메뉴 건너뛰기




Volumn 120, Issue 12, 2010, Pages 746-751

Phoshphodiesterase-5 inhibitors: Novel weapons against Alzheimer's disease

Author keywords

Alzheimer's disease; Neurogenesis; Sildenafil

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; CYCLIC GMP; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIN 1; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; PHOSPHODIESTERASE V;

EID: 78149249616     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2010.520381     Document Type: Review
Times cited : (24)

References (56)
  • 1
    • 1542268981 scopus 로고    scopus 로고
    • For the long run: Maintaining germinal niches in the adult brain
    • Alvarez-Buylla, A., & Lim, D. A. (2004). For the long run: Maintaining germinal niches in the adult brain. Neuron, 41, 683-686.
    • (2004) Neuron , vol.41 , pp. 683-686
    • Alvarez-Buylla, A.1    Lim, D.A.2
  • 2
    • 38049187090 scopus 로고    scopus 로고
    • Chronic administration of sildenafil improves markers of endothelial function in men with type 2 diabetes
    • Aversa, A., Vitale, C., Volterrani, M., Fabbri, A., Spera, G., Fini, M., et al. (2008). Chronic administration of sildenafil improves markers of endothelial function in men with type 2 diabetes. Diabetic Medicine, 25, 37-44.
    • (2008) Diabetic Medicine , vol.25 , pp. 37-44
    • Aversa, A.1    Vitale, C.2    Volterrani, M.3    Fabbri, A.4    Spera, G.5    Fini, M.6
  • 3
    • 47249165979 scopus 로고    scopus 로고
    • Amyloid beta toxicity dependent upon endothelial cell state
    • Balcells, M., Wallins, J. S., & Edelman, E. R. (2008). Amyloid beta toxicity dependent upon endothelial cell state. Neuroscience Letters, 441, 319-322.
    • (2008) Neuroscience Letters , vol.441 , pp. 319-322
    • Balcells, M.1    Wallins, J.S.2    Edelman, E.R.3
  • 5
    • 4243121730 scopus 로고    scopus 로고
    • Specific localized expression of cgmp pdes in purkinje neurons and macrophages
    • Bender, A. T., & Beavo, J. A. (2004). Specific localized expression of cgmp pdes in purkinje neurons and macrophages. Neurochemistry International, 45, 853-857.
    • (2004) Neurochemistry International , vol.45 , pp. 853-857
    • Bender, A.T.1    Beavo, J.A.2
  • 7
    • 0242640310 scopus 로고    scopus 로고
    • Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease
    • Boger, R. H., Bode-Boger, S. M., Thiele, W., Junker, W., Alexander, K., & Frolich, J. C. (1997). Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation, 95, 2068-2074.
    • (1997) Circulation , vol.95 , pp. 2068-2074
    • Boger, R.H.1    Bode-Boger, S.M.2    Thiele, W.3    Junker, W.4    Alexander, K.5    Frolich, J.C.6
  • 8
    • 0037192332 scopus 로고    scopus 로고
    • Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension
    • Cardillo, C., Campia, U., Kilcoyne, C. M., Bryant, M. B., & Panza, J. A. (2002). Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension. Circulation, 105, 452-456.
    • (2002) Circulation , vol.105 , pp. 452-456
    • Cardillo, C.1    Campia, U.2    Kilcoyne, C.M.3    Bryant, M.B.4    Panza, J.A.5
  • 9
    • 54549112294 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling
    • Caretti, A., Bianciardi, P., Ronchi, R., Fantacci, M., Guazzi, M., & Samaja, M. (2008). Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling. Experimental Biology and Medicine (Maywood), 233, 1222-1230.
    • (2008) Experimental Biology and Medicine (Maywood) , vol.233 , pp. 1222-1230
    • Caretti, A.1    Bianciardi, P.2    Ronchi, R.3    Fantacci, M.4    Guazzi, M.5    Samaja, M.6
  • 11
    • 1842665660 scopus 로고    scopus 로고
    • The localization of neuronal nitric oxide synthase may influence its role in neuronal precursor proliferation and synaptic maintenance
    • Chen, J., Tu, Y., Moon, C., Matarazzo, V., Palmer, A. M., & Ronnett, G. V. (2004). The localization of neuronal nitric oxide synthase may influence its role in neuronal precursor proliferation and synaptic maintenance. Developmental Biology, 269, 165-182.
    • (2004) Developmental Biology , vol.269 , pp. 165-182
    • Chen, J.1    Tu, Y.2    Moon, C.3    Matarazzo, V.4    Palmer, A.M.5    Ronnett, G.V.6
  • 13
    • 0036723924 scopus 로고    scopus 로고
    • Nitric oxide regulates cgmp-dependent camp-responsive element binding protein phosphorylation and bcl-2 expression in cerebellar neurons: Implication for a survival role of nitric oxide
    • Ciani, E., Guidi, S., Bartesaghi, R., & Contestabile, A. (2002). Nitric oxide regulates cgmp-dependent camp-responsive element binding protein phosphorylation and bcl-2 expression in cerebellar neurons: Implication for a survival role of nitric oxide. Journal of Neurochemistry, 82, 1282-1289.
    • (2002) Journal of Neurochemistry , vol.82 , pp. 1282-1289
    • Ciani, E.1    Guidi, S.2    Bartesaghi, R.3    Contestabile, A.4
  • 14
    • 0037116573 scopus 로고    scopus 로고
    • Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the international brachial artery reactivity task force
    • Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D., Charbonneau, F., Creager, M. A., et al. (2002). Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the international brachial artery reactivity task force. Journal of the American College of Cardiology, 39, 257-265.
    • (2002) Journal of the American College of Cardiology , vol.39 , pp. 257-265
    • Corretti, M.C.1    Anderson, T.J.2    Benjamin, E.J.3    Celermajer, D.4    Charbonneau, F.5    Creager, M.A.6
  • 15
    • 37149055806 scopus 로고    scopus 로고
    • Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in alzheimer disease
    • Counts, S. E., He, B., Che, S., Ikonomovic, M. D., Dekosky, S. T., Ginsberg, S. D., et al. (2007). Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in alzheimer disease. Archives of Neurology, 64, 1771-1776.
    • (2007) Archives of Neurology , vol.64 , pp. 1771-1776
    • Counts, S.E.1    He, B.2    Che, S.3    Ikonomovic, M.D.4    Dekosky, S.T.5    Ginsberg, S.D.6
  • 16
    • 0031902295 scopus 로고    scopus 로고
    • Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities
    • discussion s65-7
    • Cummings, J. L., Vinters, H. V., Cole, G. M., & Khachaturian, Z. S. (1998). Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology, 51, s2-17; discussion s65-7.
    • (1998) Neurology , vol.51
    • Cummings, J.L.1    Vinters, H.V.2    Cole, G.M.3    Khachaturian, Z.S.4
  • 17
    • 16844382827 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling
    • Das, A., Xi, L., & Kukreja, R. C. (2005). Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. Journal of Biological Chemistry, 280, 12944-12955.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 12944-12955
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 20
    • 4243092575 scopus 로고    scopus 로고
    • CGMP: A second messenger for acetylcholine in the brain
    • De Vente, J. (2004). cGMP: A second messenger for acetylcholine in the brain? Neurochemistry International, 45, 799-812.
    • (2004) Neurochemistry International , vol.45 , pp. 799-812
    • De Vente, J.1
  • 21
    • 33846008395 scopus 로고    scopus 로고
    • Research update: Neurogenesis in adult brain and neuropsychiatric disorders
    • Elder, G. A., De Gasperi, R., & Gama Sosa, M. A. (2006). Research update: Neurogenesis in adult brain and neuropsychiatric disorders. Mount Sinai Journal of Medicine, 73, 931-940.
    • (2006) Mount Sinai Journal of Medicine , vol.73 , pp. 931-940
    • Elder, G.A.1    De Gasperi, R.2    Gama Sosa, M.A.3
  • 22
    • 0036634250 scopus 로고    scopus 로고
    • Involvement of cyclic gmp and protein kinase G in the regulation of apoptosis and survival in neural cells
    • Fiscus, R. R. (2002). Involvement of cyclic gmp and protein kinase G in the regulation of apoptosis and survival in neural cells. Neurosignals, 11, 175-190.
    • (2002) Neurosignals , vol.11 , pp. 175-190
    • Fiscus, R.R.1
  • 23
    • 33746584053 scopus 로고    scopus 로고
    • Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond
    • Ghofrani, H. A., Osterloh, I. H., & Grimminger, F. (2006). Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond. Nature Reviews. Drug Discovery, 5, 689-702.
    • (2006) Nature Reviews. Drug Discovery , vol.5 , pp. 689-702
    • Ghofrani, H.A.1    Osterloh, I.H.2    Grimminger, F.3
  • 24
    • 4644232338 scopus 로고    scopus 로고
    • Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: A randomized prospective study
    • Ghofrani, H. A., Voswinckel, R., Reichenberger, F., Olschewski, H., Haredza, P., Karadas, B., et al. (2004). Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: A randomized prospective study. Journal of the American College of Cardiology, 44, 1488-1496.
