-
1
-
-
0019430432
-
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
-
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 1981; 41: 1967-1972.
-
(1981)
Cancer Res
, vol.41
, pp. 1967-1972
-
-
Tsuruo, T.1
Iida, H.2
Tsukagoshi, S.3
Sakurai, Y.4
-
2
-
-
0034917716
-
The human ATP-binding cassette (ABC) transporter superfamily
-
Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 2001; 11: 1156-1166.
-
(2001)
Genome Res
, vol.11
, pp. 1156-1166
-
-
Dean, M.1
Rzhetsky, A.2
Allikmets, R.3
-
3
-
-
44649084920
-
Transport proteins of the ABC family and multidrug resistance of tumor cells
-
Stavrovskaya AA, Stromskaya TP. Transport proteins of the ABC family and multidrug resistance of tumor cells. Biochemistry (Mosc) 2008; 73: 592-604.
-
(2008)
Biochemistry (Mosc)
, vol.73
, pp. 592-604
-
-
Stavrovskaya, A.A.1
Stromskaya, T.P.2
-
4
-
-
31844444140
-
The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research
-
Gottesman MM, Ling V. The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett 2006; 580: 998-1009.
-
(2006)
FEBS Lett
, vol.580
, pp. 998-1009
-
-
Gottesman, M.M.1
Ling, V.2
-
5
-
-
84860535245
-
Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds
-
Palmeira A, Sousa E, Vasconcelos MH, Pinto MM. Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds. Curr Med Chem 2012; 19(13):1946-2025.
-
(2012)
Curr Med Chem
, vol.19
, Issue.13
, pp. 1946-2025
-
-
Palmeira, A.1
Sousa, E.2
Vasconcelos, M.H.3
Pinto, M.M.4
-
6
-
-
63449139456
-
Structure of Pglycoprotein reveals a molecular basis for poly-specific drug binding
-
Aller SG, Yu J, Ward A, Weng Y, et al. Structure of Pglycoprotein reveals a molecular basis for poly-specific drug binding. Science 2009; 323: 1718-1722.
-
(2009)
Science
, vol.323
, pp. 1718-1722
-
-
Aller, S.G.1
Yu, J.2
Ward, A.3
Weng, Y.4
-
7
-
-
13244292479
-
Three-dimensional structure of P-glycoprotein: The transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state
-
Rosenberg MF, Callaghan R, Modok S, Higgins CF, Ford RC. Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state. J Biol Chem 2005; 280: 2857-2862.
-
(2005)
J Biol Chem
, vol.280
, pp. 2857-2862
-
-
Rosenberg, M.F.1
Callaghan, R.2
Modok, S.3
Higgins, C.F.4
Ford, R.C.5
-
8
-
-
0037424343
-
Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding
-
Rosenberg MF, Kamis AB, Callaghan R, Higgins CF, Ford RC. Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding. J Biol Chem 2003; 278: 8294-8299.
-
(2003)
J Biol Chem
, vol.278
, pp. 8294-8299
-
-
Rosenberg, M.F.1
Kamis, A.B.2
Callaghan, R.3
Higgins, C.F.4
Ford, R.C.5
-
9
-
-
17944370228
-
Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle
-
Rosenberg MF, Velarde G, Ford RC, et al. Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. EMBO J 2001; 20: 5615-5625.
-
(2001)
EMBO J
, vol.20
, pp. 5615-5625
-
-
Rosenberg, M.F.1
Velarde, G.2
Ford, R.C.3
-
10
-
-
0030971840
-
Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis
-
Rosenberg MF, Callaghan R, Ford RC, Higgins CF. Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis. J Biol Chem 1997; 272: 10685-10694.
-
(1997)
J Biol Chem
, vol.272
, pp. 10685-10694
-
-
Rosenberg, M.F.1
Callaghan, R.2
Ford, R.C.3
Higgins, C.F.4
-
11
-
-
0031160951
-
Structure of the multidrug resistance P-glycoprotein
-
Higgins CF, Callaghan R, Linton KJ, Rosenberg MF, Ford RC. Structure of the multidrug resistance P-glycoprotein. Semin Cancer Biol 1997; 8: 135-142.
-
(1997)
Semin Cancer Biol
, vol.8
, pp. 135-142
-
-
Higgins, C.F.1
Callaghan, R.2
Linton, K.J.3
Rosenberg, M.F.4
Ford, R.C.5
-
12
-
-
0032751615
-
Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies
-
Sharom FJ, Liu R, Romsicki Y, Lu P. Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies. Biochim Biophys Acta 1999; 1461: 327-345.
-
(1999)
Biochim Biophys Acta
, vol.1461
, pp. 327-345
-
-
Sharom, F.J.1
Liu, R.2
Romsicki, Y.3
Lu, P.4
-
13
-
-
33846215616
-
A primer on the mechanics of Pglycoprotein the multidrug transporter
-
Hennessy M, Spiers JP. A primer on the mechanics of Pglycoprotein the multidrug transporter. Pharmacol Res 2007; 55: 1-15.
-
(2007)
Pharmacol Res
, vol.55
, pp. 1-15
-
-
Hennessy, M.1
Spiers, J.P.2
-
14
-
-
65549121495
-
Human ATP-binding cassette (ABC) transporter family
-
Vasiliou V, Vasiliou K, Nebert DW. Human ATP-binding cassette (ABC) transporter family. Hum Genomics 2009; 3: 281-290.
-
(2009)
Hum Genomics
, vol.3
, pp. 281-290
-
-
Vasiliou, V.1
Vasiliou, K.2
Nebert, D.W.3
-
15
-
-
33846419807
-
How can we best use structural information on P-glycoprotein to design inhibitors?
-
McDevitt CA, Callaghan R. How can we best use structural information on P-glycoprotein to design inhibitors? Pharmacol Ther 2007; 113: 429-441.
-
(2007)
Pharmacol Ther
, vol.113
, pp. 429-441
-
-
McDevitt, C.A.1
Callaghan, R.2
-
16
-
-
0030597326
-
Competitive inhibition of photoaffinity labelling of P-glycoprotein by anticancer drugs and modulators including S9788
-
Demmer A, Dunn T, Hoof T, Kubesch P, Tummler B. Competitive inhibition of photoaffinity labelling of P-glycoprotein by anticancer drugs and modulators including S9788. Eur J Pharmacol 1996; 315: 339-343.
-
(1996)
Eur J Pharmacol
, vol.315
, pp. 339-343
-
-
Demmer, A.1
Dunn, T.2
Hoof, T.3
Kubesch, P.4
Tummler, B.5
-
17
-
-
0025103799
-
Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells
-
Tamai I, Safa AR. Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. J Biol Chem 1990; 265: 16509-16513.
-
(1990)
J Biol Chem
, vol.265
, pp. 16509-16513
-
-
Tamai, I.1
Safa, A.R.2
-
18
-
-
0037358040
-
Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein
-
Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 2003; 10: 159-165.
-
(2003)
Cancer Control
, vol.10
, pp. 159-165
-
-
Thomas, H.1
Coley, H.M.2
-
19
-
-
0032544087
-
Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse Pglycoprotein
-
Conseil G, Baubichon-Cortay H, Dayan G, Jault JM, Barron D, di Pietro A. Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse Pglycoprotein. Proc Natl Acad Sci USA 1998; 95: 9831-9836.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9831-9836
-
-
Conseil, G.1
Baubichon-Cortay, H.2
Dayan, G.3
Jault, J.M.4
Barron, D.5
di Pietro, A.6
-
20
-
-
21844451868
-
The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment
-
Rothnie A, Storm J, McMahon R, Taylor A, Kerr ID, Callaghan R. The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment. FEBS Lett 2005; 579: 3984-3990.
