Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships

Journal of Medicinal Chemistry

Volumn 42, Issue 3, 1999, Pages 478-489

  Ferté, Jacques ^a   Kühnel, Jean Marc ^a,c   Chapuis, Geneviève ^a,b   Rolland, Yves ^b   Lewin, Guy ^a   Schwaller, Marc A ^a  

^a CNRS   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,3' DIHYDROXY 4' METHOXY 7 [4 [(2,3,4 TRIMETHOXYPHENYL)METHYL]PIPERAZIN 1 YLCARBONYLMETHOXY]FLAVANONE; 5,3' DIHYDROXY 4' METHOXY 7 [4 [(2,3,4 TRIMETHOXYPHENYL)METHYL]PIPERAZIN 1 YLCARBONYLMETHOXY]FLAVONE; 5,3' DIPIVALOXY 4' METHOXY 7 [4 [(2,3,4 TRIMETHOXYPHENYL)METHYL]PIPERAZIN 1 YLCARBONYLMETHOXY]FLAVANONE; 7,3' BIS(BENZYLOXY) 4' METHOXY 5 [4 [(2,3,4 TRIMETHOXYPHENYL)METHYL]PIPERAZIN 1 YLCARBONYLMETHOXY]FLAVONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; FLAVONOID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CELL STRAIN K 562; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOTOPE LABELING; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION;

ANTIBIOTICS, ANTINEOPLASTIC; CALCIUM CHANNEL BLOCKERS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; FLAVONOIDS; HUMANS; K562 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; VERAPAMIL;

EID: 0345491352     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981064b     Document Type: Article

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