    • (2004) Journal of the American College of Cardiology , vol.44 , pp. 1488-1496
    • Ghofrani, H.A.1    Voswinckel, R.2    Reichenberger, F.3    Olschewski, H.4    Haredza, P.5    Karadas, B.6
  • 25
    • 77049084060 scopus 로고    scopus 로고
    • Evaluation of plasma abeta(40) and abeta(42) as predictors of conversion to alzheimer's disease in patients with mild cognitive impairment
    • Hansson, O., Zetterberg, H., Vanmechelen, E., Vanderstichele, H., Andreasson, U., Londos, E., et al. (2010). Evaluation of plasma abeta(40) and abeta(42) as predictors of conversion to alzheimer's disease in patients with mild cognitive impairment. Neurobiology of Aging, 31, 357-367.
    • (2010) Neurobiology of Aging , vol.31 , pp. 357-367
    • Hansson, O.1    Zetterberg, H.2    Vanmechelen, E.3    Vanderstichele, H.4    Andreasson, U.5    Londos, E.6
  • 26
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of alzheimer's disease: Progress and problems on the road to therapeutics. Science, 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 27
    • 0036358623 scopus 로고    scopus 로고
    • Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: Implications for the patho-genesis of alzheimer's disease
    • Haughey, N. J., Liu, D., Nath, A., Borchard, A. C., & Mattson, M. P. (2002). Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: Implications for the patho-genesis of alzheimer's disease. Neuromolecular Medicine, 1, 125-135.
    • (2002) Neuromolecular Medicine , vol.1 , pp. 125-135
    • Haughey, N.J.1    Liu, D.2    Nath, A.3    Borchard, A.C.4    Mattson, M.P.5
  • 29
    • 24744470477 scopus 로고    scopus 로고
    • Rescuing troubled vessels in alzheimer's disease
    • Iadecola, C. (2005). Rescuing troubled vessels in alzheimer's disease. Nature Medicine, 11, 923-924.
    • (2005) Nature Medicine , vol.11 , pp. 923-924
    • Iadecola, C.1
  • 31
    • 0036455153 scopus 로고    scopus 로고
    • Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task
    • Kempermann, G., & Gage, F. H. (2002). Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. European Journal of Neuroscience, 16, 129-136.
    • (2002) European Journal of Neuroscience , vol.16 , pp. 129-136
    • Kempermann, G.1    Gage, F.H.2
  • 33
    • 58749103648 scopus 로고    scopus 로고
    • Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils
    • Ko, I. G., Shin, M. S., Kim, B. K., Kim, S. E., Sung, Y. H., Kim, T. S., et al. (2009). Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils. Pharmacology, Biochemistry, and Behavior, 91, 629-635.
    • (2009) Pharmacology, Biochemistry, and Behavior , vol.91 , pp. 629-635
    • Ko, I.G.1    Shin, M.S.2    Kim, B.K.3    Kim, S.E.4    Sung, Y.H.5    Kim, T.S.6
  • 34
    • 0035783739 scopus 로고    scopus 로고
    • The nitric oxide system modulates the in vivo release of acetylcholine in the nucleus accum-bens induced by stimulation of the hippocampal fornix/fimbria-projection
    • Kraus, M. M., & Prast, H. (2001). The nitric oxide system modulates the in vivo release of acetylcholine in the nucleus accum-bens induced by stimulation of the hippocampal fornix/fimbria-projection. European Journal of Neuroscience, 14, 1105-1112.
    • (2001) European Journal of Neuroscience , vol.14 , pp. 1105-1112
    • Kraus, M.M.1    Prast, H.2
  • 35
    • 0034062912 scopus 로고    scopus 로고
    • A protein phosphatase is involved in the cholinergic suppression of the ca(2+)-activated k(+) current si(ahp) in hippocampal pyramidal neurons
    • Krause, M., & Pedarzani, P. (2000). A protein phosphatase is involved in the cholinergic suppression of the ca(2+)-activated k(+) current si(ahp) in hippocampal pyramidal neurons. Neuropharma-cology, 39, 1274-1283.
    • (2000) Neuropharmacology , vol.39 , pp. 1274-1283
    • Krause, M.1    Pedarzani, P.2
  • 37
    • 56649124807 scopus 로고    scopus 로고
    • Glutamate and neurotrophic factors in neuronal plasticity and disease
    • Mattson, M. P. (2008). Glutamate and neurotrophic factors in neuronal plasticity and disease. Annals of the New York Academy of Sciences, 1144, 97-112.