-
(2005)
FEBS Lett
, vol.579
, pp. 3984-3990
-
-
Rothnie, A.1
Storm, J.2
McMahon, R.3
Taylor, A.4
Kerr, I.D.5
Callaghan, R.6
-
21
-
-
33744942933
-
Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1)
-
Maki N, Dey S. Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1). Biochem Pharmacol 2006; 72: 145-155.
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 145-155
-
-
Maki, N.1
Dey, S.2
-
22
-
-
0038043182
-
Allosteric modulation of human Pglycoprotein. Inhibition of transport by preventing substrate translocation and dissociation
-
Maki N, Hafkemeyer P, Dey S. Allosteric modulation of human Pglycoprotein. Inhibition of transport by preventing substrate translocation and dissociation. J Biol Chem 2003; 278: 18132-18139.
-
(2003)
J Biol Chem
, vol.278
, pp. 18132-18139
-
-
Maki, N.1
Hafkemeyer, P.2
Dey, S.3
-
23
-
-
0028589070
-
Dexniguldipine-HCl is a potent allosteric inhibitor of [3H]vinblastine binding to P-glycoprotein of CCRF ADR 5000 cells
-
Malkhandi J, Ferry DR, Boer R, Gekeler V, Ise W, Kerr DJ. Dexniguldipine-HCl is a potent allosteric inhibitor of [3H]vinblastine binding to P-glycoprotein of CCRF ADR 5000 cells. Eur J Pharmacol 1994; 288: 105-114.
-
(1994)
Eur J Pharmacol
, vol.288
, pp. 105-114
-
-
Malkhandi, J.1
Ferry, D.R.2
Boer, R.3
Gekeler, V.4
Ise, W.5
Kerr, D.J.6
-
24
-
-
38549085409
-
Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)
-
Ravna AW, Sylte I, Sager G. Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5). Theor Biol Med Model 2007; 4: 33.
-
(2007)
Theor Biol Med Model
, vol.4
, pp. 33
-
-
Ravna, A.W.1
Sylte, I.2
Sager, G.3
-
25
-
-
77953005237
-
Making membrane proteins for structures: A trillion tiny tweaks
-
Baker M. Making membrane proteins for structures: a trillion tiny tweaks. Nat Methods 2010; 7: 429-434.
-
(2010)
Nat Methods
, vol.7
, pp. 429-434
-
-
Baker, M.1
-
26
-
-
77950672853
-
The structure and unctions of P-glycoprotein
-
Li Y, Yuan H, Yang K, Xu W, Tang W, Li X. The structure and unctions of P-glycoprotein. Curr Med Chem 2010; 17: 786-800.
-
(2010)
Curr Med Chem
, vol.17
, pp. 786-800
-
-
Li, Y.1
Yuan, H.2
Yang, K.3
Xu, W.4
Tang, W.5
Li, X.6
-
27
-
-
84866311233
-
Influence of Pglycoprotein on embryotoxicity of the antifouling biocides to sea urchin (Strongylocentrotus intermedius)
-
Xu X, Fu J, Wang H, Zhang B, Wang X, Wang Y. Influence of Pglycoprotein on embryotoxicity of the antifouling biocides to sea urchin (Strongylocentrotus intermedius). Ecotoxicology 2010.
-
(2010)
Ecotoxicology
-
-
Xu, X.1
Fu, J.2
Wang, H.3
Zhang, B.4
Wang, X.5
Wang, Y.6
-
28
-
-
84866311228
-
Probing the Stereoselectivity of P-glycoprotein-synthesis, Biological Activity and Ligand Docking Studies of a Set of Enantiopure Benzopyrano[3,4-b][1,4]oxazines
-
Jabeen I, Wetwitayaklung P, Klepsch F, Parveen Z, Chiba P, Ecker GF. Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines. Chem Commun (Camb) 2010.
-
(2010)
Chem Commun (Camb)
-
-
Jabeen, I.1
Wetwitayaklung, P.2
Klepsch, F.3
Parveen, Z.4
Chiba, P.5
Ecker, G.F.6
-
29
-
-
79958172123
-
Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of p-glycoprotein
-
Klepsch F, Chiba P, Ecker GF. Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of p-glycoprotein. PLoS Comput Biol 2011; 7: e1002036.
-
(2011)
PLoS Comput Biol
, vol.7
-
-
Klepsch, F.1
Chiba, P.2
Ecker, G.F.3
-
30
-
-
0038799725
-
Structure of MsbA from Vibrio cholera: A multidrug resistance ABC transporter homolog in a closed conformation
-
Chang G. Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation. J Mol Biol 2003; 330: 419-430.
-
(2003)
J Mol Biol
, vol.330
, pp. 419-430
-
-
Chang, G.1
-
31
-
-
70349512492
-
Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure
-
Ravna AW, Sylte I, Sager G. Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure. Theor Biol Med Model 2009; 6: 20.
-
(2009)
Theor Biol Med Model
, vol.6
, pp. 20
-
-
Ravna, A.W.1
Sylte, I.2
Sager, G.3
-
32
-
-
63349106226
-
Molecular models of human P-glycoprotein in two different catalytic states
-
Becker JP, Depret G, Van Bambeke F, Tulkens PM, Prevost M. Molecular models of human P-glycoprotein in two different catalytic states. BMC Struct Biol 2009; 9: 3.
-
(2009)
BMC Struct Biol
, vol.9
, pp. 3
-
-
Becker, J.P.1
Depret, G.2
van Bambeke, F.3
Tulkens, P.M.4
Prevost, M.5
-
33
-
-
33645993917
-
New light on multidrug binding by an ATP-binding-cassette transporter
-
Shilling RA, Venter H, Velamakanni S, et al. New light on multidrug binding by an ATP-binding-cassette transporter. Trends Pharmacol Sci 2006; 27: 195-203.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 195-203
-
-
Shilling, R.A.1
Venter, H.2
Velamakanni, S.3
-
34
-
-
13444266621
-
P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: A combined photoaffinity labeling-protein homology modeling approach
-
Pleban K, Kopp S, Csaszar E, Peer M, Hrebicek T, Rizzi A, Ecker GF, Chiba P. P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach. Mol Pharmacol 2005; 67: 365-374.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 365-374
-
-
Pleban, K.1
Kopp, S.2
Csaszar, E.3
Peer, M.4
Hrebicek, T.5
Rizzi, A.6
Ecker, G.F.7
Chiba, P.8
-
35
-
-
2342533129
-
Structure-function relationships of multidrug resistance P-glycoprotein
-
Pajeva IK, Globisch C, Wiese M. Structure-function relationships of multidrug resistance P-glycoprotein. J Med Chem 2004; 47: 2523-2533.
-
(2004)
J Med Chem
, vol.47
, pp. 2523-2533
-
-
Pajeva, I.K.1
Globisch, C.2
Wiese, M.3
-
36
-
-
0642272487
-
An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide crosslinking and homology modeling
-
Stenham DR, Campbell JD, Sansom MS, Higgins CF, Kerr ID, Linton KJ. An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide crosslinking and homology modeling. FASEB J 2003; 17: 2287-2289.
