Effect of sildenafil on anxiety in the plus-maze test in mice

Polish Journal of Pharmacology

Volumn 56, Issue 3, 2004, Pages 353-357

  Kurt, Mehmet ^a   Bilge, Sirri S ^a   Aksoz, Elif ^a   Kukula, Osman ^a   Celik, Suleyman ^a   Kesim, Yuksel ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

Anxiety; cGMP; Methylene blue; Sildenafil

Indexed keywords

ARGININE; DIAZEPAM; METHYLENE BLUE; SILDENAFIL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; OUTCOMES RESEARCH; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TIME;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; MALE; METHYLENE BLUE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES;

EID: 3543046150     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Baratti CM, Boccia MM: Effects of sildenafil on long-term retention of an inhibitory avoidance response in mice. Behav Pharmacol, 1999, 10, 731-737.
2. Beavo JA: Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev, 1995, 75, 725-748.
3. Eroglu L, Caglayan B: Anxiolytic and antidepressant properties of methylene blue in animal models. Pharmacol Res, 1997, 36, 381-385.
4. Faria MS, Muscara MN, Moreno JH, Teixeira SA, Dias HB, De Oliveira B, Graeff FG, De Nucci G: Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test. Eur J Pharmacol, 1997, 323, 37-43.
5. Fidecka S: Study on the influence of potent inhibitors of neuronal nitric oxide synthase on the antinociceptive and anticonvulsant activity of benzodiazepines in mice. Pol J Pharmacol, 2003, 55, 193-201.
6. Ishizuka N, Saito K, Akima M, Matsubara S, Saito M: Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation. Jpn J Pharmacol, 2000, 84, 316-324.
7. Jain NK, Patil CS, Singh A, Kulkarni SK: Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Brain Res, 2001, 3, 170-178.
8. Kraus MM, Prast H: Involvement of nitric oxide, cyclic GMP and phosphodiesterase 5 in excitatory amino acid and GABA release in the nucleus accumbens evoked by activation of the hippocampal fimbria. Neuroscience, 2002, 112, 331-343.
9. Langtry HE, Markham A: Sildenafil - a review of its use in erectile dysfunction. Drugs, 1999, 57, 967-989.
10. Lister RG: The use of plus-maze to measure anxiety in the mouse. Psychopharmacology, 1987, 92, 180-185.
11. Mayer B, John M, Heinzel B, Werner ER, Wachter H, Schultz G, Bohme E: Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. FEBS Lett, 1991, 288, 187-191.
12. Milman HA, Arnold SB: Neurologic, psychological, and aggressive disturbances with sildenafil. Ann Pharmacother, 2002, 36, 1129-1134.
13. Mixcoatl-Zecuatl T, Aguirre-Banuelos P, Granados-Soto V: Sildenafil produces antinociception and increases morphine antinociception in the formalin test. Eur J Pharmacol, 2000, 14, 81-87.
14. Pellow S, File SE: Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav, 1986, 24, 524-529.
15. Talarek S, Fidecka S: Role of nitric oxide in benzodiazepines-induced antinociception in mice. Pol J Pharmacol, 2002, 54, 27-34.
16. Vincent SR: Nitric oxide: a radical neurotransmitter in the central nervous system. Prog Neurobiol, 1994, 42, 129-160.
17. Volke V, Koks S, Vasar E, Bourin M, Bradwejn J, Mannisto PT: Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze. Neuroreport, 1995, 6, 1285-1288.
18. Volke V, Vasar E: Phosphodiesterase type 5 inhibitor sildenafil has anxiogenic-like properties in mouse light-dark compartment test. 15th ECNP Congress, Barcelona, Spain, 1997, P.6.023.