Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5′-fluorosulfonylbenzoyl 5′-adenosine: Evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites

Biochemistry

Volumn 50, Issue 18, 2011, Pages 3724-3735

  Ohnuma, Shinobu ^a   Chufan, Eduardo ^a   Nandigama, Krishnamachary ^a   Jenkins, Lisa M Miller ^a   Durell, Stewart R ^a   Appella, Ettore ^a   Sauna, Zuben E ^b   Ambudkar, Suresh V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPATHIC; ANTI-CANCER AGENTS; ATP HYDROLYSIS; ATP-BINDING CASSETTE TRANSPORTERS; ATP-BINDING SITE; ATPASES; BIOCHEMICAL STUDIES; CANCER CELLS; CATALYTIC CYCLES; COVALENT MODIFICATIONS; HOMOLOGY MODELS; MASS SPECTROMETRIC ANALYSIS; MULTIDRUG RESISTANCE; NUCLEOTIDE-BINDING DOMAIN; NUCLEOTIDE-BINDING SITES; P-GLYCOPROTEIN; PHOTOCROSS-LINKING; RHODAMINE 123; SATURATING CONCENTRATION; TRANS-MEMBRANE DOMAINS; TRANSPORT SUBSTRATES;

ACTIVATION ANALYSIS; BINDING ENERGY; BIOCHEMISTRY; DRUG INTERACTIONS; GLYCOPROTEINS; HYDROLYSIS; NUCLEOTIDES;

BINDING SITES;

5' FLUOROSULFONYLBENZOYL 5' ADENOSINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; IODOARYLAZIDOPRAZOSIN I 125; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEOTIDE BINDING PROTEIN; PRAZOSIN; RHODAMINE 123; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME SUBSTRATE; HYDROLYSIS; IC 50; MASS SPECTROMETRY; MEMBRANE POTENTIAL; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TRANSPORT;

ADENOSINE; ADENOSINE TRIPHOSPHATE; AFFINITY LABELS; BINDING SITES; CROSS-LINKING REAGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MASS SPECTROMETRY; NUCLEOTIDES; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN TRANSPORT;

EID: 79955629985     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200073f     Document Type: Article

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