Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats

Neuropsychopharmacology

Volumn 34, Issue 8, 2009, Pages 1914-1925

  Rutten, Kris ^a   Van Donkelaar, Eva L ^a   Ferrington, Linda ^b   Blokland, Arjan ^a   Bollen, Eva ^a   Steinbusch, Harry W M ^a   Kelly, Paul A T ^b   Prickaerts, Jos H ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Bay 60 7550; Cerebrovascular; Cognition enhancement; Cyclic nucleotide; Rolipram; Vardenafil

Indexed keywords

BAY 60 7550; CYCLIC AMP; CYCLIC GMP; DEOXYGLUCOSE; DEOXYGLUCOSE C 14; GLUCOSE; IODOPHENAZONE C 14; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V; ROLIPRAM; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG; VARDENAFIL;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; DRUG EFFECT; ENZYME INHIBITION; GLUCOSE UTILIZATION; HIPPOCAMPUS; HYPEREMIA; IMAGE ANALYSIS; MALE; MEMORY; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; RHINAL CORTEX; SPATIAL MEMORY; TEMPORAL LOBE;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; ANIMALS; BRAIN; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENERGY METABOLISM; GLUCOSE; LEARNING; MALE; MEMORY; MEMORY DISORDERS; NEUROPSYCHOLOGICAL TESTS; NOOTROPIC AGENTS; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; VASODILATION;

EID: 67449124349     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2009.24     Document Type: Article

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