Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats

Metabolic Brain Disease

Volumn 27, Issue 3, 2012, Pages 337-340

  Liebenberg, Nico ^a,b   Harvey, Brian H ^a   Brand, Linda ^a   Wegener, Gregers ^b   Brink, Christiaan B ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Anxiety; Anxiolytic; CGMP; Flinders sensitive line; Phosphodiesterase 5; Sildenafil; Social interaction; Tadalafil

Indexed keywords

ATROPINE; FLUOXETINE; SILDENAFIL; TADALAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; BRAIN CORTEX; CONTROLLED STUDY; DEPRESSION; EXPERIMENTAL MODEL; HIPPOCAMPUS; LIQUID CHROMATOGRAPHY; NONHUMAN; RAT; SOCIAL INTERACTION; TANDEM MASS SPECTROMETRY; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY DISORDERS; CARBOLINES; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, INBRED STRAINS; SULFONES;

RATTUS;

EID: 84864475807     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-012-9284-z     Document Type: Article

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