Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocyclic diterpenes from euphorbia species

Journal of Chemical Information and Modeling

Volumn 51, Issue 6, 2011, Pages 1315-1324

  Ferreira, Ricardo J ^a   Dos Santos, Daniel J V A ^a   Ferreira, Maria José U ^a   Guedes, Rita C ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; HYDROGEN BONDS; HYDROPHOBICITY; MOLECULES;

CHEMOTHERAPEUTIC TREATMENTS; DRUG BINDING SITES; ELECTRON ACCEPTOR MOIETIES; ESSENTIAL FEATURES; ISOLATED COMPOUNDS; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; PROTONATION STATE;

PHARMACODYNAMICS;

DITERPENE; GLYCOPROTEIN P; MACROCYCLIC COMPOUND; RESERPINE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DATA MINING; DRUG DEVELOPMENT; ENZYME SPECIFICITY; EUPHORBIA; FACTUAL DATABASE; HUMAN; METABOLISM; METHODOLOGY; PROTEIN CONFORMATION;

DATA MINING; DATABASES, FACTUAL; DITERPENES; DRUG DISCOVERY; EUPHORBIA; HUMANS; MACROCYCLIC COMPOUNDS; MODELS, MOLECULAR; P-GLYCOPROTEINS; PROTEIN CONFORMATION; RESERPINE; SUBSTRATE SPECIFICITY;

EID: 79959764016     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci200145p     Document Type: Article

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