda KH, Taniguchi M, Stein-Streilein J. 2002. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J. Immunol. 168:2028-34
63. Faunce DE, Sonoda KH, Stein-Streilein J. 2001. MIP-2 recruits NKT cells to the spleen during tolerance induction. J. Immunol. 166:313-21
64. Mottonen M, Isomaki P, Saario R, Toivanen P, Punnonen J, Lassila O. 1998. Interleukin-10 inhibits the capacity of synovial macrophages to function as antigen-presenting cells. Br. J. Rheumatol. 37:1207-14
65. Gao JX, Madrenas J, Zeng W, Cameron MJ, Zhang Z, et al. 1999. CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection. Immunology 98:159-70
66. Kojima A, Taguchi O, Nishizuka Y. 1980. Experimental production of possible autoimmune castritis followed by macrocytic anemia in athymic nude mice. Lab. Invest. 42:387-95
67. + Vα14 natural killer T cells are essential for acceptance of rat islet xenografts in mice. J. Clin. Invest. 105:1761-67
68. Seino KI, Fukao K, Muramoto K, Yanagisawa K, Takada Y, et al. 2001. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 98:2577-81
69. Smyth MJ, Thia KY, Street SE, Cretney E, Trapani JA, et al. 2000. Differential tumor surveillance by natural killer (NK) and NKT cells. J. Exp. Med. 191:661-68
70. Whiteside TL, Herberman RB. 1995. The role of natural killer cells in immune surveillance of cancer. Curr. Opin. Immunol. 7:704-10
71. + NK T cells associated with disease development in autoimmune-prone mice. J. Immunol. 156:4035-40
72. Zeng D, Lee MK, Tung J, Brendolan A, Strober S. 2000. Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J. Immunol. 164:5000-4
73. Sumida T, Sakamoto A, Murata H, Makino Y, Takahashi H, et al. 1995. Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis. J. Exp. Med. 182:1163-68
74. + double-negative regulatory natural killer T cells in autoimmune diseases. Arthritis Rheum. 44:1127-38
75. Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, et al. 1998. Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 391:177-81
76. Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, et al. 2000. Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci. USA 97:7411-16
77. Kukreja A, Cost G, Marker J, Zhang C, Sun Z, et al. 2002. Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Invest. 109:131-40
78. Illes Z, Kondo T, Newcombe J, Oka N, Tabira T, Yamamura T. 2000. Differential expression of NK T cell Vα24JαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J. Immunol. 164:4375-81
79. -Vα24JαQ T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis. Clin. Immunol. 98:11-17
80. +-like thymocytes in the NOD mouse. Eur. J. Immunol. 26:2989-98
81. Iwakoshi NN, Greiner DL, Rossini AA, Mordes JP. 1999. Diabetes prone BB rats are severely deficient in natural killer T cells. Autoimmunity 31:1-14
82. - T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46:572-82
83. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187:1047-56
84. Lehuen A, Lantz O, Beaudoin L, Laloux V, Carnaud C, et al. 1998. Overexpression of natural killer T cells protects Vα14Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188:1831-39
85. Laloux V, Beaudoin L, Jeske D, Carnaud C, Lehuen A. 2001. NK T cell-induced protection against diabetes in Vα14Jα281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen. J. Immunol. 166:3749-56
86. Trembleau S, Penna G, Bosi E, Mortara A, Gately MK, Adorini L. 1995. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:817-21
87. Wang B, Geng YB, Wang CR. 2001. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194:313-20
88. Shi FD, Flodstrom M, Balasa B, Kim SH, Van Gunst K, et al. 2001. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 98:6777-82
89. Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, et al. 2001. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc. Natl. Acad. Sci. USA 98:13838-43
90. Tiegs G, Hentschel J, Wendel A. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90:196-203
91. + T cells for concanavalin A-induced hepatic injury in mice. J. Immunol. 159:1537-42
92. Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, et al. 2000. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:105-14
93. Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, Okumura K. 2000. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. USA 97:5498-503
94. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, et al. 1993. Lethal effect of the anti-Fas anti-body in mice. Nature 364:806-9
95. Dieli F, Sireci G, Russo D, Taniguchi M, Ivanyi J, et al. 2000. Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. J. Exp. Med. 192:1645-52
96. Ozmen L, Pericin M, Hakimi J, Chizzonite RA, Wysocka M, et al. 1994. Interleukin 12, interferon γ, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med. 180:907-15
97. Altare F, Durandy A, Laminas D, Emile JF, Lamhamedi S, et al. 1998. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280:1432-35
98. Apostolou I, Takahama Y, Belmant C, Kawano T, Huerre M, et al. 1999. Murine natural killer T (NKT) cells contribute to the granulomatous reaction caused by mycobacterial cell walls. Proc. Natl. Acad. Sci. USA 96:5141-46
99. Sousa AO, Mazzaccaro RJ, Russell RG, Lee FK, Turner OC, et al. 2000. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc. Natl. Acad. Sci. USA 97:4204-8
100. Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB. 1999. Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J. Exp. Med. 189:1973-80
101. + T cells during mycobacterial infections. Science 295:2255-58
102. + natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans. Infect. Immun. 69:213-20