    • (2008) Annals of the New York Academy of Sciences , vol.1144 , pp. 97-112
    • Mattson, M.P.1
  • 38
    • 0041856595 scopus 로고    scopus 로고
    • Epidemiology of neurodegeneration
    • Mayeux, R. (2003). Epidemiology of neurodegeneration. Annual Review of Neuroscience, 26, 81-104.
    • (2003) Annual Review of Neuroscience , vol.26 , pp. 81-104
    • Mayeux, R.1
  • 39
    • 0035105140 scopus 로고    scopus 로고
    • Electrical activity modulates growth cone guidance by diffusible factors
    • Ming, G., Henley, J., Tessier-lavigne, M., Song, H., & Poo, M. (2001). Electrical activity modulates growth cone guidance by diffusible factors. Neuron, 29, 441-452.
    • (2001) Neuron , vol.29 , pp. 441-452
    • Ming, G.1    Henley, J.2    Tessierlavigne, M.3    Song, H.4    Poo, M.5
  • 40
    • 23244458855 scopus 로고    scopus 로고
    • Adult neurogenesis in the mammalian central nervous system
    • Ming, G. L., & Song, H. (2005). Adult neurogenesis in the mammalian central nervous system. Annual Review of Neuroscience, 28, 223-250.
    • (2005) Annual Review of Neuroscience , vol.28 , pp. 223-250
    • Ming, G.L.1    Song, H.2
  • 41
    • 0036895966 scopus 로고    scopus 로고
    • Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cgmp-dependent protein kinase, and cgmp-degrading phosphodiesterase
    • Monfort, P., Munoz, M. D., Kosenko, E., & Felipo, V. (2002). Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cgmp-dependent protein kinase, and cgmp-degrading phosphodiesterase. Journal of Neuroscience, 22, 10116-10122.
    • (2002) Journal of Neuroscience , vol.22 , pp. 10116-10122
    • Monfort, P.1    Munoz, M.D.2    Kosenko, E.3    Felipo, V.4
  • 42
    • 35748977390 scopus 로고    scopus 로고
    • Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: A double-blind, placebo-controlled study
    • Morano, S., Mandosi, E., Fallarino, M., Gatti, A., Tiberti, C., Sensi, M., et al. (2007). Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: A double-blind, placebo-controlled study. European Urology, 52, 1768-1774.
    • (2007) European Urology , vol.52 , pp. 1768-1774
    • Morano, S.1    Mandosi, E.2    Fallarino, M.3    Gatti, A.4    Tiberti, C.5    Sensi, M.6
  • 43
    • 33746381229 scopus 로고    scopus 로고
    • Modulatory effect of sildenafil in diabetes and electroconvulsive shock-induced cognitive dysfunction in rats
    • Patil, C. S., Singh, V. P., & Kulkarni, S. K. (2006). Modulatory effect of sildenafil in diabetes and electroconvulsive shock-induced cognitive dysfunction in rats. Pharmacological Reports, 58, 373-380.
    • (2006) Pharmacological Reports , vol.58 , pp. 373-380
    • Patil, C.S.1    Singh, V.P.2    Kulkarni, S.K.3
  • 44
    • 0031814906 scopus 로고    scopus 로고
    • Nitric oxide-induced release of acetylcholine in the nucleus accumbens: Role of cyclic gmp, glutamate, and gaba
    • Prast, H., Tran, M. H., Fischer, H., & Philippu, A. (1998). Nitric oxide-induced release of acetylcholine in the nucleus accumbens: Role of cyclic gmp, glutamate, and gaba. Journal of Neurochemistry, 71, 266-273.
    • (1998) Journal of Neurochemistry , vol.71 , pp. 266-273
    • Prast, H.1    Tran, M.H.2    Fischer, H.3    Philippu, A.4
  • 46
    • 0037067992 scopus 로고    scopus 로고
    • Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic gmp levels in the rat
    • Prickaerts, J., Van Staveren, W. C., Sik, A., Markerink-Van Ittersum, M., Niewohner, U., Van Der staay, F. J., et al. (2002b). Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic gmp levels in the rat. Neuroscience, 113, 351-361.
    • (2002) Neuroscience , vol.113 , pp. 351-361
    • Prickaerts, J.1    Van Staveren, W.C.2    Sik, A.3    Markerink-Van Ittersum, M.4    Niewohner, U.5    Van Der Staay, F.J.6
  • 47
    • 67649342620 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an alzheimer's disease mouse model
    • Puzzo, D., Staniszewski, A., Deng, S. X., Privitera, L., Leznik, E., Liu, S., et al. (2009). Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an alzheimer's disease mouse model. Journal of Neuroscience, 29, 8075-8086.