-
(2003)
FASEB J
, vol.17
, pp. 2287-2289
-
-
Stenham, D.R.1
Campbell, J.D.2
Sansom, M.S.3
Higgins, C.F.4
Kerr, I.D.5
Linton, K.J.6
-
37
-
-
0042531543
-
A structural model for the open conformation of the mdr1 P-glycoprotein based on the MsbA crystal structure
-
Seigneuret M, Garnier-Suillerot A. A structural model for the open conformation of the mdr1 P-glycoprotein based on the MsbA crystal structure. J Biol Chem 2003; 278: 30115-30124.
-
(2003)
J Biol Chem
, vol.278
, pp. 30115-30124
-
-
Seigneuret, M.1
Garnier-Suillerot, A.2
-
38
-
-
15744403992
-
Modulation of P-glycoprotein function and reversal of multidrug resistance by (-)-epigallocatechin gallate in human cancer cells
-
Qian F, Wei D, Zhang Q, Yang S. Modulation of P-glycoprotein function and reversal of multidrug resistance by (-)-epigallocatechin gallate in human cancer cells. Biomed Pharmacother 2005; 59: 64-69.
-
(2005)
Biomed Pharmacother
, vol.59
, pp. 64-69
-
-
Qian, F.1
Wei, D.2
Zhang, Q.3
Yang, S.4
-
39
-
-
33847134349
-
Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP
-
Dawson RJ, Locher KP. Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP. FEBS Lett 2007; 581: 935-938.
-
(2007)
FEBS Lett
, vol.581
, pp. 935-938
-
-
Dawson, R.J.1
Locher, K.P.2
-
40
-
-
70350507783
-
Function and frustration of multi-drug ABC exporter protein and design of model proteins for drug delivery using protein hydration thermodynamics
-
Urry DW, Urry KD, Szaflarski W, Nowicki M, Zabel M. Function and frustration of multi-drug ABC exporter protein and design of model proteins for drug delivery using protein hydration thermodynamics. Curr Pharm Des 2009; 15: 2833-2867.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 2833-2867
-
-
Urry, D.W.1
Urry, K.D.2
Szaflarski, W.3
Nowicki, M.4
Zabel, M.5
-
41
-
-
50849114847
-
Multidrug transport by the ABC transporter Sav1866 from Staphylococcus aureus
-
Velamakanni S, Yao Y, Gutmann DA, van Veen HW. Multidrug transport by the ABC transporter Sav1866 from Staphylococcus aureus. Biochemistry 2008; 47: 9300-9308.
-
(2008)
Biochemistry
, vol.47
, pp. 9300-9308
-
-
Velamakanni, S.1
Yao, Y.2
Gutmann, D.A.3
van Veen, H.W.4
-
42
-
-
47049126229
-
Identification of putative binding sites of P-glycoprotein based on its homology model
-
Globisch C, Pajeva IK, Wiese M. Identification of putative binding sites of P-glycoprotein based on its homology model. ChemMed-Chem 2008; 3: 280-295.
-
(2008)
ChemMed-Chem
, vol.3
, pp. 280-295
-
-
Globisch, C.1
Pajeva, I.K.2
Wiese, M.3
-
43
-
-
34548133239
-
P-glycoprotein models of the apo and ATP-bound states based on homology with Sav1866 and MalK
-
O'Mara ML, Tieleman DP. P-glycoprotein models of the apo and ATP-bound states based on homology with Sav1866 and MalK. FEBS Lett 2007; 581: 4217-4222.
-
(2007)
FEBS Lett
, vol.581
, pp. 4217-4222
-
-
O'Mara, M.L.1
Tieleman, D.P.2
-
44
-
-
84866342881
-
-
Palmeira A, Vasconcelos MH, Paiva A, Fernandes MX, Pinto MM, Sousa E. Design of dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones. 2011: 83(1):57-68.
-
(2011)
Design of Dual Inhibitors of P-glycoprotein and Tumor Cell Growth: (re)discovering Thioxanthones
, vol.83
, Issue.1
, pp. 57-68
-
-
Palmeira, A.1
Vasconcelos, M.H.2
Paiva, A.3
Fernandes, M.X.4
Pinto, M.M.5
Sousa, E.6
-
45
-
-
0037052565
-
The E. coli BtuCD structure: A framework for ABC transporter architecture and mechanism
-
Locher KP, Lee AT, Rees DC. The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science 2002; 296: 1091-1098.
-
(2002)
Science
, vol.296
, pp. 1091-1098
-
-
Locher, K.P.1
Lee, A.T.2
Rees, D.C.3
-
46
-
-
0034669176
-
Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis
-
Diederichs K, Diez J, Greller G, Muller C, Breed J, Schnell C, Vonrhein C, Boos W, Welte W. Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J 2000; 19: 5951-5961.
-
(2000)
EMBO J
, vol.19
, pp. 5951-5961
-
-
Diederichs, K.1
Diez, J.2
Greller, G.3
Muller, C.4
Breed, J.5
Schnell, C.6
Vonrhein, C.7
Boos, W.8
Welte, W.9
-
47
-
-
0032542358
-
Crystal structure of the ATP-binding subunit of an ABC transporter
-
Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH. Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 1998; 396: 703-707.
-
(1998)
Nature
, vol.396
, pp. 703-707
-
-
Hung, L.W.1
Wang, I.X.2
Nikaido, K.3
Liu, P.Q.4
Ames, G.F.5
Kim, S.H.6
-
48
-
-
0035801375
-
Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing
-
Gaudet R, Wiley DC. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J 2001; 20: 4964-4972.
-
(2001)
EMBO J
, vol.20
, pp. 4964-4972
-
-
Gaudet, R.1
Wiley, D.C.2
-
49
-
-
33645972931
-
In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain
-
Badhan R, Penny J. In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain. Eur J Med Chem 2006; 41: 285-295.
-
(2006)
Eur J Med Chem
, vol.41
, pp. 285-295
-
-
Badhan, R.1
Penny, J.2
-
50
-
-
33646186248
-
Molecular model and ATPase activity of carboxyl-terminal nucleotide binding domain from human Pglycoprotein
-
Qian F, Wei D, Liu J, Yang S. Molecular model and ATPase activity of carboxyl-terminal nucleotide binding domain from human Pglycoprotein. Biochemistry (Mosc) 2006; 71 Suppl 1: S18-S24, 1-2.
-
(2006)
Biochemistry (Mosc)
, vol.71
, Issue.SUPPL. 1
-
-
Qian, F.1
Wei, D.2
Liu, J.3
Yang, S.4
-
51
-
-
0023553574
-
ATP-binding properties of P glycoprotein from multidrug-resistant KB cells
-
Cornwell MM, Tsuruo T, Gottesman MM, Pastan I. ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. FASEB J 1987; 1: 51-54.
-
(1987)
FASEB J
, vol.1
, pp. 51-54
-
-
Cornwell, M.M.1
Tsuruo, T.2
Gottesman, M.M.3
Pastan, I.4
-
52
-
-
0023019651
-
Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance
-
Gerlach JH, Endicott JA, Juranka PF, Henderson G, Sarangi F, Deuchars KL, Ling V. Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature 1986; 324: 485-489.