103. Kawakami K, Kinjo Y, Uezu K, Yara S, Miyagi K, et al. 2001. Monocyte chemoattractant protein-1-dependent increase of Vα14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection. J. Immunol. 167:6525-32
104. Brener Z. 1973. Biology of Trypanosoma cruzi. Annu. Rev. Microbiol. 27:347-82
105. Duthie MS, Wleklinski-Lee M, Smith S, Nakayama T, Taniguchi M, Kahn SJ. 2002. During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect. Immun. 70:36-48
106. +NKT ceils: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J. Immunol. 163:93-101
107. Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, et al. 1999. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 189:1121-28
108. Carnaud C, Lee D, Donnars O, Park SH, Beavis A, et al. 1999. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163:4647-50
109. Kitamura H, Ohta A, Sekimoto M, Sato M, Iwakabe K, et al. 2000. α-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell. Immunol. 199:37-42
110. + αβ T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis. J. Immunol. 156:3366-73
111. Eberl G, MacDonald HR. 2000. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells. Eur. J. Immunol. 30:985-92
112. + T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide. Blood 99:1259-66
113. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. 2001. Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19:423-74
114. Osaki T, Peron JM, Cai Q, Okamura H, Robbins PD, et al. 1998. IFN-γ-inducing factor/IL-18 administration mediates IFN-γ- and IL-12-independent antitumor effects. J. Immunol. 160:1742-49
115. Wilson SB, Byrne MC. 2001. Gene expression in NKT cells: defining a functionally distinct CD1d-restricted T cell subset. Curr. Opin. Immunol. 13:555-61
116. Leite-de-Moraes MC, Hameg A, Pacilio M, Koezuka Y, Taniguchi M, et al. 2001. IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. J. Immunol. 166:945-51
117. Nakagawa R, Nagafune I, Tazunoki Y, Ehara H, Tomura H, et al. 2001. Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by α-galactosylceramide in mice. J. Immunol. 166:6578-84
118. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, et al. 1998. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells. Proc. Natl. Acad. Sci. USA 95:5690-93
119. Toura I, Kawano T, Akutsu Y, Nakayama T, Ochiai T, Taniguchi M. 1999. Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with α-galactosylceramide. J. Immunol. 163:2387-91
120. Brossay L, Chioda M, Burdin N, Koezuka Y, Casorati G, et al. 1998. CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J. Exp. Med. 188:1521-28
121. Spada FM, Koezuka Y, Porcelli SA. 1998. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J. Exp. Med. 188:1529-34
122. Kawano T, Tanaka Y, Shimizu E, Kaneko Y, Kamata N, et al. 1999. A novel recognition motif of human NKT antigen receptor for a glycolipid ligand. Int. Immunol. 11:881-87
123. Kawano T, Nakayama T, Kamada N, Kaneko Y, Harada M, et al. 1999. Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells. Cancer Res. 59:5102-5
124. H2 response and in immunoglobulin E production. Science 270:1845-47
125. Bendelac A, Hunziker RD, Lantz O. 1996. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med. 184:1285-93
126. Bendelac A, Rivera MN, Park SH, Roark JH. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535-62
127. Cui J, Watanabe N, Kawano T, Yamashita M, Kamata T, et al. 1999. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 190:783-92
128. Gonzalez-Aseguinolaza G, de Oliveira C, Tomaska M, Hong S, Bruna-Romero O, et al. 2000. α-galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria. Proc. Natl. Acad. Sci. USA 97:8461-66
129. Gonzalez-Aseguinolaza G, Van Kaer L, Bergmann CC, Wilson JM, Schmieg J, et al. 2002. Natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 195:617-24
130. + effector function against intracellular infection. J. Exp. Med. 184:131-39
131. McClary H, Koch R, Chisari FV, Guidotti LG. 2000. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol. 74:2255-64
132. Kakimi K, Guidotti LG, Koezuka Y, Chisari FV. 2000. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J. Exp. Med. 192:921-30
133. Ito K, Karasawa M, Kawano T, AkasakaT, Koseki H, et al. 2000. Involvement of decidual Vα14 NKT cells in abortion. Proc. Natl. Acad. Sci. USA 97:740-44
134. Burdin N, Brossay L, Kronenberg M. 1999. Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur. J. Immunol. 29:2014-25
135. Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, et al. 1999. Cutting edge: activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J. Immunol. 163:2373-77
136. + T cell-defective IL-4 production in the non-obese diabetic mouse. Int. Immunol. 8:1751-58
137. + T cells. J. Immunol. 162:7067-74
138. Hong S, Wilson MT, Serizawa I, Wu L, Singh N, et al. 2001. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in nonobese diabetic mice. Nat. Med. 7:1052-56
139. Sharif S, Arreaza GA, Zucker P, Mi QS, Sondhi J, et al. 2001. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat. Med. 7:1057-62
140. Acha-Orbea H, Steinman L, McDevitt HO. 1989. T cell receptors in murine autoimmune diseases. Annu. Rev. Immunol. 7:371-405
141. Zhang B, Yamamura T, Kondo T, Fujiwara M, Tabira T. 1997. Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J. Exp. Med. 186:1677-87
142. Pal E, Tabira T, Kawano T, Taniguchi M, Miyake S, Yamamura T. 2001. Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of Vα14 NK T cells. J. Immunol. 166:662-68
143. Singh AK, Wilson MT, Hong S, Olivares-Villagomez D, Du C, et al. 2001. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 194:1801-11
144. H2 bias of natural killer T cells. Nature 413:531-34