Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man

Science Translational Medicine

Volumn 4, Issue 115, 2012, Pages

  Barnes, Eleanor ^a,b   Folgori, Antonella ^c   Capone, Stefania ^c   Swadling, Leo ^a   Aston, Stephen ^a   Kurioka, Ayako ^a   Meyer, Joel ^a   Huddart, Rachel ^a   Smith, Kira ^a   Townsend, Rachel ^a   Brown, Anthony ^a   Antrobus, Richard ^a   Ammendola, Virginia ^c   Naddeo, Mariarosaria ^c   O'Hara, Geraldine ^a   Willberg, Chris ^a   Harrison, Abby ^a   Grazioli, Fabiana ^d   Esposito, Maria Luisa ^d   Siani, Loredana ^c   Traboni, Cinzia ^c   Oo, Ye ^e   Adams, David ^e   Hill, Adrian ^a,b   Colloca, Stefano ^c   Nicosia, Alfredo ^c   Cortese, Riccardo ^c   Klenerman, Paul ^a,b   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c Okairos ^*  (Italy)

^d CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GAMMA INTERFERON; HEPATITIS C VACCINE; INTERLEUKIN 2; TETRAMER; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN; HEPATITIS VACCINE;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CHIMPANZEE; CROSS REACTION; DRUG SAFETY; DRUG TOLERABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN ADENOVIRUS; HUMAN ADENOVIRUS 6; MAJOR HISTOCOMPATIBILITY COMPLEX; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTYPE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VIRUS STRAIN; ADENOVIRUS; BIOSYNTHESIS; CELL STRAIN HEK293; CYTOLOGY; GENETICS; METABOLISM; MONONUCLEAR CELL; TIME; VIROLOGY;

ADENOVIRIDAE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; GENOTYPE; HEK293 CELLS; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; T-LYMPHOCYTES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; VIRAL HEPATITIS VACCINES;

EID: 84855388574     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003155     Document Type: Article

References (29)