-
(1986)
Nature
, vol.324
, pp. 485-489
-
-
Gerlach, J.H.1
Endicott, J.A.2
Juranka, P.F.3
Henderson, G.4
Sarangi, F.5
Deuchars, K.L.6
Ling, V.7
-
53
-
-
79955629985
-
Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: Evidence for an atp analogue that interacts with both drug-substrate-and nucleotide-binding sites
-
Ohnuma S, Chufan E, Nandigama K, Jenkins LM, Durell SR, Appella E, Sauna ZE, Ambudkar SV. Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an atp analogue that interacts with both drug-substrate-and nucleotide-binding sites. Biochemistry 2011; 50: 3724-3735.
-
(2011)
Biochemistry
, vol.50
, pp. 3724-3735
-
-
Ohnuma, S.1
Chufan, E.2
Nandigama, K.3
Jenkins, L.M.4
Durell, S.R.5
Appella, E.6
Sauna, Z.E.7
Ambudkar, S.V.8
-
54
-
-
0026621245
-
ABC transporters: From microorganisms to man
-
Higgins CF. ABC transporters: from microorganisms to man. Annu Rev Cell Biol 1992; 8: 67-113.
-
(1992)
Annu Rev Cell Biol
, vol.8
, pp. 67-113
-
-
Higgins, C.F.1
-
55
-
-
0041833334
-
ABC-transporters: Implications on drug resistance from microorganisms to human cancers
-
Lage H. ABC-transporters: implications on drug resistance from microorganisms to human cancers. Int J Antimicrob Agents 2003; 22: 188-199.
-
(2003)
Int J Antimicrob Agents
, vol.22
, pp. 188-199
-
-
Lage, H.1
-
56
-
-
44949249999
-
Structure, function, and evolution of bacterial ATP-binding cassette systems
-
table of contents
-
Davidson AL, Dassa E, Orelle C, Chen J. Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev 2008; 72: 317-364, table of contents.
-
(2008)
Microbiol Mol Biol Rev
, vol.72
, pp. 317-364
-
-
Davidson, A.L.1
Dassa, E.2
Orelle, C.3
Chen, J.4
-
57
-
-
0036015623
-
Mystery of multidrug transporters: The answer can be simple
-
Neyfakh AA. Mystery of multidrug transporters: the answer can be simple. Mol Microbiol 2002; 44: 1123-1130.
-
(2002)
Mol Microbiol
, vol.44
, pp. 1123-1130
-
-
Neyfakh, A.A.1
-
58
-
-
0346887115
-
Structure and function of efflux pumps that confer resistance to drugs
-
Borges-Walmsley MI, McKeegan KS, Walmsley AR. Structure and function of efflux pumps that confer resistance to drugs. Biochem J 2003; 376: 313-338.
-
(2003)
Biochem J
, vol.376
, pp. 313-338
-
-
Borges-Walmsley, M.I.1
McKeegan, K.S.2
Walmsley, A.R.3
-
59
-
-
37649004412
-
Flexibility in the ABC transporter MsbA: Alternating access with a twist
-
Ward A, Reyes CL, Yu J, Roth CB, Chang G. Flexibility in the ABC transporter MsbA: Alternating access with a twist. Proc Natl Acad Sci USA 2007; 104: 19005-19010.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19005-19010
-
-
Ward, A.1
Reyes, C.L.2
Yu, J.3
Roth, C.B.4
Chang, G.5
-
60
-
-
33748644877
-
Structure of a bacterial multidrug ABC transporter
-
Dawson RJ, Locher KP. Structure of a bacterial multidrug ABC transporter. Nature 2006; 443: 180-185.
-
(2006)
Nature
, vol.443
, pp. 180-185
-
-
Dawson, R.J.1
Locher, K.P.2
-
61
-
-
0036342413
-
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer
-
Smith PC, Karpowich N, Millen L, Moody JE, Rosen J, Thomas PJ, Hunt JF. ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol Cell 2002; 10: 139-149.
-
(2002)
Mol Cell
, vol.10
, pp. 139-149
-
-
Smith, P.C.1
Karpowich, N.2
Millen, L.3
Moody, J.E.4
Rosen, J.5
Thomas, P.J.6
Hunt, J.F.7
-
62
-
-
36849079744
-
Evidence for a Sav1866- like architecture for the human multidrug transporter Pglycoprotein
-
Zolnerciks JK, Wooding C, Linton KJ. Evidence for a Sav1866- like architecture for the human multidrug transporter Pglycoprotein. FASEB J 2007; 21: 3937-3948.
-
(2007)
FASEB J
, vol.21
, pp. 3937-3948
-
-
Zolnerciks, J.K.1
Wooding, C.2
Linton, K.J.3
-
63
-
-
27644456826
-
Targeting drug-efflux pumps -- a pharmacoinformatic approach
-
Pleban K, Kaiser D, Kopp S, Peer M, Chiba P, Ecker GF. Targeting drug-efflux pumps -- a pharmacoinformatic approach. Acta Biochim Pol 2005; 52: 737-740.
-
(2005)
Acta Biochim Pol
, vol.52
, pp. 737-740
-
-
Pleban, K.1
Kaiser, D.2
Kopp, S.3
Peer, M.4
Chiba, P.5
Ecker, G.F.6
-
64
-
-
73449087038
-
Structure- and ligand-based drug design: Advances and perspectives
-
Andricopulo AD. Structure- and ligand-based drug design: advances and perspectives. Curr Top Med Chem 2009; 9: 754.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 754
-
-
Andricopulo, A.D.1
-
65
-
-
0033739115
-
Structure-activity relationship of Pglycoprotein substrates and modifiers
-
Seelig A, Landwojtowicz E. Structure-activity relationship of Pglycoprotein substrates and modifiers. Eur J Pharm Sci 2000; 12: 31-40.
-
(2000)
Eur J Pharm Sci
, vol.12
, pp. 31-40
-
-
Seelig, A.1
Landwojtowicz, E.2
-
66
-
-
0345415712
-
QSAR studies on P-glycoprotein-regulated multidrug resistance and on its reversal by phenothiazines
-
Dearden JC, Al-Noobi A, Scott AC, Thomson SA. QSAR studies on P-glycoprotein-regulated multidrug resistance and on its reversal by phenothiazines. SAR QSAR Environ Res 2003; 14: 447-454.
-
(2003)
SAR QSAR Environ Res
, vol.14
, pp. 447-454
-
-
Dearden, J.C.1
Al-Noobi, A.2
Scott, A.C.3
Thomson, S.A.4
-
67
-
-
0034936606
-
3D-QSAR analysis of 2,4,5- and 2,3,4,5-substituted imidazoles as potent and nontoxic modulators of P-glycoprotein mediated MDR
-
Kim KH. 3D-QSAR analysis of 2,4,5- and 2,3,4,5-substituted imidazoles as potent and nontoxic modulators of P-glycoprotein mediated MDR. Bioorg Med Chem 2001; 9: 1517-1523.
-
(2001)
Bioorg Med Chem
, vol.9
, pp. 1517-1523
-
-
Kim, K.H.1
-
68
-
-
0037137614
-
Pharmacophore model of drugs involved in Pglycoprotein multidrug resistance: Explanation of structural variety (hypothesis)
-
Pajeva IK, Wiese M. Pharmacophore model of drugs involved in Pglycoprotein multidrug resistance: explanation of structural variety (hypothesis). J Med Chem 2002; 45: 5671-5686.
