A novel function of interleukin-10 promoting self-renewal of hematopoietic stem cells

Stem Cells

Volumn 25, Issue 7, 2007, Pages 1814-1822

  Kang, Young Ju ^a   Yang, Seung Jip ^a   Park, Gyeongsin ^a   Cho, Bin ^a   Min, Chang Ki ^a   Kim, Tae Yoon ^a   Lee, Joon Sung ^a   Oh, Il Hoan ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Hematopoiesis; Self renewal; Stem cells; Transplantation

Indexed keywords

FLUOROURACIL; INTERLEUKIN 10;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL ACTIVITY; CELL CULTURE; CELL MATURATION; CELL POPULATION; CELL RENEWAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HEMATOPOIETIC STEM CELL; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MICROENVIRONMENT; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN FUNCTION; STEADY STATE; STEM CELL TRANSPLANTATION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELL DIVISION; CELLS, CULTURED; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-10; LIGANDS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER; STROMAL CELLS;

CUCURBITA; MUS;

EID: 34547201175     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0002     Document Type: Article

References (62)

1. Eaves C, Miller C, Cashman J et al. Hematopoietic stem cells: Inferences from in vivo assays. STEM CELLS 1997;15(suppl 1):1-5.
2. Dick JE, Magli MC, Huszar D et al. Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell 1985;42:71-79.
3. Lemischka IR, Raulet DH, Mulligan RC. Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 1986;45:917-927.
4. Szilvassy SJ, Humphries RK, Lansdorp PM et al. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci U S A 1990;87:8736-8740.
5. Szilvassy SJ NF, Eaves C, Miller CL. Quantitation of murine and human hematopoietic stem cells by limiting-dilution analysis in competitively repopulated hosts. In: Klug CA, Jordan CT, eds. Hematopoietic Stem Cell Protocols. New Jersey: Humana Press, 2002:167-187.
6. Bhatia M, Bonnet D, Kapp U et al. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 1997;186:619-624.
7. Pawliuk R, Eaves C, Humphries RK. Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo. Blood 1996;88:2852-2858.
8. Siminovitch L, McCulloch EA, Till JE. The distribution of colony-forming cells among spleen colonies. J Cell Physiol 1963;62:327-336.
9. Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 2002;109:39-45.
10. Sauvageau G, Thorsteinsdottir U, Eaves CJ et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 1995;9:1753-1765.
11. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-260.
12. Park IK, Qian D, Kiel M et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003;423:302-305.
13. Zhang P, Iwasaki-Arai J, Iwasaki H et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 2004;21:853-863.
14. Chung YJ, Park BB, Kang YJ et al. Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration. Blood 2006;108:1208-1215.
15. Cheng T, Rodrigues N, Shen H et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 2000;287:1804-1808.
16. Ema H, Takano H, Sudo K et al. In vitro self-renewal division of hematopoietic stem cells. J Exp Med 2000;192:1281-1288.
17. Fox N, Priestley G, Papayannopoulou T et al. Thrombopoietin expands hematopoietic stem cells after transplantation. J Clin Invest 2002;110:389-394.
18. Miller CL, Eaves CJ. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci U S A 1997;94:13648-13653.
19. Audet J, Miller CL, Rose-John S et al. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc Natl Acad Sci U S A 2001;98:1757-1762.
20. Reya T, Duncan AW, Ailles L et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003;423:409-414.
21. Ohishi K, Katayama N, Shiku H et al. Notch signalling in hematopoiesis. Semin Cell Dev Biol 2003;14:143-150.
22. Zandstra PW, Conneally E, Petzer AL et al. Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci U S A 1997;94:4698-4703.
23. Zhang CC, Kaba M, Ge G et al. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med 2006;12:240-245.
24. Stier S, Ko Y, Forkert R et al. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med 2005;201:1781-1791.
25. Christopherson KW 2nd, Hangoc G, Mantel CR et al. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004;305:1000-1003.
26. Ito K, Hirao A, Arai F et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004;431:997-1002.
27. Pestka S, Krause CD, Sarkar D et al. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol 2004;22:929-979.
28. Kuhn R, Lohler J, Rennick D et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993;75:263-274.
29. Bettelli E, Das MP, Howard ED et al. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 1998;161:3299-3306.
30. Samoilova EB, Horton JL, Chen Y. Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: Roles of interleukin-10 in disease progression and recovery. Cell Immunol 1998;188:118-124.
31. Fine JS, Macosko HD, Grace MJ et al. Influence of IL-10 on murine CFU-pre-B formation. Exp Hematol 1994;22:1188-1196.
32. Rennick D, Hunte B, Dang W et al. Interleukin-10 promotes the growth of megakaryocyte, mast cell, and multilineage colonies: Analysis with committed progenitors and Thy1loSca1+ stem cells. Exp Hematol 1994;22:136-141.
33. Sosman JA, Verma A, Moss S et al. Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: Evidence for decreased platelet production. Br J Haematol 2000;111:104-111.
34. Wagner T, Fritsch G, Thalhammer R et al. IL-10 increases the number of CFU-GM generated by ex vivo expansion of unmanipulated human MNCs and selected CD34+ cells. Transfusion 2001;41:659-666.
35. Wang CQ, Udupa KB, Lipschitz DA. Evidence suggesting a stimulatory role for interleukin-10 in erythropoiesis in vitro. J Cell Physiol 1996;166:305-310.
36. Asano Y, Shibata S, Kobayashi S et al. Effect of interleukin 10 on the hematopoietic progenitor cells from patients with aplastic anemia. STEM CELLS 1999;17:147-151.
37. Geissler K, Kabrna E, Kollars M et al. Interleukin-10 inhibits in vitro hematopoietic suppression and production of interferon-gamma and tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with aplastic anemia. Hematol J 2002;3:206-213.
38. Oehler L, Foedinger M, Koeller M et al. Interleukin-10 inhibits spontaneous colony-forming unit-granulocyte-macrophage growth from human peripheral blood mononuclear cells by suppression of endogenous granulocyte-macrophage colony-stimulating factor release. Blood 1997;89:1147-1153.
39. Goodell MA, Brose K, Paradis G et al. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 1996;183:1797-1806.
40. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-74.
41. Oh IH, Eaves CJ. Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity. Oncogene 2002;21:4778-4787.
42. Oh IH, Fabry ME, Humphries RK et al. Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells. Exp Hematol 2004;32:461-469.
43. Lemieux ME, Rebel VI, Lansdorp PM et al. Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures. Blood 1995;86:1339-1347.
44. Zhang PJ, Goldblum JR, Pawel BR et al. PDGF-A, PDGF-Rbeta, TGF-beta3 and bone morphogenic protein-4 in desmoplastic small round cell tumors with EWS-WT1 gene fusion product and their role in stromal desmoplasia: An immunohistochemical study. Mod Pathol 2005;18:382-387.
45. Agnello D, Villa P, Ghezzi P. Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10- deficient mice. Brain Res 2000;869:241-243.
46. Szilvassy SJ, Cory S. Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow. Blood 1993;81:2310-2320.
47. Selleri C, Sato T, Anderson S et al. Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol 1995;165:538-546.
48. Snoeck HW, Van Bockstaele DR, Nys G et al. Interferon gamma selectively inhibits very primitive CD342+CD38- and not more mature CD34+CD38+ human hematopoietic progenitor cells. J Exp Med 1994;180:1177-1182.
49. Oh IH, Lau A, Eaves CJ. During ontogeny primitive (CD34(+)CD38(-)) hematopoietic cells show altered expression of a subset of genes associated with early cytokine and differentiation responses of their adult counterparts. Blood 2000;96:4160-4168.
50. Zhang CC, Lodish HF. Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood 2005;105:4314-4320.
51. Matsuzaki Y, Kinjo K, Mulligan RC et al. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 2004;20:87-93.
52. Calvi LM, Adams GB, Weibrecht KW et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-846.
53. Zhang J, Niu C, Ye L et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-841.
54. Sauvageau G, Iscove NN, Humphries RK. In vitro and in vivo expansion of hematopoietic stem cells. Oncogene 2004;23:7223-7232.
55. Keil F, Elahi F, Greinix HT et al. Ex vivo expansion of long-term culture initiating marrow cells by IL-10, SCF, and IL-3. Transfusion 2002;42:581-587.
56. Veiby OP, Borge OJ, Martensson A et al. Bidirectional effect of interleukin-10 on early murine B-cell development: Stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells. Blood 1997;90:4321-4331.
57. Zandstra PW, Conneally E, Piret JM et al. Ontogeny-associated changes in the cytokine responses of primitive human haemopoietic cells. Br J Haematol 1998;101:770-778.
58. Conneally E, Eaves CJ, Humphries RK. Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential. Blood 1998;91:3487-3493.
59. Tilg H, Ulmer H, Kaser A et al. Role of IL-10 for induction of anemia during inflammation. J Immunol 2002;169:2204-2209.
60. Papadaki HA, Kritikos HD, Gemetzi C et al. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: Evidence for a tumor necrosis factor alpha-mediated effect. Blood 2002;99:1610-1619.
61. Porta C, Caporali R, Epis O et al. Impaired bone marrow hematopoietic progenitor cell function in rheumatoid arthritis patients candidated to autologous hematopoietic stem cell transplantation. Bone Marrow Transplant 2004;33:721-728.
62. Boggs DR. The total marrow mass of the mouse: A simplified method of measurement. Am J Hematol 1984;16:277-286.