    • (2009) Journal of Neuroscience , vol.29 , pp. 8075-8086
    • Puzzo, D.1    Staniszewski, A.2    Deng, S.X.3    Privitera, L.4    Leznik, E.5    Liu, S.6
  • 48
    • 27744508710 scopus 로고    scopus 로고
    • The efficacy and safety of pde5 inhibitors
    • Rashid, A. (2005). The efficacy and safety of pde5 inhibitors. Clinical Cornerstone, 7, 47-56.
    • (2005) Clinical Cornerstone , vol.7 , pp. 47-56
    • Rashid, A.1
  • 50
    • 0037066021 scopus 로고    scopus 로고
    • Functional and biochemical analysis of endothelial (dys) function and no/cgmp signaling in human blood vessels with and without nitroglycerin pretreatment
    • Schulz, E., Tsilimingas, N., Rinze, R., Reiter, B., Wendt, M., Oelze, M., et al. (2002). Functional and biochemical analysis of endothelial (dys) function and no/cgmp signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation, 105, 1170-1175.
    • (2002) Circulation , vol.105 , pp. 1170-1175
    • Schulz, E.1    Tsilimingas, N.2    Rinze, R.3    Reiter, B.4    Wendt, M.5    Oelze, M.6
  • 51
    • 4644333076 scopus 로고    scopus 로고
    • Protective role of bcl-2 on beta-amyloid-induced cell death of differentiated pc12 cells: Reduction of nf-kappab and p38 map kinase activation
    • Song, Y. S., Park, H. J., Kim, S. Y., Lee, S. H., Yoo, H. S., Lee, H. S., et al. (2004). Protective role of bcl-2 on beta-amyloid-induced cell death of differentiated pc12 cells: Reduction of nf-kappab and p38 map kinase activation. Neuroscience Research, 49, 69-80.
    • (2004) Neuroscience Research , vol.49 , pp. 69-80
    • Song, Y.S.1    Park, H.J.2    Kim, S.Y.3    Lee, S.H.4    Yoo, H.S.5    Lee, H.S.6
  • 52
    • 0037129910 scopus 로고    scopus 로고
    • Mental stress induces prolonged en-dothelial dysfunction via endothelin - A receptors
    • Spieker, L. E., Hurlimann, D., Ruschitzka, F., Corti, R., Enseleit, F., Shaw, S., et al. (2002). Mental stress induces prolonged en-dothelial dysfunction via endothelin - a receptors. Circulation, 105, 2817-2820.
    • (2002) Circulation , vol.105 , pp. 2817-2820
    • Spieker, L.E.1    Hurlimann, D.2    Ruschitzka, F.3    Corti, R.4    Enseleit, F.5    Shaw, S.6
  • 53
    • 0042433479 scopus 로고    scopus 로고
    • The cholinergic hypothesis of age and alzheimer's disease-related cognitive deficits: Recent challenges and their implications for novel drug development
    • Terry, A. V., Jr., & Buccafusco, J. J. (2003). The cholinergic hypothesis of age and alzheimer's disease-related cognitive deficits: Recent challenges and their implications for novel drug development. The Journal of Pharmacology and Experimental Therapeutics, 306, 821-827.
    • (2003) The Journal of Pharmacology and Experimental Therapeutics , vol.306 , pp. 821-827
    • Terry Jr., A.V.1    Buccafusco, J.J.2
  • 55
    • 2942653014 scopus 로고    scopus 로고
    • Presenilin 1 familial alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis
    • Wang, R., Dineley, K. T., Sweatt, J. D., & Zheng, H. (2004). Presenilin 1 familial alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience, 126, 305-312.
    • (2004) Neuroscience , vol.126 , pp. 305-312
    • Wang, R.1    Dineley, K.T.2    Sweatt, J.D.3    Zheng, H.4
  • 56
    • 0036843061 scopus 로고    scopus 로고
    • Sildenafil (viagra) induces neurogenesis and promotes functional recovery after stroke in rats
    • Zhang, R., Wang, Y., Zhang, L., Zhang, Z., Tsang, W., Lu, M., et al. (2002). Sildenafil (viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke, 33, 2675-2680.
    • (2002) Stroke , vol.33 , pp. 2675-2680
    • Zhang, R.1    Wang, Y.2    Zhang, L.3    Zhang, Z.4    Tsang, W.5    Lu, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.