-
(2002)
J Med Chem
, vol.45
, pp. 5671-5686
-
-
Pajeva, I.K.1
Wiese, M.2
-
69
-
-
0023748077
-
Effects of indole alkaloids on multidrug resistance and labeling of Pglycoprotein by a photoaffinity analog of vinblastine
-
Beck WT, Cirtain MC, Glover CJ, Felsted RL, Safa AR. Effects of indole alkaloids on multidrug resistance and labeling of Pglycoprotein by a photoaffinity analog of vinblastine. Biochem Biophys Res Commun 1988; 153: 959-966.
-
(1988)
Biochem Biophys Res Commun
, vol.153
, pp. 959-966
-
-
Beck, W.T.1
Cirtain, M.C.2
Glover, C.J.3
Felsted, R.L.4
Safa, A.R.5
-
70
-
-
0023898749
-
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells
-
Zamora JM, Pearce HL, Beck WT. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol Pharmacol 1988; 33: 454-462.
-
(1988)
Mol Pharmacol
, vol.33
, pp. 454-462
-
-
Zamora, J.M.1
Pearce, H.L.2
Beck, W.T.3
-
71
-
-
0000887546
-
Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance
-
Pearce HL, Safa AR, Bach NJ, Winter MA, Cirtain MC, Beck WT. Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance. Proc Natl Acad Sci USA 1989; 86: 5128-5132.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 5128-5132
-
-
Pearce, H.L.1
Safa, A.R.2
Bach, N.J.3
Winter, M.A.4
Cirtain, M.C.5
Beck, W.T.6
-
72
-
-
0024595844
-
Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of Pglycoprotein
-
Nogae I, Kohno K, Kikuchi J, Kuwano M, Akiyama S, Kiue A, Suzuki K, Yoshida Y, Cornwell MM, Pastan I, et al. Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of Pglycoprotein. Biochem Pharmacol 1989; 38: 519-527.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 519-527
-
-
Nogae, I.1
Kohno, K.2
Kikuchi, J.3
Kuwano, M.4
Akiyama, S.5
Kiue, A.6
Suzuki, K.7
Yoshida, Y.8
Cornwell, M.M.9
Pastan, I.10
-
73
-
-
0024507079
-
Circumvention of adriamycin resistance by dipyridamole analogues: A structure-activity relationship study
-
Ramu N, Ramu A. Circumvention of adriamycin resistance by dipyridamole analogues: a structure-activity relationship study. Int J Cancer 1989; 43: 487-491.
-
(1989)
Int J Cancer
, vol.43
, pp. 487-491
-
-
Ramu, N.1
Ramu, A.2
-
74
-
-
0024534226
-
Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance
-
Ford JM, Prozialeck WC, Hait WN. Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance. Mol Pharmacol 1989; 35: 105-115.
-
(1989)
Mol Pharmacol
, vol.35
, pp. 105-115
-
-
Ford, J.M.1
Prozialeck, W.C.2
Hait, W.N.3
-
75
-
-
0025640935
-
Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells
-
Pommerenke EW, Osswald H, Hahn EW, Volm M. Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells. Cancer Lett 1990; 55: 17-23.
-
(1990)
Cancer Lett
, vol.55
, pp. 17-23
-
-
Pommerenke, E.W.1
Osswald, H.2
Hahn, E.W.3
Volm, M.4
-
76
-
-
0025084766
-
Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines
-
Thimmaiah KN, Horton JK, Qian XD, Beck WT, Houghton JA, Houghton PJ. Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines. Cancer Commun 1990; 2: 249-259.
-
(1990)
Cancer Commun
, vol.2
, pp. 249-259
-
-
Thimmaiah, K.N.1
Horton, J.K.2
Qian, X.D.3
Beck, W.T.4
Houghton, J.A.5
Houghton, P.J.6
-
77
-
-
0026624915
-
Reversal of multidrug resistance by phenothiazines and structurally related compounds
-
Ramu A, Ramu N. Reversal of multidrug resistance by phenothiazines and structurally related compounds. Cancer Chemother Pharmacol 1992; 30: 165-173.
-
(1992)
Cancer Chemother Pharmacol
, vol.30
, pp. 165-173
-
-
Ramu, A.1
Ramu, N.2
-
78
-
-
0028107822
-
Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds
-
Ramu A, Ramu N. Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds. Cancer Chemother Pharmacol 1994; 34: 423-430.
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, pp. 423-430
-
-
Ramu, A.1
Ramu, N.2
-
79
-
-
0026635292
-
New triazine derivatives as potent modulators of multidrug resistance
-
Dhainaut A, Regnier G, Atassi G, et al. New triazine derivatives as potent modulators of multidrug resistance. J Med Chem 1992; 35: 2481-2496.
-
(1992)
J Med Chem
, vol.35
, pp. 2481-2496
-
-
Dhainaut, A.1
Regnier, G.2
Atassi, G.3
-
80
-
-
0028793277
-
Structure-activity relationship of verapamil analogs and reversal of multidrug resistance
-
Toffoli G, Simone F, Corona G, et al. Structure-activity relationship of verapamil analogs and reversal of multidrug resistance. Biochem Pharmacol 1995; 50: 1245-1255.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 1245-1255
-
-
Toffoli, G.1
Simone, F.2
Corona, G.3
-
81
-
-
0030668258
-
Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein
-
Bain LJ, McLachlan JB, LeBlanc GA. Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein. Environ Health Perspect 1997; 105: 812-818.
-
(1997)
Environ Health Perspect
, vol.105
, pp. 812-818
-
-
Bain, L.J.1
McLachlan, J.B.2
Leblanc, G.A.3
-
82
-
-
0030943029
-
Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer
-
Suzuki T, Fukazawa N, San-nohe K, Sato W, Yano O, Tsuruo T. Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer. J Med Chem 1997; 40: 2047-2052.
-
(1997)
J Med Chem
, vol.40
, pp. 2047-2052
-
-
Suzuki, T.1
Fukazawa, N.2
San-Nohe, K.3
Sato, W.4
Yano, O.5
Tsuruo, T.6
-
83
-
-
0031017789
-
Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge
-
Lampidis TJ, Kolonias D, Podona T, et al. Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge. Biochemistry 1997; 36: 2679-2685.
-
(1997)
Biochemistry
, vol.36
, pp. 2679-2685
-
-
Lampidis, T.J.1
Kolonias, D.2
Podona, T.3
-
84
-
-
0030800078
-
Quantitative structure-activity relationship of multidrug resistance reversal agents
-
Klopman G, Shi LM, Ramu A. Quantitative structure-activity relationship of multidrug resistance reversal agents. Mol Pharmacol 1997; 52: 323-334.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 323-334
-
-
Klopman, G.1
Shi, L.M.2
Ramu, A.3
-
85
-
-
0030791978
-
Structure-activity relationships of P-glycoprotein interacting drugs: Kinetic characterization of their effects on ATPase activity
-
Litman T, Zeuthen T, Skovsgaard T, Stein WD. Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity. Biochim Biophys Acta 1997; 1361: 159-168.