1. G. M. Lauer, B. D. Walker, Hepatitis C virus infection. N. Engl. J. Med. 345, 41-52 (2001).
2. R. Thimme, D. Oldach, K. M. Chang, C. Steiger, S. C. Ray, F. V. Chisari, Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 194, 1395-1406 (2001).
3. F. Lechner, D. K. Wong, P. R. Dunbar, R. Chapman, R. T. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, B. D. Walker, Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191, 1499-1512 (2000).
4. A. Grakoui, N. H. Shoukry, D. J. Woollard, J. H. Han, H. L. Hanson, J. Ghrayeb, K. K. Murthy, C. M. Rice, C. M. Walker, HCV persistence and immune evasion in the absence of memory T cell help. Science 302, 659-662 (2003).
5. + T cells are required for protection from persistent hepatitis C virus infection. J. Exp. Med. 197, 1645-1655 (2003).
6. E. Spada, A. Mele, A. Berton, L. Ruggeri, L. Ferrigno, A. R. Garbuglia, M. P. Perrone, G. Girelli, P. Del Porto, E. Piccolella, M. U. Mondelli, P. Amoroso, R. Cortese, A. Nicosia, A. Vitelli, A. Folgori, Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut 53, 1673-1681 (2004).
7. D. L. Thomas, C. L. Thio, M. P. Martin, Y. Qi, D. Ge, C. O'Huigin, J. Kidd, K. Kidd, S. I. Khakoo, G. Alexander, J. J. Goedert, G. D. Kirk, S. M. Donfield, H. R. Rosen, L. H. Tobler, M. P. Busch, J. G. McHutchison, D. B. Goldstein, M. Carrington, Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461, 798-801 (2009).
8. W. O. Osburn, B. E. Fisher, K. A. Dowd, G. Urban, L. Liu, S. C. Ray, D. L. Thomas, A. L. Cox, Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection. Gastroenterology 138, 315-324 (2010).
9. A. Folgori, S. Capone, L. Ruggeri, A. Meola, E. Sporeno, B. B. Ercole, M. Pezzanera, R. Tafi, M. Arcuri, E. Fattori, A. Lahm, A. Luzzago, A. Vitelli, S. Colloca, R. Cortese, A. Nicosia, A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat. Med. 12, 190-197 (2006).
10. + T-cell responses. Infect. Immun. 78, 145-153 (2010).
11. S. Colloca, E. Barnes, A. Folgori, V. Ammendola, S. Capone, A. Cirillo, L. Siani, M. Naddeo, F. Grazioli, M. Esposito, M. Ambrosio, A. Sparacino, M. Bartiromo, A. Meola, K. Smith, A. Kurioka, G. A. O'Hara, K. J. Ewer, N. Anagnostou, C. Bliss, A. V. S. Hill, C. Traboni, P. Klenerman, R. Cortese, A. Nicosia, Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci. Transl. Med. 4, 115ra2 (2012).
12. G. M. Lauer, E. Barnes, M. Lucas, J. Timm, K. Ouchi, A. Y. Kim, C. L. Day, G. K. Robbins, D. R. Casson, M. Reiser, G. Dusheiko, T. M. Allen, R. T. Chung, B. D. Walker, P. Klenerman, High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 127, 924-936 (2004).
13. +T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection. J. Virol. 71, 6011-6019 (1997).
14. G. Missale, R. Bertoni, V. Lamonaca, A. Valli, M. Massari, C. Mori, M. G. Rumi, M. Houghton, F. Fiaccadori, C. Ferrari, Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Invest. 98, 706-714 (1996).
15. + T cells defines a distinct functional subset with tissue-homing properties. Proc. Natl. Acad. Sci. U.S.A. 107, 3006-3011 (2010).
16. D. L. Barber, E. J. Wherry, D. Masopust, B. Zhu, J. P. Allison, A. H. Sharpe, G. J. Freeman, R. Ahmed, Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687 (2006).
17. + T cells during acute HCV infection, irrespective of clinical outcome. J. Virol. 82, 3154-3160 (2008).
18. A. Rauch, I. James, K. Pfafferott, D. Nolan, P. Klenerman, W. Cheng, L. Mollison, G. McCaughan, N. Shackel, G. P. Jeffrey, R. Baker, E. Freitas, I. Humphreys, H. Furrer, H. F. Günthard, B. Hirschel, S. Mallal, M. John, M. Lucas, E. Barnes, S. Gaudieri, Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure. Hepatology 50, 1017-1029 (2009).
19. R. A. Seder, P. A. Darrah, M. Roederer, T-cell quality in memory and protection: Implications for vaccine design. Nat. Rev. Immunol. 8, 247-258 (2008).
20. E. J. Wherry, C. L. Day, R. Draenert, J. D. Miller, P. Kiepiela, T. Woodberry, C. Brander, M. Addo, P. Klenerman, R. Ahmed, B. D. Walker, HIV-specific CD8 T cells express low levels of IL-7Ra: Implications for HIV-specific T cell memory. Virology 353, 366-373 (2006).
21. EMRA cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point. J. Virol. 81, 5759-5765 (2007).
22. S. G. Hansen, J. C. Ford, M. S. Lewis, A. B. Ventura, C. M. Hughes, L. Coyne-Johnson, N. Whizin, K. Oswald, R. Shoemaker, T. Swanson, A. W. Legasse, M. J. Chiuchiolo, C. L. Parks, M. K. Axthelm, J. A. Nelson, M. A. Jarvis, M. Piatak Jr., J. D. Lifson, L. J. Picker, Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473, 523-527 (2011).
23. + T cell response. J. Immunol. 183, 7919-7930 (2009).
24. A. L. Cox, K. Page, J. Bruneau, N. H. Shoukry, G. M. Lauer, A. Y. Kim, H. R. Rosen, H. Radziewicz, A. Grakoui, D. S. Fierer, A. D. Branch, D. E. Kaplan, K. M. Chang, Rare birds in North America: Acute hepatitis C cohorts. Gastroenterology 136, 26-31 (2009).
25. C. S. Klade, H. Wedemeyer, T. Berg, H. Hinrichsen, G. Cholewinska, S. Zeuzem, H. Blum, M. Buschle, S. Jelovcan, V. Buerger, E. Tauber, J. Frisch, M. P. Manns, Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41. Gastroenterology 134, 1385-1395 (2008).
26. F. Habersetzer, G. Honnet, C. Bain, M. Maynard-Muet, V. Leroy, J. P. Zarski, C. Feray, T. F. Baumert, J. P. Bronowicki, M. Doffoël, C. Trépo, D. Agathon, M. L. Toh, M. Baudin, J. Y. Bonnefoy, J. M. Limacher, G. Inchauspé, A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C. Gastroenterology 141, 890-899.e1-4 (2011).
27. S. Capone, A. Meola, B. B. Ercole, A. Vitelli, M. Pezzanera, L. Ruggeri, M. E. Davies, R. Tafi, C. Santini, A. Luzzago, T. M. Fu, A. Bett, S. Colloca, R. Cortese, A. Nicosia, A. Folgori, A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that overcomes preexisting anti-ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques. J. Virol. 80, 1688-1699 (2006).
28. M. Aste-Amézaga, A. J. Bett, F. Wang, D. R. Casimiro, J. M. Antonello, D. K. Patel, E. C. Dell, L. L. Franlin, N. M. Dougherty, P. S. Bennett, H. C. Perry, M. E. Davies, J. W. Shiver, P. M. Keller, M. D. Yeager, Quantitative adenovirus neutralization assays based on the secreted alkaline phosphatase reporter gene: Application in epidemiologic studies and in the design of adenovector vaccines. Hum. Gene Ther. 15, 293-304 (2004).
29. M. Roederer, J. L. Nozzi, M. C. Nason, SPICE: Exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 79, 167-174 (2011).