The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment

FEBS Letters

Volumn 579, Issue 18, 2005, Pages 3984-3990

  Rothnie, Alice ^a   Storm, Janet ^a   McMahon, Roisin ^a   Taylor, Andrew ^a   Kerr, Ian D ^b   Callaghan, Richard ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Coupling; Drug transport; Multidrug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATE; COUMARIN; CYSTEINE; GLYCOPROTEIN P; MALEIMIDE; NICARDIPINE; PACLITAXEL; TARIQUIDAR; THIOL; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING; DRUG POTENCY; HYDROLYSIS; INSECT CELL; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; BACULOVIRIDAE; BINDING SITES; CATALYSIS; CELL LINE; CELL MEMBRANE; COUMARINS; CYSTEINE; HYDROLYSIS; INSECTS; KINETICS; LINEAR MODELS; MUTAGENESIS, SITE-DIRECTED; NICARDIPINE; P-GLYCOPROTEIN; PACLITAXEL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; QUINOLINES; RECOMBINANT PROTEINS; SULFHYDRYL COMPOUNDS; TIME FACTORS; VINBLASTINE;

EID: 21844451868     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.06.030     Document Type: Article

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