-
(1997)
Biochim Biophys Acta
, vol.1361
, pp. 159-168
-
-
Litman, T.1
Zeuthen, T.2
Skovsgaard, T.3
Stein, W.D.4
-
86
-
-
0031609835
-
Characterization of 2-chloro-N10-substituted phenoxazines for reversing multidrug resistance in cancer cells
-
Thimmaiah KN, Jayashree BS, Germain GS, Houghton PJ, Horton JK. Characterization of 2-chloro-N10-substituted phenoxazines for reversing multidrug resistance in cancer cells. Oncol Res 1998; 10: 29-41.
-
(1998)
Oncol Res
, vol.10
, pp. 29-41
-
-
Thimmaiah, K.N.1
Jayashree, B.S.2
Germain, G.S.3
Houghton, P.J.4
Horton, J.K.5
-
87
-
-
0032497591
-
Halogenated chalcones with high-affinity binding to Pglycoprotein: Potential modulators of multidrug resistance
-
Bois F, Beney C, Boumendjel A, Mariotte AM, Conseil G, di Pietro A. Halogenated chalcones with high-affinity binding to Pglycoprotein: potential modulators of multidrug resistance. J Med Chem 1998; 41: 4161-4164.
-
(1998)
J Med Chem
, vol.41
, pp. 4161-4164
-
-
Bois, F.1
Beney, C.2
Boumendjel, A.3
Mariotte, A.M.4
Conseil, G.5
di Pietro, A.6
-
88
-
-
0033578034
-
Novel multidrug resistance reversal agents
-
Berger D, Citarella R, Dutia M, et al. Novel multidrug resistance reversal agents. J Med Chem 1999; 42: 2145-2161.
-
(1999)
J Med Chem
, vol.42
, pp. 2145-2161
-
-
Berger, D.1
Citarella, R.2
Dutia, M.3
-
89
-
-
0345491352
-
Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships
-
Ferte J, Kuhnel JM, Chapuis G, Rolland Y, Lewin G, Schwaller MA. Flavonoid-related modulators of multidrug resistance: synthesis, pharmacological activity, and structure-activity relationships. J Med Chem 1999; 42: 478-489.
-
(1999)
J Med Chem
, vol.42
, pp. 478-489
-
-
Ferte, J.1
Kuhnel, J.M.2
Chapuis, G.3
Rolland, Y.4
Lewin, G.5
Schwaller, M.A.6
-
90
-
-
0034077338
-
Theoretical calculation and prediction of P-glycoprotein-interacting drugs using MolSurf parametrization and PLS statistics
-
Osterberg T, Norinder U. Theoretical calculation and prediction of P-glycoprotein-interacting drugs using MolSurf parametrization and PLS statistics. Eur J Pharm Sci 2000; 10: 295-303.
-
(2000)
Eur J Pharm Sci
, vol.10
, pp. 295-303
-
-
Osterberg, T.1
Norinder, U.2
-
91
-
-
0038480045
-
Structure-activity relationship: Analyses of p-glycoprotein substrates and inhibitors
-
Wang RB, Kuo CL, Lien LL, Lien EJ. Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors. J Clin Pharm Ther 2003; 28: 203-228.
-
(2003)
J Clin Pharm Ther
, vol.28
, pp. 203-228
-
-
Wang, R.B.1
Kuo, C.L.2
Lien, L.L.3
Lien, E.J.4
-
92
-
-
0038155173
-
Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead
-
Corea G, Fattorusso E, Lanzotti V, et al. Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead. J Med Chem 2003; 46: 3395-3402.
-
(2003)
J Med Chem
, vol.46
, pp. 3395-3402
-
-
Corea, G.1
Fattorusso, E.2
Lanzotti, V.3
-
93
-
-
3042845152
-
Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR
-
Choi CH, Kim JH, Kim SH. Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR. Biochem Biophys Res Commun 2004; 320: 672-679.
-
(2004)
Biochem Biophys Res Commun
, vol.320
, pp. 672-679
-
-
Choi, C.H.1
Kim, J.H.2
Kim, S.H.3
-
94
-
-
20444403742
-
Classification of substrates and inhibitors of P-glycoprotein using unsupervised machine learning approach
-
Wang YH, Li Y, Yang SL, Yang L. Classification of substrates and inhibitors of P-glycoprotein using unsupervised machine learning approach. J Chem Inf Model 2005; 45: 750-757.
-
(2005)
J Chem Inf Model
, vol.45
, pp. 750-757
-
-
Wang, Y.H.1
Li, Y.2
Yang, S.L.3
Yang, L.4
-
95
-
-
34249939511
-
Structure-activity relationships of novel N-acyloxy-1,4-dihydropyridines as Pglycoprotein inhibitors
-
Voigt B, Coburger C, Monar J, Hilgeroth A. Structure-activity relationships of novel N-acyloxy-1,4-dihydropyridines as Pglycoprotein inhibitors. Bioorg Med Chem 2007; 15: 5110-5113.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 5110-5113
-
-
Voigt, B.1
Coburger, C.2
Monar, J.3
Hilgeroth, A.4
-
96
-
-
52449108379
-
Novel insight in structure- activity relationship and bioanalysis of P-glycoprotein targeting highly potent tetrakishydroxymethyl substituted 3,9-diazatetraasteranes
-
Coburger C, Wollmann J, Baumert C, et al. Novel insight in structure- activity relationship and bioanalysis of P-glycoprotein targeting highly potent tetrakishydroxymethyl substituted 3,9-diazatetraasteranes. J Med Chem 2008; 51: 5871-5874.
-
(2008)
J Med Chem
, vol.51
, pp. 5871-5874
-
-
Coburger, C.1
Wollmann, J.2
Baumert, C.3
-
97
-
-
41649087983
-
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells
-
Fong WF, Shen XL, Globisch C, et al. Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. Bioorg Med Chem 2008; 16: 3694-3703.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 3694-3703
-
-
Fong, W.F.1
Shen, X.L.2
Globisch, C.3
-
98
-
-
68349131384
-
Development of decision tree models for substrates, inhibitors, and inducers of p-glycoprotein
-
Hammann F, Gutmann H, Jecklin U, Maunz A, Helma C, Drewe J. Development of decision tree models for substrates, inhibitors, and inducers of p-glycoprotein. Curr Drug Metab 2009; 10: 339-346.
-
(2009)
Curr Drug Metab
, vol.10
, pp. 339-346
-
-
Hammann, F.1
Gutmann, H.2
Jecklin, U.3
Maunz, A.4
Helma, C.5
Drewe, J.6
-
99
-
-
65549092069
-
Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: Structure- activity relationships
-
Chan KF, Zhao Y, Chow TW, et al. Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure- activity relationships. ChemMedChem 2009; 4: 594-614.
-
(2009)
ChemMedChem
, vol.4
, pp. 594-614
-
-
Chan, K.F.1
Zhao, Y.2
Chow, T.W.3
-
100
-
-
77956304287
-
A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport
-
Sheu MT, Liou YB, Kao YH, Lin YK, Ho HO. A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport. Chem Pharm Bull (Tokyo) 2010; 58: 1187-1194.
-
(2010)
Chem Pharm Bull (Tokyo)
, vol.58
, pp. 1187-1194
-
-
Sheu, M.T.1
Liou, Y.B.2
Kao, Y.H.3
Lin, Y.K.4
Ho, H.O.5
-
101
-
-
79952779478
-
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields
-
Broccatelli F, Carosati E, Neri A, et al. A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields. J Med Chem 2011; 54: 1740-1751.
-
(2011)
J Med Chem
, vol.54
, pp. 1740-1751
-
-
Broccatelli, F.1
Carosati, E.2
Neri, A.3
-
102
-
-
0142026020
-
Quantitative structureactivity relationship methods: Perspectives on drug discovery and toxicology
-
Perkins R, Fang H, Tong W, Welsh WJ. Quantitative structureactivity relationship methods: perspectives on drug discovery and toxicology. Environ Toxicol Chem 2003; 22: 1666-1679.
-
(2003)
Environ Toxicol Chem
, vol.22
, pp. 1666-1679
-
-
Perkins, R.1
Fang, H.2
Tong, W.3
Welsh, W.J.4
-
103
-
-
77958099641
-
Multiple drug resistance mechanisms in cancer
-
Baguley BC. Multiple drug resistance mechanisms in cancer. Mol Biotechnol 2010; 46: 308-316.
-
(2010)
Mol Biotechnol
, vol.46
, pp. 308-316
-
-
Baguley, B.C.1
-
104
-
-
84866311240
-
-
Puzyn T, Leszczynski J, Cronin MT. Multiple regression, principal components analysis, cluster analysis, and partial-least squares New York 2009.
-
(2009)
Multiple Regression, Principal Components Analysis, Cluster Analysis, and Partial-least Squares New York
-
-
Puzyn, T.1
Leszczynski, J.2
Cronin, M.T.3
-
105
-
-
0028874573
-
Strategies and recent technologies in drug discovery
-
Kubinyi H. Strategies and recent technologies in drug discovery. Pharmazie 1995; 50: 647-662.
-
(1995)
Pharmazie
, vol.50
, pp. 647-662
-
-
Kubinyi, H.1
-
106
-
-
35448949586
-
Mini review on molecular modeling of P-glycoprotein (Pgp)
-
Ha SN, Hochman J, Sheridan RP. Mini review on molecular modeling of P-glycoprotein (Pgp). Curr Top Med Chem 2007; 7: 1525-1529.
-
(2007)
Curr Top Med Chem
, vol.7
, pp. 1525-1529
-
-
Ha, S.N.1
Hochman, J.2
Sheridan, R.P.3
-
107
-
-
79953327578
-
Genetic algorithm optimization in drug design QSAR: Bayesian-regularized genetic neural networks (BRGNN) and genetic algorithm-optimized support vectors machines (GA-SVM)
-
Fernandez M, Caballero J, Fernandez L, Sarai A. Genetic algorithm optimization in drug design QSAR: Bayesian-regularized genetic neural networks (BRGNN) and genetic algorithm-optimized support vectors machines (GA-SVM). Mol Divers 2010; 15: 269-289.
-
(2010)
Mol Divers
, vol.15
, pp. 269-289
-
-
Fernandez, M.1
Caballero, J.2
Fernandez, L.3
Sarai, A.4
-
108
-
-
0037204543
-
Progress in understanding the structure- activity relationships of P-glycoprotein
-
Stouch TR, Gudmundsson O. Progress in understanding the structure- activity relationships of P-glycoprotein. Adv Drug Deliv Rev 2002; 54: 315-328.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 315-328
-
-
Stouch, T.R.1
Gudmundsson, O.2
-
109
-
-
0028879438
-
Structure-activity-relationship studies on modulators of the multidrug transporter P-glycoprotein--an overview
-
Ecker G, Chiba P. Structure-activity-relationship studies on modulators of the multidrug transporter P-glycoprotein--an overview. Wien Klin Wochenschr 1995; 107: 681-686.
-
(1995)
Wien Klin Wochenschr
, vol.107
, pp. 681-686
-
-
Ecker, G.1
Chiba, P.2
-
110
-
-
17444419056
-
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRINDbased 3D-QSAR
-
Cianchetta G, Singleton RW, Zhang M, et al. A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRINDbased 3D-QSAR. J Med Chem 2005; 48: 2927-2935.
-
(2005)
J Med Chem
, vol.48
, pp. 2927-2935
-
-
Cianchetta, G.1
Singleton, R.W.2
Zhang, M.3
-
111
-
-
77958126601
-
Recent advances in fragment-based QSAR and multi-dimensional QSAR methods
-
Myint KZ, Xie XQ. Recent advances in fragment-based QSAR and multi-dimensional QSAR methods. Int J Mol Sci 2010; 11: 3846-3866.
-
(2010)
Int J Mol Sci
, vol.11
, pp. 3846-3866
-
-
Myint, K.Z.1
Xie, X.Q.2
-
112
-
-
0031406294
-
Molecular modeling study of the multidrug resistance modifiers cis- and trans-flupentixol
-
Wiese M, Pajeva IK. Molecular modeling study of the multidrug resistance modifiers cis- and trans-flupentixol. Pharmazie 1997; 52: 679-685.
-
(1997)
Pharmazie
, vol.52
, pp. 679-685
-
-
Wiese, M.1
Pajeva, I.K.2
-
113
-
-
0032554868
-
Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: A comparative molecular field analysis study
-
Pajeva I, Wiese M. Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: a comparative molecular field analysis study. J Med Chem 1998; 41: 1815-1826.
-
(1998)
J Med Chem
, vol.41
, pp. 1815-1826
-
-
Pajeva, I.1
Wiese, M.2
-
114
-
-
1642540576
-
SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrugresistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter
-
Cortes-Selva F, Campillo M, Reyes CP, et al. SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrugresistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter. J Med Chem 2004; 47: 576-587.
-
(2004)
J Med Chem
, vol.47
, pp. 576-587
-
-
Cortes-Selva, F.1
Campillo, M.2
Reyes, C.P.3
-
115
-
-
33748101221
-
Structure-activity relationship of natural and synthetic coumarins inhibiting the multidrug transporter P-glycoprotein
-
Raad I, Terreux R, Richomme P, et al. Structure-activity relationship of natural and synthetic coumarins inhibiting the multidrug transporter P-glycoprotein. Bioorg Med Chem 2006; 14: 6979-6987.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 6979-6987
-
-
Raad, I.1
Terreux, R.2
Richomme, P.3
-
116
-
-
34948839413
-
Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-betaagarofuran sesquiterpenes as modulators of P-glycoproteindependent multidrug resistance
-
Reyes CP, Munoz-Martinez F, Torrecillas IR, et al. Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-betaagarofuran sesquiterpenes as modulators of P-glycoproteindependent multidrug resistance. J Med Chem 2007; 50: 4808-4817.
-
(2007)
J Med Chem
, vol.50
, pp. 4808-4817
-
-
Reyes, C.P.1
Munoz-Martinez, F.2
Torrecillas, I.R.3
-
117
-
-
40749136927
-
Functional assay and structure-activity relationships of new third-generation Pglycoprotein inhibitors
-
Muller H, Pajeva IK, Globisch C, Wiese M. Functional assay and structure-activity relationships of new third-generation Pglycoprotein inhibitors. Bioorg Med Chem 2008; 16: 2448-2462.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 2448-2462
-
-
Muller, H.1
Pajeva, I.K.2
Globisch, C.3
Wiese, M.4
-
118
-
-
78951492928
-
In Silico Quantitative Structure-Activity Relationship Studies on P-gp Modulators of Tetrahydroisoquinoline-Ethyl-Phenylamine Series
-
Gadhe CG, Madhavan T, Kothandan G, Cho SJ. In Silico Quantitative Structure-Activity Relationship Studies on P-gp Modulators of Tetrahydroisoquinoline-Ethyl-Phenylamine Series. BMC Struct Biol 2011; 11: 5.
