Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

EMBO Journal

Volumn 20, Issue 20, 2001, Pages 5615-5625

  Rosenberg, Mark F ^a   Velarde, Giles ^a   Ford, Robert C ^a   Martin, Catherine ^b   Berridge, Georgina ^b   Kerr, Ian D ^b   Callaghan, Richard ^b   Schmidlin, Andreas ^c   Wooding, Carol ^c   Linton, Kenneth J ^c   Higgins, Christopher F ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

ABC transporters; Membrane protein structure; Multidrug resistance; Two dimensional crystals

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; MEMBRANE PROTEIN; NUCLEOTIDE;

ARTICLE; CELL MEMBRANE TRANSPORT; CONFORMATIONAL TRANSITION; ELECTRON MICROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PURIFICATION; PROTEIN TRANSPORT;

4-CHLOROMERCURIBENZENESULFONATE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; CATALYSIS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CRYOELECTRON MICROSCOPY; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; HYDROLYSIS; INSECTS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; P-CHLOROMERCURIBENZOIC ACID; P-GLYCOPROTEIN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 17944370228     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.20.5615     Document Type: Article

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