Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease

Neuropharmacology

Volumn 64, Issue , 2013, Pages 124-136

  Sierksma, Annerieke S R ^a,b   Rutten, Kris ^a,b,d   Sydlik, Sebastian ^a,b   Rostamian, Somayeh ^a,b   Steinbusch, Harry W M ^a,b   Van Den Hove, Daniel L A ^a,b,c   Prickaerts, Jos ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b European Graduate School of Neuroscience   (Netherlands)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d GRÜNENTHAL GMBH   (Germany)

Author keywords

Alzheimer's disease (AD); APPswe PS1dE9; BDNF; Cognition; CREB; Phosphodiesterase inhibitors (PDEIs)

Indexed keywords

AMYLOID BETA PROTEIN; BAY 60 7550; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PHOSPHODIESTERASE INHIBITOR; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; DEPRESSION; ENZYME INHIBITION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL STRATUM LUCIDUM; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LONG TERM CARE; MEMORY; MOUSE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPSE;

ALZHEIMER DISEASE; ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; IMIDAZOLES; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; NOOTROPIC AGENTS; PHOSPHODIESTERASE INHIBITORS; RANDOM ALLOCATION; RECOGNITION (PSYCHOLOGY); SPATIAL BEHAVIOR; TRIAZINES;

EID: 84866392909     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.06.048     Document Type: Article

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