-
(2011)
BMC Struct Biol
, vol.11
, pp. 5
-
-
Gadhe, C.G.1
Madhavan, T.2
Kothandan, G.3
Cho, S.J.4
-
119
-
-
80052957000
-
Docking and 3D-QSAR (Quantitative Structure Activity Relationship) Studies of Flavones, the Potent Inhibitors of p-Glycoprotein Targeting the Nucleotide Binding Domain
-
In Press
-
Kothandan G, Gadhe CG, Madhavan T, Choi CH, Cho SJ. Docking and 3D-QSAR (Quantitative Structure Activity Relationship) Studies of Flavones, the Potent Inhibitors of p-Glycoprotein Targeting the Nucleotide Binding Domain. European Journal of Medicinal Chemistry 2011; In Press.
-
(2011)
European Journal of Medicinal Chemistry
-
-
Kothandan, G.1
Gadhe, C.G.2
Madhavan, T.3
Choi, C.H.4
Cho, S.J.5
-
120
-
-
0032518454
-
A general pattern for substrate recognition by Pglycoprotein
-
Seelig A. A general pattern for substrate recognition by Pglycoprotein. Eur J Biochem 1998; 251: 252-261.
-
(1998)
Eur J Biochem
, vol.251
, pp. 252-261
-
-
Seelig, A.1
-
121
-
-
0036893219
-
Characterization of two pharmacophores on the multidrug transporter P-glycoprotein
-
Garrigues A, Loiseau N, Delaforge M, et al. Characterization of two pharmacophores on the multidrug transporter P-glycoprotein. Mol Pharmacol 2002; 62: 1288-1298.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1288-1298
-
-
Garrigues, A.1
Loiseau, N.2
Delaforge, M.3
-
122
-
-
18344364851
-
Application of threedimensional quantitative structure-activity relationships of Pglycoprotein inhibitors and substrates
-
Ekins S, Kim RB, Leake BF, et al. Application of threedimensional quantitative structure-activity relationships of Pglycoprotein inhibitors and substrates. Mol Pharmacol 2002; 61: 974-981.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 974-981
-
-
Ekins, S.1
Kim, R.B.2
Leake, B.F.3
-
123
-
-
0037171818
-
A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein
-
Penzotti JE, Lamb ML, Evensen E, Grootenhuis PD. A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein. J Med Chem 2002; 45: 1737-1740.
-
(2002)
J Med Chem
, vol.45
, pp. 1737-1740
-
-
Penzotti, J.E.1
Lamb, M.L.2
Evensen, E.3
Grootenhuis, P.D.4
-
124
-
-
33751525373
-
Rapid identification of P-glycoprotein substrates and inhibitors
-
Chang C, Bahadduri PM, Polli JE, Swaan PW, Ekins S. Rapid identification of P-glycoprotein substrates and inhibitors. Drug Metab Dispos 2006; 34: 1976-1984.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1976-1984
-
-
Chang, C.1
Bahadduri, P.M.2
Polli, J.E.3
Swaan, P.W.4
Ekins, S.5
-
125
-
-
70449714688
-
Combined pharmacophore modeling, docking, and 3D QSAR studies of ABCB1 and ABCC1 transporter inhibitors
-
Pajeva IK, Globisch C, Wiese M. Combined pharmacophore modeling, docking, and 3D QSAR studies of ABCB1 and ABCC1 transporter inhibitors. ChemMedChem 2009; 4: 1883-1896.
-
(2009)
ChemMedChem
, vol.4
, pp. 1883-1896
-
-
Pajeva, I.K.1
Globisch, C.2
Wiese, M.3
-
126
-
-
79958812376
-
New Uses for Old Drugs: Pharmacophore-Based Screening for the Discovery of P-Glycoprotein Inhibitors
-
Palmeira A, Rodrigues F, Sousa E, Pinto M, Vasconcelos MH, Fernandes MX. New Uses for Old Drugs: Pharmacophore-Based Screening for the Discovery of P-Glycoprotein Inhibitors. Chem Biol Drug Des 2011; 78: 57-72.
-
(2011)
Chem Biol Drug Des
, vol.78
, pp. 57-72
-
-
Palmeira, A.1
Rodrigues, F.2
Sousa, E.3
Pinto, M.4
Vasconcelos, M.H.5
Fernandes, M.X.6
-
127
-
-
79959764016
-
Toward a Better Pharmacophore Description of P-Glycoprotein Modulators, Based on Macrocyclic Diterpenes from Euphorbia Species
-
Ferreira RJ, Dos Santos DJ, Ferreira MJ, Guedes RC. Toward a Better Pharmacophore Description of P-Glycoprotein Modulators, Based on Macrocyclic Diterpenes from Euphorbia Species. J Chem Inf Model 2011; 51: 1315-1324.
-
(2011)
J Chem Inf Model
, vol.51
, pp. 1315-1324
-
-
Ferreira, R.J.1
Dos Santos, D.J.2
Ferreira, M.J.3
Guedes, R.C.4
-
128
-
-
4043109757
-
Lead identification for modulators of multidrug resistance based on in silico screening with a pharmacophoric feature model
-
Langer T, Eder M, Hoffmann RD, Chiba P, Ecker GF. Lead identification for modulators of multidrug resistance based on in silico screening with a pharmacophoric feature model. Arch Pharm (Weinheim) 2004; 337: 317-327.
-
(2004)
Arch Pharm (Weinheim)
, vol.337
, pp. 317-327
-
-
Langer, T.1
Eder, M.2
Hoffmann, R.D.3
Chiba, P.4
Ecker, G.F.5
-
129
-
-
0035047222
-
Structure-activity relationships of multidrug resistance reversers
-
Wiese M, Pajeva IK. Structure-activity relationships of multidrug resistance reversers. Curr Med Chem 2001; 8: 685-713.
-
(2001)
Curr Med Chem
, vol.8
, pp. 685-713
-
-
Wiese, M.1
Pajeva, I.K.2
-
130
-
-
0037252194
-
Chris Lipinski discusses life and chemistry after the Rule of Five
-
Lipinski CA. Chris Lipinski discusses life and chemistry after the Rule of Five. Drug Discov Today 2003; 8: 12-16.
-
(2003)
Drug Discov Today
, vol.8
, pp. 12-16
-
-
Lipinski, C.A.1
-
131
-
-
1842586876
-
Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model
-
Gombar VK, Polli JW, Humphreys JE, Wring SA, Serabjit-Singh CS. Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model. J Pharm Sci 2004; 93: 957-968.
-
(2004)
J Pharm Sci
, vol.93
, pp. 957-968
-
-
Gombar, V.K.1
Polli, J.W.2
Humphreys, J.E.3
Wring, S.A.4
Serabjit-Singh, C.S.5
-
133
-
-
0035674849
-
Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein
-
Taylor AM, Storm J, Soceneantu L, et al. Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein. Br J Pharmacol 2001; 134: 1609-1618.
-
(2001)
Br J Pharmacol
, vol.134
, pp. 1609-1618
-
-
Taylor, A.M.1
Storm, J.2
Soceneantu, L.3
|