ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

Molecular Cell

Volumn 10, Issue 1, 2002, Pages 139-149

  Smith, Paul C ^a   Karpowich, Nathan ^a   Millen, Linda ^b   Moody, Jonathan E ^b   Rosen, Jane ^a   Thomas, Philip J ^b   Hunt, John F ^a  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER;

ARTICLE; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; MUTATION; PROTEIN DOMAIN; PROTEIN MOTIF; STEREOCHEMISTRY;

EID: 0036342413     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00576-2     Document Type: Article

References (44)

1. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
2. Crystallography & NMR system: A new software suite for macromolecular structure determination
3. Structure of MsbA from E. coli: A homolog of the multidrug resistance ATP binding cassette (ABC) transporters
4. The CCP4 suite: Programs for protein crystallography
5. Analytical molecular surface calculation
6. The escherichia coli ABC transporters: An update
7. Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transporters
8. Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon thermococcus litoralis
9. Accurate bond and angle parameters for x-ray protein structure refinement
10. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing
11. P-glycoprotein and multidrug resistance
12. Molecular and biochemical analysis of MalK, the ATP-hydrolyzing subunit of the trehalose/maltose transport system of the hyperthermophilic archaeon Thermococcus litoralis
13. ABC transporters: From microorganisms to man
14. ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans
15. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
16. Crystal structure of the ATP-binding subunit of an ABC transporter
17. Subunit interactions in ABC transporters: Towards a functional architecture
18. Improved methods for building protein models in electron density maps and the location of errors in these models
19. Crystal structures of the MJ1267 ATP-binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter
20. The crystal structure of Na-ATP
21. Protein exporter function and in vitro ATPase activity are correlated in ABC-domain mutants of HlyB
22. Molscript: A program to produce both detailed and schematic plots of proteins
23. Procheck: A program to check the stereochemical quality of protein structures
24. Shape complementarity at protein/protein interfaces
25. The Escherichia coli ATP-binding cassette (ABC) proteins
26. Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains
27. The E. coli BtuCD structure: A framework for ABC transporter architecture and mechanism
28. Raster3D photorealistic molecular graphics
29. Cooperative, ATP-dependent dimerization of ATP-binding cassettes during the catalytic cycle of ABC transporters
30. AMoRe: An automated package for molecular replacement
31. Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity
32. Processing of x-ray diffraction data collected in oscillation mode
33. Microbial genome analyses: Global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities
34. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
35. Functional consequences of mutations in the conserved 'signature sequence' of the ATP-binding-cassette protein MalK
36. Nucleotide-induced conformational changes of MalK, a bacterial ATP binding cassette transporter protein
37. A snapshot of Nature's favorite pump
38. Investigation of the role of glutamine-471 and glutamine-1114 in the two catalytic sites of P-glycoprotein
39. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
40. Beta-turns and their distortions: A proposed new nomenclature
41. The crystal structure of the MJ0796 ATP-binding cassette: Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter