SAR Studies of Dihydro-β-agarofuran Sesquiterpenes as Inhibitors of the Multidrug-Resistance Phenotype in a Leishmania tropica Line Overexpressing a P-Glycoprotein-Like Transporter

Journal of Medicinal Chemistry

Volumn 47, Issue 3, 2004, Pages 576-587

  Cortés Selva, Fernando ^a   Campillo, Mercedes ^b   Reyes, Carolina P ^c   Jiménez, Ignacio A ^c   Castanys, Santiago ^a   Bazzocchi, Isabel L ^c   Pardo, Leonardo ^b   Gamarro, Francisco ^a   Ravelo, Angel G ^c  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b INSTITUT DE NEUROCIÈNCIES   (Spain)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROFURAN DERIVATIVE; CARRIER PROTEIN; DIHYDRO BETA AGAROFURAN; GLYCOPROTEIN P; HYDROGEN; P GLYCOPROTEIN LIKE TRANSPORTER; SESQUITERPENE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; DRUG EFFICACY; DRUG ISOLATION; DRUG STRUCTURE; HYDROGEN BOND; LEISHMANIA TROPICA; LIPOPHILICITY; MAYTENUS; MAYTENUS CUZCOINA; MEDICINAL PLANT; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PLANT LEAF; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, MULTIPLE; FLUORESCEINS; FLUORESCENT DYES; LEISHMANIA TROPICA; MODELS, MOLECULAR; PHENOTYPE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SESQUITERPENES; TRYPANOCIDAL AGENTS;

EID: 1642540576     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0309699     Document Type: Article

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