Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity

Journal of Virology

Volumn 75, Issue 15, 2001, Pages 7142-7148

  Weiner, A J ^a   Paliard, X ^a   Selby, M J ^a   Medina Selby, A ^a   Coit, D ^a   Nguyen, S ^a   Kansopon, J ^a   Arian, C L ^a   Ng, P ^a   Tucker, J ^a   Lee, C T ^a   Polakos, N K ^a   Han, J ^a   Wong, S ^a   Lu, H H ^a   Rosenberg, S ^a   Brasky, K M ^a   Chien, D ^a   Kuo, G ^a   Houghton, M ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; VIRUS RNA;

ARTICLE; CHIMPANZEE; CONTROLLED STUDY; HEPATITIS C; HEPATITIS C VIRUS; HUMORAL IMMUNITY; IMMUNITY; INOCULATION; INTERFERON PRODUCTION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CROSS REACTIONS; HEPACIVIRUS; HEPATITIS C; HUMANS; INJECTIONS, INTRAVENOUS; INTERFERON-ALPHA; LIVER; MOLECULAR SEQUENCE DATA; PAN TROGLODYTES; RNA, VIRAL;

EID: 0034959575     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.15.7142-7148.2001     Document Type: Article

References (50)

1. Transmissible agent in non-A, non-B hepatitis
2. Recovery, persistence, and sequelae in hepatitis C virus infection: A perspective on long-term outcome
3. Viral persistence, antibody to E1 and E2, and hypervariable region 1 sequence stability in hepatitis C virus-inoculated chimpanzees
4. Experimental infection of chimpanzees with antihemophilic (factor VIII) materials: Recovery of virus-like particles associated with non-A, non-B hepatitis
5. Non-A/non-B hepatitis in experimentally infected chimpanzees: Cross-challenge and electron microscopic studies
6. Genetic heterogeneity of hepatitis C virus: Quasispecies and genotypes
7. Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: Reevaluation of the role of HCV in liver disease
8. Vaccination of chimpanzees against infection by the hepatitis C virus
9. Genetic organization and diversity of the hepatitis C virus
10. Hepatitis C virus: The major causative agent of viral non-A, non-B hepatitis
11. Analysis of a successful immune response against hepatitis C virus
12. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
13. The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor
14. Lack of protective immunity against reinfection with hepatitis C virus
15. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization
16. Clinical significance of hepatitis C virus genotypes and quasispecies
17. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein
18. Non-A, non-B hepatitis in chimpanzees and marmosets
19. Interferon action: Binding of viral RNA to the 40-kilodalton 2′,5′-oligoadenylate synthetase in interferon-treated HeLa cells infected with encephalomyocarditis virus
20. Isolation and characterization of human papillomavirus type 6-specific T cells infiltrating genital warts
21. Hepatitis C viruses
22. Cytoplasmic tubular structures in liver of HBsAg carrier chimpanzees infected with delta agent and comparison with cytoplasmic structures in non-A, non-B hepatitis
23. Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus
24. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
25. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA
26. Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo
27. Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children
28. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
29. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
30. Nucleotide sequence and mutation rate of the H strain of hepatitis C virus
31. Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability
32. Binding of hepatitis C virus to CD81
33. Hepatitis C virus/human immunodeficiency virus coinfection: Clinical management issues
34. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus
35. Immunity in hepatitis C infection
36. Two successive hepatitis C virus infections in an intravenous drug user
37. Non-A, non-B hepatitis: Ultrastructural evidence for two agents in experimentally infected chimpanzees
38. A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures
39. Cytoplasmic antigen in hepatocytes of chimpanzees infected with non-A, non-B hepatitis virus or hepatitis delta virus: Relationship to interferon
40. Viral heterogeneity of the hepatitis C virus
41. Transmission of non-A, non-B hepatitis from man to chimpanzee
42. Structure of the 3′ terminus of the hepatitis C virus genome
43. Sequence evolution of the hypervariable region in the putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral immune responses
44. Serological and molecular analysis of hepatitis C virus envelope regions 1 and 2 during acute and chronic infections in chimpanzees
45. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
46. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins
47. Global surveillance and control of hepatitis C: Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium
48. Human hepatitis delta virus RNA subfragments contain an autocleavage activity
49. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee